Dietary Anti-Aging Polyphenols and Potential Mechanisms

Antioxidants, Journal Year: 2021, Volume and Issue: 10(2), P. 283 - 283

Published: Feb. 13, 2021

For years, the consumption of a diet rich in fruits and vegetables has been considered healthy, increasing longevity, decreasing morbidities. With assistance basic research investigating potential mechanisms, it become clear that beneficial effects plant-based foods are mainly due to large amount bioactive phenolic compounds contained. Indeed, substantial dietary intervention studies humans have supported supplementation polyphenols various health-promoting effects, especially elderly population. In vitro examinations on anti-aging mechanisms widely performed, using different types natural synthetic compounds. The aim this review is critically evaluate experimental evidence demonstrating aging-related diseases. We highlight polyphenols, including antioxidant signaling, preventing cellular senescence, targeting microRNA, influencing NO bioavailability, promoting mitochondrial function. While trends utilizing disorders getting growing attention, we suggest exploration combination multiple or polyphenol-rich foods, as would be more physiologically relevant daily life.

Language: Английский

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Nutraceuticals and Cancer: Potential for Natural Polyphenols

Nutrients, Journal Year: 2021, Volume and Issue: 13(11), P. 3834 - 3834

Published: Oct. 27, 2021

Cancer is one of the leading causes death globally, associated with multifactorial pathophysiological components. In particular, genetic mutations, infection or inflammation, unhealthy eating habits, exposition to radiation, work stress, and/or intake toxins have been found contribute development and progression cancer disease states. Early detection proper treatment enhance chances survival healing, but side effects anticancer drugs still produce detrimental responses that counteract benefits in terms hospitalization survival. Recently, several natural bioactive compounds were possess properties, capable killing transformed cancerous cells without being toxic their normal counterparts. This effect occurs when products are conventional treatments, thereby suggesting nutraceutical supplementation may successful therapy. review aims discuss current literature on four extracts mostly characterized by a specific polyphenolic profile. activities reported support treatment: (1) inhibition cell proliferation, (2) antioxidant activity, (3) anti-inflammatory activity. On other hand, owing attenuation therapies, antioxidants improving compliance patients undergoing treatment. Thus, supplementation, along drug treatment, be considered for better cancer. It should noted, however, data from studies plant preparations discussed, it appropriate ensure experiments conducted accordance accepted pharmacological research practices so as not disclose information only partially correct.

Language: Английский

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Polyphenols in Metabolic Diseases

Molecules, Journal Year: 2022, Volume and Issue: 27(19), P. 6280 - 6280

Published: Sept. 23, 2022

Polyphenols (PPs) are a large group of phytochemicals containing phenolic rings with two or more hydroxyl groups. They possess powerful antioxidant properties, multiple therapeutic effects, and possible health benefits in vivo vitro, as well reported clinical studies. Considering their free-radical scavenging anti-inflammatory these substances can be used to treat different kinds conditions associated metabolic disorders. Many symptoms syndrome (MtS), including obesity, dyslipidemia, atherosclerosis, elevated blood sugar, accelerating aging, liver intoxication, hypertension, cancer neurodegenerative disorders, substantially relieved by dietary PPs. The present study explores the bioprotective properties underlying mechanisms A detailed understanding natural compounds will open up new opportunities for producing unique PP-rich medicinal plans, ultimately affirming benefits.

Language: Английский

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Possible Side Effects of Polyphenols and Their Interactions with Medicines

Molecules, Journal Year: 2023, Volume and Issue: 28(6), P. 2536 - 2536

Published: March 10, 2023

Polyphenols are an important component of plant-derived food with a wide spectrum beneficial effects on human health. For many years, they have aroused great interest, especially due to their antioxidant properties, which used in the prevention and treatment diseases. Unfortunately, as any chemical substance, depending conditions, dose, interactions environment, it is possible for polyphenols also exert harmful effects. This review presents comprehensive current state knowledge negative impact health, describing side polyphenol intake, form supplements. The begins brief overview physiological role potential use disease prevention, followed by exerted particular situations. individual chapters discuss consequences polyphenols’ ability block iron uptake, some subpopulations can be harmful, well inhibition digestive enzymes, intestinal microbiota, polyphenolic compounds drugs, hormonal balance. Finally, prooxidative activity mutagenic, carcinogenic, genotoxic presented. According authors, there need raise public awareness about supplementation, case vulnerable subpopulations.

Language: Английский

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Dietary Polyphenols as Natural Inhibitors of α-Amylase and α-Glucosidase

Life, Journal Year: 2022, Volume and Issue: 12(11), P. 1692 - 1692

Published: Oct. 25, 2022

It is well known that carbohydrates are the main source of calories in most diets. However, by inhibiting carbohydrases, intake reduced and weight loss improved. α-amylase an enzyme hydrolyses α-1,4 glycosidic linkages α-linked polysaccharides, resulting low-molecular-weight products such as glucose, maltose maltotriose, while α-glucosidase catalyzes hydrolysis nonreducing α-1,4-linked glucose moieties from disaccharides or oligosaccharides. Currently, one common nutritional disorders world hyperglycemia. One new therapeutic approaches to treat this disease application natural inhibitors, polyphenols, control starch digestion regulate blood level. Dietary polyphenols showed potential inhibitory activity against review summarizes recently published literature studied inhibition mechanisms structure–activity relationship between individual dietary mentioned digestive enzymes. higher binding interactions cause activities; thus, different can affect steps polysaccharides. The aim clarify these introduce polyphenol-rich functional foods tools for α-glucosidase.

Language: Английский

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Engineering functional mesoporous materials from plant polyphenol based coordination polymers

Coordination Chemistry Reviews, Journal Year: 2022, Volume and Issue: 468, P. 214649 - 214649

Published: June 9, 2022

Language: Английский

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Diet strategies for promoting healthy aging and longevity: An epidemiological perspective

Journal of Internal Medicine, Journal Year: 2023, Volume and Issue: 295(4), P. 508 - 531

Published: Oct. 23, 2023

Abstract In recent decades, global life expectancies have risen significantly, accompanied by a marked increase in chronic diseases and population aging. This narrative review aims to summarize findings on the dietary factors influencing longevity, primarily from large cohort studies. First, maintaining healthy weight throughout is pivotal for aging mirroring benefits of lifelong, moderate calorie restriction today's obesogenic food environment. Second, specific types or sources fat, protein, carbohydrates are more important disease risk mortality than their quantity. Third, some traditional diets (e.g., Mediterranean, Nordic, Okinawa) contemporary patterns, such as plant‐based diet index, DASH (dietary approaches stop hypertension) diet, alternate eating been associated with lower longevity. These patterns share many common components predominance nutrient‐rich plant foods; limited red processed meats; culinary herbs spices prevalent cuisines) while embracing distinct elements different cultures. Fourth, combining other lifestyle could extend disease‐free 8–10 years. While adhering core principles diets, it crucial adapt recommendations individual preferences cultures well nutritional needs populations. Public health strategies should aim create healthier environment where nutritious options readily accessible, especially public institutions care facilities elderly. Although further mechanistic studies human trials needed better understand molecular effects aging, there pressing need establish maintain long‐term cohorts studying culturally diverse

Language: Английский

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Role of Hydroxytyrosol and Oleuropein in the Prevention of Aging and Related Disorders: Focus on Neurodegeneration, Skeletal Muscle Dysfunction and Gut Microbiota

Nutrients, Journal Year: 2023, Volume and Issue: 15(7), P. 1767 - 1767

Published: April 4, 2023

Aging is a multi-faceted process caused by the accumulation of cellular damage over time, associated with gradual reduction physiological activities in cells and organs. This degeneration results reduced ability to adapt homeostasis perturbations an increased incidence illnesses such as cognitive decline, neurodegenerative cardiovascular diseases, cancer, diabetes, skeletal muscle pathologies. Key features aging include chronic low-grade inflammation state decrease autophagic process. The Mediterranean diet has been longevity counteract onset age-related disorders. Extra virgin olive oil, fundamental component this diet, contains bioactive polyphenolic compounds hydroxytyrosol (HTyr) oleuropein (OLE), known for their antioxidant, anti-inflammatory, neuroprotective properties. review focused on brain, muscle, gut microbiota, these systems are interact at several levels. After description chemistry pharmacokinetics HTyr OLE, we summarize studies reporting effects vivo vitro models diseases central/peripheral nervous system, adult neurogenesis depression, senescence lifespan, disorders, well impact composition microbiota.

Language: Английский

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Antioxidant Metabolism Pathways in Vitamins, Polyphenols, and Selenium: Parallels and Divergences

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(5), P. 2600 - 2600

Published: Feb. 23, 2024

Free radicals (FRs) are unstable molecules that cause reactive stress (RS), an imbalance between oxygen and nitrogen species in the body its ability to neutralize them. These generated by both internal external factors can damage cellular lipids, proteins, DNA. Antioxidants prevent or slow down oxidation process interrupting transfer of electrons substances agents. This is particularly important at level because reactions lead formation FR contribute various diseases. As we age, RS accumulates leads organ dysfunction age-related disorders. Polyphenols; vitamins A, C, E; selenoproteins possess antioxidant properties may have a role preventing treating certain human diseases associated with RS. In this review, explore current evidence on potential benefits dietary supplementation investigate intricate connection SIRT1, crucial regulator aging longevity; transcription factor NRF2; polyphenols, vitamins, selenium. Finally, discuss positive effects molecules, such as reducing RS, their slowing several

Language: Английский

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Hormetic Nutrition and Redox Regulation in Gut–Brain Axis Disorders

Antioxidants, Journal Year: 2024, Volume and Issue: 13(4), P. 484 - 484

Published: April 18, 2024

The antioxidant and anti-inflammatory effects of hormetic nutrition for enhancing stress resilience overall human health have received much attention. Recently, the gut-brain axis has attracted prominent interest preventing therapeutically impacting neuropathologies gastrointestinal diseases. Polyphenols polyphenol-combined nanoparticles in synergy with probiotics shown to improve gut bioavailability blood-brain barrier (BBB) permeability, thus inhibiting oxidative stress, metabolic dysfunction inflammation linked dysbiosis ultimately onset progression central nervous system (CNS) disorders. In accordance hormesis, polyphenols display biphasic dose-response by activating at a low dose Nrf2 pathway resulting upregulation

Language: Английский

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