A Review of Colorectal Cancer in Terms of Epidemiology, Risk Factors, Development, Symptoms and Diagnosis

Cancers, Journal Year: 2021, Volume and Issue: 13(9), P. 2025 - 2025

Published: April 22, 2021

This review article contains a concise consideration of genetic and environmental risk factors for colorectal cancer. Known associated with cancer include familial hereditary lifestyle-related ecological factors. Lifestyle are significant because the potential improving our understanding disease. Physical inactivity, obesity, smoking alcohol consumption can also be addressed through therapeutic interventions. We made efforts to systematize available literature data on epidemiology, diagnosis, type nature symptoms disease stages. Further study progress globally is crucial inform future strategies in controlling disease’s burden population-based preventative initiatives.

Language: Английский

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Advancements in Liposomal Nanomedicines: Innovative Formulations, Therapeutic Applications, and Future Directions in Precision Medicine

International Journal of Nanomedicine, Journal Year: 2025, Volume and Issue: Volume 20, P. 1213 - 1262

Published: Jan. 1, 2025

Liposomal nanomedicines have emerged as a pivotal approach for the treatment of various diseases, notably cancer and infectious diseases. This manuscript provides an in-depth review recent advancements in liposomal formulations, highlighting their composition, targeted delivery strategies, mechanisms action. We explore evolution products currently clinical trials, emphasizing potential addressing diverse medical challenges. The integration immunotherapeutic agents within liposomes marks paradigm shift, enabling design 'immuno-modulatory hubs' capable orchestrating precise immune responses while facilitating theranostic applications. COVID-19 pandemic has accelerated research liposomal-based vaccines antiviral therapies, underscoring need improved to overcome challenges like rapid clearance organ toxicity. Furthermore, we discuss "smart" liposomes, which can respond specific disease microenvironments, enhancing efficacy precision. artificial intelligence machine learning optimizing designs promises revolutionize personalized medicine, paving way innovative strategies detection therapeutic interventions. comprehensive underscores significance ongoing technologies, with implications future applications enhanced patient outcomes.

Language: Английский

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Current trends and future perspectives of nanomedicine for the management of colon cancer

European Journal of Pharmacology, Journal Year: 2021, Volume and Issue: 910, P. 174464 - 174464

Published: Aug. 30, 2021

Language: Английский

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Gut mucosal microbiota profiles linked to colorectal cancer recurrence

World Journal of Gastroenterology, Journal Year: 2022, Volume and Issue: 28(18), P. 1946 - 1964

Published: May 6, 2022

Emerging evidence links gut microbiota to various human diseases including colorectal cancer (CRC) initiation and development. However, profiles associated with CRC recurrence patient prognosis are not completely understood yet, especially in a Chinese cohort.

Language: Английский

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The long non-coding RNA ZFAS1 promotes colorectal cancer progression via miR200b/ZEB1 axis

Pathology - Research and Practice, Journal Year: 2023, Volume and Issue: 247, P. 154567 - 154567

Published: May 24, 2023

Language: Английский

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Identification of key genes in colorectal cancer diagnosis by weighted gene co-expression network analysis

Computers in Biology and Medicine, Journal Year: 2023, Volume and Issue: 157, P. 106779 - 106779

Published: March 11, 2023

Language: Английский

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Review of 5-FU resistance mechanisms in colorectal cancer: clinical significance of attenuated on-target effects

Cancer Drug Resistance, Journal Year: 2023, Volume and Issue: 6(2), P. 257 - 272

Published: Jan. 1, 2023

The emergence of chemoresistant disease during chemotherapy with 5-Fluorouracil-based (5-FU-based) regimens is an important factor in the mortality metastatic CRC (mCRC). causes 5-FU resistance are multi-factorial, and besides DNA mismatch repair deficiency (MMR-D), there no widely accepted criteria for determining which patients not likely to be responsive 5-FU-based therapy. Thus, a need systematically understand mechanistic basis treatment failure urgent develop new approaches circumventing major resistance. In this manuscript, we review mechanisms emphasis on: (1) altered anabolic metabolism limiting formation primary active metabolite Fluorodeoxyuridylate (5-Fluoro-2'-deoxyuridine-5'-O-monophosphate; FdUMP); (2) elevated expression or activity enzymatic target thymidylate synthase (TS); (3) dysregulated programmed cell death as Importantly, these can potentially overcome through use next-generation fluoropyrimidine (FP) polymers (e.g., CF10) that display reduced dependence on more potent TS inhibitory activity.

Language: Английский

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Clinical Impact of Exosomes in Colorectal Cancer Metastasis

ACS Applied Bio Materials, Journal Year: 2023, Volume and Issue: 6(7), P. 2576 - 2590

Published: June 14, 2023

Cancer is a complex deadly disease that has caused global health crisis in recent epochs. Colorectal cancer (CRC) the third most common malignant gastrointestinal disease. It led to high mortality due early diagnostic failure. Extracellular vesicles (EVs) come with promising solutions for CRC. Exosomes (a subpopulation of EVs) play vital role as signaling molecules CRC tumor microenvironment. secreted from all active cells. Exosome-based molecular transport (DNA, RNA, proteins, lipids, etc.) transforms recipient cell's nature. In CRC, cell-derived exosomes (TEXs) regulate multiple events development and progression such immunogenic suppression, angiogenesis, epithelial–mesenchymal transitions (EMT), physical changes extracellular matrix (ECM), metastasis. Biofluid-circulated tumor-derived are potential tool liquid biopsy. colorectal detection creates great impact biomarker research. The exosome-associated theranostics approach state-of-the-art method. this review, we address associated progression, on screening (diagnostic prognostic biomarkers), also highlight several clinical trials, well future directions exosome-based Hopefully, it will encourage researchers develop theranostic fight

Language: Английский

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Current Status and Emerging Trends in Colorectal Cancer Screening and Diagnostics

Biosensors, Journal Year: 2023, Volume and Issue: 13(10), P. 926 - 926

Published: Oct. 13, 2023

Colorectal cancer (CRC) is a prevalent and potentially fatal disease categorized based on its high incidences mortality rates, which raised the need for effective diagnostic strategies early detection management of CRC. While there are several conventional diagnostics available, they have certain limitations that hinder their effectiveness. Significant research efforts currently being dedicated to elucidating novel methodologies aim at comprehending intricate molecular mechanism underlies Recently, microfluidic emerged as pivotal solution, offering non-invasive approaches real-time monitoring progression treatment response. Microfluidic devices enable integration multiple sample preparation steps into single platform, speeds up processing improves sensitivity. Such advancements in technologies hold immense promise revolutionizing field CRC diagnosis enabling efficient strategies. This article elucidates latest developments technology diagnostics. In addition diagnostics, artificial intelligence (AI) holds great further enhancing capabilities. Advancements systems AI-driven can revolutionize colorectal accurate, efficient, personalized improve patient outcomes transform management.

Language: Английский

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Clinical Biochemistry of Cancer

Published: Jan. 1, 2024

Language: Английский

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