Altered epidermal proliferation, differentiation, and lipid composition: Novel key elements in the vitiligo puzzle DOI Creative Commons
Daniela Kovacs, Emanuela Bastonini, Stefania Briganti

et al.

Science Advances, Journal Year: 2022, Volume and Issue: 8(35)

Published: Sept. 2, 2022

Vitiligo is an acquired skin depigmentation disease involving multiple pathogenetic mechanisms, which ultimately direct cytotoxic CD8 + cells to destroy melanocytes. Abnormalities have been described in several even pigmented as expression of a functional inherited defect. Keratinocytes regulate homeostasis by the assembly proper barrier and releasing responding cytokines growth factors. Alterations epidermal proliferation, differentiation, lipid composition triggers for immune response activation vitiligo not yet investigated. By applying cellular lipidomic approaches, we revealed deregulated keratinocyte differentiation with altered composition, associated impaired energy metabolism increased glycolytic enzyme expression. keratinocytes secreted inflammatory mediators, further following mild mechanical stress, thus evidencing activation. These findings identify intrinsic alterations nonlesional epidermis, can be prime instigator local milieu that stimulates responses targeting

Language: Английский

The heterogeneity and complexity of skin surface lipids in human skin health and disease DOI Creative Commons
Dalibor Mijaljica,

Joshua P. Townley,

Fabrizio Spada

et al.

Progress in Lipid Research, Journal Year: 2023, Volume and Issue: 93, P. 101264 - 101264

Published: Nov. 6, 2023

The outermost epidermal layer of the skin, stratum corneum, is not simply a barrier that safeguards skin integrity from external insults and invaders, it also delicately integrated interface composed firm, essentially dead corneocytes distinctive lipid matrix. Together, corneum matrix sebum lipids derived sebaceous glands give rise to remarkably complex but quite unique blend surface demonstrates tremendous heterogeneity provides with its indispensable protective coating. primarily three major classes: ceramides, non-esterified fatty acids cholesterol, whereas waxy mixture predominantly acylglycerols, wax esters, acids, squalene, cholesterol esters. balance these in terms their relative abundance, composition, molecular organisation dynamics, intricate interactions play crucial role maintenance healthy skin. For reason, even minuscule alterations properties or overall profile have been implicated aetiology many common diseases including atopic dermatitis, psoriasis, xerosis, ichthyosis acne. Novel lipid-based interventions aimed at correcting abnormalities potential repair symptoms associated such diseases, though exact mechanisms restoration remain elusive.

Language: Английский

Citations

27
Advancements in zinc oxide nanomaterials: Synthesis, properties, and diverse applications DOI
Hussain Gulab,

Nusrat Fatima,

Urooj Tariq

et al.

Nano-Structures & Nano-Objects, Journal Year: 2024, Volume and Issue: 39, P. 101271 - 101271

Published: July 24, 2024

Language: Английский

Citations

15
Inflammatory Skin Diseases: Focus on the Role of Suppressors of Cytokine Signaling (SOCS) Proteins DOI Creative Commons
Antonia Cianciulli, Rosa Calvello, Chiara Porro

et al.

Cells, Journal Year: 2024, Volume and Issue: 13(6), P. 505 - 505

Published: March 13, 2024

Inflammatory skin diseases include a series of disorders characterized by strong activation the innate and adaptive immune system in which proinflammatory cytokines play fundamental role supporting inflammation. Skin inflammation is complex process influenced various factors, including genetic environmental dysfunction both non-immune cells. Psoriasis (PS) atopic dermatitis (AD) are most common chronic inflammatory conditions whose pathogeneses very multifactorial. Both an immunological involving predominance Th1 Th17 cells PS Th2 AD. Suppressor cytokine signaling (SOCS) proteins intracellular that control responses regulating pathways activated cytokines. SOCS involved regulation progression skin-resident non-resident cells, recent data suggest these negative modulators dysregulated such as This review focuses on current understanding about modulating activity mediators implicated pathogenesis

Language: Английский

Citations

10
A systematic review and meta‐analysis of nutritional and dietary interventions in randomized controlled trials for skin symptoms in children with atopic dermatitis and without food allergy: An EAACI task force report DOI Creative Commons
Εmilia Vassilopoulou, Anna Comotti, Nikolaos Douladiris

et al.

Allergy, Journal Year: 2024, Volume and Issue: 79(7), P. 1708 - 1724

Published: May 23, 2024

Abstract This systematic review and meta‐analysis aimed to consolidate evidence on dietary interventions for atopic eczema/dermatitis (AD) skin symptoms in children without food allergies, following PRISMA 2020 guidelines. Systematic updates were conducted May 2022 June 2023, focusing randomized placebo‐controlled trials (RCTs) involving with AD but allergies. Specific diets or supplements, such as vitamins, minerals, probiotics, prebiotics, symbiotics, postbiotics, explored these trials. Exclusions comprised descriptive studies, reviews, meta‐analyses, letters, case reports, studies elimination diets, those reporting allergens adolescents. Additionally, assessing exacerbation of due allergy/sensitization evaluating diets' effects excluded. Nutritional supplementation eligible regardless sensitization profile. Evaluation their impact clinical expression was performed using SCORAD scores, a outcomes random‐effect models (CRD42022328702). The encompassed 27 RCTs examining Vitamin D, evening primrose oil, substituting cow's milk formula partially hydrolyzed whey formula. A 20 alone combined revealed significant reduction suggesting consistent trend alleviating Nonetheless, other remains limited, underscoring the necessity well‐designed intervention targeting multiple factors understand etiological interactions propose reliable manipulation strategies.

Language: Английский

Citations

10
Natural Nrf2 Modulators for Skin Protection DOI Creative Commons
Yong Chool Boo

Antioxidants, Journal Year: 2020, Volume and Issue: 9(9), P. 812 - 812

Published: Sept. 1, 2020

Since the discovery of antioxidant responsive elements (ARE), which are commonly found in promoter Phase II metabolism/antioxidant enzymes, and nuclear factor erythroid 2-related 2 (Nrf2), transcription that binds to ARE, study conducted this field has expanded remarkably over decades, Nrf2-mediated pathway is now recognized occupy a central position cell defense mechanisms. Induction enzymes through direct activation Nrf2 can be promising strategy for preventing degenerative diseases general, but dark side should considered, as enhance survival cancer cells. In review, we discuss historical regulatory mechanism pathway, focusing on interacting proteins post-translational modifications. addition, latest studies examined various natural modulators protective roles skin, consideration their dermatological cosmetic applications. Studies reviewed order time research much possible, help understand how why such were under circumstances time. We hope review serve steppingstone conducting more advanced by providing scientific basis researchers newly entering field.

Language: Английский

Citations

55
Comparative Analysis of the Microbiome across the Gut–Skin Axis in Atopic Dermatitis DOI Open Access

Dong Hoon Park,

Joo Wan Kim,

Hi‐Joon Park

et al.

International Journal of Molecular Sciences, Journal Year: 2021, Volume and Issue: 22(8), P. 4228 - 4228

Published: April 19, 2021

Atopic dermatitis (AD) is a refractory and relapsing skin disease with complex multifactorial etiology. Various congenital malformations environmental factors are thought to be involved in the onset of disease. The etiology has been investigated, respect clinical symptoms systemic immune response factors. A gut microbiome-mediated connection between emotional disorders such as depression anxiety, dermatologic conditions acne, based on comorbidities these two seemingly unrelated disorders, long hypothesized. Many aspects this gut-brain-skin integration theory have recently revalidated identify treatment options for AD recent advances metagenomic analysis involving powerful sequencing techniques bioinformatics that overcome need isolation cultivation individual microbial strains from or gut. Comparative clusters across gut-skin axis can provide new information regarding research. Herein, we historical perspective modern investigation implications connections terms clusters.

Language: Английский

Citations

48
Role of Basophils in a Broad Spectrum of Disorders DOI Creative Commons
Kensuke Miyake, Junya Ito, Hajime Karasuyama

et al.

Frontiers in Immunology, Journal Year: 2022, Volume and Issue: 13

Published: May 27, 2022

Basophils are the rarest granulocytes and have long been overlooked in immunological research due to their rarity similarities with tissue-resident mast cells. In last two decades, non-redundant functions of basophils clarified or implicated a broad spectrum immune responses, particularly by virtue development novel analytical tools for basophils. infiltrate inflamed tissues patients various disorders, even though they circulate bloodstream under homeostatic conditions. Depletion results amelioration exaggeration inflammation, depending on models disease, indicating can play either beneficial deleterious roles context-dependent manner. this review, we summarize recent findings basophil pathophysiology conditions mice humans, including allergy, autoimmunity, tumors, tissue repair, fibrosis, COVID-19. Further mechanistic studies biology could lead identification biomarkers therapeutic targets range diseases.

Language: Английский

Citations

37
Physiological, Pathological, and Circadian Factors Impacting Skin Hydration DOI Open Access

Jose V Camilion,

Siya Khanna,

Sheela Anasseri

et al.

Cureus, Journal Year: 2022, Volume and Issue: unknown

Published: Aug. 4, 2022

This manuscript focuses on the physiological, environmental, nutritional, circadian, and aging factors affecting skin tissue water hydration parameters. The literature findings indicate a multiplicity of interacting processes among these parameters, ultimately impacting in normal playing role conditions such as atopic dermatitis psoriasis. maintenance adequate hydration, aided by proper functioning skin’s protective barrier, is facilitated stratum corneum integrity with presence tight junctions lipids ceramides, each which impacted changes most evaluated Abnormalities aquaporin 3 (AQP3) expression associated deficits appear to have AQP3 hydration-related aspects are influenced circadian rhythms via modulations CLOCK genes that alter protein expression. Ultraviolet exposure, aging, low temperatures those affect ceramide composition, potentially leading increased transepidermal loss negatively hydration. Vitamin C, collagen, probiotics may increase production improve extent different affects varies but usually large enough consider their potential effects when investigating research clinical settings.

Language: Английский

Citations

31
Ursolic acid ameliorates DNCB-induced atopic dermatitis-like symptoms in mice by regulating TLR4/NF-κB and Nrf2/HO-1 signaling pathways DOI

Zhehuan Wang,

Huiru Zhang,

Caihong Qi

et al.

International Immunopharmacology, Journal Year: 2023, Volume and Issue: 118, P. 110079 - 110079

Published: March 29, 2023

Language: Английский

Citations

17
More yeast, more problems?: reevaluating the role of Malassezia in seborrheic dermatitis DOI

Christy H. Chang,

Raj Chovatiya

Archives of Dermatological Research, Journal Year: 2024, Volume and Issue: 316(4)

Published: March 12, 2024

Language: Английский

Citations

8