Potential Therapeutic Value of the STING Inhibitors DOI Creative Commons
Shangran Zhang, Runan Zheng, Yanhong Pan

et al.

Molecules, Journal Year: 2023, Volume and Issue: 28(7), P. 3127 - 3127

Published: March 31, 2023

The stimulator of interferon genes (STING) is a critical protein in the activation immune system response to DNA. It can participate inflammatory process by modulating inflammation-preferred translation program through STING-PKR-like endoplasmic reticulum kinase (PERK)-eIF2α pathway or inducing secretion type I interferons (IFNs) and variety proinflammatory factors recruitment TANK-binding 1 (TBK1) regulatory factor 3 (IRF3) regulation nuclear kappa-B (NF-κB) pathway. Based on structure, location, function, genotype, mechanism STING, this review summarizes potential value STING inhibitors prevention treatment infectious diseases, psoriasis, systemic lupus erythematosus, non-alcoholic fatty liver disease, other autoimmune diseases.

Language: Английский

The impact of air pollution on skin and related disorders: A comprehensive review DOI Open Access

Ruhollah Abolhasani,

Farnaz Araghi, Mohammadreza Tabary

et al.

Dermatologic Therapy, Journal Year: 2021, Volume and Issue: 34(2)

Published: Feb. 3, 2021

As the largest organ in body, human skin is constantly exposed to harmful compounds existing surrounding environment as first-line barrier. Studies have indicated that exposure high concentrations of many environmental factors, such ultraviolet (UV) radiation, outdoor air pollutants, including polycyclic aromatic hydrocarbons (PAHs), volatile organic (VOCs), particulate matter (PM), heavy metals, gaseous carbon monoxide (CO), nitric oxides (NOx ), sulfur oxide (SO2 ozone (O3 and indoor pollutants (solid fuels consumption), might interrupt skin's normal barrier function. Besides, intensity length be a contributing factor. Air are believed induce or exacerbate range conditions, aging, inflammatory diseases (atopic dermatitis, cellulitis, psoriasis), acne, hair loss, even cancers (mainly melanoma Squamous Cell Carcinoma) through various mechanisms. The interaction between differ based on each agent's particular characteristics. Also, damaging seems closely related increased production reactive oxygen species (ROS), induction oxidative stress, activation aryl hydrocarbon receptor (AhR), cytokines. This article reviews recent studies correlation diseases, along with

Language: Английский

Citations

77
Air pollution and skin disorders DOI Creative Commons
Wendy E. Roberts

International Journal of Women’s Dermatology, Journal Year: 2020, Volume and Issue: 7(1), P. 91 - 97

Published: Nov. 25, 2020

Air pollution is being shown to play an increasing causation role in our most common skin diseases. Acne, hyperpigmentation, atopic dermatitis, and psoriasis have been be influenced by air pollution. It important for added as a risk factor these disorders, thus we must discuss mitigating its negative affects with patients. the contamination of outdoor (ambient) indoor (household) environments any chemical, physical, or biological agent that modifies natural characteristics atmosphere. Nearly all (90%) world's population experience daily In 2019, was considered World Health Organization biggest environmental health humans, responsible killing more than 7 million people prematurely every year. Preliminary studies link COVID-19 deaths, there were high death tolls some globally polluted areas. many organ systems such cardiovascular, pulmonary, central nervous, reproductive, integumentary systems. this study, detail current evidence linking specific disorders

Language: Английский

Citations

71
Key Signaling Pathways in Psoriasis: Recent Insights from Antipsoriatic Therapeutics DOI Creative Commons
Hakim Ben Abdallah, Claus Johansen, Lars Iversen

et al.

Psoriasis Targets and Therapy, Journal Year: 2021, Volume and Issue: Volume 11, P. 83 - 97

Published: June 1, 2021

Abstract: Psoriasis is a common chronic inflammatory skin disease associated with several comorbidities and reduced quality of life. In the past decades, highly effective targeted therapies have led to breakthroughs in management psoriasis, providing important insights into pathogenesis. This article reviews current concepts pathophysiological pathways recent progress antipsoriatic therapeutics, highlighting key targets, signaling clinical effects psoriasis. Keywords: small molecules, pathways, novel treatments, biologics

Language: Английский

Citations

58
Curcumin and Curcuma longa Extract in the Treatment of 10 Types of Autoimmune Diseases: A Systematic Review and Meta-Analysis of 31 Randomized Controlled Trials DOI Creative Commons

Liuting Zeng,

Tiejun Yang, Kailin Yang

et al.

Frontiers in Immunology, Journal Year: 2022, Volume and Issue: 13

Published: Aug. 1, 2022

Objective To evaluate the randomized controlled trials (RCTs) of Curcumin and Curcuma longa Extract in treatment autoimmune diseases. Methods Databases such as Embase, Web Science, PubMed The Cochrane Library were searched from database establishment to February 2022 collect RCTs Then literature was screened data extracted. Meta-analysis performed using RevMan 5.3 software. Results A total 34 records included, involving 31 10 types disease. Among them, ankylosing spondylitis (AS) involves one RCT, Behcet ‘s disease (BD) Crohn two RCTs, multiple sclerosis (MS) oral lichen planus six psoriasis rheumatoid arthritis (RA) five systemic lupus erythematosus (SLE) arteritis ulcerative colitis (UC) nine RCTs. most (UC), planus, RA showed that curcumin extracts improved clinical or laboratory results. ‘ s disease, MS, SLE, included RCTs; they all improvements (at least RCT reported outcomes). AS, BD only results improvement. However, due small number patients involved each there is still a need for more high-quality Conclusion had good efficacy Psoriasis, UC RA, so could be used above diseases future. did not show while Takayasu arteritis, CD report sufficient meta-analysis. Therefore, large-sample, multi-center are needed revision validation.

Language: Английский

Citations

45
Psoriasis: Interplay between dysbiosis and host immune system DOI
Bhupinder Kapoor,

Monica Gulati,

Pooja Rani

et al.

Autoimmunity Reviews, Journal Year: 2022, Volume and Issue: 21(11), P. 103169 - 103169

Published: Aug. 12, 2022

Language: Английский

Citations

39
Microneedles as a momentous platform for psoriasis therapy and diagnosis: A state-of-the-art review DOI
B.H. Jaswanth Gowda, Mohammed Gulzar Ahmed, Umme Hani

et al.

International Journal of Pharmaceutics, Journal Year: 2023, Volume and Issue: 632, P. 122591 - 122591

Published: Jan. 7, 2023

Language: Английский

Citations

39
The Prevalent Comorbidome at the Onset of Psoriasis Diagnosis DOI Creative Commons
Alessandra Buja, Andrea Miatton, Claudia Cozzolino

et al.

Dermatology and Therapy, Journal Year: 2023, Volume and Issue: 13(9), P. 2093 - 2105

Published: Aug. 5, 2023

Psoriasis (PsO) is currently regarded as a systemic inflammatory disease with growing burden of post-diagnosis associated comorbidities. To determine the initial comorbiditis we evaluated comorbidome at PsO onset.In matched case-control study, extracted data on 57,228 patients and 125 morbidities from Clalit Health Services Israeli insurance database. cases were control individuals by sex age enrolment. As pre-existing comorbidities, considered all conditions already present in controls same case time their diagnosis. test for differences odds comorbidities between groups, logistic regression analyses run to calculate ratio (OR) each comorbidity, after which was graphically represented.In this study enrolled 28,614 an average 45.3 ± 19.6 years. At diagnosis, more likely be diagnosed 2-4 (28.8% vs 23.8%) > 5 (19.6% 12.9%,). patients' specific comorbidomes evidenced several pathological cores: autoimmune diseases [i.e., hidradenitis suppurativa (OR 3.55, 95% CI 1.88-7.28) or polymyalgia rheumatica 3.01 1.96-4.77)], bowel Crohn's 2.99 2.20-4.13)], pulmonary chronic obstructive 1.81 1.61-2.04)], hepatological cirrhosis 2.00 1.36-3.00)], endocrine [dysthyroidisms 1.82 1.30-2.59)], mental disorders depression 1.72 1.57-1.87)], cardiovascular (i.e., hypertension 1.47 1.41-1.53)].The PsO-onset may help health professionals plan comprehensive patient management. By screening these common PsO-linked conditions, early diagnosis treatment become frequent, thus greatly benefiting medical journey.

Language: Английский

Citations

33
Lipid Alterations and Metabolism Disturbances in Selected Inflammatory Skin Diseases DOI Open Access
Julia Nowowiejska, Anna Baran, Iwona Flisiak

et al.

International Journal of Molecular Sciences, Journal Year: 2023, Volume and Issue: 24(8), P. 7053 - 7053

Published: April 11, 2023

Lipidomics is a term used to define the field that analyzes structure, functions, and interactions of lipids. Inflammatory dermatoses lipid disturbances are interrelated, especially due chronic inflammatory conditions. This review discusses lipidomics in selected skin diseases: psoriasis, lichen planus, atopic dermatitis, as well less commonly mentioned hidradenitis suppurativa, rosacea, acne vulgaris. Lipid homeostasis disorders common; they well-documented dermatitis. Future studies required for better insight into this issue, particularly on lipidome. Understanding lipidomics, particular diseases, increases our knowledge about their pathogenesis, may become useful adjusting tailored management each patient establishing prognosis. Noteworthily, it seems advisable alert doctors need analyze parameters complications abnormal metabolism dermatological patients, which could decrease comorbidities improve life quality health condition patients.

Language: Английский

Citations

31
Climate Change, Skin Health, and Dermatologic Disease: A Guide for the Dermatologist DOI
Annika Belzer, Eva Rawlings Parker

American Journal of Clinical Dermatology, Journal Year: 2023, Volume and Issue: 24(4), P. 577 - 593

Published: June 20, 2023

Language: Английский

Citations

29
Review of natural compounds for potential psoriasis treatment DOI Creative Commons
Omali Y. El‐khawaga,

Mohamed M. Ellety,

Sheref O. Mofty

et al.

Inflammopharmacology, Journal Year: 2023, Volume and Issue: 31(3), P. 1183 - 1198

Published: March 30, 2023

Abstract Psoriasis represents an immune-mediated disease with unclear cause that’s marked by inflammation triggered dysfunction in the immune system, which results various parts of skin. There could be obvious symptoms, such as elevated plaques; these plaques may appear differently depending on type This can elbows, lower back, scalp, knees, or other regions body. It begin at any age, although it most commonly affects individuals between ages 50 and 60. Specific cells (such T cells) have been observed to play role pathogenesis psoriasis, addition specific immunological molecules TNF-, IL-12, IL-23, IL-17, that aid psoriasis. So, during past two decades, biologists created chemical drugs target therefore prevent from occurring. Alefacept, efalizumab, Adalimumab, Ustekinumab, Secukinumab are a few examples drugs. was discovered long-term side effects defects patient's body, development rare but life-threatening disorder progressive multifocal leukoencephalopathy (PCL). Its rapidly infection central nervous system caused JC virus increased production neutralising anti-drug antibodies (ADA) risk infusion reactions like pruritus, flushing, hypertension, headache, rash. our context intends talk review about natural products plants therapeutic characteristics for this no

Language: Английский

Citations

27