The Vicious Cycle of Type 2 Diabetes Mellitus and Skeletal Muscle Atrophy: Clinical, Biochemical, and Nutritional Bases

Nutrients, Journal Year: 2024, Volume and Issue: 16(1), P. 172 - 172

Published: Jan. 4, 2024

Today, type 2 diabetes mellitus (T2DM) and skeletal muscle atrophy (SMA) have become increasingly common occurrences. Whether the onset of T2DM increases risk SMA or vice versa has long been under investigation. Both conditions are associated with negative changes in health, which can, turn, lead to impaired physical function, a lowered quality life, an increased mortality. Poor nutrition can exacerbate both SMA. linked by vicious cycle events that reinforce worsen each other. Muscle insulin resistance appears be pathophysiological link between To explore this association, our review (i) compiles evidence on clinical association SMA, (ii) reviews mechanisms underlying biochemical muscles people at (iii) examines how nutritional therapy activity as muscle-targeted treatments benefit population. Based evidence, we conclude effective treatment patients T2DM-SMA depends restoration maintenance mass. We thus propose regular intake key functional nutrients, along guidance for activity, help maintain euglycemia improve status all

Language: Английский

---

Gut microbiota bridges the iron homeostasis and host health

Science China Life Sciences, Journal Year: 2023, Volume and Issue: 66(9), P. 1952 - 1975

Published: July 27, 2023

Language: Английский

---

Defining and diagnosing sarcopenia: Is the glass now half full?

Metabolism, Journal Year: 2023, Volume and Issue: 143, P. 155558 - 155558

Published: April 7, 2023

Language: Английский

---

Probiotics and muscle health: the impact of Lactobacillus on sarcopenia through the gut-muscle axis

Frontiers in Microbiology, Journal Year: 2025, Volume and Issue: 16

Published: March 14, 2025

Sarcopenia refers to the decline in skeletal muscle mass and function. Due its increased mortality rate severe disability, clinical importance of sarcopenia is becoming increasingly prominent. Although exact cause not fully understood, gut microbiota (GM) plays a crucial role pathogenesis sarcopenia, increasing evidence suggests that dysbiosis may be associated with disease development. In past few decades, use probiotics has surged, studies have explored their impact on prevention treatment. Lactobacillus are commonly used for health immune support, but mechanism via gut-muscle axis remains uncertain. This review highlights treatment challenges, GM's potential as an adjunct therapy. addition, we also discuss possible mechanisms by which affect function, such alleviating inflammatory states, clearing excessive reactive oxygen species (ROS), improving metabolism, enhancing intestinal barrier function modulating metabolites. These collectively contribute preservation offering promising avenue advancing microbial therapies sarcopenia.

Language: Английский

---

The Contribution of Diet Therapy and Probiotics in the Treatment of Sarcopenia Induced by Prolonged Immobilization Caused by the COVID-19 Pandemic

Nutrients, Journal Year: 2022, Volume and Issue: 14(21), P. 4701 - 4701

Published: Nov. 7, 2022

The prolonged immobilization associated with COVID-19 infection and the restrictions imposed by pandemic have determined major changes in physical activity eating habits, a negative impact on performance. This study monitored non-pharmacological interventions (diet therapy probiotics) managing sarcopenia for patients recent SARS-CoV-2 history (14 days). A prospective was performed 200 (between December 2020–December 2021), SPPB score < 9, randomly divided into: Group K—DP (93 patients) dietary (protein 1.2–1.5 g/kg) probiotics two months; K—non-DP (107 without diet probiotics. All were included specific training program (40 min), three sessions per week. Skeletal muscle index (SMI), serum albumin, hemoglobin determined. SMI initially low both groups significant statistical differences (6.5 ± 0.52 kg/m2 vs. 6.7 0.57 Kg/m2 K—DP, p = 0.135). After months, difference between initial final values (6.92 0.50 6.77 0.56 kg/m2, 0.048). In at end of study, more normal (n 32 → N 70) (p 0.001) fewer 0.001). albumin means (Group K—non-DP, 4.17 1.04 g/dL, 3.95 0.98 g/dL) not statistically significantly different 0.122). level improved following hyper protein enriched pro-biotics 0.003). Diet therapy, consisting increased intake demonstrated superiority improving functional status infection.

Language: Английский

---

Progress of linking gut microbiota and musculoskeletal health: casualty, mechanisms, and translational values

Gut Microbes, Journal Year: 2023, Volume and Issue: 15(2)

Published: Oct. 6, 2023

The musculoskeletal system is important for balancing metabolic activity and maintaining health. Recent studies have shown that distortions in homeostasis of the intestinal microbiota are correlated with or may even contribute to abnormalities function. Research has also flora its secondary metabolites can impact by regulating various phenomena, such as inflammation immune activities. Most existing literature supports reasonable nutritional intervention helps improve maintain microbiota, a positive on purpose organizing, summarizing discussing explore whether methods, including supplement moderate exercise, affect muscle bone health microecology flora. More in-depth efficacy verification experiments will be helpful clinical applications.

Language: Английский

---

Higher systemic immune-inflammation index is associated with sarcopenia in individuals aged 18–59 years: a population-based study

Scientific Reports, Journal Year: 2023, Volume and Issue: 13(1)

Published: Dec. 13, 2023

Abstract The association between the systemic immune-inflammation index (SII) and risk of sarcopenia has not yet been revealed. purpose this study was to investigate relationship SII in individuals aged 18–59 years. All data for are from National Health Nutrition Examination Survey (NHANES) database, including 7258 participants (age range: years). We divided values by quartiles (quartiles 1–4: 0.3–3.1, 3.2–4.4, 4.4–6.2, 6.2–58.5). constructed a multivariate logistic regression model assess sarcopenia, an interaction test run stability identify high-risk with sarcopenia. Compared nonsarcopenia participants, patients had significantly higher value (weighted average: 6.65 vs. 5.16) ( P = 0.002). Multivariate results showed positive linear (OR [odds ratio] 1.12, 95% CI [confidence interval] 1.03–1.21). quartile 1 group, 4 group associated 3.94, 1.42–10.94). OR 2 groups upwards trend < 0.001) as level increased. Subgroup analysis also indicate that correlation stable. There significant indicating can increase United States. findings will be beneficial promoting use alone or combination other tools screening communities large populations.

Language: Английский

---

Quality of life, household income, and dietary habits are associated with the risk of sarcopenia among the Chinese elderly

Aging Clinical and Experimental Research, Journal Year: 2024, Volume and Issue: 36(1)

Published: Feb. 9, 2024

Abstract Background Health-related quality of life (HRQoL), which can be influenced by various aspects, especially socioeconomic status and lifestyle, has been identified as an important predictor the prognosis older adults. Dietary habit, a major part affect nutritional status, is closely correlated with development geriatric syndromes in elderly. Aims The aim study was to examine association HRQoL, lifestyle risk severity sarcopenia, syndrome characterized progressive loss skeletal muscle mass, strength function. Methods A cross-sectional retrospective 2877 participants aged ≥65 years performed. HRQoL assessed using EuroQoL Five Dimensions questionnaire. Socioeconomic educational attainment, occupation, household income. Lifestyle 12 items related Chinese living habits. information daily dietary habits including tea, alcohol, type diet, volume drinking water were collected. associations sarcopenia examined multivariate regression logistical analysis. potential causal role age, body mass index, waist circumference effect on analyzed mediation Results High [adjusted odds ratio (OR) =0.85, 95% confidence interval (CI) =0.69–0.95, P =0.034] income levels (adjusted OR =0.74, CI =0.57–0.95, =0.019) inversely associated sarcopenia. Meanwhile, more consumption spicy food =1.34, =1.09–1.81, =0.037) occasionally =1.46, =1.07–2.00, =0.016, compared those never drinking) higher while skipping breakfast =0.37, =0.21–0.64, <0.001, eating every day) less salt =0.71, =0.52–0.96, =0.026, consuming high amount salt) lower Further analysis aimed explore how much might explain showed that estimated proportion mediated age 28.0%. Conclusions In summary, our findings demonstrate low income, intake food, occasional alcohol are population

Language: Английский

---

Effects of Bile Acid Modulation by Dietary Fat, Cholecystectomy, and Bile Acid Sequestrant on Energy, Glucose, and Lipid Metabolism and Gut Microbiota in Mice

International Journal of Molecular Sciences, Journal Year: 2022, Volume and Issue: 23(11), P. 5935 - 5935

Published: May 25, 2022

Bile acid metabolism, involved with the digestion and absorption of nutrients in gut, is linked to gut microbiota community, greatly impacting host’s metabolism. We examined hypothesis that modulation bile metabolism by dietary fat contents, gallbladder removal (GBX; cholecystectomy), sequestrant (BAS; cholestyramine) treatment could alter energy, glucose, lipid through changes microbiota. Mice were randomly assigned following six groups: (1) Sham GBX surgery (Sham) + low fat/high carbohydrate diet (LFD), (2) high (HFD), (3) HFD BAS, (4) LFD, (5) HFD, (6) BAS. BAS groups received 2% cholestyramine. After an 8-week intervention, community measured. exhibited higher body weight gain than increased comped regardless (p < 0.05). Homeostatic model assessment for insulin resistance (HOMA-IR) was it Serum profiles worsened compared whereas alleviated them, except serum HDL cholesterol. Hepatic tumor-necrosis-factor-α (TNF-α) mRNA expression peroxide contents no sterol regulatory element-binding transcription factor 1c (SREBP1c) peroxisome proliferator-activated receptor gamma (PPAR-γ) same trend as tumor necrosis factor-α (TNF-α). The α-diversity bacteria decreased Akkermentia, Dehalobacterium, SMB53, Megamonas Veillonella Streptococcus rich while Oscillospira Olsenella LFD Lactobacillus Sutterella elevated Clostridium, Alistipes, Blautia, Eubacterium, Coprobacillus In conclusion, influences metabolisms, might be modulation.

Language: Английский

---

Association of skeletal muscle mass and its change with diabetes occurrence: a population-based cohort study

Diabetology & Metabolic Syndrome, Journal Year: 2023, Volume and Issue: 15(1)

Published: March 22, 2023

Abstract Background Low muscle mass likely results in reduced capacity for glucose disposal, leading to a significant but under-appreciated contribution increasing the risk of diabetes. But few prospective studies have investigated association between loss and occurrence We aimed investigate whether short-term changes affect incidence diabetes Chinese population. Methods This study included 1275 individuals without evident at baseline. In baseline re-examination, completed factors survey underwent body composition measurement. Muscle index was defined as percentage skeletal mass, which measured by an automatic bioelectric analyzer. Results After median follow-up 2.1 years, 142 developed (11.1%). There inverse basal participants with impaired regulation not those normal tolerance. Multivariate-adjusted hazard ratios developing were 0.85 (95% CI: 0.74–0.98) 1.15 0.98–1.34), respectively. Furthermore, Cox regression analysis revealed that two-year change also inversely associated both tolerance (HR: 0.76, 95% 0.65–0.89; HR: 0.81, 0.71–0.91). Conclusions These findings emphasized importance early detection control prevention

Language: Английский

---