Toxics,
Journal Year:
2024,
Volume and Issue:
12(5), P. 320 - 320
Published: April 28, 2024
Microplastics
(MPs)
are
now
ubiquitous
environmental
contaminants
that
lead
to
unavoidable
human
exposure;
they
have
received
increasing
attention
in
recent
years
and
become
an
emerging
area
of
research.
The
greatest
concern
is
the
negative
impacts
MPs
on
marine,
fresh-water,
terrestrial
ecosystems,
as
well
health,
extent
World
Health
Organization
(WHO)
calls
for
increased
research
standardized
methods
assess
exposure
MPs.
Many
countries
international
organizations
implementing
or
proposing
legislation
this
regard.
This
review
aims
summarize
current
state
legislation,
indoor
outdoor
contamination,
potential
health
risk
due
airborne
MPs,
considering
occupational
also
becoming
a
growing
concern.
Even
though
regarding
has
continuously
last
twenty
years,
effects
been
scarcely
investigated,
toxicity
studies
still
limited
not
directly
comparable,
lack
field.
International Journal of Molecular Sciences,
Journal Year:
2023,
Volume and Issue:
24(7), P. 6328 - 6328
Published: March 28, 2023
Neuroinflammation
is
a
critical
factor
in
developing
and
progressing
numerous
brain
diseases,
including
neurodegenerative
diseases.
Chronic
or
excessive
neuroinflammation
can
lead
to
neurotoxicity,
causing
damage
contributing
the
onset
progression
of
various
Therefore,
understanding
mechanisms
strategies
control
them
crucial
for
treating
Studies
have
shown
that
plays
vital
role
such
as
Alzheimer's
(AD)
Parkinson's
(PD),
stroke.
Additionally,
effects
PM
Environment International,
Journal Year:
2022,
Volume and Issue:
171, P. 107706 - 107706
Published: Dec. 19, 2022
Fine
particulate
matter
(PM2.5)
has
been
widely
reported
to
contribute
the
pathogenesis
of
pulmonary
diseases.
The
direct
hazardous
effect
PM2.5
on
respiratory
system
at
high
concentrations
in
vitro
and
vivo
have
well
identified.
However,
its
pre-existing
diseases
patients
environment-related
remains
unclear.
Diesel
exhaust
as
a
primary
representative
ambient
fine
particles
were
used
investigated
fibrosis
progression
existing
disease
models.
This
study
that
could
result
enhanced
sensitivity
fibrotic
response,
which
may
be
ascribed
ferroptosis
induced
by
damaged
lung
areas.
Proteomic
analysis
revealed
upregulation
HO-1
key
mechanism
exacerbation
PM2.5.
As
result,
degraded
heme-containing
protein
released
iron
cells,
leading
generation
mitochondrial
ROS
impaired
function.
Transmission
electron
microscopic
assay
verified
entered
mitochondria
cells
was
accompanied
significant
morphological
changes
characterized
increased
membrane
density
reduced
size.
inhibitor
zinc
protoporphyrin
mitochondrion-targeted
antioxidant
Mito-TEMPO
significantly
attenuated
PM2.5-induced
fibrosis.
In
addition,
AMPK-ULK1
axis-triggered
autophagy
activation
NCOA4-mediated
degradation
ferritin
found
related
cells.
evidenced
inhibition
with
3-methyladenine
or
AMPK
inhibitor,
NCOA4
knockdown
decreased
intracellular
accumulation
lipid
peroxidation,
thereby
relieving
epithelial-mesenchymal
transition
cell
death
Overall,
this
provided
experimental
support
for
idea
greatly
deteriorates
process
fibrosis,
HO-1-mediated
dysfunction
ferritinophagy
are
jointly
required
effects.
International Immunology,
Journal Year:
2024,
Volume and Issue:
36(5), P. 211 - 222
Published: Jan. 16, 2024
Abstract
The
epithelial
barrier
theory
links
the
recent
rise
in
chronic
non-communicable
diseases,
notably
autoimmune
and
allergic
disorders,
to
environmental
agents
disrupting
barrier.
Global
pollution
toxic
agent
exposure
have
worsened
over
six
decades
because
of
uncontrolled
growth,
modernization,
industrialization,
affecting
human
health.
Introducing
new
chemicals
without
any
reasonable
control
their
health
effects
through
these
years
has
led
documented
adverse
effects,
especially
on
skin
mucosal
barriers.
These
substances,
such
as
particulate
matter,
detergents,
surfactants,
food
emulsifiers,
micro-
nano-plastics,
diesel
exhaust,
cigarette
smoke,
ozone,
been
shown
compromise
integrity.
This
disruption
is
linked
opening
tight-junction
barriers,
inflammation,
cell
death,
oxidative
stress,
metabolic
regulation.
Consideration
must
be
given
interplay
underlying
inflammatory
medications,
affected
tissues.
review
article
discusses
detrimental
effect
barrier-damaging
compounds
involves
cellular
molecular
mechanisms.
Epigenomes,
Journal Year:
2024,
Volume and Issue:
8(2), P. 13 - 13
Published: March 31, 2024
The
effects
of
PM2.5
on
human
health
fluctuate
greatly
among
various
age
groups,
influenced
by
a
range
physiological
and
immunological
reactions.
This
paper
compares
the
pathogenesis
disease
caused
in
people
different
ages,
focusing
how
children,
adults,
elderly
are
each
susceptible
to
it
because
differences
their
bodies.
Regarding
exposure
is
linked
many
negative
consequences.
These
factors
consist
inflammation,
oxidative
stress,
respiratory
problems,
which
might
worsen
pre-existing
conditions
potentially
cause
neurotoxicity
developmental
issues.
Epigenetic
changes
can
affect
immune
system
make
more
likely
get
diseases.
On
other
hand,
exposures
during
pregnancy
change
cardiovascular
central
nervous
systems
develop.
In
inhalation
associated
with
wide
problems.
include
difficulties,
reduced
pulmonary
function,
an
increased
susceptibility
illnesses
such
as
asthma,
chronic
obstructive
(COPD),
lung
cancer.
addition,
induces
systemic
diseases,
insulin
resistance,
neurotoxic
Evident
disturbances
cognitive
function
demonstrate
broad
impact
PM2.5.
population
prone
developing
issues
raise
risk
decline
neurological
illnesses.
Having
additional
medical
conditions,
peptic
ulcer
disease,
significantly
increases
likelihood
being
admitted
hospital.
Remote Sensing,
Journal Year:
2025,
Volume and Issue:
17(1), P. 126 - 126
Published: Jan. 2, 2025
Estimating
surface-level
PM2.5
concentrations
at
any
given
location
is
crucial
for
public
health
monitoring
and
cohort
studies.
Existing
models
datasets
this
purpose
have
limited
precision,
especially
on
high-concentration
days.
Additionally,
due
to
the
lack
of
open-source
code,
generating
estimates
other
areas
time
periods
remains
cumbersome.
We
developed
a
novel
deep
learning-based
model
that
improves
concentration
by
capitalizing
temporal
dynamics
air
quality.
Specifically,
we
improve
estimation
precision
developing
Long
Short-Term
Memory
(LSTM)
network
with
Attention
integrating
multiple
data
sources,
including
in
situ
measurements,
remotely
sensed
data,
wildfire
smoke
density
observations,
which
model’s
ability
capture
events.
rigorously
evaluate
against
existing
products,
demonstrating
2.2%
improvement
overall
RMSE,
9.8%
reduction
RMSE
days,
highlighting
superior
performance
our
approach,
particularly
Using
model,
produced
comprehensive
dataset
from
2005
2021
contiguous
United
States
are
releasing
an
framework
ensure
reproducibility
facilitate
further
adaptation
quality
