The role of oxidative stress in ovarian aging: a review

Journal of Ovarian Research, Journal Year: 2022, Volume and Issue: 15(1)

Published: Sept. 1, 2022

Abstract Ovarian aging refers to the process by which ovarian function declines until eventual failure. The pathogenesis of is complex and diverse; oxidative stress (OS) considered be a key factor. This review focuses on fact that OS status accelerates promoting apoptosis, inflammation, mitochondrial damage, telomere shortening biomacromolecular damage. Current evidence suggests aging, smoking, high-sugar diets, pressure, superovulation, chemotherapeutic agents industrial pollutants can factors accelerate exacerbating status. In addition, we role nuclear factor E2-related 2 (Nrf2), Sirtuin (Sirt), mitogen-activated protein kinase (MAPK), B (AKT), Forkhead box O (FoxO) Klotho signaling pathways during aging. We also explore antioxidant therapies such as melatonin, vitamins, stem cell therapies, monomers Traditional Chinese Medicine (TCM), investigate roles these supplements with respect reduction improvement function. provides rationale for therapy improve

Language: Английский

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The Potential Impact of Probiotics on Human Health: An Update on Their Health-Promoting Properties

Microorganisms, Journal Year: 2024, Volume and Issue: 12(2), P. 234 - 234

Published: Jan. 23, 2024

Probiotics, known to be live microorganisms, have been shown improve or restore the gut microbiota, which in turn has linked improved health. It is believed that probiotics are modern equivalent of a panacea, with claims they may treat prevent different diseases both children and adults (e.g., from colic babies cardiovascular disease, respiratory infection, cancer adults). Ever since early 2000s, probiotic-based fermented foods had resurgence popularity, mostly due made regarding their health benefits. Fermented associated prevention irritable bowel syndrome, lactose intolerance, gastroenteritis, obesity, but also other conditions such as chronic diarrhea, allergies, dermatitis, bacterial viral infections, all closely related an unhealthy lifestyle. Recent ongoing developments microbiome/microbiota science given us new research directions for probiotics. The types, mechanisms, applications studied so far, those currently under study, great potential change scientific understanding probiotics’ nutritional human care. expansion fields study microbiome involvement its improvement foreshadow era significant changes. An expanding range candidate probiotic species emerging can address newly elucidated data-driven microbial niches host targets. In field, variants microbiome-modulating interventions being developed, including prebiotics, symbiotics, postbiotics, consortia, biotherapeutic products, genetically modified organisms, renewed interest polyphenols, fibers, ensure This manuscript aims analyze recent, emerging, anticipated trends (sources, doses, mechanism action, administered, side effects, risks) create vision development areas influence field.

Language: Английский

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Oxidative Stress in Health and Disease

Biomedicines, Journal Year: 2023, Volume and Issue: 11(11), P. 2925 - 2925

Published: Oct. 29, 2023

Oxidative stress, resulting from the excessive intracellular accumulation of reactive oxygen species (ROS), nitrogen (RNS), and other free radical species, contributes to onset progression various diseases, including diabetes, obesity, diabetic nephropathy, neuropathy, neurological such as Alzheimer’s disease (AD), amyotrophic lateral sclerosis (ALS), Parkinson’s (PD). stress is also implicated in cardiovascular cancer. Exacerbated oxidative leads accelerated formation advanced glycation end products (AGEs), a complex mixture crosslinked proteins protein modifications. Relatively high levels AGEs are generated AD, I diseases. Ne-carboxymethyllysine (CML) serve markers for progression. AGEs, through interaction with receptors (RAGE), initiate cascade deleterious signaling events form inflammatory cytokines, thereby further exacerbate vicious cycle. AGE inhibitors, breakers, RAGE inhibitors therefore potential therapeutic agents multiple diabetes AD. The complexity lack well-established mechanisms largely responsible effective therapeutics targeting AGE-related This review addresses role pathogenesis chronic disorders, recent progress development based on antioxidants, breakers inhibitors. Furthermore, this outlines strategies single-atom nanozymes that attenuate sequestering (ROS) (RNS).

Language: Английский

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Whole grain benefit: synergistic effect of oat phenolic compounds and β-glucan on hyperlipidemiaviagut microbiota in high-fat-diet mice

Food & Function, Journal Year: 2022, Volume and Issue: 13(24), P. 12686 - 12696

Published: Jan. 1, 2022

Increasing evidence has confirmed that whole grain oats are effective in regulating hyperlipidemia. However, which specific ingredient is crucial remains unclear. This study focused on components, oat phenolic compounds (OPC) or β-glucan (OBG), can regulate lipid metabolism and gut microbiota. The experiment unveiled OPC and/or OBG not only reduced the body weight fasting blood glucose (FBG) but also regulated serum hepatic levels high-fat-diet (HFD) fed mice. There was no significant difference regulatory effects of (p > 0.05). combination (OPC + OBG) significantly decreased < 0.01) profile 0.01). real-time quantitative PCR (RT-qPCR) revealed altered mRNA expression related to metabolism. Histopathological analysis showed improved liver deposition as well oxidative stress In addition, microbiota community phenotype increased probiotics. abundance Bacteroidetes Firmicutes 0.05) compared with conclusion, a synergistic effect alleviating hyperlipidemia via composition. finding provided potential justification for advantages grains preventing

Language: Английский

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The Effects of the Mediterranean Diet on Health and Gut Microbiota

Nutrients, Journal Year: 2023, Volume and Issue: 15(9), P. 2150 - 2150

Published: April 29, 2023

The Mediterranean Diet (MD) is plant-based and consists of multiple daily portions vegetables, fruit, cereals, olive oil. Although there are challenges with isolating the MD from typical lifestyle culture (including prolonged ‘social’ meals siestas), much evidence supports health benefits that include improved longevity, reduced metabolic risk Diabetes Mellitus, obesity, Metabolic Syndrome, malignancy cardiovascular disease, cognitive function. also associated characteristic modifications to gut microbiota, mediated through its constituent parts (primarily dietary fibres, extra virgin oil, polyunsaturated fatty acids [including ω-3]). These enhanced growth species produce short-chain (butyrate), such as Clostridium leptum Eubacterium rectale, Bifidobacteria, Bacteroides, Faecalibacterium prausnitzii species, Firmicutes Blautia species. Such changes in microbiota known be favourably inflammatory oxidative status, propensity for overall health. A key challenge future explore extent which by microbiota. confers both environmental benefits. Adoption should perhaps encouraged facilitated more generally not just restricted populations regions. However, this approach limited perennial availability some non-Mediterranean regions, intolerability a high-fibre diet people, potential cultural disconnects juxtapose traditional Western) diets MD.

Language: Английский

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Beneficial Effects of Red Wine Polyphenols on Human Health: Comprehensive Review

Current Issues in Molecular Biology, Journal Year: 2023, Volume and Issue: 45(2), P. 782 - 798

Published: Jan. 17, 2023

Polyphenols are secondary plant metabolites synthesized during the development of grape berry as a response to stress conditions. They important constituents in red wines that contribute sensory properties and antioxidant activity wines. Due highly sophisticated analytical devices, it is now possible characterize structure polymerized polyphenols obtain full polyphenol profile Red wine include ones present grapes well new products formed winemaking process. Among them, most groups their representatives flavanols (catechin), stilbenes (trans-resveratrol), flavonols (quercetin) hydroxybenzoic acids (gallic acid). It known exhibit beneficial effects on human health, such anti-inflammatory, anticarcinogenic cardio-protective effects. Many studies have been conducted health cancer chemopreventive activities, neuroprotective impact cardiovascular diseases, gut microbiota humans, etc. This review will provide major scientific findings main features.

Language: Английский

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Effects of ultra-processed foods on the microbiota-gut-brain axis: The bread-and-butter issue

Food Research International, Journal Year: 2023, Volume and Issue: 167, P. 112730 - 112730

Published: March 21, 2023

Language: Английский

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Research advances of advanced glycation end products in milk and dairy products: Formation, determination, control strategy and immunometabolism via gut microbiota

Food Chemistry, Journal Year: 2023, Volume and Issue: 417, P. 135861 - 135861

Published: March 5, 2023

Language: Английский

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The Role of Diet and Gut Microbiota in Alzheimer’s Disease

Nutrients, Journal Year: 2024, Volume and Issue: 16(3), P. 412 - 412

Published: Jan. 31, 2024

Alzheimer’s disease (AD), the most prevalent form of dementia, is characterized by accumulation amyloid-beta (Aβ) plaques and hyperphosphorylated tau tangles. Currently, (AD) impacts 50 million individuals, with projections anticipating an increase to 152 year 2050. Despite increasing global prevalence AD, its underlying pathology remains poorly understood, posing challenges for early diagnosis treatment. Recent research suggests a link between gut dysbiosis aggregation Aβ, development proteins, occurrence neuroinflammation oxidative stress are associated AD. However, investigations into gut–brain axis (GBA) in context AD progression have yielded inconsistent findings. This review aims enhance our understanding microbial diversity at species level role these pathology. Additionally, this addresses influence confounding elements, including diet, probiotics, prebiotics, on throughout different stages (preclinical, mild cognitive impairment (MCI), AD) progression.

Language: Английский

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Potential inhibitory effect of Auricularia auricula polysaccharide on advanced glycation end-products (AGEs)

International Journal of Biological Macromolecules, Journal Year: 2024, Volume and Issue: 262, P. 129856 - 129856

Published: Feb. 29, 2024

Language: Английский

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