Wireless, closed-loop, smart bandage with integrated sensors and stimulators for advanced wound care and accelerated healing

Nature Biotechnology, Journal Year: 2022, Volume and Issue: 41(5), P. 652 - 662

Published: Nov. 24, 2022

Language: Английский

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Self‐Assembling Peptide‐Based Hydrogels for Wound Tissue Repair

Advanced Science, Journal Year: 2022, Volume and Issue: 9(10)

Published: Feb. 9, 2022

Wound healing is a long-term, multistage biological process that includes hemostasis, inflammation, proliferation, and tissue remodeling requires intelligent designs to provide comprehensive convenient treatment. The complexity of wounds has led lack adequate wound treatment materials, which must systematically regulate unique microenvironments. Hydrogels have significant advantages in due their ability spatiotemporal control over the process. Self-assembling peptide-based hydrogels are particularly attractive innate biocompatibility biodegradability along with additional including ligand-receptor recognition, stimulus-responsive self-assembly, mimic extracellular matrix. materials self-assemble response physiological environment, resulting functionalized microscopic structures, makes them conducive This review introduces several self-assembling systems various emphasizes recent advances allow for precise during different stages healing. Moreover, development multifunctional can remodel immune microenvironment therapy also been summarized. Overall, this sheds light on future clinical practical applications hydrogels.

Language: Английский

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Research advances in smart responsive-hydrogel dressings with potential clinical diabetic wound healing properties

Military Medical Research, Journal Year: 2023, Volume and Issue: 10(1)

Published: Aug. 22, 2023

The treatment of chronic and non-healing wounds in diabetic patients remains a major medical problem. Recent reports have shown that hydrogel wound dressings might be an effective strategy for treating due to their excellent hydrophilicity, good drug-loading ability sustained drug release properties. As typical example, hyaluronic acid dressing (Healoderm) has been demonstrated clinical trials improve wound-healing efficiency healing rates foot ulcers. However, the degradation behavior clinically-used cannot adjusted according microenvironment. Due intricacy wounds, antibiotics other medications are frequently combined with practice, although these easily hindered by hostile environment. In this case, scientists created responsive-hydrogel based on microenvironment features (such as high glucose low pH) or external stimuli light magnetic field) achieve controllable release, gel degradation, improvements order overcome issues. These anticipated play significant role therapeutic dressings. Here, we review recent advances towards healing, focus structure design, principle responsiveness, degradation. Last but not least, advantages limitations responsive-hydrogels applications will also discussed. We hope contribute furthering progress hydrogels improved practical application.

Language: Английский

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Progress in Hydrogels for Skin Wound Repair

Macromolecular Bioscience, Journal Year: 2022, Volume and Issue: 22(7)

Published: April 7, 2022

Abstract As the first defensive line between human body and outside world, skin is vulnerable to damage from external environment. Skin wounds can be divided into acute (mechanical injuries, chemical surgical wounds, etc.) chronic (burns, infections, diabetes, etc.). In order manage wound, a variety of wound dressings have been developed, including gauze, films, foams, nanofibers, hydrocolloids, hydrogels. Recently, hydrogels received much attention because their natural extracellular matrix (ECM)‐mimik structure, tunable mechanical properties, facile bioactive substance delivery capability. They show great potential application in repair. This paper introduces anatomy function skin, process healing conventional dressings, then composition construction methods Next, this necessary properties repair latest research progress hydrogel for Finally, future development goals materials field are proposed.

Language: Английский

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Smart bioadhesives for wound healing and closure

Bioactive Materials, Journal Year: 2022, Volume and Issue: 19, P. 360 - 375

Published: April 26, 2022

The high demand for rapid wound healing has spurred the development of multifunctional and smart bioadhesives with strong bioadhesion, antibacterial effect, real-time sensing, wireless communication, on-demand treatment capabilities. Bioadhesives bio-inspired structures chemicals have shown unprecedented adhesion strengths, as well tunable optical, electrical, bio-dissolvable properties. Accelerated been achieved via directly released growth factors, material or drug-induced host immune responses, delivery curative cells. Most recently, integration biosensing modules units in a closed-loop system yielded bioadhesives, allowing sensing physiological conditions (e.g., pH, temperature, uric acid, glucose, cytokine) iterative feedback drastically enhanced, stage-specific by triggering drug to avoid infection prolonged inflammation. Despite advances burgeoning field, challenges still exist design fabrication integrated systems, particularly chronic wounds, presenting significant opportunities future next-generation materials systems.

Language: Английский

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An Overview of Cellulose Derivatives-Based Dressings for Wound-Healing Management

Pharmaceuticals, Journal Year: 2021, Volume and Issue: 14(12), P. 1215 - 1215

Published: Nov. 24, 2021

Presently, notwithstanding the progress regarding wound-healing management, treatment of majority skin lesions still represents a serious challenge for biomedical and pharmaceutical industries. Thus, attention researchers has turned to development novel materials based on cellulose derivatives. Cellulose derivatives are semi-synthetic biopolymers, which exhibit high solubility in water represent an advantageous alternative water-insoluble cellulose. These biopolymers possess excellent properties, such as biocompatibility, biodegradability, sustainability, non-toxicity, non-immunogenicity, thermo-gelling behavior, mechanical strength, abundance, low costs, antibacterial effect, hydrophilicity. They have efficient ability absorb retain large quantity wound exudates interstitial sites their networks can maintain optimal local moisture. also proper scaffold incorporate various bioactive agents with beneficial therapeutic effects tissue restoration. Due these suitable versatile characteristics, attractive captivating applications. This review presents extensive overview recent research promising derivatives-based multiple applications, dressings, drug delivery devices, engineering.

Language: Английский

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A Multifunctional Janus Electrospun Nanofiber Dressing with Biofluid Draining, Monitoring, and Antibacterial Properties for Wound Healing

ACS Applied Materials & Interfaces, Journal Year: 2022, Volume and Issue: 14(11), P. 12984 - 13000

Published: March 10, 2022

Wound healing greatly affects patients' health and produces medical burden. Therefore, we developed a multifunctional electrospun nanofiber dressing, which can inhibit methicillin-resistant Staphylococcus aureus (MRSA), drain excessive biofluid to promote wound healing, simultaneously monitor pH level. The polyoxometalate (α-K6P2W18O62·14H2O, P2W18) oxacillin (OXA) are encapsulated in hydrophobic polylactide (PLA) synergistically MRSA. phenol red (PSP) is hydrophilic polyacrylonitrile (PAN) sensitively indicate situ. PSP/PAN directly on the patterning OXA/P2W18/PLA layer form Janus dressing. By taking advantage of wettability difference between two layers, excess be drained away from wound. In addition, dressing exhibits good biocompatibility accelerates via its antimicrobial activity skin repairing function. This would beneficial for management treatment.

Language: Английский

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Biomaterials-Based Regenerative Strategies for Skin Tissue Wound Healing

ACS Applied Bio Materials, Journal Year: 2022, Volume and Issue: 5(5), P. 2069 - 2106

Published: April 22, 2022

Skin tissue wound healing proceeds through four major stages, including hematoma formation, inflammation, and neo-tissue culminates with remodeling. These steps significantly overlap each other are aided by various factors such as cells, cytokines (both anti- pro-inflammatory), growth that aid in the formation. In all these advanced biomaterials provide several functional advantages, removing exudates, providing cover, transporting oxygen to site, preventing infection from microbes. addition, serve vehicles carry proteins/drug molecules/growth and/or antimicrobial agents target site. this review, we report recent advancements biomaterials-based regenerative strategies augment skin process. conjunction medical sciences, designing nanoengineered is gaining significant attention for numerous functionalities trigger repair. regard, highlight advent of nanomaterial-based constructs healing, especially those being evaluated clinical settings. Herein, also emphasize competence versatility three-dimensional (3D) bioprinting technique management. Finally, discuss challenges perspective biomaterial-based dressings, along prospective future directions. With utilize a cocktail cell sources, agents, drugs, factors, it expected patient-specific will be developed near future, resulting complete no scar

Language: Английский

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Developing natural polymers for skin wound healing

Bioactive Materials, Journal Year: 2023, Volume and Issue: 33, P. 355 - 376

Published: Nov. 26, 2023

Natural polymers are complex organic molecules that occur in the natural environment and have not been subjected to artificial synthesis. They frequently encountered various creatures, including mammals, plants, microbes. The aforementioned commonly derived from renewable sources, possess a notable level of compatibility with living organisms, limited adverse effect on environment. As result, they hold considerable significance development sustainable environmentally friendly goods. In recent times, there has advancement investigation potential uses field biomedicine, specifically relation biomaterials exhibit antibacterial antioxidant characteristics. This review provides comprehensive overview prevalent utilized biomedical domain throughout preceding two decades. this paper, we present examination components typical methods for preparation based polymers. Furthermore, summarize application polymer materials each stage skin wound repair. Finally, key findings insights into limitations current elucidate prospects their future field.

Language: Английский

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Responsive hydrogel dressings for intelligent wound management

BMEMat, Journal Year: 2023, Volume and Issue: 1(2)

Published: April 15, 2023

Abstract Due to global aging problems, the rising number of patients suffering from chronic or hard‐to‐heal acute wounds imposes a significant burden on healthcare systems. Wound healing is complicated and dynamic physiological process with distinct molecular cellular levels at each phase. Despite numerous strategies advanced wound dressings being developed, successful management through smart dressing materials that can adapt changing microenvironments address needs different stages remains big challenge. Over last decade, hydrogel‐based have emerged as one most potent biomaterials for treatment favorable biological characteristics high potential active intervention during wound‐curing process. In current contribution, we present recent progress in hydrogel regulate release therapeutics response external stimuli (such light) well endogenous changes environments (e.g., temperature, pH, glucose, reactive oxygen species) facilitate healing. We also introduce cutting‐edge technologies intelligent “sense‐and‐treat” combination built‐in sensors sensing molecules responsive hydrogels, which enable real‐time monitoring conditions prompt on‐demand therapy.

Language: Английский

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