Mechanisms of Plant Responses and Adaptation to Soil Salinity

The Innovation, Journal Year: 2020, Volume and Issue: 1(1), P. 100017 - 100017

Published: May 1, 2020

Soil salinity is a major environmental stress that restricts the growth and yield of crops. Understanding physiological, metabolic, biochemical responses plants to salt mining tolerance-associated genetic resource in nature will be extremely important for us cultivate salt-tolerant In this review, we provide comprehensive summary mechanisms plants, including stress-triggered physiological responses, oxidative stress, sensing signaling pathways, organellar ion homeostasis, hormonal gene expression regulation, metabolic changes, as well tolerance halophytes. Important questions regarding need addressed future are discussed.

Language: Английский

---

Liquid Crystals: Versatile Self-Organized Smart Soft Materials

Chemical Reviews, Journal Year: 2021, Volume and Issue: 122(5), P. 4887 - 4926

Published: Dec. 23, 2021

Smart soft materials are envisioned to be the building blocks of next generation advanced devices and digitally augmented technologies. In this context, liquid crystals (LCs) owing their responsive adaptive attributes could serve as promising smart materials. LCs played a critical role in revolutionizing information display industry 20th century. However, turn 21st century, numerous beyond-display applications have been demonstrated, which elegantly exploit controllable stimuli-responsive characteristics. For these applications, new LC rationally designed developed. Review, we present recent developments light driven chiral LCs, i.e., cholesteric blue phases, based windows that control entrance heat from outdoor interior buildings built environments depending on weather conditions, elastomers for bioinspired, biological, actuator biosensors detection proteins, nucleic acids, viruses, porous membranes separation ions, molecules, microbes, living under macro- nanoscopic confinement. The Review concludes with summary perspectives challenges opportunities This is anticipated stimulate eclectic ideas toward implementation nature's delicate phase matter future generations beyond.

Language: Английский

---

Wound Healing: From Passive to Smart Dressings

Advanced Healthcare Materials, Journal Year: 2021, Volume and Issue: 10(16)

Published: June 26, 2021

Abstract The universal increase in the number of patients with nonhealing skin wounds imposes a huge social and economic burden on healthcare systems. Although, application traditional wound dressings contributes to an effective healing outcome, yet, complexity process remains major health challenge. Recent advances materials fabrication technologies have led that provide proper conditions for healing. 3D‐printed dressings, biomolecule‐loaded as well smart flexible bandages are among recent alternatives been developed accelerate Additionally, new generation contains variety microelectronic sensors real‐time monitoring environment is able apply required actions support progress. Moreover, manufacturing enable development next dressing substrates, known electronic skin, whole physiochemical markers single platform. current study reviews importance emerging strategy care management highlights different types promoting process.

Language: Английский

---

Tissue-Engineered Grafts from Human Decellularized Extracellular Matrices: A Systematic Review and Future Perspectives

International Journal of Molecular Sciences, Journal Year: 2018, Volume and Issue: 19(12), P. 4117 - 4117

Published: Dec. 18, 2018

Tissue engineering and regenerative medicine involve many different artificial biologic materials, frequently integrated in composite scaffolds, which can be repopulated with various cell types. One of the most promising scaffolds is decellularized allogeneic extracellular matrix (ECM) then recellularized by autologous or stem cells, order to develop fully personalized clinical approaches. Decellularization protocols have efficiently remove immunogenic cellular maintaining nonimmunogenic ECM, endowed specific inductive/differentiating actions due its architecture bioactive factors. In present paper, we review available literature about development grafts from human tissues/organs. Human tissues may obtained not only surgery but also cadavers, suggesting possible BioBanks body donation programs. Many tissues/organs been for tissue purposes, such as cartilage, bone, skeletal muscle, tendons, adipose tissue, heart, vessels, lung, dental pulp, intestine, liver, pancreas, kidney, gonads, uterus, childbirth products, cornea, peripheral nerves. vitro recellularizations reported types procedures (seeding, injection, perfusion). Conversely, studies vivo behaviour are poorly represented. Actually, future challenge will implanted restored all their structural/functional aspects.

Language: Английский

---

Advanced smart biomaterials and constructs for hard tissue engineering and regeneration

Bone Research, Journal Year: 2018, Volume and Issue: 6(1)

Published: Oct. 19, 2018

Abstract Hard tissue repair and regeneration cost hundreds of billions dollars annually worldwide, the need has substantially increased as population aged. tissues include bone tooth structures that contain calcium phosphate minerals. Smart biomaterial-based engineering regenerative medicine methods have exciting potential to meet this urgent need. biomaterials constructs refer possess instructive/inductive or triggering/stimulating effects on cells by material’s responsiveness internal external stimuli intelligently tailored properties functions can promote regeneration. The smart material-based approaches scaffolds stem cell for engineering; drug delivery systems enhance regeneration; dental resins respond pH protect structures; pH-sensitive materials selectively inhibit acid-producing bacteria; polymers modulate biofilm species away from a pathogenic composition shift towards healthy composition; suppress biofilms avoid resistance. These not only deliver guide improve drugs bioactive agents with spatially temporarily controlled releases but also modulate/suppress combat infections in wound sites. new generation provides is promising opportunity hard efficacy.

Language: Английский

---

Smart Hydrogels for Advanced Drug Delivery Systems

International Journal of Molecular Sciences, Journal Year: 2022, Volume and Issue: 23(7), P. 3665 - 3665

Published: March 27, 2022

Since the last few decades, development of smart hydrogels, which can respond to stimuli and adapt their responses based on external cues from environments, has become a thriving research frontier in biomedical engineering field. Nowadays, drug delivery systems have received great attention hydrogels be potentially used these due high stability, physicochemical properties, biocompatibility. Smart change hydrophilicity, swelling ability, physical molecules permeability, influenced by such as pH, temperature, electrical magnetic fields, light, biomolecules' concentration, thus resulting controlled release loaded drugs. Herein, this review encompasses latest investigations field stimuli-responsive drug-loaded our contribution matter.

Language: Английский

---

Antimicrobial Ionic Liquid‐Based Materials for Biomedical Applications

Advanced Functional Materials, Journal Year: 2021, Volume and Issue: 31(42)

Published: July 23, 2021

Abstract Excessive and unwarranted administration of antibiotics has invigorated the evolution multidrug‐resistant microbes. There is, therefore, an urgent need for advanced active compounds. Ionic liquids with short‐lived ion‐pair structures are highly tunable have diverse applications. Apart from their unique physicochemical features, newly discovered biological activities ionic fascinated biochemists, microbiologists, medical scientists. In particular, antimicrobial properties opened new vistas in overcoming current challenges associated combating antibiotic‐resistant pathogens. Discussions regarding liquid derivatives monomeric polymeric forms presented here. The mechanism parameters that affect activities, such as chain length, cation/anion type, cation density, polymerization, considered. potential applications biomedical arena, including regenerative medicine, biosensing, drug/biomolecule delivery, to stimulate scientific community further improve efficacy liquids.

Language: Английский

---

Elastin-Like Polypeptides for Biomedical Applications

Annual Review of Biomedical Engineering, Journal Year: 2020, Volume and Issue: 22(1), P. 343 - 369

Published: April 28, 2020

Elastin-like polypeptides (ELPs) are stimulus-responsive biopolymers derived from human elastin. Their unique properties-including lower critical solution temperature phase behavior and minimal immunogenicity-make them attractive materials for a variety of biomedical applications. ELPs also benefit recombinant synthesis genetically encoded design; these enable control over the molecular weight precise incorporation peptides pharmacological agents into sequence. Because their size sequence defined, exquisite structure function, qualities that cannot be matched by synthetic polymers. As such, have been engineered to assemble architectures display bioactive This review discusses design representative applications ELPs, focusing primarily on use in tissue engineering drug delivery.

Language: Английский

---

Bioactive potential of natural biomaterials: identification, retention and assessment of biological properties

Signal Transduction and Targeted Therapy, Journal Year: 2021, Volume and Issue: 6(1)

Published: March 19, 2021

Biomaterials have had an increasingly important role in recent decades, biomedical device design and the development of tissue engineering solutions for cell delivery, drug integration, replacement, more. There is increasing trend to use natural substrates, such as macromolecules native plants animals improve biocompatibility biodegradability delivered materials. At same time, these materials favourable mechanical properties often considered be biologically inert. More importantly, possess innate functions due their unique chemical composition structure, which increase bioactivity therapeutic potential a wide range applications. While much focus has been on integrating into devices via spectrum cross-linking mechanisms, little attention drawn residual that hampered during isolation, purification, production processes. Herein, we discuss methods initial material characterisation determine bioactivity, means processing including cross-linking, decellularisation, purification techniques finally, biological assessment retained final product. This review aims address considerations biomaterials from polymers, through optimisation preservation bioactive components maximise inherent potency substrate promote regeneration.

Language: Английский

---

Stimuli-Responsive Materials for Tissue Engineering and Drug Delivery

International Journal of Molecular Sciences, Journal Year: 2020, Volume and Issue: 21(13), P. 4724 - 4724

Published: July 2, 2020

Smart or stimuli-responsive materials are an emerging class of used for tissue engineering and drug delivery. A variety stimuli (including temperature, pH, redox-state, light, magnet fields) being investigated their potential to change a material’s properties, interactions, structure, and/or dimensions. The specificity response, ability respond endogenous cues inherently present in living systems provide possibilities develop novel delivery strategies (for example composed responsive polymers that self-assemble undergo phase transitions morphology transformations). Herein, smart as controlled release vehicles described, highlighting the precise quantities drugs at specific locations times promoting repair remodeling tissues.

Language: Английский

---