Dietary Polysaccharides Exert Anti-Fatigue Functions via the Gut-Muscle Axis: Advances and Prospectives DOI Creative Commons
Yaping Zhou,

Zhongxing Chu,

Yi Luo

et al.

Foods, Journal Year: 2023, Volume and Issue: 12(16), P. 3083 - 3083

Published: Aug. 17, 2023

Due to today’s fast-paced lifestyle, most people are in a state of sub-health and face “unexplained fatigue”, which can seriously affect their health, work efficiency, quality life. Fatigue is also common symptom several serious diseases such as Parkinson’s, Alzheimer’s, cancer, etc. However, the contributing mechanisms not clear, there currently no official recommendations for treatment fatigue. Some dietary polysaccharides often used health care supplements; these have been reported specific anti-fatigue effects, with minor side effects rich pharmacological activities. Dietary be activated during food processing or gastrointestinal transit, exerting unique effects. This review aims comprehensively summarize evaluate latest advances biological processes exercise-induced fatigue, understand possible molecular alleviating systematically elaborate roles gut microbiota gut-muscle axis this process. From perspective axis, investigating relationship between fatigue will enhance our understanding may lead significant breakthrough regarding mechanism paper provide new perspectives further research into use science nutrition, could help develop potential agents open up novel therapies conditions.

Language: Английский

Gut microbes and muscle function: can probiotics make our muscles stronger? DOI
Muriel Giron, Muriel Thomas, Dominique Dardevet

et al.

Journal of Cachexia Sarcopenia and Muscle, Journal Year: 2022, Volume and Issue: 13(3), P. 1460 - 1476

Published: March 12, 2022

Language: Английский

Citations

120
Association between physical activity and changes in intestinal microbiota composition: A systematic review DOI Creative Commons
Viviana Aya,

Alberto Flórez,

Luis Ignacio Gordillo Pérez

et al.

PLoS ONE, Journal Year: 2021, Volume and Issue: 16(2), P. e0247039 - e0247039

Published: Feb. 25, 2021

Introduction The intestinal microbiota comprises bacteria, fungi, archaea, protists, helminths and viruses that symbiotically inhabit the digestive system. To date, research has provided limited data on possible association between an active lifestyle a healthy composition of human microbiota. This review was aimed to summarize results studies comparing microbiome individuals with different physical activity amounts. Methods We searched Medline/Ovid, NIH/PubMed, Academic Search Complete August–October 2020. Inclusion criteria comprised: (a) cross-sectional focused gut among subjects levels; (b) describing responses any type exercise stimulus; (c) containing adult women men. excluded diet modifications, probiotic or prebiotic consumption, as well diabetes, hypertension, cancer, hormonal dysfunction. Methodological quality risk bias for each study were assessed using Risk Of Bias In Non-randomized Studies—of Interventions tool. from longitudinal are shown independently. Results A total 17 articles eligible inclusion: ten seven studies. Main outcomes vary significantly according amounts in identified discrete changes diversity indexes relative abundance certain bacteria people. Conclusion As literature this field is rapidly growing, it important incorporate diverse methods evaluate other aspects related lifestyles such sleep dietary patterns. Exploration groups viruses, archaea parasites may lead better understanding adaptation sports its potentially beneficial effects host metabolism endurance.

Language: Английский

Citations

119
The Effects of Lifestyle and Diet on Gut Microbiota Composition, Inflammation and Muscle Performance in Our Aging Society DOI Open Access
Barbara Strasser, Maike Wolters, Christopher Weyh

et al.

Nutrients, Journal Year: 2021, Volume and Issue: 13(6), P. 2045 - 2045

Published: June 15, 2021

Living longer is associated with an increased risk of chronic diseases, including impairments the musculoskeletal and immune system as well metabolic disorders certain cancers, each which can negatively affect relationship between host microbiota up to occurrence dysbiosis. On other hand, lifestyle factors, regular physical exercise a healthy diet, skeletal muscle aging positively at all ages. Accordingly, health benefits could partly depend on effect such interventions that influence biodiversity functionality intestinal microbiota. In present review, we first discuss physiological effects gut microbiota, system, muscle. Secondly, describe human epidemiological evidence about associations activity fitness composition in older adults. The third part highlights relevance restorative mechanisms protection through specific during aging. Fourth, important research findings protein nutrients performance Finally, provide nutritional recommendations prevent malnutrition support active focus Key nutrition-related concerns include need for adequate energy intake preventing low mass higher demand (e.g., dietary fiber, polyphenols polyunsaturated fatty acids) modify composition, diversity, capacity may thus practical means enhancing systemic function.

Language: Английский

Citations

108
Role of Hydroxytyrosol and Oleuropein in the Prevention of Aging and Related Disorders: Focus on Neurodegeneration, Skeletal Muscle Dysfunction and Gut Microbiota DOI Open Access
Laura Micheli, Laura Bertini,

Agnese Bonato

et al.

Nutrients, Journal Year: 2023, Volume and Issue: 15(7), P. 1767 - 1767

Published: April 4, 2023

Aging is a multi-faceted process caused by the accumulation of cellular damage over time, associated with gradual reduction physiological activities in cells and organs. This degeneration results reduced ability to adapt homeostasis perturbations an increased incidence illnesses such as cognitive decline, neurodegenerative cardiovascular diseases, cancer, diabetes, skeletal muscle pathologies. Key features aging include chronic low-grade inflammation state decrease autophagic process. The Mediterranean diet has been longevity counteract onset age-related disorders. Extra virgin olive oil, fundamental component this diet, contains bioactive polyphenolic compounds hydroxytyrosol (HTyr) oleuropein (OLE), known for their antioxidant, anti-inflammatory, neuroprotective properties. review focused on brain, muscle, gut microbiota, these systems are interact at several levels. After description chemistry pharmacokinetics HTyr OLE, we summarize studies reporting effects vivo vitro models diseases central/peripheral nervous system, adult neurogenesis depression, senescence lifespan, disorders, well impact composition microbiota.

Language: Английский

Citations

44
Sarcopenia Is a Cause and Consequence of Metabolic Dysregulation in Aging Humans: Effects of Gut Dysbiosis, Glucose Dysregulation, Diet and Lifestyle DOI Creative Commons
James W. Daily, Sunmin Park

Cells, Journal Year: 2022, Volume and Issue: 11(3), P. 338 - 338

Published: Jan. 20, 2022

Skeletal muscle mass plays a critical role in healthy lifespan by helping to regulate glucose homeostasis. As seen sarcopenia, decreased skeletal impairs homeostasis, but it may also be caused dysregulation. Gut microbiota modulates lipopolysaccharide (LPS) production, short-chain fatty acids (SCFA), and various metabolites that affect the host metabolism, including tissues, have sarcopenia etiology. Here, we aimed review relationship between mass, gut microbiota, effect of consuming probiotics prebiotics on development pathological consequences aging human population. This includes discussions about effects metabolism interaction dietary intake, physical activity, microbiome influence through modulating gut–muscle axis. Emerging evidence suggests can both function, part metabolisms branch-chain amino might act directly humans or indirectly brain liver. Dietary factors such as fats, proteins, indigestible carbohydrates lifestyle interventions exercise, smoking, alcohol intake help hinder putative The presented this loss function are not an inevitable consequence process, prevent delay sarcopenia.

Language: Английский

Citations

64
Linking the gut microbiota to persistent symptoms in survivors of COVID-19 after discharge DOI Creative Commons
Yaya Zhou, Jianchu Zhang, Dongmei Zhang

et al.

The Journal of Microbiology, Journal Year: 2021, Volume and Issue: 59(10), P. 941 - 948

Published: Aug. 11, 2021

Language: Английский

Citations

60
Population‐based metagenomics analysis reveals altered gut microbiome in sarcopenia: data from the Xiangya Sarcopenia Study DOI
Yilun Wang, Yuqing Zhang, Nancy E. Lane

et al.

Journal of Cachexia Sarcopenia and Muscle, Journal Year: 2022, Volume and Issue: 13(5), P. 2340 - 2351

Published: July 18, 2022

Language: Английский

Citations

59
Mechanisms Linking the Gut-Muscle Axis With Muscle Protein Metabolism and Anabolic Resistance: Implications for Older Adults at Risk of Sarcopenia DOI Creative Commons
Konstantinos Prokopidis, Edward S. Chambers, Mary Ní Lochlainn

et al.

Frontiers in Physiology, Journal Year: 2021, Volume and Issue: 12

Published: Oct. 26, 2021

Aging is associated with a decline in skeletal muscle mass and function—termed sarcopenia—as mediated, part, by anabolic resistance. This metabolic phenomenon describes the impaired response of protein synthesis (MPS) to provision dietary amino acids practice resistance-based exercise. Recent observations highlight gut-muscle axis as physiological target for combatting resistance reducing risk sarcopenia. Experimental studies, primarily conducted animal models aging, suggest mechanistic link between gut microbiota atrophy, mediated via modulation systemic acid availability low-grade inflammation that are both factors known underpin Moreover, vivo vitro studies demonstrate action specific bacteria ( Lactobacillus Bifidobacterium ) increase elicit an anti-inflammatory intestinal lumen. Prospective lifestyle approaches have recently been examined context mitigating sarcopenia risk. These include increasing fiber intake promotes growth development bacteria, thus enhancing production short-chain fatty (SCFA) (acetate, propionate, butyrate). Prebiotic/probiotic/symbiotic supplementation also generates SCFA may mitigate older adults microbiota. Preliminary evidence highlights role exercise SCFA. Accordingly, combine diets rich probiotic training serve produce microbial diversity, adults. Future warranted establish direct distinct phenotypes on utilization postprandial stimulation

Language: Английский

Citations

58
Gut microbiota as a promising therapeutic target for age-related sarcopenia DOI Open Access
Ting Zhang,

Jin-Ke Cheng,

Yaomin Hu

et al.

Ageing Research Reviews, Journal Year: 2022, Volume and Issue: 81, P. 101739 - 101739

Published: Sept. 28, 2022

Language: Английский

Citations

54
Differences in the gut microbiome and reduced fecal butyrate in elders with low skeletal muscle mass DOI
Der‐Sheng Han, Wei‐Kai Wu, Po‐Yu Liu

et al.

Clinical Nutrition, Journal Year: 2022, Volume and Issue: 41(7), P. 1491 - 1500

Published: May 24, 2022

Language: Английский

Citations

53