Advances in clinical chemistry, Journal Year: 2022, Volume and Issue: unknown, P. 69 - 117
Published: Dec. 20, 2022
Language: Английский
Journal of Nanobiotechnology, Journal Year: 2022, Volume and Issue: 20(1)
Published: March 5, 2022
Liver cancer is considered one of the deadliest diseases with highest disease burdens worldwide. Among different types liver cancer, hepatocellular carcinoma to be most common type. Multiple conventional approaches are being used in treating carcinoma. Focusing on drug treatment, regular agents forms fail achieve intended clinical outcomes. In order improve treatment outcomes, utilizing nanoparticles-specifically lipid based nanoparticles-are promising set motion. nanoparticles exist including liposomes, solid nanoparticles, nanostructured carriers, microemulsion, nanoemulsion, phytosomes, coated and nanoassemblies. enhance tumor uptake as well specificity such intratumoral injection, passive targeting, active stimuli responsive nanoparticles. this review, effect lipidic discussed enhancement techniques used.
Language: Английский
Citations
66
Cancer Cell International, Journal Year: 2021, Volume and Issue: 21(1)
Published: April 13, 2021
Abstract Hepatocellular carcinoma (HCC) is the second leading cause of death due to cancer. Although there are different treatment options, these strategies not efficient in terms restricting tumor cell’s proliferation and metastasis. The liver microenvironment contains non-parenchymal cells with supportive or inhibitory effects on cancerous phenotype HCC. Several signaling pathways dis-regulated HCC uncontrolled cell propagation, metastasis, recurrence cells. Recent studies have established new approaches for prevention using small molecules. Small molecules compounds a low molecular weight that usually inhibit specific targets signal transduction pathways. These components can induce cycle arrest, apoptosis, block growth. Devising simultaneously targeting population could lead more relevant research outcomes. may open avenues minimal cytotoxic healthy This study provides latest findings critical governing behavior control both vitro vivo models.
Language: Английский
Citations
59
Journal of Molecular Structure, Journal Year: 2023, Volume and Issue: 1291, P. 136021 - 136021
Published: June 16, 2023
Language: Английский
Citations
37
Journal of Proteomics, Journal Year: 2017, Volume and Issue: 169, P. 21 - 32
Published: March 30, 2017
Language: Английский
Citations
71
BMC Surgery, Journal Year: 2020, Volume and Issue: 20(1)
Published: Feb. 12, 2020
Abstract Background Post-hepatectomy liver failure contributes significantly to postoperative mortality after resection. The prediction of the individual risk for is challenging. This review aimed provide an overview cytokine and growth factor triggered signaling pathways involved in regeneration Methods MEDLINE Cochrane databases were searched without language restrictions articles from time inception till March 2019. All studies with comparative data on effect cytokines factors animals humans included. Results Overall 3.353 comprising 40 involving 1.498 patients 101 animal identified met inclusion criteria. included trials retrospective cohort/observational studies. There was substantial heterogeneity across all respect analyzed described endpoints. Conclusion High-level evidence serial measurements blood samples used predict resection still lacking. To address potential markers, high throughput analyses may offer a method individual’s regenerative future.
Language: Английский
Citations
70
International Journal of Oncology, Journal Year: 2020, Volume and Issue: unknown
Published: April 1, 2020
Tumor biomarkers are important in the early screening, diagnosis, therapeutic evaluation, recurrence and prognosis prediction of tumors. Primary liver cancer is one most common malignant tumors; it has high incidence mortality rates seriously endangers human health. The main pathological types primary include hepatocellular carcinoma (HCC), intrahepatic cholangiocarcinoma (ICC) combined HCC‑cholangiocarcinoma (cHCC‑CC). In present review, a systematic outline current presented, from conventional blood biomarkers, histochemical potential to resistance‑associated biomarkers. relationships deeply elucidated between prognosis, clinicopathological features resistance, as well their clinical significance, patients with three cancer. Moreover, summary several biomarker signaling pathways provided, which helpful for studying biological mechanism purpose this review provide help or medical researchers differential treatment HCC.
Language: Английский
Citations
67
Cell Death and Disease, Journal Year: 2018, Volume and Issue: 9(2)
Published: Jan. 26, 2018
Abstract The δ opioid receptor (DOR) is involved in the regulation of malignant transformation and tumor progression hepatocellular carcinoma (HCC). However, DOR HCC remains poorly defined. We found that miR-874 was identified as a negative regulator DOR, which direct functional target via its 3′ untranslated region (UTR). Moreover, downregulated expression inversely correlated with expression. Downregulation also associated larger size, more vascular invasion, poor TNM stage, differentiation, inferior patient outcomes. Functionally, overexpression cell line SK-hep-1 inhibited growth, migration, vitro vivo tumorigenicity. Furthermore, suppressed resulting epidermal growth factor (EGFR) extracellular signal-regulated kinase (ERK) phosphorylation. EGFR activator—epidermal (EGF)—can rescue proliferation migration suppression induced by overexpression, effects EGF were blocked an ERK inhibitor. Our study results suggest miRNA-874 can suppress metastasis targeting DOR/EGFR/ERK pathway, may be potential for treatment.
Language: Английский
Citations
55
Journal of Trace Elements in Medicine and Biology, Journal Year: 2017, Volume and Issue: 46, P. 117 - 127
Published: Dec. 22, 2017
Language: Английский
Citations
54
Molecular & Cellular Proteomics, Journal Year: 2018, Volume and Issue: 17(4), P. 619 - 630
Published: Jan. 21, 2018
Breast cancer mortality predominantly results from dormant micrometastases that emerge as fatal outgrowths years after initial diagnosis. In order to gain insights concerning factors associated with emergence of liver metastases, we recreated spontaneous dormancy in an all-human
Language: Английский
Citations
52
Toxicological Sciences, Journal Year: 2018, Volume and Issue: 162(2), P. 622 - 634
Published: Jan. 6, 2018
The purpose of this study is to identify an environmentally relevant shared receptor target for endocrine and metabolism disrupting chemical pollutants. A feature the tested chemicals was that they induced Cyp2b10 in vivo implicating activation constitutive androstane (CAR). Recent studies suggest these compounds could be indirect CAR activators via epidermal growth factor (EGFR) inhibition. Assays included a activity reporter assay, EGF endocytosis EGFR phosphorylation assay. Docking simulations were used putative binding sites environmental on EGFR. Whole-weight lipid-adjusted serum mean pollutant exposures determined using data from National Health Examination Survey (NHANES) compared with IC50 values vitro. Chlordane, trans-nonachlor, PCB-126, PCB-153, atrazine most potent inhibitors tested. trans-nonachlor appeared competitive antagonists as displaced bound However, acted through different mechanism tyrosine kinase inhibitor. inhibition relative effect potencies compounds. In NHANES, concentrations PCB-153 greatly exceeded their calculated values. common action three diverse classes metabolic characterized by measuring EGF-EGFR endocytosis. Based NHANES data, may mode some PCBs, pesticides, herbicides.
Language: Английский
Citations
49