IntechOpen eBooks,
Journal Year:
2020,
Volume and Issue:
unknown
Published: Sept. 17, 2020
In
the
1950s,
Nobel
Prize
winner
Dr.
E.
Donnall
Thomas
was
first
to
successfully
transplant
hematopoietic
stem
cells.
Since
then,
studies
on
cells
have
evolved
and
expanded
worldwide.
There
are
more
than
650,000
scientific
publications
8000
cell
clinical
trials.
This
book
summarizes
types
of
cells,
key
studies,
ongoing
trials,
future
perspectives.
It
also
includes
ethical,
formal,
legal
aspects
give
reader
a
comprehensive
view
field.
Frontiers in Aging Neuroscience,
Journal Year:
2022,
Volume and Issue:
14
Published: May 18, 2022
The
complexity
of
central
nervous
system
diseases
together
with
their
intricate
pathogenesis
complicate
the
establishment
effective
treatment
strategies.
Presently,
superiority
adipose-derived
mesenchymal
stem
cells
(ADSCs)
on
neuronal
injuries
has
attracted
significant
attention.
Similarly,
extracellular
vesicles
(EVs)
are
potential
interventional
agents
that
could
identify
and
treat
nerve
injuries.
Herein,
we
reviewed
effects
ADSCs
EVs
amyotrophic
lateral
sclerosis
(ALS)
injured
nerves,
expound
practical
application
in
clinic
setting.
This
article
predominantly
focused
therapeutic
role
concerning
ALS,
protective
reparative
injury,
as
well
impact
following
combined
usage
ALS.
Toxicology Reports,
Journal Year:
2021,
Volume and Issue:
8, P. 1156 - 1168
Published: Jan. 1, 2021
Mesenchymal
stem
cells
(MSCs)
possess
a
preventive
capacity
against
free
radical
toxicity
in
various
tissues.
The
present
study
aimed
to
demonstrate
the
reformative
and
treatment
roles
of
adipose-derived
MSCs
(AD-MSCs)
severe
hippocampal
brain
caused
by
aluminum
oxide
nanoparticles
(Al2O3-NPs).
Rats
were
divided
into
five
experimental
groups:
an
untreated
control
group,
group
receiving
NaCl,
Al2O3-NPs
(6
mg/kg)
for
20
days,
that
was
allowed
recover
(R)
days
following
with
Al2O3-NPs,
+
AD-MSCs
where
each
rat
injected
0.8
×
106
via
caudal
vein.
Oral
administration
increased
protein
levels
P53,
cleaved
caspase-3,
CYP2E1,
beta-amyloid
(Aβ);
contrarily,
transplantation
downregulated
these
proteins.
In
addition,
AD-MSCs-treated
protected
from
Al2O3-NPs-induced
toxicity,
as
detected
expression
Sox2
Oct4
are
essential
maintenance
self-renewal.
It
also
found
injection
significantly
altered
total
peroxide
monoamine
oxidase
(MAO)-A
MAO-B
activities.
Histologically,
our
results
indicated
alleviated
damage
induced
Al2O3-NPs.
Moreover,
role
reducing
cell
death
reinforced
regulation
Aβ,
CYP2E1
proteins,
well
SOX2
OCT4
MAO-A
Cell and Organ Transplantology,
Journal Year:
2023,
Volume and Issue:
11(2)
Published: Nov. 11, 2023
One
of
the
promising
directions
in
cell
therapy
for
Parkinson's
disease
or
parkinsonism
is
transplantation
multipotent
mesenchymal
stromal
cells
from
various
sources,
including
human
umbilical
cord
(hUC-MMSCs),
effectiveness
which
may
depend
on
recipient's
genotype.
Objective.
To
compare
impact
transplanted
MMSC-P
behavior,
T-lymphocytes,
and
macrophages
brain
lymphoid
organs
mice
different
lines
with
a
toxic
model
parkinsonism.
Materials
methods.
Adult
(6-7
months
old)
male
FVB/N
(genotype
H-2q)
129/Sv
H-2b)
strains
were
administered
neurotoxin
1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine
(MPTP)
at
dose
30
mg/kg
(control
group),
after
7
days,
hUC-MMSCs
(500,000
cells)
into
tail
vein.
Behavioral
reactions
assessed
open
field,
rigidity,
rotarod
tests.
The
relative
content
T-lymphocytes
activated
was
measured
by
flow
cytometry,
mass
determined.
Results.
Under
influence
MPTP,
number
rearings,
"sniffs
nest,"
body
length,
step
length
decreased,
boluses
increased
mice,
squares
crossed
field
test
decreased
mice.
In
both
lines,
increased,
also
increased.
thymus
while
spleen
only
improved
predominantly
motor
activity
emotional
improved,
manifestations
rigidity
lines.
as
well
mass,
corresponded
to
values
intact
animals.
MMSC
promoted
survival
MPTP-induced
model.
Conclusions.
behavioral
disorders,
changes
brain,
model,
positive
effects
these
animals,
largely
their
genotype
according
H-2
system
(analogous
HLA
humans).
results
provide
basis
developing
personalized
this
pathology
using
cells.
Medicinski Glasnik,
Journal Year:
2022,
Volume and Issue:
20(2), P. 148 - 155
Published: Dec. 1, 2022
Aim
Type
1
diabetes
mellitus
(T1DM)
is
an
autoimmune
disease
characterized
by
the
chronic
inflammation
of
pancreatic
islets
Langerhans.
Hyperglycaemia
leads
to
suppressed
antioxidant
enzyme
and
increased
in
cell,
resulting
cell
death.
Hypoxic
secretome
mesenchymal
stem
cells
(HS-MSCs)
are
soluble
molecules
secreted
MSCS
that
have
antiinflammation
ability
secreting
various
cytokines
including
IL-10
TGF-β
which
potent
as
a
promising
therapeutic
modality
for
T1DM.
This
study
aims
investigate
role
HS-MSCs
regulating
superoxide
dismutase
(SOD)
caspase-3
gene
expression
T1DM
model.
Methods
Twenty
male
Wistar
rats
(6
8
weeks
old)
were
randomly
divided
into
four
groups
(sham,
control,
0.5
mL
intraperitoneal
treatment
group).
Streptozotocin
(STZ)
60mg/kgBB
was
conducted
once
on
day
1,
0.5mL
(T1)
(T2)
administrated
intraperitoneally
7,
14,
21
after
STZ
administration.
The
sacrificed
28;
SOD
IL-6
analysed
qRT-PCR.
Results
showed
ratio
significantly
associated
with
suppression
expression.
Conclusion
administration
suppresses
oxidative
stress
up
inhibiting
control
IntechOpen eBooks,
Journal Year:
2020,
Volume and Issue:
unknown
Published: Sept. 17, 2020
In
the
1950s,
Nobel
Prize
winner
Dr.
E.
Donnall
Thomas
was
first
to
successfully
transplant
hematopoietic
stem
cells.
Since
then,
studies
on
cells
have
evolved
and
expanded
worldwide.
There
are
more
than
650,000
scientific
publications
8000
cell
clinical
trials.
This
book
summarizes
types
of
cells,
key
studies,
ongoing
trials,
future
perspectives.
It
also
includes
ethical,
formal,
legal
aspects
give
reader
a
comprehensive
view
field.
