Circadian disruption and human health

Journal of Clinical Investigation, Journal Year: 2021, Volume and Issue: 131(19)

Published: Sept. 30, 2021

Circadian disruption is pervasive and can occur at multiple organizational levels, contributing to poor health outcomes individual population levels. Evidence points a bidirectional relationship, in that circadian increases disease severity many diseases disrupt rhythms. Importantly, increase the risk for expression development of neurologic, psychiatric, cardiometabolic, immune disorders. Thus, harnessing rich findings from preclinical translational research biology enhance via circadian-based approaches represents unique opportunity personalized/precision medicine overall societal well-being. In this Review, we discuss implications human using bench-to-bedside approach. science applied clinical population-based Given broad regulation health, Review focuses its discussion on selected examples metabolic, cardiovascular, allergic, immunologic disorders highlight interrelatedness between potential interventions, such as bright light therapy exogenous melatonin, well chronotherapy improve and/or modify outcomes.

Language: Английский

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Chrono-Nutrition: Circadian Rhythm and Personalized Nutrition

International Journal of Molecular Sciences, Journal Year: 2023, Volume and Issue: 24(3), P. 2571 - 2571

Published: Jan. 29, 2023

The human circadian system has a period of approximately 24 h and studies on the consequences “chornodisruption” have greatly expanded. Lifestyle environmental factors modern societies (i.e., artificial lighting, jetlag, shift work, around-the-clock access to energy-dense food) can induce disruptions thereby adversely affect individual health. Growing evidence demonstrates complex reciprocal relationship between metabolism system, in which perturbations one other one. From nutritional genomics perspective, genetic variants clock genes both influence metabolic health modify response diet. Moreover, an interplay rhythm, gut microbiome, epigenome been demonstrated, with diet turn able modulate this link suggesting remarkable plasticity underlying mechanisms. In view, study impact timing eating by matching elements from research chrono-biology, that is, chrono-nutrition, could significant implications for personalized nutrition terms reducing prevalence burden chronic diseases. This review provides overview current interactions nutrition, highlighting how microbiome. addition, possible strategies manage circadian-aligned feeding are suggested.

Language: Английский

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Circadian disruption, clock genes, and metabolic health

Journal of Clinical Investigation, Journal Year: 2024, Volume and Issue: 134(14)

Published: July 14, 2024

A growing body of research has identified circadian-rhythm disruption as a risk factor for metabolic health. However, the underlying biological basis remains complex, and complete molecular mechanisms are unknown. There is emerging evidence from animal human to suggest that expression core circadian genes, such locomotor output cycles kaput gene (CLOCK), brain muscle ARNT-Like 1 (BMAL1), period (PER), cyptochrome (CRY), consequent hundreds genes integral regulation cellular metabolism. These represent potential pathophysiological pathways linking adverse health outcomes, including obesity, syndrome, type 2 diabetes. Here, we aim summarize select in vivo models compare these results with epidemiologic findings advance understanding existing foundational mechanistic links between altered clock contributions health-related pathologies. Findings have important implications treatment, prevention, control pathologies leading causes death disability, diabetes, cardiovascular disease, cancer.

Language: Английский

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Late eating is associated with cardiometabolic risk traits, obesogenic behaviors, and impaired weight loss

American Journal of Clinical Nutrition, Journal Year: 2020, Volume and Issue: 113(1), P. 154 - 161

Published: Aug. 26, 2020

Language: Английский

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Cellular, Molecular, and Physiological Adaptations of Hibernation: The Solution to Environmental Challenges

Annual Review of Cell and Developmental Biology, Journal Year: 2020, Volume and Issue: 36(1), P. 315 - 338

Published: Sept. 8, 2020

Thriving in times of resource scarcity requires an incredible flexibility behavioral, physiological, cellular, and molecular functions that must change within a relatively short time. Hibernation is collection physiological strategies allows animals to inhabit inhospitable environments, where they experience extreme thermal challenges food water. Many different kinds employ hibernation, there spectrum hibernation phenotypes. Here, we focus on obligatory mammalian hibernators identify the unique face adaptations allow overcome them. This includes cellular used combat low environmental body temperatures lack We discuss metabolic, neuronal, hormonal cues regulate how are thought be coordinated by internal clocks. Last, touch questions left addressed field research. Studies from last century more recent work reveal not simply passive reduction temperature vital parameters but rather active process seasonally regulated at molecular, organismal levels.

Language: Английский

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Beneficial Effects of Early Time-Restricted Feeding on Metabolic Diseases: Importance of Aligning Food Habits with the Circadian Clock

Nutrients, Journal Year: 2021, Volume and Issue: 13(5), P. 1405 - 1405

Published: April 22, 2021

The importance of metabolic health is a major societal concern due to the increasing prevalence diseases such as obesity, diabetes, and various cardiovascular diseases. circadian clock clearly implicated in development these Indeed, it regulates physiological processes by hormone modulation, thus helping body perform them at ideal time day. Since industrial revolution, actions rhythms everyday life have been modified are characterized changes sleep pattern, work schedules, eating habits. These modifications turn lead night shift, social jetlag, late-night eating, meal skipping, group customs that causes rhythm disruption leads an increase risks. Intermittent fasting, especially time-restricted proposes solution: restraining feeding window from 6 10 h per day match with clock. This approach seems improve markers could be therapeutic solution fight against review summarizes matching habits for assesses advantages limits application fasting objective treating preventing

Language: Английский

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A Growing Link between Circadian Rhythms, Type 2 Diabetes Mellitus and Alzheimer’s Disease

International Journal of Molecular Sciences, Journal Year: 2022, Volume and Issue: 23(1), P. 504 - 504

Published: Jan. 3, 2022

Type 2 diabetes mellitus (T2DM) patients are at a higher risk of developing Alzheimer’s disease (AD). Mounting evidence suggests the emerging important role circadian rhythms in many diseases. Circadian rhythm disruption is considered to contribute both T2DM and AD. Here, we review relationship among disruption, AD, suggest that occurrence progression AD may part be associated with disruption. Then, summarize promising therapeutic strategies targeting dysfunction for including pharmacological treatment such as melatonin, orexin, molecules, well non-pharmacological treatments like light therapy, feeding behavior, exercise.

Language: Английский

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Physiological Rhythms and Biological Variation of Biomolecules: The Road to Personalized Laboratory Medicine

International Journal of Molecular Sciences, Journal Year: 2023, Volume and Issue: 24(7), P. 6275 - 6275

Published: March 27, 2023

The concentration of biomolecules in living systems shows numerous systematic and random variations. Systematic variations can be classified based on the frequency as ultradian (<24 h), circadian (approximately 24 infradian (>24 which are partly predictable. Random biological known between-subject that among set points an analyte from different individuals within-subject variation, is variation around individuals' points. cannot predicted but estimated using appropriate measurement statistical procedures. Physiological rhythms analytes could considered essential elements predictive, preventive, particularly personalized laboratory medicine. This review aims to summarize research have been done about types physiological rhythms, variations, their effects tests. We searched PubMed Web Science databases for rhythm articles English without time restrictions with terms "Biological Within-subject Between-subject Ultradian Circadian rhythm, Infradian rhythms". It was concluded that, effective management predicting, preventing, personalizing medicine, safe valid interpretation patients' test results, both measurands should simultaneously.

Language: Английский

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The REV-ERB Nuclear Receptors: Timekeepers for the Core Clock Period and Metabolism

Endocrinology, Journal Year: 2023, Volume and Issue: 164(6)

Published: April 17, 2023

REV-ERB nuclear receptors are potent transcriptional repressors that play an important role in the core mammalian molecular clock and metabolism. Deletion of both REV-ERBα its largely redundant isoform REV-ERBβ a murine tissue-specific manner have shed light on their specific functions mechanisms circadian This review highlights recent findings establish REV-ERBs as crucial timekeepers variety tissues, regulating overlapping distinct processes maintain normal physiology protect from metabolic dysfunction.

Language: Английский

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Phenotypic and fitness consequences of plasticity in the rhythmic replication of malaria parasites

Philosophical Transactions of the Royal Society B Biological Sciences, Journal Year: 2025, Volume and Issue: 380(1918)

Published: Jan. 23, 2025

The environments that parasites experience within hosts change dramatically over 24 h. How rhythms shape host–parasite–vector interactions is poorly understood owing to the challenges of disentangling roles multiple interacting species in context complex lifecycles parasites. Using canonical circadian clock-disrupted hosts, we probe limits flexibility rhythmic replication malaria ( Plasmodium ) and quantify consequences for fitness proxies both parasite host. We reveal alter duration their rhythm resonate with host have short (21 h) daily T-cycles as accurately when infecting h cycles, but appear less capable extending long (27 cycles. Despite matching period T-cycle are unable lock correct phase, likely leading lower within-host productivity a reduction transmission potential. However, do not substantial costs. Furthermore, does affect disease severity hosts. Understanding offers opportunity interfere timing improve health reduce transmission. This article part Theo Murphy meeting issue ‘Circadian infection immunity’.

Language: Английский

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