Extraction of phenolic compounds: A review

Current Research in Food Science, Journal Year: 2021, Volume and Issue: 4, P. 200 - 214

Published: Jan. 1, 2021

Phenolic compounds are parts of secondary metabolites mostly found in plant species with enormous structural diversities. They can exist as glycosides or aglycones; matrix free-bound compounds; and comprising polymerized monomer structures. Additionally, these not universally dispensed within plants varied stability. This has contributed to challenging extraction processes; implying that employing a single step inappropriate technique might change the recovery phenolic components from samples. Hence, it is important select an appropriate method so recover targeted compounds. will helps substantial yields sample matrix. Therefore, this review mainly focuses on several methods used obtaining them materials. These includes both conventional unconventional techniques.

Language: Английский

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Concept, mechanism, and applications of phenolic antioxidants in foods

Journal of Food Biochemistry, Journal Year: 2020, Volume and Issue: 44(9)

Published: July 20, 2020

In this review, the concept of phenolic antioxidants, mechanisms action, and applications have been reviewed. Phenolic compounds (PCs) acts as an antioxidant by reacting with a variety free radicals. The mechanism actions involved either hydrogen atom transfer, transfer single electron, sequential proton loss electron chelation transition metals. foods, PCs act antioxidants which are measured several in vitro spectroscopic methods. found milk wide range dairy products sole purposes color, taste, storage stability, quality enhancement. role three types food additives, that is, antimicrobial, antioxidant, flavoring agents critically literature revealed present foods possess health benefits such antibacterial, antihyperlipidemic, anticancer, cardioprotective, neuroprotective, antidiabetic properties. Practical strong safer than synthetic antioxidants. occurrence plant warranted continuous review applications. This therefore, presented updated comprehensive overview concept, mechanism, foods.

Language: Английский

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Polyphenols from Food and Natural Products: Neuroprotection and Safety

Antioxidants, Journal Year: 2020, Volume and Issue: 9(1), P. 61 - 61

Published: Jan. 10, 2020

Polyphenols are naturally occurring micronutrients that present in many food sources. Besides being potent antioxidants, these molecules may also possess anti-inflammatory properties. Many studies have highlighted their potential role the prevention and treatment of various pathological conditions connected to oxidative stress inflammation (e.g., cancer, cardiovascular neurodegenerative disorders). Neurodegenerative diseases globally one main causes death represent an enormous burden terms human suffering, social distress, economic costs. Recent data expanded on initial antioxidant-based mechanism polyphenols' action by showing they able modulate several cell-signaling pathways mediators. The proposed benefits polyphenols, either as protective/prophylactic substances or therapeutic molecules, be achieved consumption a natural polyphenol-enriched diet, use supplements, with formulations pharmaceutical drugs/nutraceuticals. It has been proved health effects polyphenols depend consumed amount bioavailability. However, overconsumption raise safety concerns due accumulation high levels organism, particularly if we consider loose regulatory legislation regarding commercialization supplements. This review addresses beneficial focuses neuroprotection issues related overconsumption.

Language: Английский

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Role of Diet in Chronic Obstructive Pulmonary Disease Prevention and Treatment

Nutrients, Journal Year: 2019, Volume and Issue: 11(6), P. 1357 - 1357

Published: June 16, 2019

Chronic obstructive pulmonary disease is one of the leading causes morbidity and mortality worldwide a growing healthcare problem. Identification modifiable risk factors for prevention treatment COPD urgent, scientific community has begun to pay close attention diet as an integral part management, from treatment. This review summarizes evidence observational clinical studies regarding impact nutrients dietary patterns on lung function development, progression, outcomes, with highlights potential mechanisms action. Several options can be considered in terms and/or progression. Although definitive data are lacking, available indicates that some foods nutrients, especially those nutraceuticals endowed antioxidant anti-inflammatory properties when consumed combinations form balanced patterns, associated better function, less decline, reduced COPD. Knowledge influences may provide health professionals evidence-based lifestyle approach counsel patients toward improved health.

Language: Английский

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Diet, Lifestyle and Cardiovascular Diseases: Linking Pathophysiology to Cardioprotective Effects of Natural Bioactive Compounds

International Journal of Environmental Research and Public Health, Journal Year: 2020, Volume and Issue: 17(7), P. 2326 - 2326

Published: March 30, 2020

Heart and blood vessels disorders comprise one of the main causes death worldwide. Pharmacologically active natural compounds have been used as a complementary therapy in cardiovascular disease around world traditional way. Dietary, bioactive compounds, well healthy lifestyles, are considered to prevent coronary artery diseases. Pre-clinical clinical studies reported that consumption plant-food derivatives including polyphenolic peptides, oligosaccharides, vitamins, unsaturated fatty acids possess protective effects on This review aims summarize risk factors, pre-clinical trials related cardioprotective properties plant-food-derived compounds. Molecular mechanisms by exert their also highlighted.

Language: Английский

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Dietary Plant Polyphenols: Effects of Food Processing on Their Content and Bioavailability

Molecules, Journal Year: 2021, Volume and Issue: 26(10), P. 2959 - 2959

Published: May 16, 2021

Dietary plant polyphenols are natural bioactive compounds that increasingly attracting the attention of food scientists and nutritionists because their nutraceutical properties. In fact, many studies have shown polyphenol-rich diets protective effects against most chronic diseases. However, these health benefits strongly related to both polyphenol content bioavailability, which in turn depend on origin, matrix, processing, digestion, cellular metabolism. Although fruits vegetables valuable sources polyphenols, they not usually consumed raw. Instead, go through some processing steps, either industrially or domestically (e.g., cooling, heating, drying, fermentation, etc.), affect content, bioaccessibility, bioavailability. This review summarizes status knowledge possible (positive negative) commonly used food-processing techniques phenolic compound bioavailability vegetables. These type applied parameters (type, duration, media, intensity). attempts shed light importance more comprehensive dietary guidelines consider recommendations take full advantage toward healthier foods.

Language: Английский

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Plant-Based Dietary Patterns, Plant Foods, and Age-Related Cognitive Decline

Advances in Nutrition, Journal Year: 2019, Volume and Issue: 10, P. S422 - S436

Published: July 4, 2019

Language: Английский

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Sulforaphane: Its “Coming of Age” as a Clinically Relevant Nutraceutical in the Prevention and Treatment of Chronic Disease

Oxidative Medicine and Cellular Longevity, Journal Year: 2019, Volume and Issue: 2019, P. 1 - 27

Published: Oct. 14, 2019

A growing awareness of the mechanisms by which phytochemicals can influence upstream endogenous cellular defence processes has led to intensified research into their potential relevance in prevention and treatment disease. Pharmaceutical medicine historically looked plants as sources starting materials for drug development; however, focus nutraceutical is retain plant bioactive close its native state possible. As a consequence, potency concentrate or an extract may be lower than required significant gene expression. The molecular structure large extent determines molecule’s bioavailability. Polyphenols are abundant dietary phytochemicals, extensive vitro established many signalling involved favourably modulating human biochemical pathways. Such pathways associated with core such redox modulation immune infection control downregulating synthesis inflammatory cytokines. Although relationship between oxidative stress chronic disease continues affirmed, direct-acting antioxidants vitamins A, C, E, beta-carotene, others have not yielded expected preventive therapeutic responses, even though several meta-analyses sought evaluate benefit supplements. Because polyphenols exhibit poor bioavailability, few impressive findings been replicated vivo. SFN, aliphatic isothiocyanate, emerges phytochemical comparatively high number clinical trials demonstrated ability produce favourable outcomes conditions there satisfactory pharmaceutical solutions, foreshadowing SFN clinically relevant nutraceutical. myrosinase-inert broccoli sprout extracts widely available, now exist myrosinase-active supplements that yield sufficient match doses used trials.

Language: Английский

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Green non-conventional techniques for the extraction of polyphenols from agricultural food by-products: A review

Journal of Chromatography A, Journal Year: 2021, Volume and Issue: 1651, P. 462295 - 462295

Published: May 28, 2021

Language: Английский

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Dietary polyphenols: regulate the advanced glycation end products-RAGE axis and the microbiota-gut-brain axis to prevent neurodegenerative diseases

Critical Reviews in Food Science and Nutrition, Journal Year: 2022, Volume and Issue: 63(29), P. 9816 - 9842

Published: May 19, 2022

Advanced glycation end products (AGEs) are formed in non-enzymatic reaction, oxidation, rearrangement and cross-linking between the active carbonyl groups of reducing sugars free amines amino acids. The Maillard reaction is related to sensory characteristics thermal processed food, while AGEs food matrix this process. a key link stress neurodegenerative disease. can interact with receptors for (RAGE), causing oxidative stress, inflammation response signal pathways activation diseases. Neurodegenerative diseases closely gut microbiota imbalance intestinal inflammation. Polyphenols multiple hydroxyl showed powerful ability scavenge ROS capture α-dicarbonyl species, which led formation mono- di- adducts, thereby inhibiting formation. be effectively prevented by production, interaction RAGEs, or regulating microbiota-gut-brain axis. These strategies include polyphenols multifunctional effects on inhibition, RAGE-ligand interactions blocking, abundance diversity microbiota, alleviation delay prevent progress. It wise promising strategy supplement dietary preventing via AGEs-RAGE axis regulation.

Language: Английский

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