The neurophysiological consequences of racism-related stressors in Black Americans

Neuroscience & Biobehavioral Reviews, Journal Year: 2024, Volume and Issue: 161, P. 105638 - 105638

Published: March 24, 2024

Language: Английский

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Allostasis, health, and development in Latin America

Neuroscience & Biobehavioral Reviews, Journal Year: 2024, Volume and Issue: 162, P. 105697 - 105697

Published: May 4, 2024

Language: Английский

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Architectural Allostatic Overloading: Exploring a Connection between Architectural Form and Allostatic Overloading

International Journal of Environmental Research and Public Health, Journal Year: 2023, Volume and Issue: 20(9), P. 5637 - 5637

Published: April 25, 2023

This paper examines, conceptually, the relationship between stress-inducing architectural features and allostatic overload by drawing on literature from neuroimmunology neuroarchitecture. The studies reviewed field of indicate that chronic or repeated exposure to events may overwhelm body’s regulatory system, resulting in a process termed overload. While there is evidence neuroarchitecture short-term particular produce acute stress responses, yet be study load. considers how design such reviewing two primary methods used measure overload: biomarkers clinimetrics. Of interest observation clinical neuroarchitectural differ substantially those Therefore, concludes while observed responses forms activity, further research needed determine whether these are leading Consequently, discrete longitudinal public health advised, one which engages indicative activity incorporates contextual data using clinimetric approach.

Language: Английский

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Leadership and the Executive Athlete

Published: Jan. 1, 2025

Language: Английский

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Vascular-related biological stress, DNA methylation, allostatic load and domain-specific cognition: an integrated machine learning and causal inference approach

BMC Neurology, Journal Year: 2025, Volume and Issue: 25(1)

Published: April 23, 2025

Vascular disease in aging populations spans a wide range of disorders including strokes, circulation and hypertension. As individuals age, vascular co-occur hence exert combined effects. In the present study we introduce vascular-related biological stress as novel biomarker to capture effects burden for more precision early detection cognitive changes aging. determine role Stress, DNA methylation-based Allostatic Load relationship between major domains global cognition, episodic memory executive function representative sample adults across age span. The included participants from MIDUS refresher sample. Vascular-related included: BMI, Average blood pressure, sitting, Waist-hip ratio, Blood hemoglobin A1c percent, dehydroepiandrosterone (ng/mL), fasting insulin levels uIU/mL, serum interleukin-8 (pg/mL), interleukin-6 glucose mg/dL fibrinogen (mg/dL). measures GrimAge2 that was constructed based on methylation surrogate markers select plasma proteins smoking-pack years. load scores were calculated biomarkers commonly used allostatic calculations: cortisol (urine), norepinephrine epinephrine dopamine glycosylated (HBA1C, blood), low density lipoprotein (LDL, C-reactive protein (CRP, blood) sulfate (DHEAS, high-density (HDL, systolic pressure (average, sitting). Least Absolute Shrinkage Selection Operator (LASSO) response models (item continuous) calculate theta scores. Four-way decomposition modeling approach natural direct indirect domains. 550 with data biomarkers, cognition assessments study. Median 54 (range = 26, 78) females representing 48% overall proportions mediated through (item-response scale) 0.60 (P 0.01); 1.1 0.308); 0.53 0.002) respectively. (GrimAge2) 0.27 0.002); 0.39 0.102); 0.20, respectively 0.10 0.08); 0.09 0.5); 0.07 0.18) (sum scores). Our findings suggest stress, some extent mediate function.

Language: Английский

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Neighborhood deprivation is a risk factor for severe child physical abuse: A multicenter cohort investigation

Journal of Trauma and Acute Care Surgery, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 6, 2025

BACKGROUND Our purpose was to investigate whether neighborhood deprivation is associated with outcomes in a multicenter population of children suspected or confirmed child physical abuse. We hypothesized that community level social determinants health are worse following METHODS This retrospective review included (18 years younger) admitted abuse at six pediatric trauma centers. A national Area Deprivation Index (ADI) score assigned each patient based on home address. divided into quartiles using the distribution our dataset. Exclusion caregiver discharge used as proxy for Descriptive statistics and stepwise logistic regression were identify covariates. Multiple test associations between ADI exclusion. RESULTS Of 1,105 patients, 512 had These patients younger (median [interquartile range], 0.50 [1.50] vs. 0.83 [1.67]; p = 0.002), more likely be Black African American (28.3% 19.5%, < 0.001), higher scores (81.0 [35.0] 66.0 [60.0], 0.001). dose-dependent relationship exclusion identified. Compared those from least vulnerable neighborhoods (ADI first quartile), most fourth quartile) 2.65 (95% confidence interval, 1.73–4.08; 0.001) times odds Despite no differences Injury Severity Scores (8.0 [6.0] 9.0 [10.0], 0.163), they also longer lengths hospital stay (1.0 [2.0] 3.0 [2.8], 0.002) mortality (1.5% 5.0%, 0.028). CONCLUSION large experience demonstrates socioeconomic disadvantage further demonstrate outcomes, including increased mortality, findings provide objective data lead suggestions interdisciplinary multiscale approaches primary prevention LEVEL OF EVIDENCE Prognostic Epidemiological; Level III.

Language: Английский

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Lower levels of positive affect and insomnia are associated with elevated allostatic load among Ukrainian refugees

Psychoneuroendocrinology, Journal Year: 2025, Volume and Issue: 175, P. 107387 - 107387

Published: Feb. 16, 2025

Language: Английский

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Comprehensive allostatic load risk index is associated with increased frontal and left parietal white matter hyperintensities in mid-life cognitively healthy adults

Scientific Reports, Journal Year: 2024, Volume and Issue: 14(1)

Published: Jan. 5, 2024

To date, there is a considerable heterogeneity of methods to score Allostatic Load (AL). Here we propose comprehensive algorithm (ALCS) that integrates commonly used approaches generate AL risk categories and assess associations brain structure deterioration. In cohort cognitively normal mid-life adults (n = 620, age 51.3 ± 5.48 years), developed composite for scoring incorporating gender differences, high quartile approach, clinical reference values, current medications, then categories. Compared the empirical approach (ALES), ALCS showed better model fit criteria strong association with sex. ALSC were regressed against white matter hyperintensity (WMH) volumes. Higher associated increased total, periventricular, frontal, left parietal WMH volumes, also showing compared ALES. When cardiovascular biomarkers removed from algorithm, only left-frontal WMHV remained AL, revealing vascular burden influencing index. Our results agree previous evidence suggest sustained stress exposure enhances deterioration in adults. Showing than ALES, our can provide more accurate estimation explore how age-related health decline.

Language: Английский

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The relevance of the contribution of psychoneuroendocrinoimmunology and psychology of reasoning and decision making to nursing science: A discursive paper

Journal of Advanced Nursing, Journal Year: 2024, Volume and Issue: 80(7), P. 2943 - 2957

Published: Feb. 6, 2024

Abstract Aim Patients' death or adverse events appear to be associated with poor healthcare decision‐making. This might due an inability have adequate representation of the problem connections among problem‐related elements. Changing how a is formulated can reduce biases in clinical reasoning. The purpose this article explore possible contributions psychoneuroendocrinoimmunology (PNEI) and psychology reasoning decision‐making (PRDM) support new nursing theoretical frame. Design Discursive paper. Method discusses main assumptions about nurses' ability face patient's problems, suggesting approach that integrates knowledge from PNEI PRDM. While explains complexity systems, highlighting importance systems affecting health, PRDM underlines informative context creating mental problem. Furthermore, suggests need pay attention information not immediately explicit its connections. Conclusion Nursing recognizes patient–nurse relationship as axiom governs care. integration theoretics allows expansion by providing essential elements read type relationship: information. relationships between biological psyche whole individual environment; provides tools for nurse's analytical thinking system correctly process Impact on Practice A renewal mandatory improve priority identification. Integrating into will modify way professionals patients, reducing cognitive medical errors. No Patient Public Contribution There was no patient public involvement design writing discursive article.

Language: Английский

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Emerging Theories of Allostatic-Interoceptive Overload in Neurodegeneration

Current topics in behavioral neurosciences, Journal Year: 2024, Volume and Issue: unknown

Published: Jan. 1, 2024

Language: Английский

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