Analysis of miRNA Profiles and the Regulatory Network in Congenital Pulmonary Airway Malformations DOI Creative Commons
Jiahang Zeng, Wei Liu, Jianhua Liang

et al.

Frontiers in Pediatrics, Journal Year: 2021, Volume and Issue: 9

Published: Nov. 18, 2021

Background: Specific diagnostic markers for congenital pulmonary airway malformations (CPAMs) have not yet been discovered. This study intends to detect differentially expressed miRNAs in type I and II CPAMs by using a miRNA chip clarify the feasibility of as different CPAM typing markers. Methods: Lung tissues were collected used assess after evaluation hematoxylin-eosin staining Masson staining. Quantitative reverse transcription-polymerase chain reaction fluorescence situ hybridization verify quality chip. The function pathways related analyzed Gene Ontology Enrichment (GO) analysis Kyoto Encyclopedia Genes Genomes (KEGG) analysis, respectively. Targets predicted targetscan7.1 mirdbV6 network between mRNA was established Cystoscope software. Results: In total, 394/34 upregulated 321/72 downregulated found CPAMs, GO KEGG showed that are involved regulation CPAM, including platelet activation, Ras, MAPK, FoxO, PI3K-Akt signaling pathways. miRNA-mRNA confirmed four major miR-4731-5p complexin 2, miR-3150a-3p vesicle amine transport 1, miR-32-5p F-box WD repeat domain containing 7, miR-454-3p SLAIN motif family member 1. Conclusion: summary, we identified candidate pattern which provide new perspective research treatment.

Language: Английский

Combating sepsis-induced acute lung injury: PARP1 inhibition mediates oxidative stress mitigation and miR-135a-5p/SMAD5/Nanog axis drives regeneration DOI
Salman Khan,

Almaz Zaki,

Muhammad Irfan Masood

et al.

International Immunopharmacology, Journal Year: 2025, Volume and Issue: 148, P. 114166 - 114166

Published: Jan. 29, 2025

Language: Английский

Citations

0
Analysis of PANoptosis-related genes in septic cardiomyopathy by bioinformatics, machine learning and experimental validation DOI Creative Commons
Yiheng Yang, Peng Yang, Xianbin Huang

et al.

Heliyon, Journal Year: 2025, Volume and Issue: unknown, P. e42882 - e42882

Published: Feb. 1, 2025

Language: Английский

Citations

0
The Role of miR‐144 in Inflammatory Diseases: A Review DOI Creative Commons
Shukun Hong,

Hongye Wang,

Lujun Qiao

et al.

Immunity Inflammation and Disease, Journal Year: 2025, Volume and Issue: 13(3)

Published: March 1, 2025

ABSTRACT Background Inflammation, often caused by various stimuli, is a common response to tissue homeostasis disruptions and considered key driver of many pathological conditions. MicroRNA‐144 (miR‐144) has emerged as critical regulator in inflammatory diseases, with its dysregulation implicated Understanding role mechanisms essential for developing therapeutic strategies. Objective This article aimed evaluate the miR‐144 diseases through literature review. Methods Electronic databases including PubMed, Web Science, Springer Link, China Knowledge Resource Integrated Database, Wanfang Data were searched relevant literature. The following keywords used combined differently according rules databases: “miR‐144,” “inflammation,” “inflammatory,” “immune response.” Studies investigating context inflammation included. extracted assess miR‐144's expression patterns association disease severity outcomes. Results was found be differentially expressed range sepsis, infectious respiratory cardiovascular digestive neuropsychiatric arthritis, pregnancy complications. varied depending on disease, both upregulation downregulation observed. modulation responses direct indirect targeting proteins pathways. review also highlighted potential diagnostic prognostic biomarker. Conclusion plays significant pathogenesis holds promise Its regulatory offer insights into processes may guide future However, further clinical studies are needed validate utility biomarker explore setting.

Language: Английский

Citations

0
An Insight into miR-1290: An Oncogenic miRNA with Diagnostic Potential DOI Open Access
Małgorzata Guz, Witold Jeleniewicz, Marek Cybulski

et al.

International Journal of Molecular Sciences, Journal Year: 2022, Volume and Issue: 23(3), P. 1234 - 1234

Published: Jan. 22, 2022

For more than two decades, the view of roles non-coding RNAs (ncRNAs) has been radically changing. These RNA molecules that are transcribed from our genome do not have capacity to encode proteins, but critical regulators gene expression at different levels. Our knowledge is constantly enriched by new reports revealing role these molecular players in development many pathological conditions, including cancer. One ncRNA classes includes short called microRNAs (miRNAs), which involved post-transcriptional control affecting various cellular processes. The aberrant miRNAs with oncogenic and tumor-suppressive function associated cancer initiation, promotion, malignant transformation, progression metastasis. Oncogenic miRNAs, also known as oncomirs, mediate downregulation tumor-suppressor genes their upregulated Nowadays, show promising application diagnosis, prediction, disease monitoring therapy response. review presents a current miR-1290 emphasis on its properties biomarker clinical medicine.

Language: Английский

Citations

20
Identification of Driver Genes and miRNAs in Ovarian Cancer through an Integrated In-Silico Approach DOI Creative Commons
Anam Beg,

Rafat Parveen,

Hassan Fouad

et al.

Biology, Journal Year: 2023, Volume and Issue: 12(2), P. 192 - 192

Published: Jan. 26, 2023

Ovarian cancer is the eighth-most common in women and has highest rate of death among all gynecological malignancies Western world. Increasing evidence shows that miRNAs are connected to progression ovarian cancer. In current study, we focus on identification miRNA its associated genes responsible for early prognosis patients with The microarray dataset GSE119055 used this study was retrieved via publicly available GEO database by NCBI analysis DEGs. includes six carcinoma samples along three healthy/primary samples. our DEM healthy subjects performed using R Software transform normalize transcriptomic data packages from Bioconductor. Results: We identified hub discovered top five upregulated (hsa-miR-130b-3p, hsa-miR-18a-5p, hsa-miR-182-5p, hsa-miR-187-3p, hsa-miR-378a-3p) downregulated (hsa-miR-501-3p, hsa-miR-4324, hsa-miR-500a-3p, hsa-miR-1271-5p, hsa-miR-660-5p) network their genes, which include seven (SCN2A, BCL2, MAF, ZNF532, CADM1, ELAVL2, ESRRG) were considered network. Similarly, found two (PRKACB TAOK1).

Language: Английский

Citations

12
Advancement in biomarker based effective diagnosis of neonatal sepsis DOI Creative Commons
Neha Gopal, Nidhi Chauhan, Utkarsh Jain

et al.

Artificial Cells Nanomedicine and Biotechnology, Journal Year: 2023, Volume and Issue: 51(1), P. 476 - 490

Published: Sept. 1, 2023

Neonatal sepsis is considered as alarming medical emergency and becomes the common global reason of neonatal mortality. Non-specific symptoms limitations conventional diagnostic methods for mandate fast reliable method to diagnose disease point care application. Recently, specific biomarkers have gained interest rapid diagnosis that led development electrochemical biosensor with enhanced specificity, sensitivity, cost-effectiveness user-friendliness. Other than biomarker C-reactive protein sepsis, several potential including Procalcitonin (PCT), Serum amyloid A (SAA) other candidates are extensively investigated. The present review provides insights on advancements abilities nucleotide based their incorporation in developing biosensors by employing novel fabrication strategies. This an overview most promising its capability fulfil future demand develop point-of-care applications.

Language: Английский

Citations

11
Intermittent hypoxia-reoxygenation-induced miRNAs inhibit expression of IRF and interferon genes but activate NF-κB and expression of pulmonary fibrosis markers in human small airway epithelial cells DOI
S.-H. Chen,

Cheng-Yu Jheng,

Yu-Chun Lee

et al.

Life Sciences, Journal Year: 2025, Volume and Issue: unknown, P. 123569 - 123569

Published: March 1, 2025

Language: Английский

Citations

0
Vitamin-D ameliorates sepsis-induced acute lung injury via augmenting miR-149-5p and downregulating ER stress DOI
Shaniya Ahmad,

Almaz Zaki,

Kailash Manda

et al.

The Journal of Nutritional Biochemistry, Journal Year: 2022, Volume and Issue: 110, P. 109130 - 109130

Published: Aug. 18, 2022

Language: Английский

Citations

16
RETRACTED: Exosomal microRNA-16-5p from adipose mesenchymal stem cells promotes TLR4-mediated M2 macrophage polarization in septic lung injury DOI
Jiakun Tian,

Xiaoqian Cui,

Jian Sun

et al.

International Immunopharmacology, Journal Year: 2021, Volume and Issue: 98, P. 107835 - 107835

Published: June 27, 2021

Language: Английский

Citations

18
Correlating tissue and plasma‑specific piRNA changes to predict their possible role in pancreatic malignancy and chronic inflammation DOI Open Access
Barsha Saha,

Shouvik Chakravarty,

Sukanta Ray

et al.

Biomedical Reports, Journal Year: 2024, Volume and Issue: 21(6)

Published: Oct. 7, 2024

The aggressiveness of pancreatic ductal adenocarcinoma is primarily due to lack effective early detection biomarkers. Circulating non-coding RNAs serve as diagnostic or prognostic biomarkers in multiple types cancer. Comparison their expression between diseased tissue and relevant body fluids such saliva, urine, bile, juice, blood etc. may reveal mechanistic involvement common RNAs. piwi-interacting (piRNAs) are a class aim the present study was investigate plasma tumour piRNA changes patients with cancer (PC) explore possible role tumorigenesis inflammation. Sequencing circulating small from PC chronic pancreatitis (CP) performed differentially expressed piRNAs were compared those tissues. Subsequent search for target genes followed by pathway cluster analysis. A total 36 shown be deregulated alteration 11 detected PC. hsa-piR-23246, hsa-piR-32858 hsa-piR-9137 key development correlated both tissue. Key piRNA-target interactions interfering biological pathways also characterized. 19 samples CP identified; these targeted responsible Therefore, provides comprehensive description malignancy inflammation; explored biomarker potential future.

Language: Английский

Citations

2