Photoaging: UV radiation-induced inflammation and immunosuppression accelerate the aging process in the skin

Inflammation Research, Journal Year: 2022, Volume and Issue: 71(7-8), P. 817 - 831

Published: June 24, 2022

Excessive exposure of the skin to UV radiation (UVR) triggers a remodeling immune system and leads photoaging state which is reminiscent chronological aging. Over 30 years ago, it was observed that UVR induced an immunosuppressive inhibited contact hypersensitivity.Original review articles encompassing inflammation immunosuppression in aging processes were examined from major databases including PubMed, Scopus, Google Scholar.Currently known treatment can trigger cellular senescence inflammatory skin. Chronic low-grade stimulates counteracting involving expansion cells, e.g., regulatory T cells (Treg), myeloid-derived suppressor (MDSC), dendritic (DCreg). This increased activity not only suppresses function effector called immunosenescence, but also induces bystander degeneration neighboring cells. Interestingly, process involves accumulation pro-inflammatory senescent signs chronic inflammation, inflammaging. There clear evidence inflammaging associated with increase anti-inflammatory activities promote immunosenescence.It seems normal evoke similar driven by system. However, likely there are different molecular mechanisms inducing accelerated processes.

Language: Английский

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Skin Aging, Cellular Senescence and Natural Polyphenols

International Journal of Molecular Sciences, Journal Year: 2021, Volume and Issue: 22(23), P. 12641 - 12641

Published: Nov. 23, 2021

The skin, being the barrier organ of body, is constitutively exposed to various stimuli impacting its morphology and function. Senescent cells have been found accumulate with age may contribute age-related skin changes pathologies. Natural polyphenols exert many health benefits, including ameliorative effects on aging. By affecting molecular pathways senescence, are able prevent or delay senescence formation and, consequently, avoid ameliorate aging age-associated pathologies skin. This review aims provide an overview current state knowledge in cellular summarize recent vitro studies related anti-senescent mechanisms natural carried out keratinocytes, melanocytes fibroblasts. Aged context COVID-19 pandemic will be also discussed.

Language: Английский

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Focus on the Contribution of Oxidative Stress in Skin Aging

Antioxidants, Journal Year: 2022, Volume and Issue: 11(6), P. 1121 - 1121

Published: June 6, 2022

Skin aging is one of the most evident signs human aging. Modification skin during life span characterized by fine lines and wrinkling, loss elasticity volume, laxity, rough-textured appearance, pallor. In contrast, photoaged associated with uneven pigmentation (age spot) markedly wrinkled. At cellular molecular level, it consists multiple interconnected processes based on biochemical reactions, genetic programs, occurrence external stimulation. The principal perturbation in driving senescence alteration oxidative balance. chronological aging, reactive oxygen species (ROS) are produced mainly through metabolism adenosine triphosphate (ATP) generation from glucose mitochondrial dysfunction, whereas extrinsic redox equilibrium caused environmental factors, such as ultraviolet radiation, pollution, cigarette smoking, inadequate nutrition. During process, stress attributed to both augmented ROS production reduced levels enzymatic non-enzymatic protectors. Apart appearance structural change, throughout gradually loses its natural functional characteristics regenerative potential. With immune system also undergoes manifested a ability counteract infections frequency autoimmune neoplastic diseases. This review proposes an update role clinical manifestation well mechanisms that underline this phenomenon sometimes accelerated factors.

Language: Английский

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Protective Role of Melatonin and Its Metabolites in Skin Aging

International Journal of Molecular Sciences, Journal Year: 2022, Volume and Issue: 23(3), P. 1238 - 1238

Published: Jan. 22, 2022

The skin, being the largest organ in human body, is exposed to environment and suffers from both intrinsic extrinsic aging factors. skin process characterized by several clinical features such as wrinkling, loss of elasticity, rough-textured appearance. This complex accompanied with phenotypic functional changes cutaneous immune cells, well structural disturbances extracellular matrix components collagens elastin. Because health considered one principal factors representing overall “well-being” perception “health” humans, anti-aging strategies have recently been developed. Thus, while fundamental mechanisms regarding are known, new substances should be for introduction into dermatological treatments. Herein, we describe melatonin its metabolites potential “aging neutralizers”. Melatonin, an evolutionarily ancient derivative serotonin hormonal properties, main neuroendocrine secretory product pineal gland. It regulates circadian rhythmicity also exerts anti-oxidative, anti-inflammatory, immunomodulatory, anti-tumor capacities. intention this review summarize within aging, research advances on molecular leading these changes, impact melatoninergic anti-oxidative system controlled metabolites, targeting prevention or reversal aging.

Language: Английский

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Current insights and future perspectives of ultraviolet radiation (UV) exposure: Friends and foes to the skin and beyond the skin

Environment International, Journal Year: 2024, Volume and Issue: 185, P. 108535 - 108535

Published: Feb. 27, 2024

Ultraviolet (UV) radiation is ubiquitous in the environment, which has been classified as an established human carcinogen. As largest and outermost organ of body, direct exposure skin to sunlight or UV can result sunburn, inflammation, photo-immunosuppression, photoaging even cancers. To date, there are tactics protect by preventing reducing amount skin. Nevertheless, deciphering essential regulatory mechanisms may pave way for therapeutic interventions against UV-induced disorders. Additionally, light considered beneficial specific skin-related conditions medical therapy. Recent evidence indicates that biological effects extend beyond include treatment inflammatory diseases, solid tumors certain abnormal behaviors. This review mainly focuses on Moreover, novel findings other organs systems also summarized. through affects organism remain be fully elucidated achieve a more comprehensive understanding its effects.

Language: Английский

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The Impact of Vitamin D on Skin Aging

International Journal of Molecular Sciences, Journal Year: 2021, Volume and Issue: 22(16), P. 9097 - 9097

Published: Aug. 23, 2021

The active metabolites of vitamin D3 (D3) and lumisterol (L3) exert a variety antiaging photoprotective effects on the skin. These are achieved through immunomodulation include anti-inflammatory actions, regulation keratinocytes proliferation, differentiation programs to build epidermal barrier necessary for maintaining skin homeostasis. In addition, they induce antioxidative responses, inhibit DNA damage repair mechanisms attenuate premature aging cancerogenesis. mechanism action would involve interaction with multiple nuclear receptors including VDR, AhR, LXR, reverse agonism RORα -γ, nongenomic actions 1,25D3-MARRS receptor binding site VDR. Therefore, forms its canonical (1,25(OH)2D3) noncanonical (CYP11A1-intitated) derivatives as well L3 promising agents prevention, attenuation, or treatment aging. They could be administrated orally and/or topically. Other parenteral application precursor should considered avoid predominant metabolism 25(OH)D3 that is not recognized by CYP11A1 enzyme. efficacy topically applied needs further clinical evaluation in future trials.

Language: Английский

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Flavonoids in Skin Senescence Prevention and Treatment

International Journal of Molecular Sciences, Journal Year: 2021, Volume and Issue: 22(13), P. 6814 - 6814

Published: June 25, 2021

Skin aging is associated with the accumulation of senescent cells and related to many pathological changes, including decreased protection against pathogens, increased susceptibility irritation, delayed wound healing, cancer susceptibility. Senescent secrete a specific set pro-inflammatory mediators, referred as senescence-associated secretory phenotype (SASP), which can cause profound changes in tissue structure function. Thus, drugs that selectively eliminate (senolytics) or neutralize SASP (senostatics) represent an attractive therapeutic strategy for age-associated skin deterioration. There growing evidence plant-derived compounds (flavonoids) slow down even prevent aging-associated deterioration appearance function by targeting cellular pathways crucial regulating senescence SASP. This review summarizes senostatic senolytic potential flavonoids context preventing aging.

Language: Английский

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Microbiome and Human Aging: Probiotic and Prebiotic Potentials in Longevity, Skin Health and Cellular Senescence

Nutrients, Journal Year: 2021, Volume and Issue: 13(12), P. 4550 - 4550

Published: Dec. 18, 2021

The role of the microbiome in human aging is important: directly impacts through gastrointestinal system. However, microbial impact on skin has yet to be fully understood. For example, cellular senescence an intrinsic process that been recently associated with imbalance. With age, cells become senescent response stress wherein they undergo irreversible growth arrest while maintaining high metabolic activity. An accumulation linked various and chronic pathologies due overexpression senescence-associated secretory phenotype (SASP) comprised proinflammatory cytokines, chemokines, factors, proteases, lipids extracellular matrix components. In particular, dermatological disorders may promoted by as a common site accumulation. gut microbiota influences disruption gut-skin axis secretion metabolites. Metabolomics can used identify quantify metabolites involved senescence. Moreover, novel anti-senescent therapeutics are warranted given poor safety profiles current pharmaceutical drugs. Probiotics prebiotics effective alternatives, considering relationship between healthy aging. further research composition under status needed develop immunomodulatory therapies.

Language: Английский

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How good is the evidence that cellular senescence causes skin ageing?

Ageing Research Reviews, Journal Year: 2021, Volume and Issue: 71, P. 101456 - 101456

Published: Sept. 3, 2021

Skin is the largest organ of body with important protective functions, which become compromised time due to both intrinsic and extrinsic ageing processes. Cellular senescence primary process at cell level, associated loss proliferative capacity, mitochondrial dysfunction significantly altered patterns expression secretion bioactive molecules. Intervention experiments have proven as a relevant cause in many organs. In case skin, accumulation all major compartments well documented might be responsible for most, if not all, molecular changes observed during ageing. Incorporation senescent cells into in-vitro skin models (specifically 3D full thickness models) recapitulates typically However, crucial evidence still missing. A beneficial effect ablation on has so far only been shown following rather unspecific interventions or transgenic mouse models. We conclude that cellular highly suggestive but yet completely conclusive.

Language: Английский

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Effects of Air Pollution on Cellular Senescence and Skin Aging

Cells, Journal Year: 2022, Volume and Issue: 11(14), P. 2220 - 2220

Published: July 17, 2022

The human skin is exposed daily to different environmental factors such as air pollutants and ultraviolet (UV) light. Air pollution considered a harmful risk known promote aging inflammation of this tissue, leading the onset disorders appearance wrinkles pigmentation issues. Besides this, components can interact synergistically with light increase impact damage skin. However, little about modulation on cellular senescence in cells how contribute aging. In review, we are summarizing current state knowledge components, their involvement processes aging, well therapeutic cosmetic interventions proposed prevent or mitigate effects

Language: Английский

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