The possible role of the endocrine disrupting chemicals on the premature and early menopause associated with the altered oxidative stress metabolism DOI Creative Commons
Duygu Aydemir, Nuriye Nuray Ulusu

Frontiers in Endocrinology, Journal Year: 2023, Volume and Issue: 14

Published: Feb. 14, 2023

OPINION article Front. Endocrinol., 14 February 2023Sec. Experimental Endocrinology Volume - 2023 | https://doi.org/10.3389/fendo.2023.1081704

Language: Английский

Effects of environmental bisphenol S exposure on male rat reproductive health and gut-blood-testicular axis integrity DOI Creative Commons
Biran Zhu,

Zequan Zhang,

Ying Xie

et al.

Ecotoxicology and Environmental Safety, Journal Year: 2025, Volume and Issue: 289, P. 117646 - 117646

Published: Jan. 1, 2025

In this study, male Sprague-Dawley (SD) rats were exposed to bisphenol S (BPS) at environmentally relevant concentrations investigate its reproductive toxicity and evaluate effects on the gut-blood-testicular axis. After 28 days of exposure BPS (0.05 20 mg/kg), results showed a reduction in weight gain induction rats, including decreased sperm parameters, lower viability, increased abnormal density mortality. These observations made by counting with hemocytometer under optical microscope. 16S rRNA untargeted metabolomic elucidated potential impacts axis: impaired physical barrier, evoked inflammation, resulted dysbiosis gut microbiota. Additionally, altered serum metabolites, phosphatidic acid diacylglycerol, which are involved Fc gamma R-mediated phagocytosis linked inflammation. Furthermore, histopathological analysis, western blot (WB), enzyme-linked immunosorbent assay (ELISA), immunofluorescence that led testicular damage, activation p38 ERK MAPK pathways, disruption blood-testis barrier (BTB). Collectively, these findings indicate impair intestinal health, disrupt microbiome, ultimately lead dysfunction through

Language: Английский

Citations

2
Impact of Bisphenol A and its alternatives on oocyte health: a scoping review DOI Creative Commons
Alexandra E. Peters, Emmalee A. Ford, Shaun D. Roman

et al.

Human Reproduction Update, Journal Year: 2024, Volume and Issue: unknown

Published: Sept. 14, 2024

Bisphenol A (BPA) is an endocrine disrupting chemical released from plastic materials, including food packaging and dental sealants, persisting in the environment ubiquitously contaminating ecosystems human populations. BPA can elicit array of damaging health effects and, alarmingly, 'BPA-free' alternatives mirror these harmful effects. exposure negatively impact female fertility, both ovary oocytes therein. Such damage diminish reproductive capacity, pregnancy success, offspring health. Despite global government regulations place to indicate 'safe' levels, policies have not considered bisphenols on oocyte

Language: Английский

Citations

12
The Ovary as a Target Organ for New Generation Bisphenols Toxicity DOI Creative Commons
Paulina Głód, John Smoleniec,

Weronika Marynowicz

et al.

Toxics, Journal Year: 2025, Volume and Issue: 13(3), P. 164 - 164

Published: Feb. 26, 2025

Bisphenols (BPs) are a group of organic compounds used extensively in plastics, coatings, and epoxy resins; they have been concern recently due to their endocrine-disrupting effects. Among these, bisphenol A (BPA) is the most studied. Regulatory measures, such as ban on BPA use baby bottles by European Union its restricted thermal paper, reflect growing awareness health risks BPA. To mitigate these risks, analogs S (BPS), F (BPF), others (BPAF, BPAP, BPB, BPP, BPZ) developed alternatives. Despite intended safety, detected environmental media, including indoor dust receipt well human biological samples. Studies report presence urine at levels comparable BPA, with BPS BPF found 78% 55% samples, respectively. In addition, BPs follicular fluid (FF) concentrations that could exert some paracrine effects ovarian function reproductive health. With increased global production BPs, occupational exposure contamination also increase. This review summarizes what currently known about ovary mechanisms which PBs toxicity, particular focus oogenesis, folliculogenesis, steroidogenesis. Further, this emphasizes influence functions need for further biosafety evaluations.

Language: Английский

Citations

1
Impact of BPA and its analogs on sperm hyperactivity, acrosome reaction, epigenetic profiles and in vitro embryo development. DOI Creative Commons

Ola S. Davis,

Olivia L M Scandlan,

Erica A Potestio

et al.

Molecular and Cellular Endocrinology, Journal Year: 2025, Volume and Issue: unknown, P. 112555 - 112555

Published: April 1, 2025

Language: Английский

Citations

1
In vivo exposure to bisphenol F induces oxidative testicular toxicity: role of Erβ and p53/Bcl-2 signaling pathway DOI Creative Commons
Adeyemi Fatai Odetayo, Wale Johnson Adeyemi,

Luqman Aribidesi Olayaki

et al.

Frontiers in Reproductive Health, Journal Year: 2023, Volume and Issue: 5

Published: Aug. 2, 2023

Bisphenol F (BPF), an alternative to bisphenol A has been implicated as a gonadotoxic substance. BPF shown induce hormonal imbalance and testicular oxidative damage. However, the mechanism associated with BPF-induced toxicity not fully explored. This study was designed explore role of tumor protein (p53)/ B-cell lymphoma 2 (BCl-2) signaling oestrogen receptor beta (Erβ) in toxicity.Male Wistar rats were randomized into control (Cntrl), BPF-treated (10, 30, 50 mg/kg for low dose (BPF-L), medium (BPF-M), high (BPF-H) respectively), recovery (Cntrl-R, BPF-L-R, BPF-M-R, BPF-H-R). The administration via gavage lasted 28 days animals groups allowed 28-days exposure free period from exposure.BPF resulted distortion histoarchitecture, which accompanied by significant rise gamma-lutamyl transferase lactate dehydrogenase activities but decline sorbitol activities. Also, caused reduction plasma gonadotropin-releasing hormone, luteinising follicle-stimulating testosterone, downregulation 3beta-hydroxysteroid 17beta-hydroxysteroid Furthermore, induced inflammation, redox imbalance, apoptosis, p53/BCl-2 overexpression Erβ. Again, observed toxic effects dose-dependent completely reversed cessation.Bisphenol gonadotoxicity distorting p53/BCl2 expression These alterations after cessation exposure.

Language: Английский

Citations

20
Reproductive toxicity of bisphenol A, at environmentally relevant concentrations, on ovarian redox balance, maturational response, and intra-oocyte signalling events in Labeo bata DOI

Urmi Mukherjee,

Sriparna Das,

Soumyajyoti Ghosh

et al.

The Science of The Total Environment, Journal Year: 2023, Volume and Issue: 906, P. 167415 - 167415

Published: Sept. 28, 2023

Language: Английский

Citations

18
Melatonin alleviates oxidative stress damage in mouse testes induced by bisphenol A DOI Creative Commons
Qi Qi,

Jiaxin Yang,

Shuang Li

et al.

Frontiers in Cell and Developmental Biology, Journal Year: 2024, Volume and Issue: 12

Published: Feb. 19, 2024

We investigated the effect of melatonin on bisphenol A (BPA)-induced oxidative stress damage in testicular tissue and Leydig cells. Mice were gavaged with 50 mg/kg BPA for 30 days, concurrently, injected (10 20 mg/kg). cells treated 10 μmol/L melatonin. The morphology organ index testis epididymis observed calculated. sperm viability density determined. expressions receptor 1A luteinizing hormone receptor, levels malonaldehyde, antioxidant enzymes, glutathione, steroid synthases, aromatase, hormone, testosterone, estradiol measured. TUNEL assay was utilized to detect cell apoptosis. administration at significantly improved mice BPA. Additionally, promoted development seminiferous tubules testes. Furthermore, treatment increased mice, while also promoting BPA-treated mice. Significantly, reduced level malonaldehyde expression enzymes (superoxide dismutase 1, superoxide 2, catalase) as well content glutathione. Moreover, number apoptotic spermatogonia, aromatase expression, level, increasing synthases (steroidogenic acute regulatory protein, cytochrome P450 family 17a1, 17α-hydroxylase/20-lyase, and, 17β-hydroxysteroid dehydrogenase) testosterone. Melatonin exhibited significant potential alleviating caused by These beneficial effects may be attributed melatonin's ability enhance capacity tissue, promote testosterone synthesis, reduce

Language: Английский

Citations

7
Relationship between emergent BPA-substitutes and renal and cardiovascular diseases in adult population DOI Creative Commons
Rafael Moreno‐Gómez‐Toledano

Environmental Pollution, Journal Year: 2022, Volume and Issue: 313, P. 120106 - 120106

Published: Sept. 6, 2022

Plastic waste pollution is one of the leading environmental problems modern society. Its use, disposal, and recycling lead to release xenobiotic compounds such as bisphenol A (BPA), a known endocrine disruptor related numerous pathologies. Due new restrictions on its it gradually being replaced by derived molecules, F or S (BPF BPS), whose health risks have not yet been adequately studied. In present work, significant relationships between BPA substitute molecules renal cardiovascular diseases detected performing binomial multinomial logistic regressions in world's largest cohorts urinary phenols. The results shown relationship BPF function heart disease (specifically congestive failure). Urinary BPS has positive with risk hypertension negative kidney disease. Consequently, applying could imply potential equivalent BPA.

Language: Английский

Citations

25
BPA and low-Se exacerbate apoptosis and autophagy in the chicken bursa of Fabricius by regulating the ROS/AKT/FOXO1 pathway DOI
Wenying Sun,

Tong Xu,

Hongjin Lin

et al.

The Science of The Total Environment, Journal Year: 2023, Volume and Issue: 908, P. 168424 - 168424

Published: Nov. 7, 2023

Language: Английский

Citations

16
Sperm capacitation and transcripts levels are altered by in vitro THC exposure DOI Creative Commons

Vivien B. Truong,

Ola S. Davis,

Jade Gracey

et al.

BMC Molecular and Cell Biology, Journal Year: 2023, Volume and Issue: 24(1)

Published: Feb. 23, 2023

Abstract Background Delta-9-tetrahydrocannabinol (THC) is the primary phytocannabinoid responsible for psychoactive properties of cannabis and known to interact with endocannabinoid system, which functionally present in male reproductive system. Since consumption highest among aged males, current study aimed further investigate effects THC exposure phenotypical, physiological, molecular parameters sperm. Bull sperm fertility were used as a translational model human subjected vitro treatment physiologically relevant experimental doses THC. Sperm parameters, capacitation, apoptosis, transcript levels evaluated following treatment. Results Motility, morphology, viability bovine was unaltered from exposure. However, 0.32µM caused an increased proportion capacitating (p < 0.05) compared control vehicle group Transcriptome analysis revealed that 39 genes found be differentially expressed by 0.032µM exposure, 196 33 3.2µM Secondary reveals pathways involving development, nucleosomes, ribosomes translation, cellular metabolism significantly enriched. Conclusion Phytocannabinoid may adversely affect function stimulating premature capacitation. These findings also show first time spermatozoal transcripts altered results add previous research demonstrating cannabinoids on warrant into fertility.

Language: Английский

Citations

14