The Preventive Effect of Exercise and Oral Branched-Chain Amino Acid Supplementation on Obesity-Induced Brain Changes in Ldlr−/−.Leiden Mice DOI Open Access

Klara J. Lohkamp,

Anita M. van den Hoek, Gemma Solé‐Guardia

et al.

Nutrients, Journal Year: 2023, Volume and Issue: 15(7), P. 1716 - 1716

Published: March 31, 2023

Exercise and dietary interventions are promising approaches to tackle obesity its obesogenic effects on the brain. We investigated impact of exercise possible synergistic branched-chain amino acids (BCAA) supplementation brain behavior in high-fat-diet (HFD)-induced obese Ldlr−/−.Leiden mice. Baseline measurements were performed chow-fed mice assess metabolic risk factors, cognition, structure using magnetic resonance imaging. Thereafter, a subgroup was sacrificed, serving as healthy reference. The remaining fed an HFD divided into three groups: (i) no exercise, (ii) or (iii) BCAA. Mice followed for 6 months aforementioned tests repeated. found that alone changed cerebral blood flow, attenuated white matter loss, reduced neuroinflammation compared non-exercising HFD-fed Contrarily, favorable combination with BCAA, increased. However, cognition slightly improved exercising Moreover, BCAA increased percentage epididymal adipose tissue muscle weight, decreased body weight fasting insulin levels, circadian rhythm, transiently grip strength. In conclusion, should be supplemented caution, although beneficial metabolism, behavior, observed.

Language: Английский

Cytokines as Key Players in Obesity Low Grade Inflammation and Related Complications DOI
Daniel Ejim Uti, Item Justin Atangwho,

Wilson Achu Omang

et al.

Obesity Medicine, Journal Year: 2025, Volume and Issue: unknown, P. 100585 - 100585

Published: Jan. 1, 2025

Language: Английский

Citations

5
Exploring the Heart–Mind Connection: Unraveling the Shared Pathways between Depression and Cardiovascular Diseases DOI Creative Commons
Justyna Sobolewska-Nowak, Katarzyna Wachowska, Artur Nowak

et al.

Biomedicines, Journal Year: 2023, Volume and Issue: 11(7), P. 1903 - 1903

Published: July 5, 2023

Civilization diseases are defined as non-communicable that affect a large part of the population. Examples such depression and cardiovascular disease. Importantly, World Health Organization warns against an increase in both these. This narrative review aims to summarize available information on measurable risk factors for CVD based existing literature. The paper reviews epidemiology main coexistence authors emphasize there is evidence link between Here, we highlight common disease, including obesity, diabetes, physical inactivity, well importance prevention treatment preventing other mental disorders. Conversely, effective can also help prevent improve health outcomes. It seems advisable introduce screening tests patients treated cardiac reasons. mood disorders, it worth controlling factors, example, by checking blood pressure pulse during routine visits. paying attention condition with CVD. study underlines interdisciplinary co-operation.

Language: Английский

Citations

42
Poor Motor Competence Affects Functional Capacities and Healthcare in Children and Adolescents with Obesity DOI Creative Commons
Matteo Vandoni, Luca Marin, Caterina Cavallo

et al.

Sports, Journal Year: 2024, Volume and Issue: 12(2), P. 44 - 44

Published: Feb. 1, 2024

From a young age, children learn different motor skills known as fundamental skills. The acquisition of these is crucial for the future development context-tailored actions that could improve adherence to physical activity (PA) practice. Motor competence and function deficits have been associated with pediatric obesity. We reviewed literature data regarding in pediatrics impaired performance adolescents

Language: Английский

Citations

12
Interaction between sleep duration and physical activity on mortality among cancer survivors: findings from National Health and Nutrition Examination Surveys 2007–2018 DOI Creative Commons
Ruyan Chen, Jianglong Han, Si Li

et al.

Frontiers in Public Health, Journal Year: 2025, Volume and Issue: 13

Published: Jan. 17, 2025

Sleep duration and physical activity (PA) are critical factors influencing mortality risk. However, the interaction between sleep PA with risk among cancer survivors has not been well explored. This cross-sectional study utilized data from National Health Nutrition Examination Survey (NHANES) spanning 2007-2018. Multivariable Cox regression analysis restricted cubic splines were employed to evaluate hazard ratios (HRs) 95% confidence intervals (CIs) of association in survivors. Multiplicative additive terms constructed assess effects. The included a total 2,528 adult (aged≥20 years). exhibited U-shaped all-cause cancer-specific mortality, while demonstrating an inverted L-shaped cardiovascular disease (CVD) mortality. Compared physically inactive participants, those adequate had lower risks (HR = 0.542, CI: 0.540-0.543), 0.486, 0.484-0.488), CVD 0.759, 0.755-0.763) A significant was found extreme on (long duration: relative excess due (RERI) 1.514, 1.504-1.525; short RERI 0.725, 0.713-0.737). Extreme lack associated independently jointly. Maintain appropriate doing regular may synergistically improve survival

Language: Английский

Citations

2
Obesity and Preventive Intervention Among Children: A Narrative Review DOI Open Access
Sayali umekar, Abhishek Joshi

Cureus, Journal Year: 2024, Volume and Issue: unknown

Published: Feb. 20, 2024

Childhood obesity has become a major public health concern around the world, with rise in prevalence over last few decades. This abstract provides an overview of pediatric obesity, including its causes, implications, and potential treatments. is caused by complex combination environmental, genetic, behavioral variables. A child's likelihood developing influenced factors, such as socioeconomic status, family dynamics, cultural norms. leads to extensive repercussions, elevating risk chronic conditions, diabetes, cardiovascular diseases, mental challenges. Furthermore, children dealing often face social stigmatization, diminished self-esteem, academic struggles. Efforts prevent manage childhood should employ comprehensive multi-tiered approach. involves enacting policies geared toward enhancing nutrition schools communities, advocating for increased physical activity (PA), curbing sedentary behaviors.

Language: Английский

Citations

7
Influence of routine exercise on the peripheral immune system to prevent and alleviate pain DOI Creative Commons
Joseph B. Lesnak, Giovanni Berardi, Kathleen A. Sluka

et al.

Neurobiology of Pain, Journal Year: 2023, Volume and Issue: 13, P. 100126 - 100126

Published: Jan. 1, 2023

Routine physical activity reduces the onset of pain and exercise is a first line treatment for individuals who develop chronic pain. In both preclinical clinical research regular (routine sessions) produces relief through multiple mechanisms such as alterations in central peripheral nervous system. More recently, it has been appreciated that can also alter immune system to prevent or reduce animal models, at site injury model induction, dorsal root ganglia, systemically throughout body produce analgesia. Most notably shows ability dampen presence pro-inflammatory cells cytokines these locations. Exercise decreases M1 macrophages IL-6, IL-1β, TFNα, while increasing M2 IL-10, IL-4, IL-1ra. research, single bout an acute inflammatory response, however repeated training lead anti-inflammatory profile leading symptom relief. Despite benefits routine exercise, direct effect on function populations remains unexplored. This review will discuss more detail which demonstrates numerous ways types closes with implications findings along suggestions future directions.

Language: Английский

Citations

15
Exergames to Limit Weight Gain and to Fight Sedentarism in Children and Adolescents with Obesity DOI Creative Commons
Valeria Calcaterra, Matteo Vandoni, Luca Marin

et al.

Children, Journal Year: 2023, Volume and Issue: 10(6), P. 928 - 928

Published: May 24, 2023

Exergames are defined as digital games that require bodily movements to play, stimulating an active gaming experience function a form of physical activity (PA). The players interact with the game through whole-body improving energy expenditure. may be effective in and psychological aspects children adolescents obesity. In this narrative review, we synthesized current evidence regarding role exergames modifying body composition weight promoting changes sedentary behavior define benefits video useful tools for fighting sedentarism outline future directions exergaming supplementation exercise rather than replacement educational programs pediatric Data from literature indicate offer interesting impact on childhood obesity considered potential strategy controlling gain composition, promote PA, decrease time spent However, exergame use also has some limits, such children’s poor self-regulation structuring use. Therefore, prudent approach should maintained, additional high-quality research is needed determine if can effectively used treatment new media, replacement, could combat prevention.

Language: Английский

Citations

14
Inflammation and Physical Performance in Overweight and Obese Schoolchildren DOI Creative Commons
Cristina Popescu, Daniela Matei,

Anca Maria Amzolini

et al.

Life, Journal Year: 2024, Volume and Issue: 14(12), P. 1583 - 1583

Published: Dec. 1, 2024

Obesity represents a critical public health concern, often linked to low-grade chronic inflammation starting in childhood. This study aimed evaluate the impact of 12-week kinesiotherapy program on physical performance and levels leptin C-reactive protein (CRP) overweight obese children. Methods: Conducted at Filantropia Municipal Clinical Hospital, 160 children aged 6 15 were randomly assigned group (SG, n = 80) control (CG, 80). The SG engaged tailored program, while CG maintained their usual activities. All families learned five key principles for preventing managing obesity. Results: Results indicated significant improvements SG, with enhancements min walking distance, Timed Up Go test, cadence (all p-values < 0.001). Notably, CRP (23.02 ± 7.17 16.62 7.83, 4.13 1.00 3.90 0.95 mg/l, respectively) decreased significantly contrasting no changes CG. Regression analysis revealed positive correlation between activity (coefficient: 0.5642, R-squared: 0.266). Conclusions: These findings suggest that targeted exercise programs can effectively enhance reduce markers children, highlighting importance interventions

Language: Английский

Citations

6
The impact of physical activity on quality of life in youth with visual impairments DOI

Kelsey Zehr,

Pamela Beach, Lauren J. Lieberman

et al.

British Journal of Visual Impairment, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 9, 2025

Youth with visual impairments (YVI) do not participate in adequate daily physical activity, which can adversely impact their health indices, fitness, and overall quality of life (QoL). However, little is known about the activity on QoL YVI. This study examined effect a sports camp Participants included 49 YVI 9 to 18 years. Thirty-three participants attended week-long 16 served as controls. completed pre- post-tests using VISION-QL Pediatric Quality-of-Life Inventory (PedsQL™) surveys. To provide further context, two focus groups were conducted from participants. There no significant differences between post-test groups, although pre-test scores did exhibit significance 7 10 domains significantly different groups. In addition, higher found intervention group for education social subscales. Considering many attending had previous experiences at camps, benefits likely illustrated more comparison pre-tests rather than across period. These findings indicate importance regular upon

Language: Английский

Citations

0
Physiological regulation of moderate-intensity exercise in improving the biomarkers visfatin and myonectin as a modulator of increasing metabolic performance in obese DOI
Sugiharto Sugiharto, Adi Pranoto, Nurul Ihsan

et al.

Journal of Basic and Clinical Physiology and Pharmacology, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 18, 2025

Abstract Objectives A well-structured, regular, and programmed physical exercise regimen is believed to be an effective physiological modulator for preventing the dysfunction of myonectin visfatin secretion. Therefore, this study aims analyze regulation moderate-intensity in improving biomarkers obese women. Methods The involved 30 physically healthy women, nonathletes, selected based on predetermined criteria, who voluntarily agreed participate. They were then divided into two groups: a control group (CRT; n=15) (ART; n=15). program lasted 8 weeks, with frequency 5 times per week at moderate intensity. Metabolic performance was analyzed using Sandwich-ELISA method. Data analysis conducted parametric paired sample t-tests independent % significance level. Results results showed significant increase secretion decrease (p≤0.05) after weeks exercise, demonstrated by 97.85 pg/mL 0.05 ng/mL. Conversely, group, decreased 3.04 pg/mL, increased 0.03 Conclusions These findings confirm that 8-week can improve biomarkers, thereby enhancing metabolic Thus, induced serve as modulators

Language: Английский

Citations

0