Anti-Cancer Potential of Cannabinoids, Terpenes, and Flavonoids Present in Cannabis

Cancers, Journal Year: 2020, Volume and Issue: 12(7), P. 1985 - 1985

Published: July 21, 2020

In recent years, and even more since its legalization in several jurisdictions, cannabis the endocannabinoid system have received an increasing amount of interest related to their potential exploitation clinical settings. Cannabinoids been suggested shown be effective treatment various conditions. cancer, is altered numerous types tumours can relate cancer prognosis disease outcome. Additionally, cannabinoids display anticancer effects models by suppressing proliferation, migration and/or invasion cells, as well tumour angiogenesis. However, therapeutic use currently limited symptoms pain associated with chemotherapy, while cytotoxic drugs chemotherapy still requires validation patients. Along cannabinoids, contains other compounds that also exert anti-tumorigenic actions. The anti-cancer terpenes flavonoids, present cannabis, are explored this literature review.

Language: Английский

---

Cannabidiol and Other Non-Psychoactive Cannabinoids for Prevention and Treatment of Gastrointestinal Disorders: Useful Nutraceuticals?

International Journal of Molecular Sciences, Journal Year: 2020, Volume and Issue: 21(9), P. 3067 - 3067

Published: April 26, 2020

Cannabis sativa is an aromatic annual flowering plant with several botanical varieties, used for different purposes, like the production of fibers, oil from seeds, and especially recreational or medical purposes. Phytocannabinoids (terpenophenolic compounds derived plant), include well-known psychoactive cannabinoid Δ9-tetrahydrocannabinol, many non-psychoactive cannabinoids, cannabidiol. The endocannabinoid system (ECS) comprises ligands, enzymes synthesis degradation such receptors. This widely distributed in gastrointestinal tract, where phytocannabinoids exert potent effects, particularly under pathological (i.e., inflammatory) conditions. Herein, we will first look at hemp as a possible source new functional food ingredients nutraceuticals that might be eventually useful to treat even prevent Subsequently, briefly describe ECS general pharmacology phytocannabinoids. Finally, revise available data showing phytocannabinoids, cannabidiol, may disorders diseases tract. With increasing interest development foods healthy life, are hoped find place also tract function.

Language: Английский

---

Disorders of cancer metabolism: The therapeutic potential of cannabinoids

Biomedicine & Pharmacotherapy, Journal Year: 2022, Volume and Issue: 157, P. 113993 - 113993

Published: Nov. 12, 2022

Abnormal energy metabolism, as one of the important hallmarks cancer, was induced by multiple carcinogenic factors and tumor-specific microenvironments. It comprises aerobic glycolysis, de novo lipid biosynthesis, glutamine-dependent anaplerosis. Considering that metabolic reprogramming provides various nutrients for tumor survival development, it has been considered a potential target cancer therapy. Cannabinoids have shown to exhibit variety anticancer activities unclear mechanisms. This paper first reviews recent progress related signaling pathways (reactive oxygen species (ROS), AMP-activated protein kinase (AMPK), mitogen-activated kinases (MAPK), phosphoinositide 3-kinase (PI3K), hypoxia-inducible factor-1alpha (HIF-1α), p53) mediating metabolism (including glucose amino acid metabolism). Then we comprehensively explore latest discoveries possible mechanisms effects cannabinoids through regulation above-mentioned pathways, provide new targets insights prevention treatment.

Language: Английский

---

Staphylococcus aureus biofilm: Formulation, regulatory, and emerging natural products-derived therapeutics

Biofilm, Journal Year: 2024, Volume and Issue: 7, P. 100175 - 100175

Published: Jan. 1, 2024

Staphylococcus aureus can readily form biofilm which enhances the drug-resistance, resulting in life-threatening infections involving different organs. Biofilm formation occurs due to a series of developmental events including bacterial adhesion, aggregation, maturation, and dispersion, are controlled by multiple regulatory systems. Rapidly increasing research development outcomes on natural products targeting S. and/or regulation led an emergent application active phytochemicals combinations. This review aimed at providing in-depth understanding mechanisms for aureus, outlining most important antibiofilm strategies potential targets products, summarizing latest progress combating with plant-derived products. These findings provided further evidence novel drugs clinical therapies.

Language: Английский

---

Critical Aspects Affecting Cannabidiol Oral Bioavailability and Metabolic Elimination, and Related Clinical Implications

CNS Drugs, Journal Year: 2020, Volume and Issue: 34(8), P. 795 - 800

Published: June 5, 2020

Language: Английский

---

Cannabis sativa: Much more beyond Δ9-tetrahydrocannabinol

Pharmacological Research, Journal Year: 2020, Volume and Issue: 157, P. 104822 - 104822

Published: April 23, 2020

Language: Английский

---

The Effects of Cannabidiol, a Non-Intoxicating Compound of Cannabis, on the Cardiovascular System in Health and Disease

International Journal of Molecular Sciences, Journal Year: 2020, Volume and Issue: 21(18), P. 6740 - 6740

Published: Sept. 14, 2020

Cannabidiol (CBD) is a non-intoxicating and generally well-tolerated constituent of cannabis which exhibits potential beneficial properties in wide range diseases, including cardiovascular disorders. Due to its complex mechanism action, CBD may affect the system different ways. Thus, we reviewed influence on this health disease determine risk side effects during use for medical wellness purposes elucidate therapeutic diseases. Administration healthy volunteers or animals usually does not markedly hemodynamic parameters. Although has been found exhibit vasodilatory antioxidant hypertension, it affected blood pressure hypertensive animals. Hypotensive action mainly revealed under stress conditions. Many positive have observed experimental models heart diseases (myocardial infarction, cardiomyopathy, myocarditis), stroke, neonatal hypoxic ischemic encephalopathy, sepsis-related encephalitis, complications diabetes, ischemia/reperfusion injures liver kidneys. In these pathological conditions decreased organ damage dysfunction, oxidative nitrative stress, inflammatory processes apoptosis, among others. Nevertheless, further clinical research needed recommend treatment

Language: Английский

---

Cannabinoids in the Pathophysiology of Skin Inflammation

Molecules, Journal Year: 2020, Volume and Issue: 25(3), P. 652 - 652

Published: Feb. 4, 2020

Cannabinoids are increasingly-used substances in the treatment of chronic pain, some neuropsychiatric disorders and more recently, skin with an inflammatory component. However, various studies cite conflicting results concerning cellular mechanisms involved, while others suggest that cannabinoids may even exert pro-inflammatory behaviors. This paper aims to detail clarify complex workings molecular setting main dermatological diseases, their interactions other emerging applications these conditions. Also, potential role as antitumoral drugs is explored relation component cancer. In vivo vitro employed either phyto-, endo-, or synthetic were considered this paper. regarded growing interest eligible conditions, anticancer effects, readiness monitoring effects facility topical application contribute support use substances. Despite promising early results, further controlled human required establish definitive products pathophysiology inflammation usefulness clinical setting.

Language: Английский

---

Inclusion complexes of cannabidiol with β-cyclodextrin and its derivative: Physicochemical properties, water solubility, and antioxidant activity

Journal of Molecular Liquids, Journal Year: 2021, Volume and Issue: 334, P. 116070 - 116070

Published: April 8, 2021

Language: Английский

---

Mechanisms of Cannabidiol (CBD) in Cancer Treatment: A Review

Biology, Journal Year: 2022, Volume and Issue: 11(6), P. 817 - 817

Published: May 26, 2022

Cannabis sativa L. (Cannabis) and its bioactive compounds, including cannabinoids non-cannabinoids, have been extensively studied for their biological effects in recent decades. Cannabidiol (CBD), a major non-intoxicating cannabinoid Cannabis, has emerged as promising intervention cancer research. The purpose of this review is to provide insights into the relationship between CBD based on research findings. anticancer are mainly mediated via interaction with endocannabinoid system, resulting alleviation pain promotion immune regulation. Published reviews focused applications management possible toxicological excessive consumption. In review, we aim summarize mechanisms action underlying activities against several common cancers. Studies efficacy prevention experimental models (i.e., cell culture- animal-based assays) human clinical studies included review.

Language: Английский

---