Cellular Senescence and Inflammaging in the Skin Microenvironment

International Journal of Molecular Sciences, Journal Year: 2021, Volume and Issue: 22(8), P. 3849 - 3849

Published: April 8, 2021

Cellular senescence and aging result in a reduced ability to manage persistent types of inflammation. Thus, the chronic low-level inflammation associated with phenotype is called "inflammaging". Inflammaging not only related age-associated systemic diseases such as cardiovascular disease diabetes, but also skin aging. As largest organ body, continuously exposed external stressors UV radiation, air particulate matter, human microbiome. In this review article, we present mechanisms for accumulation cells different compartments based on cell types, their association resident immune describe changes cutaneous immunity during process.

Language: Английский

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Interactions of Melanin with Electromagnetic Radiation: From Fundamentals to Applications

Chemical Reviews, Journal Year: 2024, Volume and Issue: 124(11), P. 7165 - 7213

Published: May 17, 2024

Melanin, especially integumentary melanin, interacts in numerous ways with electromagnetic radiation, leading to a set of critical functions, including radiation protection, UV-protection, pigmentary and structural color productions, thermoregulation. By harnessing these melanin melanin-like materials can be widely applied diverse applications extraordinary performance. Here we provide unified overview the family (all materials) their interactions complete spectrum (X-ray, Gamma-ray, UV, visible, near-infrared), which until now has been absent from literature is needed establish solid fundamental base facilitate future investigation development. We begin by discussing chemistries morphologies both natural artificial then fundamentals melanin–radiation interactions, finally exciting new developments high-performance melanin-based functional that exploit interactions. This Review provides comprehensive discussion perspectives for each subfield will help direct development perspectives.

Language: Английский

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Typha pollen extract inhibit melanogenesis via α-MSH/MC1R signaling pathway in B16 and melasma mouse model

Archives of Dermatological Research, Journal Year: 2025, Volume and Issue: 317(1)

Published: Jan. 31, 2025

Language: Английский

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microRNAs in the Regulation of Melanogenesis

International Journal of Molecular Sciences, Journal Year: 2021, Volume and Issue: 22(11), P. 6104 - 6104

Published: June 5, 2021

Melanogenesis is the process leading to synthesis of melanin, main substance that influences skin color and plays a pivotal role against UV damage. Altered melanogenesis observed in several pigmentation disorders. occurs specialized cells called melanocytes, physically functionally related by means autocrine paracrine interplay other cell types. Several external internal factors control melanin biosynthesis operate through different intracellular signaling pathways, which finally leads regulation microphthalmia-associated transcription factor (MITF), key involved expression melanogenic enzymes, including TYR, TYRP-1, TYRP-2. Epigenetic factors, microRNAs (miRNAs), are regulation. miRNAs small, single-stranded, non-coding RNAs, approximately 22 nucleotides length, behavior regulating gene expression, mainly binding 3' untranslated region (3'-UTR) target mRNAs. This review collects data on how these can modulate expression. Bringing light biological function could lead wider understanding epigenetic its dysregulation. knowledge may constitute basis for developing innovative treatment approaches

Language: Английский

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mTORC1 activity negatively regulates human hair follicle growth and pigmentation

EMBO Reports, Journal Year: 2023, Volume and Issue: 24(7)

Published: May 22, 2023

Abstract Dysregulation of the activity mechanistic target rapamycin complex 1 (mTORC1) is commonly linked to aging, cancer, and genetic disorders such as tuberous sclerosis (TS), a rare neurodevelopmental multisystemic disease characterized by benign tumors, seizures, intellectual disability. Although patches white hair on scalp (poliosis) are considered early signs TS, underlying molecular mechanisms potential involvement mTORC1 in depigmentation remain unclear. Here, we have used healthy, organ‐cultured human follicles (HFs) interrogate role prototypic (mini‐)organ. Gray/white HFs exhibit high activity, while inhibition stimulated HF growth pigmentation, even gray/white that still contained some surviving melanocytes. Mechanistically, this occurred via increased intrafollicular production melanotropic hormone, α‐MSH. In contrast, knockdown TSC2, negative regulator mTORC1, significantly reduced pigmentation. Our findings introduce an important pigmentation suggest pharmacological could become novel strategy management loss disorders.

Language: Английский

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The Challenging Melanoma Landscape: From Early Drug Discovery to Clinical Approval

Cells, Journal Year: 2021, Volume and Issue: 10(11), P. 3088 - 3088

Published: Nov. 9, 2021

Melanoma is recognized as the most dangerous type of skin cancer, with high mortality and resistance to currently used treatments. To overcome limitations available therapeutic options, discovery development new, more effective, safer therapies required. In this review, different research steps involved in process antimelanoma drug evaluation selection are explored, including information regarding silico, vitro, vivo experiments, well clinical trial phases. Details given about cell lines assays perform both two- three-dimensional vitro screening candidates towards melanoma. For studies, murine models are, undoubtedly, widely for assessing potential new compounds study underlying mechanisms action. Here, main melanoma described other animal species. A section dedicated ongoing demonstrating wide interest successful efforts devoted therapy, particular at advanced stages disease, a final includes some considerations approval marketing by regulatory agencies. Overall, considerable commitment being directed continuous optimized experimental models, important understanding biology validation novel strategies.

Language: Английский

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Loss of ‘Epidermal Melanin Unit’ Integrity in Human Skin During Melanoma-Genesis

Frontiers in Oncology, Journal Year: 2022, Volume and Issue: 12

Published: April 27, 2022

Cutaneous melanoma can be a most challenging neoplasm of high lethality, in part due to its extreme heterogeneity and characteristic aggressive invasive nature. Indeed, moniker ‘the great masquerader’ reflects that not all melanomas are created equal terms their originating cellular contexts, but also cells the malignant tumor adopt wide range different cell states variable organotropism. In this review, we focus on early phases melanomagenesis by discussing how pigment melanocyte lineage influenced embark fates with distinctive microanatomical pathways. particular, assess differ maturation status (stem cell; melanoblast; transiently amplifying differentiated; post-mitotic; terminally-differentiated) as well micro-environmental niche (in stratum basale epidermis; within skin appendages like hair follicle, eccrine gland, etc). We discuss above contexts may influence susceptibility epidermal-melanin unit (EMU) become unstable, which presage cutaneous development. unique features follicular-melanin unit(s) (FMUs) can, contrast, protect melanocytes from melanomagenesis. Lastly, postulate vitiligo, albinism, psoriasis, alopecia areata provide new insights into immune-/non immune-mediated outcomes for melanin units.

Language: Английский

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Fermented Fish Collagen Attenuates Melanogenesis via Decreasing UV-Induced Oxidative Stress

Marine Drugs, Journal Year: 2024, Volume and Issue: 22(9), P. 421 - 421

Published: Sept. 15, 2024

Excessive melanogenesis leads to hyperpigmentation-related cosmetic problems. UV exposure increases oxidative stress, which promotes melanogenesis-related signal pathways such as the PKA, microphthalmia-associated transcription factor (MITF), tyrosinase (TYR), tyrosinase-related protein-1 (TRP1), and protein-2 (TRP2) pathways. Glycine is a source of endogenous antioxidants, including glutathione. Fermented fish collagen (FC) contains glycine; thus, we evaluated effect FC on decreasing via stress. The glycine receptor (GlyR) transporter-1 (GlyT1) levels were decreased in UV-irradiated keratinocytes; however, expression these proteins increased upon treatment with FC. indicated by NOX1/2/4, GSH/GSSG, SOD activity, 8-OHdG keratinocytes. Administration conditioned media from FC-treated keratinocytes melanocytes led p38, PKC, MITF, TRP1, TRP2 expression. These changes induced also observed animal skin. GlyR GlyT, was accompanied stress Moreover, negatively regulated signaling pathways, leading melanin content In conclusion, UV-induced could be used hyperpigmentation

Language: Английский

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Melanoma metastasis: What role does melanin play? (Review)

Oncology Reports, Journal Year: 2022, Volume and Issue: 48(6)

Published: Oct. 21, 2022

Language: Английский

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308-nm excimer laser combined with piperine promotes melanin synthesis through PTEN/PDK1/GSK3b regulation of keratinocyte paracrine

Archives of Dermatological Research, Journal Year: 2025, Volume and Issue: 317(1)

Published: March 19, 2025

Language: Английский

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