Environmental Pollution,
Journal Year:
2023,
Volume and Issue:
333, P. 121957 - 121957
Published: June 15, 2023
Phthalates
are
chemicals
widely
used
in
plastic-based
consumer
products,
and
human
exposure
is
universal.
They
classified
as
endocrine
disruptors,
specific
phthalate
metabolites
have
been
associated
with
an
increased
risk
of
cardiometabolic
diseases.
The
aim
this
study
was
to
assess
the
association
between
metabolic
syndrome
general
population.
A
comprehensive
literature
search
performed
four
databases
(Web
Science,
Medline,
PubMed,
Scopus).
We
included
all
observational
studies
that
evaluate
available
until
January
31st,
2023.
Pooled
Odds
Ratios
(OR)
their
95%
confidence
intervals
were
calculated
by
using
inverse-variance
weighted
method.
Nine
cross-sectional
25,365
participants
aged
from
12
80
included.
Comparing
extreme
categories
exposure,
pooled
ORs
for
were:
1.08
(95%
CI,
1.02-1.16,
I2
=
28%)
low
molecular
weight
phthalates,
1.11
1.07-1.16,
7%)
high
phthalates.
For
individual
metabolites,
achieved
statistical
significance
1.13
1.00-1.27,
24%)
MiBP;
1.89
1.17-3.07,
15%)
MMP
men;
1.12
1.00-1.25,
22%)
MCOP;
1.09
0.99-1.20,
0%)
MCPP;
1.16
1.05-1.28,
6%)
MBzP;
1.09-1.24,
14%)
DEHP
(including
ΣDEHP
its
metabolites).
In
conclusion,
both
phthalates
8
11%
higher
prevalence
MetS,
respectively.
six
a
MetS.
Molecules,
Journal Year:
2022,
Volume and Issue:
27(8), P. 2577 - 2577
Published: April 16, 2022
The
ever-increasing
rate
of
pollution
has
attracted
considerable
interest
in
research.
Several
anthropogenic
activities
have
diminished
soil,
air,
and
water
quality
led
to
complex
chemical
pollutants.
This
review
aims
provide
a
clear
idea
about
the
latest
most
prevalent
pollutants
such
as
heavy
metals,
PAHs,
pesticides,
hydrocarbons,
pharmaceuticals—their
occurrence
various
mixtures
how
several
environmental
factors
influence
their
interaction.
mechanism
adopted
by
these
contaminants
form
leading
rise
new
class
contaminants,
thus
resulting
severe
threats
human
health
environment,
also
been
exhibited.
Additionally,
this
provides
an
in-depth
vivo,
vitro,
trending
biomarkers
used
for
risk
assessment
identifies
mixed
even
at
very
minute
concentrations.
Much
importance
given
remediation
technologies
understand
our
current
position
handling
can
be
improved.
paper
create
awareness
among
readers
ubiquitous
simple
ways
tackle
same.
International Journal of Molecular Sciences,
Journal Year:
2022,
Volume and Issue:
23(3), P. 1216 - 1216
Published: Jan. 21, 2022
The
role
of
endocrine
disruptors
(EDs)
in
the
human
prostate
gland
is
an
overlooked
issue
even
though
essential
for
male
fertility.
From
experimental
models,
it
known
that
EDs
can
influence
several
molecular
mechanisms
involved
homeostasis
and
diseases,
including
cancer
(PCa),
one
most
common
cancers
male,
whose
onset
progression
characterized
by
deregulation
cellular
pathways
androgen
receptor
(AR)
signaling.
essentiality
relies
on
its
function
to
produce
secrete
prostatic
fluid,
a
component
seminal
needed
keep
alive
functional
sperms
upon
ejaculation.
In
physiological
condition,
epithelium
more-active
androgen,
5α-dihydrotestosterone
(DHT),
formed
from
testosterone
(T)
5α-reductase
enzyme
(SRD5A),
binds
AR
and,
homodimerization
nuclear
translocation,
recognizes
promoter
target
genes
modulating
them.
pathological
conditions,
mutations
and/or
less
specific
binding
ligands
modulate
differently
targeted
leading
altered
regulation
cell
proliferation
triggering
PCa
development.
acting
AR-dependent
signaling
within
contribute
exacerbating
Environmental Pollution,
Journal Year:
2023,
Volume and Issue:
333, P. 121957 - 121957
Published: June 15, 2023
Phthalates
are
chemicals
widely
used
in
plastic-based
consumer
products,
and
human
exposure
is
universal.
They
classified
as
endocrine
disruptors,
specific
phthalate
metabolites
have
been
associated
with
an
increased
risk
of
cardiometabolic
diseases.
The
aim
this
study
was
to
assess
the
association
between
metabolic
syndrome
general
population.
A
comprehensive
literature
search
performed
four
databases
(Web
Science,
Medline,
PubMed,
Scopus).
We
included
all
observational
studies
that
evaluate
available
until
January
31st,
2023.
Pooled
Odds
Ratios
(OR)
their
95%
confidence
intervals
were
calculated
by
using
inverse-variance
weighted
method.
Nine
cross-sectional
25,365
participants
aged
from
12
80
included.
Comparing
extreme
categories
exposure,
pooled
ORs
for
were:
1.08
(95%
CI,
1.02-1.16,
I2
=
28%)
low
molecular
weight
phthalates,
1.11
1.07-1.16,
7%)
high
phthalates.
For
individual
metabolites,
achieved
statistical
significance
1.13
1.00-1.27,
24%)
MiBP;
1.89
1.17-3.07,
15%)
MMP
men;
1.12
1.00-1.25,
22%)
MCOP;
1.09
0.99-1.20,
0%)
MCPP;
1.16
1.05-1.28,
6%)
MBzP;
1.09-1.24,
14%)
DEHP
(including
ΣDEHP
its
metabolites).
In
conclusion,
both
phthalates
8
11%
higher
prevalence
MetS,
respectively.
six
a
MetS.
