The immunomodulatory mechanisms for acupuncture practice

Frontiers in Immunology, Journal Year: 2023, Volume and Issue: 14

Published: April 6, 2023

The system physiology approaches that emerge in western countries recent years echo the holistic view of ancient Traditional Chinese Medicine (TCM) practices deal with root, rather than only symptoms diseases. Particularly, TCM practices, including acupuncture, emphasize mobilization self-healing mechanisms to bring back body homeostasis. Acupuncture has been practiced for over two thousand modulate via stimulation at specific regions (acupoints). With development various research on acupuncture therapy, its regulatory effect immune gradually recognized, especially immunological diseases, infectious and allergic In this study, we reviewed immunomodulatory mechanism systematically integrates existing respectively elucidate modulatory innate system, adaptive well-known neuroanatomical mechanisms, intact somatosensory-autonomic reflex pathway. advances made systems studies, now have a great opportunity gain insight into how modulates immunity, subsequently improves efficacy.

Language: Английский

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Effects of TCM on polycystic ovary syndrome and its cellular endocrine mechanism

Frontiers in Endocrinology, Journal Year: 2023, Volume and Issue: 14

Published: May 16, 2023

Polycystic ovary syndrome (PCOS) is a reproductive endocrine disease characterized by menstrual disorders, infertility, and obesity, often accompanied insulin resistance metabolic disorders. The pathogenesis of PCOS relatively complex has certain relationship with increase androgen luteinizing hormone (LH) the main cause series symptoms. Traditional Chinese medicine (TCM) obvious advantages significant curative effects in treatment this disease. It can effectively reduce level patients, regulate lipid metabolism, ovulation rate pregnancy fewer side effects. This article reviews efficacy safety herbs other TCM (such as acupuncture) its complications recent years, well effect mechanism on cellular endocrine, order to provide new clinical idea for PCOS.

Language: Английский

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Objectivization study of acupuncture Deqi and brain modulation mechanisms: a review

Frontiers in Neuroscience, Journal Year: 2024, Volume and Issue: 18

Published: May 3, 2024

Deqi is an important prerequisite for acupuncture to achieve optimal efficacy. Chinese medicine has long been concerned with the relationship between and clinical efficacy of acupuncture. However, underlying mechanisms are complex there a lack systematic summaries objective quantitative studies . Acupuncture can purpose treating diseases by regulating interaction local neighboring acupoints, brain centers, target organs. At change their tissue structure, temperature, blood perfusion, energy metabolism, electrophysiological indicators. central level, activate regions thalamus, parahippocampal gyrus, postcentral insular, middle temporal cingulate etc. It also extensive effects on limbic-paralimbic-neocortical-network default mode network. The vary depending techniques points chosen. In addition, 's mechanism action involves correcting abnormalities in multi-targeted multi-layered. biological closely related centers. This study will help explore from local-central-target-organ perspective provide information future decision-making.

Language: Английский

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Electroacupuncture Promotes Liver Regeneration by Activating DMV Acetylcholinergic Neurons‐Vagus‐Macrophage Axis in 70% Partial Hepatectomy of Mice

Advanced Science, Journal Year: 2024, Volume and Issue: 11(32)

Published: June 25, 2024

Abstract Lack of liver regenerative capacity is the primary cause hepatic failure and even mortality in patients undergoing hepatectomy, with no effective intervention strategies currently available. Therefore, identifying efficacious interventions to enhance regeneration pivotal for optimizing clinical outcomes. Recent studies have demonstrated that vagotomy exerts an inhibitory effect on following partial thereby substantiating role played by vagus nerve process regeneration. In recent years, electroacupuncture (EA) has emerged as a non‐invasive technique stimulating nerve. However, EA remains uncertain. this study, 70% hepatectomy (PH) mouse model utilized investigate effects acute elucidate its underlying molecular mechanisms. It observed at ST36 acutely activated cholinergic neurons dorsal motor nucleus (DMV), resulting increased release acetylcholine from vagal endings subsequent activation IL‐6 signaling macrophages. Ultimately, these events promoted hepatocyte proliferation facilitated These findings provide insights into fundamental brain‐liver axis mechanism through which promotes regeneration, offering novel therapeutic approach post‐hepatectomy disorders.

Language: Английский

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Acupuncture modulates emotional network resting-state functional connectivity in patients with insomnia disorder: a randomized controlled trial and fMRI study

BMC Complementary Medicine and Therapies, Journal Year: 2024, Volume and Issue: 24(1)

Published: Aug. 21, 2024

Insomnia disorder (ID) is one of the most common sleep problems, usually accompanied by anxiety and depression symptoms. Functional magnetic resonance imaging (fMRI) study suggests that both poor quality negative emotion are linked to dysregulation brain network related processing in ID patients. Acupuncture therapy has been proven effective improving mood patients, but involved neurobiological mechanism remains unclear. We aimed investigate modulation effect acupuncture on resting-state functional connectivity (rsFC) emotional (EN) patients experiencing insomnia. A total 30 healthy controls (HCs) 60 were enrolled this study. Sixty randomly assigned real sham groups attended fMRI scans before after 4 weeks treatment. HCs completed an MRI/fMRI scan at baseline. The rsFC values within EN calculated, Hamilton Anxiety Scale (HAMA), Depression (HAMD), Pittsburgh Sleep Quality Index (PSQI), Hyperarousal (HAS), actigraphy data collected for clinical efficacy evaluation. Resting-state FC analysis showed abnormalities centered thalamus dorsolateral prefrontal cortex compared HCs. After treatment, anterior cingulate cortex, hippocampus, amygdala increased with group (p < 0.05, FDR corrected). In group, value was decreased between left treatment trend correlation found right hippocampus positively correlated HAMA scores across all negatively efficiency group. Our findings could produce a positive modulating which may illustrate central underlying insomnia regulation. http://www.chictr.org.cn ., ChiCTR1800015282, 20/03/2018.

Language: Английский

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Comparative efficacy of seven nonpharmacological interventions on global cognition in older adults with and without mild cognitive impairment: a network meta-analysis of randomized controlled trials

Scientific Reports, Journal Year: 2024, Volume and Issue: 14(1)

Published: April 10, 2024

Abstract To maintain current cognitive function and access greater reserves, nonpharmacological interventions may be a viable alternative for older adults with or without impairment. This study aimed to compare different enhancing global cognition, including mind–body exercise, physical non-invasive brain stimulation, training intervention (CTI), acutherapy (ACU), meditation, music therapy, by applying network meta-analysis (NMA). Sixty-one randomized controlled trials evaluating the efficacy of on cognition in mild decline were selected. An NMA was conducted interventions. The revealed that exercise (standardized mean difference, 1.384; 95% confidence interval, 0.777–1.992); ACU (1.283; 0.478–2.088); meditation (0.910; 0.097–1.724); stimulation (1.242; 0.254–2.230); CTI (1.269; 0.736–1.802); (0.977; 0.212–1.742), showed positive effects compared passive controls. There no significant differences between efficacies other Nonpharmacological potentially enhance through various pathways, such as memorizing movements plasticity reducing stress adult population. Additional studies are needed clarify impact variables, methods psychological variables.

Language: Английский

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Retrospective analysis on Lou Bei Er Chen decoction and acupuncture in gastroesophageal reflux disease post-gastric cancer surgery

World Journal of Gastrointestinal Surgery, Journal Year: 2025, Volume and Issue: 17(3)

Published: Feb. 24, 2025

BACKGROUND Gastric cancer is a growing clinical challenge, particularly due to the increased risk of postoperative gastroesophageal reflux disease (GERD) following surgical treatment. traditional Chinese medicine (TCM), including acupuncture and herbal medicine, has been proposed as an adjunctive therapy promote gastrointestinal recovery alleviate GERD symptoms. AIM To retrospectively study efficacy modified Lou Bei Er Chen decoction combined with in treating patients after radical gastrectomy gastric cancer. METHODS A retrospective was conducted, or malignant tumors stomach from January 2019 December 2023 Affiliated Taizhou People’s Hospital Nanjing Medical University. Patients TCM diagnosis qi depression phlegm obstruction (n = 128) were selected on basis prescription treatment principles. They then divided into control group 61) observation 67). The received Western domperidone. treated orally, at specific acupoints (bilateral Hegu, bilateral Neiguan, Zusanli), addition group, for continuous period 8 weeks. improvement time function indicators, dysfunction scores, GERD-Q syndrome scores further observed both groups. RESULTS showed significantly shorter times first flatus, defecation, bowel sound recovery, initiation nasogastric enteral nutrition than (P < 0.05). Upon treatment, two groups demonstrated significant reduction more 0.001). decreased weeks 0.05), compared baseline. 4 effective rate higher that (χ 2 13.648, P 0.003), it 13.879, 0.003). CONCLUSION can effectively symptoms surgery improve their life quality. It worthy promotion application.

Language: Английский

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Effect of electroacupuncture at Zusanli reduced Olanzapine‐induced lipid disturbances in mice via potential liver‐brain interaction

The FASEB Journal, Journal Year: 2025, Volume and Issue: 39(8)

Published: April 16, 2025

Olanzapine-induced weight gain and disruptions in lipid metabolism represent multifactorial processes that compromise treatment adherence schizophrenia contribute to substantial clinical challenges. While acupuncture has been reported promote loss, the neural substrates mediating its metabolic effects olanzapine-induced models remain largely undefined. In this study, we evaluated efficacy of electroacupuncture (EA) at Zusanli (ST36) acupoint ameliorating obesity dyslipidemia, investigated underlying liver-brain regulatory mechanisms. We further assessed EA through Reverse Transcription Polymerase Chain Reaction (RT-PCR), ELISA, lipidomics analysis. Comprehensive evaluations were conducted using three-dimensional fine behavioral analysis cages. Additionally, ultrasound functional imaging (fUS), retrograde tracing with pseudorabies virus 152 (PRV152), c-Fos mapping techniques employed investigate interactions. ST36 effectively reduced body weight, reversed adipocyte hypertrophy hepatocyte damage, restored disturbances free fatty acids (FFA) liver metabolism. These also involved restoration respiratory exchange rate (RER) during dark cycle. explored potential mechanisms, successfully demonstrated stimulation significantly deactivated Agouti-related protein (AGRP)-expressing neurons lateral septal nucleus (LS), accumbens (NAc), pallidum, suggesting AGRP+ these brain regions are interaction treatment. findings highlight critical role metabolism-regulating acupuncture-mediated axis provide insights into mechanisms information integration from liver.

Language: Английский

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Does perioperative electroacupuncture reduce postoperative pain in dogs undergoing ovariohysterectomy?

Frontiers in Veterinary Science, Journal Year: 2025, Volume and Issue: 11

Published: Jan. 7, 2025

This study aimed to investigate the analgesic efficacy of perioperative electroacupuncture in fifty-six healthy female dogs undergoing ovariohysterectomy as part a catch-neuter-release project. Ten minutes after sedation with 20 μg/kg medetomidine combined 0.3 mg/kg butorphanol intramuscularly, were randomly allocated into two groups and received either (EA, n = 27) or sham acupuncture (C, 29) treatment for 10 min (after until end surgery) at 6 different points LI-4 (Large intestine 4), LIV-3 (Liver 3), ST-36 (Stomach 36), SP-6 (Spleen 6) bilateral. After administration 0.2 meloxicam anesthesia induction 2 ketamine intravenously, was performed by same experienced surgeon using midline surgical approach dorsal recumbency. Pain evaluated blinded independent anesthetists Short Form Multimodal Glasgow Composite Scale (mCMPS-SF) before (T0), three (T3), six (T6), 24 h (T24) induction. Postoperative pain scores did not differ significantly between (p 0.36), but increased (T3) 0.001) (T6) hours surgery compared postoperative both groups. Three 89.4% postoperatively 71.4% exceeded intervention threshold mCMPS-SF, indicating need rescue analgesia. The results indicate that improve ovariohysterectomy. Therefore, 10-min may be insufficient provide effective assessment feral notably impacted anxious behavior, which have influenced final outcome ¾ early phase (T3, T6), suggesting widely used protocol consisting butorphanol, combination long-lasting sufficient relief.

Language: Английский

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The insular cortex-nucleus tractus solitarius glutamatergic pathway involved in acute stress-induced gastric mucosal damage in rats

Neurobiology of Stress, Journal Year: 2025, Volume and Issue: unknown, P. 100723 - 100723

Published: April 1, 2025

Language: Английский

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