The interplay between sleep and gut microbiota

Brain Research Bulletin, Journal Year: 2022, Volume and Issue: 180, P. 131 - 146

Published: Jan. 13, 2022

Language: Английский

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The Role of Gut Microbiome in Sleep Quality and Health: Dietary Strategies for Microbiota Support

Nutrients, Journal Year: 2024, Volume and Issue: 16(14), P. 2259 - 2259

Published: July 13, 2024

Dietary components, including dietary fiber, unsaturated fatty acids, and polyphenols, along with meal timing spacing, significantly affect the microbiota’s capacity to produce various metabolites essential for quality sleep overall health. This review explores role of gut microbiota in regulating through such as short-chain tryptophan, serotonin, melatonin, gamma-aminobutyric acid. A balanced diet rich plant-based foods enhances production these sleep-regulating metabolites, potentially benefiting aims investigate how habits composition, it produces, subsequent impact on related health conditions.

Language: Английский

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Association of sleep duration and sleep disorders with post-stroke depression and all-cause and cardiovascular disease mortality in US stroke survivors: results from NHANES 2005–2018

European journal of medical research, Journal Year: 2025, Volume and Issue: 30(1)

Published: Jan. 3, 2025

Sleep disturbance is a common concern among stroke survivors, yet the association of sleep duration and disorders with post-stroke depression all-cause cardiovascular disease (CVD) mortality remains elusive. We aimed to explore these associations using data from National Health Nutrition Examination Survey (NHANES). Adult survivors NHANES 2005–2018 were included. information diagnoses derived self-reports on relevant questionnaires. Mortality collected by prospectively matching Death Index. Multivariate logistic regression Cox proportional hazards used calculate odds ratio (OR) hazard (HR), respectively. A total 1101 participants In fully adjusted model, associated increased (OR 2.689, p = 0.0146). was inversely depression; compared normal duration, short 2.196, 0.0059), whereas long not (p 0.1435). CVD (HR 1.948, 0.026) but 0.224) in survivors. positively 1.075, 0.042); however, neither nor duration. Restricted cubic spline modeling suggested that nonlinearly linearly mortality, Age influenced between depression, These findings underscore achieving improving may reduce mortality.

Language: Английский

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Sleep patterns and cardiovascular disease risk in US participants: a comprehensive analysis

Frontiers in Neuroscience, Journal Year: 2025, Volume and Issue: 18

Published: Jan. 9, 2025

To evaluate the association between sleep-related factors, including sleep duration, self-reported disturbances, and diagnosed disorders, risk of cardiovascular disease (CVD) in US participants. The data this study from National Health Nutrition Examination Survey (NHANES) conducted 2007 2014. Sleep factors were assessed using a standardized questionnaire, overall scores calculated on scale 0 to 3. participants classified into three pattern groups: poor (overall score ≤ 1), intermediate = 2), healthy 3). CVD was defined based questionnaire responses. Logistic regression models used investigate CVD. Among 21,115 participants, 2,245 (10.6%) with Participants patterns had significantly higher (OR 1.82, 95% CI: 1.52-2.16, p < 0.001). Self-reported trouble sleeping 1.53, 1.32-1.78, 0.001), disorder 2.09, 1.75-2.50, 0.001) related an increased However, no such observed for either short 1.12, 0.95-1.33, 0.174) or long durations 1.14, 0.90-1.45, 0.266). Our also suggested interaction age (P 0.002). This highlights significant

Language: Английский

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Systemic immune-inflammation index is associated with coronary heart disease: a cross-sectional study of NHANES 2009–2018

Frontiers in Cardiovascular Medicine, Journal Year: 2023, Volume and Issue: 10

Published: July 7, 2023

Background Inflammation has been linked to the development of coronary heart disease (CHD). The systemic immune inflammation index (SII) is a useful biomarker inflammation. Our study aimed explore correlation between SII and CHD. Methods We conducted multivariate logistic regression analysis, smoothing curve fitting, segmented model comparison on 15,905 participants with CHD prevalence 3.31% mean age 46.97 years. Results Adjusting for gender, age, race, we found negative association [odds ratio (OR) 0.66; 95% confidence interval (CI) 0.48, 0.90]. There was an inverse trend where increasing associated decreasing odds ( p = 0.0017). After further adjustment, strengthened, similar 0.0639). Smoothing fitting demonstrated gender-specific Conclusions findings suggest that higher values may be incidence CHD, which varies by gender. cost-effective convenient method detect Further studies are needed confirm causality these in larger prospective cohort.

Language: Английский

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Obstructive Sleep Apnea and Its Cardiac Implications in the United States: An Age‐Stratified Analysis Between Young and Older Adults

Journal of the American Heart Association, Journal Year: 2024, Volume and Issue: 13(12)

Published: June 6, 2024

Background Obstructive sleep apnea (OSA) is a common disorder associated with cardiovascular risks. This study aimed to assess the prevalence of probable OSA and its relationship risks diseases focusing on age‐stratified young adults (20–40 years) older (>40 years). Methods Results The used cross‐sectional design, analyzing data from National Health Nutrition Examination Survey conducted between 2013 2018, comprising 9887 community‐dwelling aged ≥20 years. Probable was determined basis self‐report OSA‐related symptoms (eg, snoring, gasping/breath cessation while sleeping). Cardiovascular risk factors, including hypertension, diabetes, hyperlipidemia, metabolic syndrome, were evaluated according established guidelines. (CVDs) included self‐reported heart conditions, congestive failure, coronary disease, angina, attacks, strokes. Individuals showed significantly higher health hypertension (adjusted ratio [aPR], 1.19; P <0.001), diabetes (aPR, 1.17; : 0.01), syndrome 1.14; attack 1.63; <0.01), stroke 1.41; 0.03), any CVD event 1.36; 0.01) after adjusting for relevant factors. Young rates events 3.44; 1.45; 1.25; angina 10.39; <0.001). Conclusions suggests early identification management in individuals at CVD. While cross‐sectional, it emphasizes that care providers should recognize as CVDs precursor adults, stressing proactive screening reduce this population.

Language: Английский

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Association between platelet to high-density lipoprotein cholesterol ratio (PHR) and hypertension: evidence from NHANES 2005–2018

Lipids in Health and Disease, Journal Year: 2024, Volume and Issue: 23(1)

Published: Oct. 26, 2024

The Platelet to High-Density Lipoprotein cholesterol Ratio (PHR) is a novel indicator of inflammatory response and metabolic disorders, linked various chronic diseases. This study aims investigate the relationship between PHR hypertension. Data from National Health Nutrition Examination Survey (NHANES), collected across seven consecutive cycles 2005 2018, were analyzed. dataset included participants' hypertension status as reported by doctor, their use antihypertensive medications, average three blood pressure measurements identify hypertensive adults, along with complete information for calculation. was calculated based on (PLT) count (HDL-C) using following formula: = [PLT (1000 cells/µL) / HDL-C (mmol/L)]. A multivariable logistic regression model employed assess association hypertension, subgroup analyses conducted explore potential influencing factors. Additionally, Restricted Cubic Spline (RCS) curves applied threshold effect analysis describe nonlinear relationships. Higher associated an increased prevalence After adjusting covariates, including race, education level, Family Poverty Income (PIR), smoking, alcohol consumption, sleep disturbances, waist circumference, diabetes, coronary heart disease, angina, attack, stroke, results remained significant (OR 1.36; 95% CI, 1.32, 1.41, P < 0.001). Participants highest levels had 104% higher risk compared those lowest 2.04; 1.89, 2.21, Elevated are strongly Specifically, when below 280, increases in proportion PHR. suggests that regular monitoring may help patients at early, allowing timely interventions slow disease progression. Larger cohort studies necessary confirm these findings.

Language: Английский

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Causal Effects of Gut Microbiota on Sleep-Related Phenotypes: A Two-Sample Mendelian Randomization Study

Clocks & Sleep, Journal Year: 2023, Volume and Issue: 5(3), P. 566 - 580

Published: Sept. 12, 2023

Increasing evidence suggests a correlation between changes in the composition of gut microbiota and sleep-related phenotypes. However, it remains uncertain whether these associations indicate causal relationship. The genome-wide association study summary statistics data (n = 18,340) was downloaded from MiBioGen consortium phenotypes were derived UK Biobank, Medical Research Council-Integrative Epidemiology Unit, Jones SE, FinnGen consortium. To test estimate effect on sleep traits, two-sample Mendelian randomization (MR) approach using multiple methods conducted. A series sensitive analyses, such as horizontal pleiotropy analysis, heterogeneity test, MR Steiger directionality "leave-one-out" analysis well reverse conducted to assess robustness results. genus Anaerofilum has negative getting up morning (odd ratio 0.977, 95% confidence interval: 0.965-0.988, p 7.28 × 10-5). higher abundance order Enterobacteriales family Enterobacteriaceae contributed becoming an "evening person". Six two taxa causally associated with longer shorter duration, respectively. Specifically, SCFA-produced genera including Lachnospiraceae UCG004 1.029, interval 1.012-1.046, 6.11 10-4) Odoribacter contribute extending duration. Two obesity-related Ruminococcus torques 1.024, 1.011-1.036, 1.74 Senegalimassilia found be increased decreased risk snoring, In addition, we insomnia Selenomonadales one its classes called Negativicutes. All results indicated that our robust. Our revealed identified protective for chronotype, snoring insomnia, which potential provide new perspectives future mechanistic clinical investigations microbiota-mediated abnormal patterns clues developing microbiota-based intervention strategies conditions.

Language: Английский

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The Causal Association Between Blood Lead and Sleep Disorders: Evidence from National Health and Nutrition Examination Survey and Mendelian Randomization Analysis

Journal of Epidemiology and Global Health, Journal Year: 2024, Volume and Issue: 14(2), P. 462 - 469

Published: Feb. 19, 2024

Abstract Background Poor sleep quality is a global public health concern. This study aimed to identify the risk factors for disorders and clarify their causal effects. Methods Data were obtained from National Health Nutrition Examination Survey (NHANES) Mendelian randomization (MR)-Base databases. Baseline characteristics of individuals with without compared. A multivariate logistic regression analysis was performed calculate effects each variable on disorders. Causal blood lead levels hypertension assessed using MR analysis. Results In total, 3660 enrolled in study. The prevalence self-reported 26.21%. Serum level, serum mercury retinol hypertension, daily vigorous work duration significantly higher those group than control group. After adjusting various covariates, stable models 1–4. showed that causally related (odds ratio (OR) = 1.09, 95% confidence interval (CI) 1.01–1.17, P 0.030). There no link between elevated pressure (OR 0.99, CI 0.94–1.04, 0.757). Goodness-of-fit tests sensitivity analyses used verify reliability results. Conclusions Blood positively associated an increased These findings provide novel perspective regarding protection. Taking effective measures reduce exposure may improve health.

Language: Английский

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Association between sleep quality and blood pressure control among hypertensive patients at a rural tertiary hospital in Southern Nigeria: a cross-sectional study

BMJ Open, Journal Year: 2024, Volume and Issue: 14(3), P. e079774 - e079774

Published: March 1, 2024

Objectives Restorative sleep is critical in preventing hypertension and other chronic diseases. Limited research has explored the relationship between quality Africa. This study investigated association blood pressure control among hypertensive patients Southern Nigeria. Design Cross-sectional study. Setting A rural tertiary hospital Nigeria, April to June 2023. Participants 250 systematically selected adults. completed a validated semistructured interviewer-administered questionnaire assess their patterns, including duration, self-reported trouble sleeping history of clinical diagnosis disorders. Sleep patterns were categorised as restorative (healthy) or non-restorative (unhealthy). The respondents was checked controlled (<140/90 mm Hg) uncontrolled (≥140/90 Hg). Data analysed descriptively using SPSS V.24.0 Outcome measures Quality control. Results Respondents had mean age 51.5±10.0 years, with majority being female (156, 62.4%), married (135, 54.0%) belonging Esan tribe (125, 50.0%). prevalence 36%, while rate 23.6%. An found (adjusted OR =4.38; 95% CI=2.37–8.10; p<0.0001). aged ≥60 years 3.5 times higher odds experiencing than those ≤40 (aOR=3.46; CI=1.37–8.74; p=0.009). Conclusion an poor Incorporating assessments interventions into comprehensive management strategies could be possible approach improve enhance Trial registration number PACTR202301917477205.

Language: Английский

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