Unfolded Protein Response Signaling in Liver Disorders: A 2023 Updated Review

International Journal of Molecular Sciences, Journal Year: 2023, Volume and Issue: 24(18), P. 14066 - 14066

Published: Sept. 14, 2023

Endoplasmic reticulum (ER) is the site for synthesis and folding of secreted transmembrane proteins. Disturbance in functioning ER leads to accumulation unfolded misfolded proteins, which finally activate protein response (UPR) signaling. The three branches UPR—IRE1 (Inositol requiring enzyme 1), PERK (Protein kinase RNA-activated (PKR)-like kinase), ATF6 (Activating transcription factor 6)—modulate gene expression pattern through increased chaperones restore homeostasis by enhancing capacity. liver a central organ performs variety functions help maintaining overall well-being our body. plays many roles cellular physiology, blood homeostasis, detoxification, main at occurs. triggered calcium level imbalance, change redox status, viral infection, so on. dysfunction subsequent UPR signaling participate various hepatic disorders like metabolic (dysfunction) associated fatty disease, cancer, hepatitis, cholestasis. exact role stress diseases not fully understood needs further investigation. Targeting with drugs subject intensive research therapeutic use diseases. present review summarizes describes why regulators are promising targets.

Language: Английский

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Raltitrexed induces apoptosis through activating ROS-mediated ER stress by impeding HSPA8 expression in prostate cancer cells

Biochimica et Biophysica Acta (BBA) - Molecular Cell Research, Journal Year: 2024, Volume and Issue: 1871(3), P. 119684 - 119684

Published: Jan. 30, 2024

Language: Английский

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The Unfolded Protein Response: A Novel Therapeutic Target in Acute Leukemias

Cancers, Journal Year: 2020, Volume and Issue: 12(2), P. 333 - 333

Published: Feb. 1, 2020

The unfolded protein response (UPR) is an evolutionarily conserved adaptive triggered by the stress of endoplasmic reticulum (ER) due, among other causes, to altered cell homeostasis (proteostasis). UPR mediated three main sensors, kinase RNA-like (PERK), activating transcription factor 6α (ATF6α), and inositol-requiring enzyme-1α (IRE1α). Given that proteostasis frequently disregulated in cancer, emerging as a critical signaling network controlling survival, selection, adaptation variety neoplasias, including breast prostate colorectal glioblastoma. Indeed, cancer cells can escape from apoptotic pathways elicited ER switching into prosurvival mechanism instead death. Although most studies on focused solid tumors, this intricate plays role hematological malignancies, especially multiple myeloma (MM), where treatment with proteasome inhibitors induce accumulation proteins severely perturb proteostasis, thereby leading stress, and, eventually, apoptosis. However, key player also acute leukemias, recent evidence points likelihood targeting UPR-driven could represent novel therapeutic strategy. In review, we focus oncogene-specific regulation individual arms, provide updated outline genetic, biochemical, preclinical findings support relevant, target leukemias.

Language: Английский

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Organelles coordinate milk production and secretion during lactation: Insights into mammary pathologies

Progress in Lipid Research, Journal Year: 2022, Volume and Issue: 86, P. 101159 - 101159

Published: March 8, 2022

Language: Английский

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Research progress on the role of reactive oxygen species in the initiation, development and treatment of breast cancer

Progress in Biophysics and Molecular Biology, Journal Year: 2024, Volume and Issue: 188, P. 1 - 18

Published: Feb. 20, 2024

Language: Английский

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