Nature Communications,
Journal Year:
2024,
Volume and Issue:
15(1)
Published: Feb. 29, 2024
Abstract
Cancer
cells
integrate
multiple
biosynthetic
demands
to
drive
unrestricted
proliferation.
How
these
cellular
processes
crosstalk
fuel
cancer
cell
growth
is
still
not
fully
understood.
Here,
we
uncover
the
mechanisms
by
which
transcription
factor
Carbohydrate
responsive
element
binding
protein
(ChREBP)
functions
as
an
oncogene
during
hepatocellular
carcinoma
(HCC)
development.
Mechanistically,
ChREBP
triggers
expression
of
PI3K
regulatory
subunit
p85α,
sustain
activity
pro-oncogenic
PI3K/AKT
signaling
pathway
in
HCC.
In
parallel,
increased
reroutes
glucose
and
glutamine
metabolic
fluxes
into
fatty
acid
nucleic
synthesis
support
PI3K/AKT-mediated
HCC
growth.
Thus,
have
a
ChREBP-driven
circuitry
that
ensures
balanced
coordination
between
appropriate
anabolism
Finally,
pharmacological
inhibition
SBI-993
significantly
suppresses
vivo
tumor
Overall,
show
targeting
with
specific
inhibitors
provides
attractive
therapeutic
window
for
treatment.
Antioxidants,
Journal Year:
2022,
Volume and Issue:
11(5), P. 911 - 911
Published: May 6, 2022
The
critical
factors
for
regulating
cancer
metabolism
are
oxidative
stress
and
phosphoinositide-3-kinase/AKT
serine-threonine
kinase/mechanistic
target
of
the
rapamycin
kinase
(PI3K/AKT/mTOR).
However,
metabolic
impacts
PI3K/AKT/mTOR
on
individual
mechanisms
such
as
glycolysis
(Warburg
effect),
pentose
phosphate
pathway
(PPP),
fatty
acid
synthesis,
tricarboxylic
cycle
(TCA)
cycle,
glutaminolysis,
phosphorylation
(OXPHOS)
complicated.
Therefore,
this
review
summarizes
interacting
functions
metabolism.
Moreover,
natural
products
providing
modulating
effects
have
anticancer
potential.
Using
example
brown
algae-derived
fucoidan,
roles
were
summarized,
although
their
potential
within
diverse
metabolisms
rarely
investigated.
We
propose
a
application
that
fucoidan
may
regulate
signaling
to
modulate
associated
regulations.
This
sheds
light
understanding
future
direction
metabolism-based
therapy
fucoidan.
Reviews in Medical Virology,
Journal Year:
2024,
Volume and Issue:
34(2)
Published: March 1, 2024
A
significant
portion
of
human
cancers
are
caused
by
oncoviruses
(12%-25%).
Oncoviruses
employ
various
strategies
to
promote
their
replication
and
induce
tumourigenesis
in
host
cells,
one
which
involves
modifying
the
gene
expression
patterns
leading
rewiring
genes
resulting
changes
cellular
processes
signalling
pathways.
In
recent
studies,
a
specific
mode
regulation
known
as
circular
RNA
(circRNA)-mediated
competing
endogenous
(ceRNA)
networks
has
emerged
key
player
this
context.
CircRNAs,
class
non-coding
molecules,
can
interact
with
other
such
mRNAs
microRNAs
(miRNAs),
through
process
ceRNA
crosstalk.
This
interaction
occurs
when
circRNAs,
acting
sponges,
sequester
miRNAs,
thereby
preventing
them
from
binding
target
modulating
expression.
By
cell
genome,
have
ability
manipulate
activity
influencing
that
profoundly
impact
proliferation,
differentiation,
apoptosis,
immune
responses.
review
focuses
on
comprehensive
evaluation
latest
findings
involvement
virus-induced
reprogramming
circRNA-mediated
development
pathophysiology
viral
cancers,
including
cervical
cancer,
gastric
nasopharyngeal
carcinoma,
Kaposi's
sarcoma,
hepatocellular
diffuse
large
B
lymphoma.
Understanding
these
mechanisms
improve
our
knowledge
how
contribute
identify
potential
targets
for
developing
optimised
therapies
diagnostic
tools
cancers.
Chinese Medicine,
Journal Year:
2023,
Volume and Issue:
18(1)
Published: Oct. 24, 2023
Abstract
Cancer
is
a
malignant
disease
that
has
plagued
human
beings
all
the
time,
but
treatment
effect
of
commonly
used
anticancer
drugs
in
clinical
practice
not
ideal
by
reason
their
drug
tolerance
and
Strong
adverse
reactions
to
patients.
Therefore,
it
imperative
find
effective
low-toxic
drugs.
Many
research
works
have
shown
natural
products
Chinese
herbal
medicine
great
potential,
such
as
6-shogaol,
monomer
composition
obtained
from
ginger,
which
been
confirmed
numerous
vitro
or
vivo
studies
be
an
excellent
anti-cancer
active
substance.
In
addition,
most
notably,
6-shogaol
different
selectivity
for
normal
cancer
cells
during
treatment,
makes
valuable
further
development.
this
review
focus
on
attributes,
mechanism
regulation
related
signaling
pathways
6-shogaol.
its
synergy
with
drugs,
potential
delivery
systems
prospects
future
are
discussed.
This
first
comprehensively
summarize
hoping
provide
theoretical
basis
guiding
significance
development
Graphical
JHEP Reports,
Journal Year:
2023,
Volume and Issue:
5(10), P. 100843 - 100843
Published: July 12, 2023
Exploiting
key
regulators
responsible
for
hepatocarcinogenesis
is
of
great
importance
the
prevention
and
treatment
hepatocellular
carcinoma
(HCC).
However,
players
contributing
to
remain
poorly
understood.
We
explored
molecular
mechanisms
underlying
carcinogenesis
progression
HCC
development
potential
new
therapeutic
targets.The
Cancer
Genome
Atlas-Liver
Hepatocellular
Carcinoma
(TCGA-LIHC)
Genotype-Tissue
Expression
(GTEx)
databases
were
used
identify
genes
with
enhanced
expression
in
liver
associated
progression.
A
murine
liver-specific
Ftcd
knockout
(Ftcd-LKO)
model
was
generated
investigate
role
formimidoyltransferase
cyclodeaminase
(FTCD)
HCC.
Multi-omics
analysis
transcriptomics,
metabolomics,
proteomics
data
applied
further
analyse
effects
FTCD
on
hepatocarcinogenesis.
Functional
biochemical
studies
performed
determine
significance
loss
Akt
inhibitors
FTCD-deficient
cancer
cells.FTCD
highly
expressed
but
significantly
downregulated
Patients
low
levels
exhibited
worse
prognosis,
patients
cirrhosis
a
notable
higher
probability
developing
Hepatocyte-specific
promoted
both
chronic
diethylnitrosamine-induced
spontaneous
mice.
showed
that
affected
fatty
acid
cholesterol
metabolism
Mechanistically,
upregulated
peroxisome
proliferator-activated
receptor
(PPAR)γ
sterol
regulatory
element-binding
protein
2
(SREBP2)
by
regulating
PTEN/Akt/mTOR
signalling
axis,
leading
lipid
accumulation
hepatocarcinogenesis.Taken
together,
we
identified
FTCD-regulated
metabolic
mechanism
involving
PPARγ
SREBP2
signaling
provide
rationale
therapeutically
targeting
driven
downregulation
FTCD.Exploiting
molecules
significant
Herein,
as
top
gene,
which
could
serve
predictive
prognostic
marker
characterised
first
model.
found
hepatocarcinogenesis,
provided
FTCD.
Biomedicine & Pharmacotherapy,
Journal Year:
2024,
Volume and Issue:
172, P. 116221 - 116221
Published: Feb. 1, 2024
The
gene
therapy
attracted
more
and
attention
for
the
tumor
therapy.
To
obtain
a
safe
system,
new
vectors
beyond
virus
were
developed
high
efficiency.
ultrasound
mediated
was
safer
plasmid
DNA
could
be
delivered
by
microbubbles
combined
with
to
increase
transfection
In
this
work,
cationic
decorated
Cyclo(Cys-Arg-Gly-Asp-Lys-Gly-Pro-AspCys)
(iRGD
peptides)
magnetic
Fe3O4
nanoparticles
(MBiM)
designed
targeted
contrast
imaging
guided
of
tumors.
image
intensity
dramatically
enhanced
at
site
that
received
MBiM
magnet
applied,
compared
those
administrated
non-targeted
(MBb)
or
only
one
target
material
on
surface
(MBM
MBbi).
pGPU6/GFP/Neo-shAKT2
used
as
sample
gene,
which
down
regulate
AKT2
protein
expression
cancer
It
illustrated
MBiM/AKT2
had
highest
efficiency
in
studied
ultrasound,
leading
downregulation
strongest
killing
effect
vitro
vivo.
summary,
novel
biocompatible
delivery
platform
via
both
endogenous
external
targeting
effects
breast
theranostics
developed.
