Association between Mediterranean diet and dementia and Alzheimer disease: a systematic review with meta-analysis

Aging Clinical and Experimental Research, Journal Year: 2024, Volume and Issue: 36(1)

Published: March 22, 2024

Abstract Background Dementia affects 5–8% of the population aged over 65 years (~50 million worldwide). Several factors are associated with increased risk, including diet. The Mediterranean diet (MedDiet) has shown potential protective effects against several chronic diseases. Aims This systematic review meta-analysis aim was to assess association between adherence MedDiet and risk dementia in elderly. Methods PRISMA-2020 guidelines were followed. PubMed/MEDLINE Scopus searched on 17 July 2023. Newcastle–Ottawa Scale tool used bias. protocol pre-registered PROSPERO (registration number: CRD 42023444368). Heterogeneity assessed using I 2 test. Publication bias by visual inspection funnel plot Egger’s regression asymmetry final effect size reported as OR or HR, depending study design included studies. Results Out 682 records, 21 analysis. pooled 0.89 (95% CI = 0.84–0.94) based 65,955 participants ( 69.94). When only cohort studies included, HR 0.84 0.76–0.94) 55,205 89.70). Alzheimer Disease considered 0.73 0.62–0.85) 38,292 63.85). Discussion Despite relatively low reduction higher among elderly, it should be that this is most affected. Conclusions Adherence could an effective non-pharmacological measure reduce burden dementia, even

Language: Английский

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Climate Change Perception and Mental Health. Results from a Systematic Review of the Literature

European Journal of Investigation in Health Psychology and Education, Journal Year: 2024, Volume and Issue: 14(1), P. 215 - 229

Published: Jan. 12, 2024

Climate change is one of the main global challenges and influences various aspects human health. Numerous studies have indeed demonstrated an association between extreme climate-related events physical mental health outcomes, but little still known about perception/awareness climate In accordance with PRISMA 2020 guidelines, a search was conducted on PubMed Scopus. The protocol registered PROSPERO. included were original observational published in English, reporting A total 3018 articles identified. 10 included. period covered ranged 2012 2022. perception consistently associated adverse effects across different types estimates. particular, identified higher level depression, anxiety, eco-anxiety, stress, adjustment disorder, substance use, dysphoria, even thoughts suicide. Qualitative data underscore impact daily activities, contributing to feelings loss suicidal ideation. Moreover, correlates lower well-being resilience. awareness complex poorly explored phenomenon. limitations are high heterogeneity terms exposure assessment reporting, which hinders quantitative analysis. These results show that impacts Better understanding phenomenon represents opportunity inform public interventions promote well-being.

Language: Английский

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Impact of adherence to the Mediterranean diet on stroke risk

GeroScience, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 7, 2025

Abstract Stroke is a leading cause of morbidity and mortality worldwide, dietary patterns have emerged as significant modifiable factor in stroke prevention. The Mediterranean diet, characterized by high intake fruits, vegetables, whole grains, nuts, olive oil, fish, has been widely recognized for its cardiovascular benefits. However, specific impact on risk requires further elucidation. We conducted comprehensive meta-analysis 30 studies, including both cohort case–control designs, to evaluate the relationship between adherence diet stroke. A systematic search was performed across multiple databases, random-effects model used estimate pooled hazard ratios (HRs) with 95% confidence intervals (CIs). Heterogeneity assessed using I 2 statistic, publication bias examined through funnel plots Egger’s regression test. Additionally, trial sequential analysis determine adequacy sample size. revealed reduction among individuals adhering HR 0.88 (95% CI: 0.84–0.91). Notably, heterogeneity detected ( = 34%). Z-score plot from confirmed that sizes were sufficient draw definitive conclusions. potential identified. studies highly effect (HR 0.54, 0.4–0.73). settings hinted at presence bias, supported Our findings provide robust evidence supporting protective against Despite some cumulative suggests promoting could serve an effective public health strategy Further research recommended explore underlying mechanisms assess diet’s diverse populations.

Language: Английский

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Examining the dietary contributions of lipids to pancreatic cancer burden (1990–2021): incidence trends and future projections

Lipids in Health and Disease, Journal Year: 2025, Volume and Issue: 24(1)

Published: Feb. 21, 2025

Pancreatic cancer (PC) ranks sixth globally among deaths, imposing a significant burden on healthcare systems worldwide. Although diet is known to be major risk factor, well-established factor for PC, the precise dietary components linked disease remain inconclusive, with studies showing varying results across different populations and regions. This study addresses this gap through comprehensive analysis of PC incidence trends from 1990 2021, specific focus associations age, patterns, socio-demographic determinants. The data utilized in were obtained 2021 Global Burden Disease (GBD) database, updated May 16, 2024. Unlike traditional single-variable correlation analyses, Bayesian generalized linear model was applied assess association between food intake during period 1990–2021. To account variations related year region, these variables incorporated as covariates model, allowing more nuanced background factors. Finally, "BAPC" package employed project age-standardized rates 2051. global increased 3.90 per 100,000 people (95% CI: 3.69, 4.08) 6.44 5.86, 6.93) 2021. revealed nuts, omega-3 fatty acids, polyunsaturated acids (PUFA), trans fats, sodium, calcium. In typical countries, higher nuts PUFA associated reduced while fats positively correlated incidence. Age-Period-Cohort (BAPC) prediction indicates that will show downward trend after From exhibited rapid upward trend, suggesting an increasing burden. findings suggest lipid significantly at level. finding underscores importance fat composition, particularly context pancreatic prevention, individuals should pay attention types sources their diets mitigate risk.

Language: Английский

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Mediterranean diet for cancer prevention and survivorship

Maturitas, Journal Year: 2023, Volume and Issue: 178, P. 107841 - 107841

Published: Aug. 24, 2023

Cancer is one of the main noncommunicable diseases in terms health impact. Factors such as a progressively aging population point to future increases incidence cancer on global level. The elevated number affected individuals, together with continuous improvements prevention and therapy, creating growing survivors, often inadequately met needs.Lifestyle key modulator risk associated morbidity mortality, included all approaches long-term management cancer. Diet principal component lifestyle, most available evidence centered Mediterranean diet. Our objective was provide narrative review effect diet threats related survivorship. For this purpose, we searched PubMed database for articles published between January 1, 2000, June 12, 2023.Current data show that inversely risk, or neutral, types Tumors digestive system have received preferential interest, but studies also been tumors other organs. evidence, however, meager due observational nature studies, although it reassuring benefit reproduced performed different populations environments. Evidence survivors limited by paucity yet several findings regarding survival, recurrence, short- suggest potential role warrants further research.

Language: Английский

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Adherence to the Mediterranean diet and its protective effects against colorectal cancer: a meta-analysis of 26 studies with 2,217,404 participants

GeroScience, Journal Year: 2024, Volume and Issue: unknown

Published: Aug. 1, 2024

Abstract Colorectal cancer (CRC) is a major global health concern and represents significant public challenge in Hungary, where it exhibits some of the highest morbidity mortality rates European Union. The Mediterranean diet has been suggested to reduce incidence CRC, but comprehensive evidence from diverse study designs needed substantiate this effect. A systematic literature search was conducted PubMed, ClinicalTrials.gov, CENTRAL, Web Science identify randomized controlled trials human clinical 2008 2024 relevant studies. Statistical analysis performed using https://metaanalysisonline.com web application random effects model estimate pooled hazard (HRs). Forest plots, funnel Z -score plots were utilized visualize results. We identified 15 9 case–control studies, encompassing total 2,217,404 subjects. indicated that adherence significantly reduced prevalence CRC (HR = 0.84, 95% CI 0.78–0.91, p < 0.01). This protective effect consistent across sexes, with HRs 0.85 (95% 0.75–0.97, 0.01) for males 0.88 0.79–0.99, 0.03) females. Case–control studies specifically showed substantial 0.51, 0.38–0.68, Notable heterogeneity observed yet priori information size substantially below cumulative sample size, ensuring sufficient data reliable conclusions. findings meta-analysis reinforce role against CRC. results will inform dietary interventions designed mitigate risk, which are within framework Semmelweis Study, an ongoing cohort at University, explore multifaceted causes unhealthy aging Hungary. These aim practical patterns reducing among Hungarian population.

Language: Английский

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Adherence to the Mediterranean Diet and its association with gastric cancer: health benefits from a Planeterranean perspective

Journal of Translational Medicine, Journal Year: 2024, Volume and Issue: 22(1)

Published: May 21, 2024

Abstract The Mediterranean Diet (MD) has garnered increasing attention for its potential protective effects against gastric cancer (GC). MD’s rich content of antioxidants, polyphenols, and other bioactive compounds contributes to ability modulate gene expression, inhibit tumor growth, regulate apoptosis. Studies have shown significant reductions in inflammatory markers such as C-reactive protein (CRP), necrosis factor-alpha (TNF-α), interleukin-6 (IL-6) among individuals adhering the MD, suggesting pivotal role mitigating chronic inflammation-associated with development. Furthermore, anti-angiogenic properties, particularly components like olive oil, red wine, fish, tomatoes, offer promising avenues reducing GC risk by inhibiting angiogenesis. Additionally, influence on intestinal microbiota composition underscores maintaining immune homeostasis systemic inflammation, factors crucial prevention. Despite challenges variability dietary adherence scoring systems need further gender geographical-specific studies, evidence supports MD a cost-effective holistic approach Emphasizing nutrition public health is strategy broad implications global prevention initiatives. Therefore, this review explores multifaceted impacts prevention, delving into anti-inflammatory, anti-angiogenic, molecular mechanisms.

Language: Английский

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Scientific evidence supporting the newly developed one-health labeling tool “Med-Index”: an umbrella systematic review on health benefits of mediterranean diet principles and adherence in a planeterranean perspective

Journal of Translational Medicine, Journal Year: 2023, Volume and Issue: 21(1)

Published: Oct. 26, 2023

Med-Index is a one-health front-of-pack (FOP) label, based on Mediterranean diet (MedDiet) principles, developed to summarize information about the nutritional properties and related-health benefits of any food as well its sustainable production processes, associated company's social responsibility parameters in new "Planeterranean" perspective. Thus, can be adopted by European region authority worldwide; this achieved consumption cooking locally available sourced foods that respect MedDiet both terms healthy nutrition production. The huge body scientific evidence health model principles requires comprehensive framework encompass reliability robustness tool. A systematic review was carried out examine association between human adherence patterns upon which "Med-Index" tool subsequently developed.

Language: Английский

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Effects of the Mediterranean Diet on metabolic indices and quality of life in cancer patients: A systematic review and meta-analysis of randomized controlled trials

Journal of Functional Foods, Journal Year: 2024, Volume and Issue: 114, P. 106074 - 106074

Published: Feb. 18, 2024

The Mediterranean diet (MD) had a protective effect on cancer prevention. However, there has not been systematic evaluation of the diet's comprehensive effects metabolic indices and quality life in patients. present meta-analysis summarizes for first time MD We conducted randomized controlled trial (RCT) search PubMed, Embase, Cochrane Library, which recruited patients receiving intervention. In this meta-analysis, nine RCTs were included. Two authors independently extracted data checked accuracy results. Compared with control group, reduced body weight (p < 0.00001), fat mass % = 0.02), waist circumference BMI 0.0001) improved scores FICT-G 0.002), Physical well-being Emotional Functional 0.0002), Fatigue 0.00001). also increased serum vitamin C level. Sensitivity analysis revealed that levels blood glucose triglyceride 0.003), total cholesterol 0.009), LDH-C 0.0002) it did affect HDL-C 0.63) A 0.97). brief, our findings indicate higher compliance can reduce patients, improve their life, alleviate fatigue. Furthermore, potentially patients' lipid metabolism enhance body's antioxidant stress capacity. Nevertheless, further high-quality trials larger sample sizes are necessary to obtain more dependable outcomes. INPLASY registration number: 202320006.

Language: Английский

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Mediterranean Diet and Mental Health in Children and Adolescents: A Systematic Review

Nutrition Reviews, Journal Year: 2024, Volume and Issue: unknown

Published: May 17, 2024

Abstract Context Childhood and adolescence are periods of critical importance in the development mental health disorders. The Mediterranean diet (MD) has been linked to multiple positive outcomes, including reduced incidence disorders fewer psychiatric symptoms. Objective This study aimed investigate association between adherence an MD outcomes children adolescents. Methods A systematic literature review was conducted original research that explored relationship symptoms or MD. search on PubMed, Scopus, Web Science, MEDES, Dialnet, Latindex from inception November 2022, Newcastle-Ottawa Scale used evaluate quality studies. Results total 13 studies (6 cross-sectional, 4 case-control, 2 randomized clinical trials, 1 longitudinal cohort) out 450 met inclusion criteria. 3058 adolescents with a mean age range 8.6 16.2 years were included. Among reviewed studies, 5 (71.42%) those looking at attention-deficit/hyperactivity disorder, (80%) examining depression, (50%) assessing anxiety found significant protective association. Seven articles (53.84%) be high 6 (46.15%) moderate quality. Conclusion Adherence could factor for child adolescent populations. suggests promoting help prevent onset symptoms, reduce symptom severity, improve prognosis young patients. Systematic Review Registration PROSPERO registration no. CRD42021276316.

Language: Английский

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