Assessing the toxicity of bisphenol A and its six alternatives on zebrafish embryo/larvae

Aquatic Toxicology, Journal Year: 2022, Volume and Issue: 246, P. 106154 - 106154

Published: March 29, 2022

Language: Английский

---

BPS‐induced ovarian dysfunction: Protective actions of melatonin via modulation of SIRT‐1/Nrf2/NFĸB and IR/PI3K/pAkt/GLUT‐4 expressions in adult golden hamster

Journal of Pineal Research, Journal Year: 2023, Volume and Issue: 75(1)

Published: April 1, 2023

Abstract Ever‐increasing occurrence of plastic‐manufacturing industries leads to environmental pollution that has been associated with declined human health and increased incidence compromised reproductive health. Female subfertility/infertility is a complex phenomenon toxicants as well lifestyle factors have crucial role play. Bisphenol S (BPS) was believed be “safer” replacement bisphenol A (BPA) but recent data documented its neurotoxic, hepatotoxic, nephrotoxic, reprotoxic attributes. Hence based on the scarcity reports, we investigated molecular insights into BPS‐induced ovarian dysfunction protective actions melatonin against it in adult golden hamsters, Mesocricetus auratus . Hamsters were administered (3 mg/kg BW i.p. alternate days) BPS (150 orally every day) for 28 days. treatment disrupted hypothalamo–pituitary–ovarian (HPO) axis evident by reduced gonadotropins such luteinizing hormone (LH) follicle‐stimulating (FSH), steroids estradiol (E2) progesterone (P4), thyroid hormones namely triiodothyronine (T3) thyroxine (T4) levels along their respective receptors (ERα, TRα, MT‐1) thereby reducing folliculogenesis. exposure also led oxidative stress/inflammation increasing reactive oxygen species metabolic disturbances. However, supplementation restored folliculogenesis/steroidogenesis indicated number growing follicles/corpora lutea E2/P4 levels. Further, stimulated key redox/survival markers silent information regulator transcript‐1 (SIRT‐1), forkhead box O‐1 (FOXO‐1), nuclear factor E2‐related factor‐2 (Nrf2), phosphoinositide 3‐kinase/protein kinase B (PI3K/pAkt) expressions enhanced antioxidant capacity. Moreover, inflammatory load including kappa‐B (NFĸB), cyclooxygenase‐2 (COX‐2), inducible nitric oxide synthase (iNOS) expressions, serum tumor necrosis α (TNFα), C‐reactive protein (CRP) nitrite–nitrate upregulated insulin receptor (IR), glucose uptake transporter‐4 (GLUT‐4), connexin‐43, proliferating cell antigen (PCNA) ovary ameliorating alterations due BPS. In conclusion, found severe deleterious impact while protected physiology from these detrimental changes suggesting potential preemptive candidate toxicant‐compromised female

Language: Английский

---

Toxicological evaluation of bisphenol analogues: preventive measures and therapeutic interventions

RSC Advances, Journal Year: 2023, Volume and Issue: 13(31), P. 21613 - 21628

Published: Jan. 1, 2023

Schematic representation of pathways bisphenol A (BPA) exposure, excretion, and metabolites in the human body.

Language: Английский

---

Bisphenol A and bisphenol S both disrupt ovine granulosa cell steroidogenesis but through different molecular pathways

Journal of Ovarian Research, Journal Year: 2023, Volume and Issue: 16(1)

Published: Feb. 3, 2023

Ovarian granulosa cells (GC) are essential for the development and maturation of a proper oocyte. GC sensitive to endocrine disruptors, including bisphenol A (BPA) its analogue S (BPS), plasticisers present in everyday consumer products. BPA exhibits greater binding affinity membrane oestrogen receptor (GPER) than nuclear receptors (ERα ERβ). Here, we analysed effects BPS on steroidogenesis ovine vitro, as well their early mechanisms action, being relevant model study human reproductive impairment. Disruption might alter oocyte quality consequently fertility rate. In addition, compared specific GPER agonist (G-1) antagonist (G-15) those BPS. Ewe were cultured with or (10 50 µM) G-1 (1 and/or G-15 48 h steroidogenesis.

Language: Английский

---

Inhibition of reactive oxygen species generation by N-Acetyl Cysteine can mitigate male germ cell toxicity induced by bisphenol analogs

Food and Chemical Toxicology, Journal Year: 2024, Volume and Issue: 188, P. 114652 - 114652

Published: April 6, 2024

Language: Английский

---

Exploring novel insights into the molecular mechanisms underlying Bisphenol A-induced toxicity: A persistent threat to human health

Environmental Toxicology and Pharmacology, Journal Year: 2024, Volume and Issue: 108, P. 104467 - 104467

Published: May 17, 2024

Language: Английский

---

Toxic effects of bisphenol A and its analogues on cyanobacteria Anabaena variabilis and Microcystis aeruginosa

Chemosphere, Journal Year: 2020, Volume and Issue: 263, P. 128299 - 128299

Published: Sept. 12, 2020

Language: Английский

---

Maternal and childhood urinary phenol concentrations, neonatal thyroid function, and behavioral problems at 10 years of age: The SMBCS study

The Science of The Total Environment, Journal Year: 2020, Volume and Issue: 743, P. 140678 - 140678

Published: July 6, 2020

Language: Английский

---

COVID-19 and Thyroid: Progress and Prospects

International Journal of Environmental Research and Public Health, Journal Year: 2020, Volume and Issue: 17(18), P. 6630 - 6630

Published: Sept. 11, 2020

The outbreak of coronavirus disease 2019 (COVID-19), caused by severe acute respiratory syndrome 2 (SARS-CoV-2), has rapidly spread worldwide. A number serious effects on various organs and systems have been reported in humans, recently emerging evidence the potential association between infection thyroid dysfunction are attracting attention from scientific community. This editorial critically summarizes main findings this topic published so far defines research lines according to translational approach bench bed epidemiological studies back again, aimed at patient care effective public health measures.

Language: Английский

---

New insights on the effects of endocrine-disrupting chemicals on children

Jornal de Pediatria, Journal Year: 2021, Volume and Issue: 98, P. S73 - S85

Published: Dec. 15, 2021

Endocrine disrupting chemicals (EDCs) are present in many areas and materials of the common life, exposure to these can occur from products personal care, air food. This review aims summarize more recent epidemiological findings for impact EDCs on endocrine system health children, including effects growth, metabolism, sexual development, reproduction. The MEDLINE database (PubMed) was searched August 24th, 2021, filtering EDCs, disruptors, humans. Intrauterine have transgenerational effects, thus laying foundation disease later life. dose-response relationship may not always be predictable as even low-level exposures that everyday life significant a susceptible individual. Although individual compounds been studied detail, combination yet understand real-life situation where human beings exposed “cocktail effect” EDCs. Epidemiological studies humans suggest EDCs’ prenatal thyroid function, glucose obesity, puberty, fertility mainly through epigenetic mechanisms. cause adverse animals, their now known irrefutable. Because people typically multiple assessing public is difficult. Legislation ban protect especially pregnant women young children required needs revised adjusted new developments regular basis.

Language: Английский

---