Melatonin and Hippo Pathway: Is There Existing Cross-Talk?

International Journal of Molecular Sciences, Journal Year: 2017, Volume and Issue: 18(9), P. 1913 - 1913

Published: Sept. 6, 2017

Melatonin is an indolic hormone that regulates a plethora of functions ranging from the regulation circadian rhythms and antioxidant properties to induction maintenance tumor suppressor pathways. It binds specific receptors as well some cytosolic proteins, leading several cellular signaling cascades. Recently, involvement melatonin in cancer insurgence progression has clearly been demonstrated. In this review, we will first describe structure its receptors, then discuss both molecular epidemiological evidence on anticancer effects. Finally, shed light potential cross-talk between Hippo pathway, along with possible implications for therapy.

Language: Английский

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Melatonin enhances cotton immunity to Verticillium wilt via manipulating lignin and gossypol biosynthesis

The Plant Journal, Journal Year: 2019, Volume and Issue: 100(4), P. 784 - 800

Published: July 26, 2019

Plants endure challenging environments in which they are constantly threatened by diverse pathogens. The soil-borne fungus Verticillium dahliae is a devastating pathogen affecting many plant species including cotton, it significantly reduces crop yield and fiber quality. Melatonin involvement immunity to pathogens has been reported, but the mechanisms of melatonin-induced resistance unclear. In this study, role melatonin enhancing cotton V. was investigated. At transcriptome level, exogenous increased expression genes phenylpropanoid, mevalonate (MVA), gossypol pathways after inoculation. As result, lignin gossypol, products these metabolic pathways, increased. Silencing serotonin N-acetyltransferase 1 (GhSNAT1) caffeic acid O-methyltransferase (GhCOMT) biosynthesis compromised resistance, with reduced levels Exogenous pre-treatment prior inoculation restored level above gene silencing effects. were higher resistant cultivars than susceptible findings indicate that affects synthesis MVA, thereby dahliae.

Language: Английский

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Melatonin: Clinical Perspectives in Neurodegeneration

Frontiers in Endocrinology, Journal Year: 2019, Volume and Issue: 10

Published: July 16, 2019

Neurodegenerative diseases such as Alzheimer's disease (AD) and Parkinson's (PD) are important health problems there is a growing recognition that both governmental non-governmental organizations must make efforts to prevent, in addition treat, them. In this context, the pineal product melatonin has promising significance. Melatonin, an unusual phylogenetically conserved molecule present all known aerobic organisms, effective chronobiotic cytoprotective. As chronobiotic, afternoon increase "opens doors of sleep" every night therapeutic use been demonstrated preserve slow wave sleep effectively. cytoprotective molecule, reverses low degree inflammatory damage seen neurodegenerative disorders ageing. One characteristics advancing age gradual decrease circulating levels melatonin. Both vitro vivo, prevented neurodegeneration observed experimental models AD PD. Melatonin also increased removal toxic proteins by brain glymphatic system. A limited number clinical trials have indicated potential value neuroprotective drug treatment AD, particularly at early stage cognitive impairment, From animal studies effects need high doses become apparent (i.e. 40-100 mg/day range). The off-label discussed.

Language: Английский

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Is Melatonin the Cornucopia of the 21st Century?

Antioxidants, Journal Year: 2020, Volume and Issue: 9(11), P. 1088 - 1088

Published: Nov. 5, 2020

Melatonin, an indoleamine hormone produced and secreted at night by pinealocytes extra-pineal cells, plays important role in timing circadian rhythms (24-h internal clock) regulating the sleep/wake cycle humans. However, recent years melatonin has gained much attention mainly because of its demonstrated powerful lipophilic antioxidant free radical scavenging action. Melatonin been proven to be twice as active vitamin E, believed most effective antioxidant. Melatonin-induced signal transduction through receptors promotes expression enzymes well inflammation-related genes. also exerts immunomodulatory action stimulation high-affinity expressed immunocompetent cells. Here, we reviewed efficacy, safety side effects supplementation treating oxidative stress- and/or disorders, such obesity, cardiovascular diseases, immune infectious cancer, neurodegenerative osteoporosis infertility.

Language: Английский

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A review on the pharmacokinetics of paeoniflorin and its anti-inflammatory and immunomodulatory effects

Biomedicine & Pharmacotherapy, Journal Year: 2020, Volume and Issue: 130, P. 110505 - 110505

Published: July 15, 2020

Increasing pharmacological evidence supports that paeoniflorin, a water-soluble monoterpene glycoside isolated from Paeonia lactiflora Pall. (Shaoyao in Chinese), has wide range of medicinal properties including anti-inflammatory, antioxidant, antithrombotic, anticonvulsive, analgesic, cardioprotective, neuroprotective, hepatoprotective, antidepressant-like, antitumoral, and immune-regulatory activities; as well enhancing cognition attenuating learning impairment. In addition to pharmacodynamic studies, information on pharmacokinetics is also significant for the further development utilization paeoniflorin. The present review focuses absorption, distribution, metabolism, excretion especially main activities paeoniflorin inflammation immune function. According findings obtained both vitro vivo, broad application prospect been opened However, studies are needed clarity direct molecular mechanisms key targets underlying beneficial effects immunity.

Language: Английский

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