Pheochromocytoma and paraganglioma syndromes: genetics and management update

Current Oncology, Journal Year: 2013, Volume and Issue: 21(1), P. 8 - 8

Published: Nov. 7, 2013

Pheochromocytomas (pheos) and paragangliomas (pgls) are rare tumours of the autonomic nervous system, originating from paraganglia, which dispersed neuroendocrine organs characterized by catecholamine peptide-producing cells derived neural crest. Medical textbooks have traditionally suggested that 10% pheos heritable. However, frequency heritable pheo has been underestimated. Three syndromic conditions-Von Hippel-Lindau (vhl), multiple endocrine neoplasia type 2 (men2), neurofibromatosis 1 (nf1)-and three genes-subunits succinate dehydrogenase (SDH) complex: SDHB, SDHC, SDHD-are established causes hereditary pheo-pgl. In last few years, four new genes (SDHA, SDHAF2, MAX, TMEM127) found to be associated with predisposition these tumours. The present review, illustrated case reports, gives an update genetic basis pheo-pgl parent-of-origin effect implicated in transmission SDHD SDHAF2. We discuss referral criteria should guide decision offer testing affected patients. also specify most likely implicated-based on particular features such as malignancy, bilateralism, or childhood-onset-to help geneticists efficiently order appropriate tests. Finally, we review screening recommendations for carriers a mutation.

Language: Английский

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Targeted therapies in metastatic non-small cell lung cancer (NSCLC): the rational approach

Current Oncology, Journal Year: 2010, Volume and Issue: 17(2)

Published: March 31, 2010

Home-based informal caregivers (CGs), such as the family members and friends of cancer patients, often suffer averse emotional symptoms, anxiety depression, due to burden associated with providing care.The natural environment has been valued a healing sanctuary for easing pain, promoting calmness, relaxation, restoration.The use virtual reality (VR) nature experiences offers an alternative option CGs manage symptoms improve their quality life.The aim this mixed-method pilot was evaluate feasibility acceptability nature-based VR experience home-based CGs.Nine participated in 10 min session completed feasibility, acceptability, symptom measures laboratory.Semi-structured interviews five provided qualitative data regarding VR.The (mean age 64.78 years) were mostly female (n = 7).Our analysis showed high (15.11 ± 1.76; range 0-16) (15.44 1.33; 0-16), well low Symptoms (1.56 0-27).Participants primarily expressed positive perceptions during interviews.Our findings show promise experiences.In next phase study, intervention will be tested on patients at end life.

Language: Английский

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Social connectedness and the role of virtual reality: experiences and perceptions of people living with dementia and their caregivers

Disability and Rehabilitation Assistive Technology, Journal Year: 2024, Volume and Issue: 19(7), P. 2615 - 2629

Published: Feb. 19, 2024

People living with dementia are often at increased risk of becoming socially disconnected due to dementia-related challenges. In recent years, digital technology has been designed help address the social health people and provide opportunities promote or maintain their connectedness. This paper presents findings from phase two a participatory action research project, which explored caregiver's experiences perceptions connectedness potential role Virtual Reality (VR) in promoting maintaining same.

Language: Английский

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Opinions on the use of welfare technologies by people with dementia -focus groups with people with dementia and their significant others

Educational Gerontology, Journal Year: 2025, Volume and Issue: unknown, P. 1 - 14

Published: Jan. 3, 2025

Dementia comprises global health issues, affecting families, healthcare systems, and broader society. Emerging technologies offer new tools for care support that people living with dementia employ to manage their daily lives. We aim at exploring needs ideas regarding digital technology how it can be used increase self-management participation dementia. Ten participants took part in this study; five persons diagnosed spouses of The data obtained the individual interviews analyzed descriptively, by reviewing protocols from interviews. focus group session were themes. All lived ordinary housing but participated activities a center Sweden. owned smartphones computers which indicates baseline familiarity tools. In results groups three themes emerged: (1) Digital as multifunctional resources, (2) Resources barriers using tools, (3) Accounting wishes when planning future. both described potential help mitigate future challenges fears concerns endeavors, e.g. facilitators staying touch family friends able listen familiar music. conclusion, may prove vital managing life socially connected. However, reliance also lead challenges, especially cognitive abilities decline.

Language: Английский

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Multi-user Virtual Reality for Social Connectedness: Exploring the Design Preferences of People Living with Dementia and Their Support Persons

Design for inclusion, Journal Year: 2025, Volume and Issue: unknown, P. 53 - 66

Published: Jan. 1, 2025

Language: Английский

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Unpaid carers of people with dementia and information communication technology: Use, impact and ideas for the future

Dementia, Journal Year: 2024, Volume and Issue: 23(5), P. 779 - 799

Published: April 25, 2024

Several 100,000s of people living with dementia in the UK are cared for at home by a spouse or relative. Few studies have considered ICT needs and experiences unpaid carers. This study explores types carers use, ways they use ICT, impact ICT-use, their ideas how could be more supportive role as carer.

Language: Английский

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A Multi-User Virtual Reality Social Connecting Space for People Living with Dementia and Their Support Persons: A Participatory Action Research Study

International Journal of Human-Computer Interaction, Journal Year: 2024, Volume and Issue: unknown, P. 1 - 19

Published: May 29, 2024

Digital technologies such as virtual reality (VR) are increasingly designed and implemented to support people living with dementia who at risk of loneliness and/or social isolation. Multi-user VR (MUVR), which involves simultaneous user engagement a sense being present together in VR, may promote maintain connectedness between their persons. This paper focuses on Phase 4 larger participatory action research (PAR) project, aimed explore the usability, acceptability feasibility MUVR application its potential The study involved five persons, trialed homes over two PAR cycles. researcher gathered feedback through individual semi-structured interviews observational field notes. Reflexive thematic analysis guided qualitative data analysis, findings suggested that is usable, acceptable, feasible for this population. also indicated shows promise promoting or maintaining among Nonetheless, further refinement necessary enhance application, these areas presented paper, design recommendations future work.

Language: Английский

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Use of Virtual Reality and Augmented Reality Technologies to Support Resilience and Skill-Building in Caregivers of Persons With Dementia: A Scoping Review

Cureus, Journal Year: 2024, Volume and Issue: unknown

Published: July 8, 2024

Dementia presents a growing public health challenge with most affected individuals living at home, placing significant responsibility on their caregivers. Various interventions, from traditional support groups and education programs to emerging technologies, more specifically virtual reality (VR) augmented (AR), aim enhance caregiver skills. While VR/AR shows promise in educating fostering empathy among caregivers healthcare professionals, its overall effectiveness practicality older adults dementia care warrant further exploration. This review aimed summarize currently available VR AR interventions tailored for family of persons (PLWD) home or clinical settings, including level effectiveness, compile summary features that contributed technology acceptance PLWD. We conducted systematic search OVID PsychInfo, CINAHL, Google Scholar, ERIC, as well CADTH's Grey Matters, OpenGrey, National Technical Information Service, OAIster, Health Quality Ontario, comprehensively the existing evidence underscoring role supporting education, resilience-building, skills training The terms were built assistance research librarian involved synonyms VR, AR, dementia. Two screeners rigorous screening data extraction analyze findings. Studies included if they focused engaging utilizing three-dimensional environment and/or Metaverse group learning psychotherapeutic modalities such psychoeducation, therapy, communication, skill-building. primary outcome studies was assessing measures well-being (e.g., quality life, interaction, personhood) outcomes caregivers, while secondary identifying barriers facilitators influencing acceptability Content analysis descriptive statistics used key trends acceptability. Of 1,641 articles found, 112 included, six meeting inclusion analysis. differed duration frequency collection, varying single events months-long programs, often employing home-based approaches using online platforms. No study AR. Usability issues unclear benefits use identified factors hinder However, technologies demonstrated user experiences, skill-building, confidence, competence Positive psychological effects also observed, facilitated by immersive resulting improved reduced stress, depression, loneliness. PLWD show potential reduce stress. Challenges technological limitations inexperience persist. Home-based aligns comfort but lacks focus financial aspects cultural competencies. Co-design offer solutions addressing concerns promoting end-user engagement empowerment.

Language: Английский

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Nature-Based Virtual Reality Feasibility and Acceptability Pilot for Caregiver Respite

Current Oncology, Journal Year: 2023, Volume and Issue: 30(7), P. 5995 - 6005

Published: June 22, 2023

Home-based informal caregivers (CGs), such as the family members and friends of cancer patients, often suffer averse emotional symptoms, anxiety depression, due to burden associated with providing care. The natural environment has been valued a healing sanctuary for easing pain, promoting calmness, relaxation, restoration. use virtual reality (VR) nature experiences offers an alternative option CGs manage symptoms improve their quality life. aim this mixed-method pilot was evaluate feasibility acceptability nature-based VR experience home-based CGs. Nine participated in 10 min session completed feasibility, acceptability, symptom measures laboratory. Semi-structured interviews five provided qualitative data regarding VR. (mean age 64.78 years) were mostly female (n = 7). Our analysis showed high (15.11 ± 1.76; range 0–16) (15.44 1.33; 0–16), well low Symptoms (1.56 0–27). Participants primarily expressed positive perceptions during interviews. findings show promise experiences. In next phase study, intervention will be tested on patients at end

Language: Английский

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The Effect of Using Virtual Reality Goggles on Psychological Well-Being and Care Burden of Informal Caregivers of Patients Hospitalized in Palliative Care Clinic

European Journal of Oncology Nursing, Journal Year: 2024, Volume and Issue: 73, P. 102711 - 102711

Published: Oct. 9, 2024

Language: Английский

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