Glycyrrhiza glabra (Licorice): A Comprehensive Review on Its Phytochemistry, Biological Activities, Clinical Evidence and Toxicology

Plants, Journal Year: 2021, Volume and Issue: 10(12), P. 2751 - 2751

Published: Dec. 14, 2021

There are more than 30 species of Glycyrrhiza genus extensively spread worldwide. It was the most prescribed herb in Ancient Egyptian, Roman, Greek, East China, and West from Former Han era. various beneficial effects licorice root extracts, such as treating throat infections, tuberculosis, respiratory, liver diseases, antibacterial, anti-inflammatory, immunodeficiency. On other hand, traditional medicines getting attraction to treat many diseases. Therefore, it is vital screen medicinal plants find potential new compounds chronic diseases cardiovascular, anticancer, hepatoprotective, etc. This work comprehensively reviews ethnopharmacological uses, phytochemistry, biological activities, clinical evidence, toxicology licorice, which will serve a resource for future fundamental studies. An attempt has been made establish pharmacological effect different In addition, focus this review article on molecular mechanism extracts their four flavonoids (isoliquiritigenin, liquiritigenin, lichalocone, glabridin) pharmacologic activities. Licorice could be natural alternative current therapy exterminate emerging disorders with mild side effects. provide systematic insights into ancient drug further development use.

Language: Английский

---

Pesticides impacts on human health and the environment with their mechanisms of action and possible countermeasures

Heliyon, Journal Year: 2024, Volume and Issue: 10(7), P. e29128 - e29128

Published: April 1, 2024

Pesticides are chemical constituents used to prevent or control pests, including insects, rodents, fungi, weeds, and other unwanted organisms. Despite their advantages in crop production disease management, the use of pesticides poses significant hazards environment public health. Pesticide elements have now perpetually entered our atmosphere subsequently contaminated water, food, soil, leading health threats ranging from acute chronic toxicities. can cause toxicity if a high dose is inhaled, ingested, comes into contact with skin eyes, while prolonged recurrent exposure leads toxicity. produce different types toxicity, for instance, neurotoxicity, mutagenicity, carcinogenicity, teratogenicity, endocrine disruption. The pesticide formulation may depend on specific active ingredient presence synergistic inert compounds that enhance modify its Safety concerns need hour contemporary pesticide-induced hazards. effectiveness implementation current legislature providing ample protection human key concerns. This review explored comprehensive summary regarding updated impacts advanced safety legislation. Implementing regulations, proper training, education help mitigate negative promote safer more sustainable agricultural practices.

Language: Английский

---

Cancer nanomedicine: a review of nano-therapeutics and challenges ahead

RSC Advances, Journal Year: 2023, Volume and Issue: 13(13), P. 8606 - 8629

Published: Jan. 1, 2023

Cancer is known as the most dangerous disease in world terms of mortality and lack effective treatment. Research on cancer treatment still active great social importance. Since 1930, chemotherapeutics have been used to treat cancer. However, such conventional treatments are associated with pain, side effects, a targeting. Nanomedicines an emerging alternative due their targeting, bioavailability, low toxicity. Nanoparticles target cells via passive mechanisms. FDA approval for Doxil®, several nano-therapeutics developed, few received use Along liposomes, solid lipid nanoparticles, polymeric nanoemulsions, even newer techniques involving extracellular vesicles (EVs) thermal nanomaterials now being researched implemented practice. This review highlights evolution current status therapy, focus clinical/pre-clinical nanomedicine studies. Insight also provided into prospects this regard.

Language: Английский

---

Advancement and New Trends in Analysis of Pesticide Residues in Food: A Comprehensive Review

Plants, Journal Year: 2022, Volume and Issue: 11(9), P. 1106 - 1106

Published: April 19, 2022

Food safety is a rising challenge worldwide due to the expanding population and need produce food feed growing population. At same time, pesticide residues found in high concentrations fresh agriculture pose significant threat safety. Presently, crop output being increased by applying herbicides, fungicides, insecticides, pesticides, fertilizers, nematicides, soil amendments. A combination of factors, including bioaccumulation, widespread usage, selective toxicity, stability, make pesticides among most toxic compounds polluting environment. They are especially harmful vegetables fruits because people exposed them. Thus, it critical monitor levels using all analytical techniques available. Any evaluation condition contamination necessitates knowledge maximum residue (MRLs). We set out problems determining various types fruits, complexity diversity matrices biological materials. This review examines different determine target analytes that must be isolated before final consumption. Many processes involved their advantages disadvantages have been discussed with recommendations. Furthermore, MRLs fruit vegetable samples context data from literature. The also MRLs’ impact on international trade vegetables. Accurate, sensitive, robust procedures ensuring products effectively regulated. Despite advances detection technology, effective sample preparation for measurement cereals feedstuffs still needed. In addition, these methods compatible current techniques. Multi-residue approaches cover wide range desired, even though pesticides’ diverse natures, classes, physio-chemical characteristics such challenging assemble. will valuable analysts regulatory authorities quality products.

Language: Английский

---

Advancements in Liposomal Nanomedicines: Innovative Formulations, Therapeutic Applications, and Future Directions in Precision Medicine

International Journal of Nanomedicine, Journal Year: 2025, Volume and Issue: Volume 20, P. 1213 - 1262

Published: Jan. 1, 2025

Liposomal nanomedicines have emerged as a pivotal approach for the treatment of various diseases, notably cancer and infectious diseases. This manuscript provides an in-depth review recent advancements in liposomal formulations, highlighting their composition, targeted delivery strategies, mechanisms action. We explore evolution products currently clinical trials, emphasizing potential addressing diverse medical challenges. The integration immunotherapeutic agents within liposomes marks paradigm shift, enabling design 'immuno-modulatory hubs' capable orchestrating precise immune responses while facilitating theranostic applications. COVID-19 pandemic has accelerated research liposomal-based vaccines antiviral therapies, underscoring need improved to overcome challenges like rapid clearance organ toxicity. Furthermore, we discuss "smart" liposomes, which can respond specific disease microenvironments, enhancing efficacy precision. artificial intelligence machine learning optimizing designs promises revolutionize personalized medicine, paving way innovative strategies detection therapeutic interventions. comprehensive underscores significance ongoing technologies, with implications future applications enhanced patient outcomes.

Language: Английский

---

Advances in metal–organic framework-based hydrogel materials: preparation, properties and applications

Journal of Materials Chemistry A, Journal Year: 2022, Volume and Issue: 11(5), P. 2092 - 2127

Published: Dec. 20, 2022

This review provides the engineering strategies, systematic classification and representative applications of MOF-based hydrogels, future prospects have also been presented in detail.

Language: Английский

---

Arsenic Exposure through Dietary Intake and Associated Health Hazards in the Middle East

Nutrients, Journal Year: 2022, Volume and Issue: 14(10), P. 2136 - 2136

Published: May 20, 2022

Dietary arsenic (As) contamination is a major public health issue. In the Middle East, food supply relies primarily on import of commodities. Among different age groups main source As exposure grains and grain-based products, particularly rice rice-based dietary products. Rice products are rich core macronutrients act as chief energy across world. The rate consumption ranges from 250 to 650 g per day person in South East Asian countries. carbohydrates through one leading causes human exposure. Gulf population consumes ready-to-eat cereals large proportion their meals. Exposure leads an increased risk non-communicable diseases such dysbiosis, obesity, metabolic syndrome, diabetes, chronic kidney disease, heart cancer, maternal fetal complications. impact arsenic-containing items outcomes among groups. countries, neurological deficit disorder (NDD) autism spectrum (ASD) cases alarming issues. Arsenic might be causative factor that should assessed by screening regulatory bodies rechecking limits all Our goals for this review outline distribution various foods water summarize complications linked with toxicity along identified modifiers add heterogeneity biological responses suggest improvements multi-disciplinary interventions minimize global influence arsenic. development validation diverse analytical techniques evaluate toxic levels contaminants our need hour. Furthermore, standard parameters guidelines As-containing developed implemented.

Language: Английский

---

Ganoderma lucidum: Novel Insight into Hepatoprotective Potential with Mechanisms of Action

Nutrients, Journal Year: 2023, Volume and Issue: 15(8), P. 1874 - 1874

Published: April 13, 2023

(

---

Preliminary trials of the gold nanoparticles conjugated chrysin: An assessment of anti-oxidant, anti-microbial, and in vitro cytotoxic activities of a nanoformulated flavonoid

Nanotechnology Reviews, Journal Year: 2022, Volume and Issue: 11(1), P. 2726 - 2741

Published: Jan. 1, 2022

Abstract Chrysin (CHR), a dihydroxy flavone, exhibits several bioactivities, i.e. , anti-oxidant, anti-inflammatory, and anti-cancer, is known to possess limited aqueous solubility causing lowered bioavailability, compromised therapeutic efficacy. Gold nanoparticles (AuNPs) conjugated chrysin (CHR–AuNPs) were prepared characterized by UV-Vis, Fourier transform infra-red, X-ray diffraction, energy dispersive (EDX), zeta potential analyses. The nanoformulated CHR–AuNPs primarily examined on trial scale for their cytotoxic, anti-microbial activity in comparison the unformulated CHR. effectively scavenged 2,2-diphenyl-1-picrylhydrazyl free radicals, also CHR AuNPs. exhibited cytotoxic effects dose-dependent manner demonstrated significant reduction ( P = 0.05) of cells proliferation, growth human breast cancer cell lines, AMJ13, which measured 3-(4,5-dimethylthiazal- z -yl)-2,5-diphenyltetrazolium, crystal violet assays, respectively. When compared with pure free-AuNPs, exerted highest bioactivity against Staphylococcus aureus Escherichia coli . strong anti-microbial, as well preparation has clinical use after considerable appropriate developments.

Language: Английский

---

Strategies of nanomedicine for targeting the signaling pathways of Colorectal cancer

Journal of Drug Delivery Science and Technology, Journal Year: 2023, Volume and Issue: 84, P. 104487 - 104487

Published: April 20, 2023

Language: Английский

---