Cancer Letters,
Journal Year:
2022,
Volume and Issue:
544, P. 215809 - 215809
Published: June 28, 2022
Exosomes
are
extracellular
vesicles
with
a
variety
of
biological
functions
that
exist
in
various
body
fluids
and
exert
their
through
proteins,
nucleic
acids,
lipids,
metabolites.
Recent
discoveries
have
revealed
the
functional
biomarker
roles
miRNAs
urological
diseases,
including
benign
diseases
malignancies.
several
uses
diagnosis,
treatment,
monitoring
especially
cancer.
Proteins
acids
can
be
used
as
alternative
biomarkers
for
detecting
diseases.
Additionally,
exosomes
detected
most
fluids,
thereby
avoiding
pathogenesis.
More
importantly,
tumors,
display
higher
sensitivity
than
circulating
tumor
cells
tumor-derived
DNA
fluid
biopsies
because
low
immunogenicity
high
stability.
These
advantages
made
it
research
hotspot
recent
years.
In
this
review,
we
focus
on
characteristics
summarize
latest
progress
diagnosis
treatment
Heliyon,
Journal Year:
2024,
Volume and Issue:
10(15), P. e35051 - e35051
Published: July 24, 2024
Hematopoietic
stem
cells
(HSCs)
are
tightly
regulated
by
specific
microenvironments
called
niches
to
produce
an
appropriate
number
of
mature
blood
cell
types.
Self-renewal
and
differentiation
two
hallmarks
hematopoietic
progenitor
cells,
their
balance
is
critical
for
proper
functioning
immune
throughout
life.
In
addition
cell-intrinsic
regulation,
extrinsic
cues
within
the
bone
marrow
niche
systemic
factors
also
affect
fate
HSCs.
Despite
this,
many
paracrine
endocrine
that
influence
function
remain
unknown.
hematological
malignancies,
malignant
remodel
into
a
permissive
environment
enhance
survival
leukemic
cells.
These
events
accompanied
loss
normal
hematopoiesis.
It
well
known
extracellular
vehicles
(EVs)
mediate
intracellular
interactions
under
physiological
pathological
conditions.
other
words,
EVs
transfer
biological
information
surrounding
contribute
not
only
functions
but
pathogenesis
some
diseases,
such
as
cancers.
Therefore,
better
understanding
cell-to-cell
may
lead
identification
potential
therapeutic
targets.
Recent
reports
have
suggested
evolutionarily
conserved
constitutive
mediators
regulate
Here,
we
focus
on
emerging
roles
in
conditions,
particularly
malignancies.
Owing
high
abundance
fluids,
use
biomarkers
tools
discussed.
Biochemical and Biophysical Research Communications,
Journal Year:
2022,
Volume and Issue:
630, P. 71 - 76
Published: Sept. 16, 2022
Exosomes
are
40-100
nm
nano-sized
extracellular
vesicles
and
receiving
increasing
attention
as
novel
structures
that
participate
in
intracellular
communication.
We
previously
found
miRNA-1
(miR-1)
functions
a
tumor
suppressor
renal
cell
carcinoma
(RCC).
In
this
study,
we
investigated
the
function
of
exosomal
miR-1
possibility
exosome
constitutes
maker
RCC.
First,
established
method
to
collect
exosomes
from
lysates
human
serum
by
spin
column-based
method.
Next,
assessed
using
Nanosight
nanoparticle
tracking
analysis
Western
blot
with
marker
CD63.
confirmed
labeled
PKH26
fused
recipient
cells.
Moreover,
expression
was
elevated
RCC
cells
treated
derived
miR-1-transfected
Functional
analyses
showed
significantly
inhibited
proliferation,
migration
invasion
compared
control
treatment.
Our
TCGA
database
RCCs
downregulated
clinical
samples
normal
kidney
samples,
patients
low
had
poorer
overall
survival
comparison
high
expression.
Furthermore,
RNA
sequence
levels
several
genes
were
altered
exposure
miR-1.
The
indicated
MYO15A
associated
outcome
addition,
RT-qPCR
patients'
sera
upregulated
healthy
controls.
This
study
treatment
might
be
an
effective
approach
treating
RCCs.
could
diagnostic
Frontiers in Oncology,
Journal Year:
2022,
Volume and Issue:
12
Published: Sept. 20, 2022
Bladder
cancer
is
one
of
the
top
ten
most
common
cancers
and
causes
death
globally.
5-year
survival
rates
have
decreased
in
Australia
from
66%
to
55%
past
three
decades.
The
current
gold
standard
for
diagnosis
cystoscopy.
However,
cystoscopies
are
an
invasive
health-resource
intensive
procedure
which
has
sub-optimal
sensitivity
flat
lesions
such
as
CIS
(carcinoma
situ)
low
specificity
differentiating
inflammation
-
hence
requiring
biopsies
under
anesthesia.
Frequent
life-long
surveillance
cystoscopy
required
patients
since
there
high
progression
local
recurrence
high-risk
non-muscle
(NMIBC)
well
poor
outcomes
associated
with
delayed
detection
muscle-invasive
bladder
(MIBC).
There
unmet
need
a
non-invasive
test
provide
better
discrimination
risk-stratification
could
aid
clinicians
by
improving
patient
selection
cystoscopy;
enhanced
risk
stratification
methods
may
guide
frequency
inform
treatment
choices.
Exosomes,
nano-sized
extracellular
vesicles
containing
genetic
material
proteins,
been
shown
functional
roles
development
cancer.
Exosomes
also
demonstrated
be
robust
source
potential
biomarkers
prognosis
therapeutic
agents.
In
this
review,
we
summarize
latest
evidence
biological
exosomes
highlight
their
clinical
significance
diagnosis,
treatment.
Micromachines,
Journal Year:
2022,
Volume and Issue:
14(1), P. 61 - 61
Published: Dec. 26, 2022
The
photo-thermoelectric
(PTE)
effect
in
electronic
materials
effectively
combines
photo-absorption-induced
local
heating
and
associated
thermoelectric
conversion
for
uncooled
broadband
photo-detection.
In
particular,
this
work
comprehensively
summarizes
the
operating
mechanism
of
carbon
nanotube
(CNT)-film-based
PTE
sensors
ubiquitous
non-destructive
inspections
realized
by
exploiting
material
properties
CNT
films.
Formation
heterogeneous
junctions
across
CNT-film-based
sensors,
namely
photo-detection
interfaces,
triggers
Seebeck
with
heating.
Typical
interfaces
include
a
channel–electrode
boundary
junction
between
P-type
CNTs
N-type
(PN
junctions).
While
original
film
channel
exhibits
positive
coefficient
values,
selections
counterpart
freely
govern
intensity
polarity
response
signals.
Based
on
these
mechanisms,
demonstrate
variety
physical
chemical
inspections.
device
aggregates
broad
multi-spectral
optical
information
regarding
targets
reconstructs
their
inner
composite
or
layered
structures.
Arbitrary
deformations
are
attributed
to
macroscopic
flexibility
films
further
monitor
from
omni-directional
viewing
angles
without
blind
spots.
Detection
blackbody
radiation
using
also
visualizes
behaviors
changes.
Cancer Letters,
Journal Year:
2022,
Volume and Issue:
544, P. 215809 - 215809
Published: June 28, 2022
Exosomes
are
extracellular
vesicles
with
a
variety
of
biological
functions
that
exist
in
various
body
fluids
and
exert
their
through
proteins,
nucleic
acids,
lipids,
metabolites.
Recent
discoveries
have
revealed
the
functional
biomarker
roles
miRNAs
urological
diseases,
including
benign
diseases
malignancies.
several
uses
diagnosis,
treatment,
monitoring
especially
cancer.
Proteins
acids
can
be
used
as
alternative
biomarkers
for
detecting
diseases.
Additionally,
exosomes
detected
most
fluids,
thereby
avoiding
pathogenesis.
More
importantly,
tumors,
display
higher
sensitivity
than
circulating
tumor
cells
tumor-derived
DNA
fluid
biopsies
because
low
immunogenicity
high
stability.
These
advantages
made
it
research
hotspot
recent
years.
In
this
review,
we
focus
on
characteristics
summarize
latest
progress
diagnosis
treatment
