Cannabidiol Exerts Sedative and Hypnotic Effects in Normal and Insomnia Model Mice Through Activation of 5-HT1A Receptor

Neurochemical Research, Journal Year: 2024, Volume and Issue: 49(5), P. 1150 - 1165

Published: Jan. 31, 2024

Language: Английский

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Current state of cannabis use, policies, and research across sixteen countries: cross-country comparisons and international perspectives

Trends in Psychiatry and Psychotherapy, Journal Year: 2021, Volume and Issue: unknown

Published: Jan. 1, 2021

Varying public views on cannabis use across countries may explain the variation in prevalence of use, policies, and research individual countries, global regulation cannabis. This paper aims to describe current state sixteen countries.PubMed Google Scholar were searched for studies published from 2010 2020. Searches conducted using relevant country interest as a search term (e.g., "Iran"), well predefined keywords such "cannabis," "marijuana," "hashish," "bhang "dual diagnosis," "use," "addiction," "prevalence," "co-morbidity," "substance disorder," "legalization" or "policy" (in English non-English languages). These used multiple combinations create string studies' titles abstracts. Official websites respective governments international organizations also languages (using national languages) identify each those countries.The main findings inconsistent heterogeneous reporting policies legalization), intervention strategies reviewed. European dominate output indexed PubMed, contrast Asian (Thailand, Malaysia, India, Iran, Nepal).Although is ongoing, existing heterogeneities terms epidemiology can increase burden disorders disproportionately unpredictably. There an urgent need develop address these cross-country barriers improve early detection, prevention, interventions related disorders.

Language: Английский

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Oxidative Stress as a Therapeutic Target in Amyotrophic Lateral Sclerosis: Opportunities and Limitations

Diagnostics, Journal Year: 2021, Volume and Issue: 11(9), P. 1546 - 1546

Published: Aug. 26, 2021

Amyotrophic lateral sclerosis (ALS), also known as motor neuron disease (MND) and Lou Gehrig’s disease, is characterized by a loss of the lower neurons in spinal cord upper cerebral cortex. Due to complex multifactorial nature various risk factors mechanisms that are related neuronal degeneration, pathological ALS not fully understood. Oxidative stress one causes pathogenesis. This has been observed patients well cellular animal models, induce mitochondrial dysfunction neurons. Numerous therapeutic agents have developed inhibit oxidative neuroinflammation. In this review, we describe role pathogenesis, discuss several anti-inflammatory anti-oxidative potential therapeutics for ALS. Although antioxidant fields meaningful approaches delay progression prolong survival ALS, it necessary investigate models or humans with different subtypes sporadic familial

Language: Английский

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Sex-dependent differences in the anxiolytic-like effect of cannabidiol in the elevated plus-maze

Journal of Psychopharmacology, Journal Year: 2022, Volume and Issue: 36(12), P. 1371 - 1383

Published: Oct. 14, 2022

Rationale: Cannabidiol (CBD), the major non-psychoactive constituent of cannabis, has therapeutic potential for treatment anxiety. Most preclinical studies investigate only acute effects CBD and in males, yet drug is most likely to be used over a sustained period clinical practice. Objectives: The objectives this study were anxiolytic-like effect female rats compared males determine whether responsiveness females was influenced by stage estrous cycle. Methods: We carried out experiments compare male elevated plus maze (EPM) response short-term (4 days) administration through complete cycle females. Results: Male behaved similar manner EPM, but late diestrus (LD) phase exhibited more anxiety-like behavior than at other stages, difference reaching statistical significance proestrus stages. produced both sexes, responsive LD 10-fold lower dose males. After sub-chronic treatment, maintained LD, remained unresponsive treatment. Conclusions: suggest that there are sex differences reflect different underlying mechanisms: based on literature data, gonadal hormone status linked GABA A receptor expression females, 5-HT 1A activation

Language: Английский

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Cannabinoids and Sleep: Exploring Biological Mechanisms and Therapeutic Potentials

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(7), P. 3603 - 3603

Published: March 22, 2024

The endogenous cannabinoid system (ECS) plays a critical role in the regulation of various physiological functions, including sleep, mood, and neuroinflammation. Phytocannabinoids such as Δ9-tetrahydrocannabinol (THC), cannabidiol (CBD), cannabinomimimetics, some N-acylethanolamides, particularly palmitoyethanolamide, have emerged potential therapeutic agents for management sleep disorders. THC, psychoactive component cannabis, may initially promote but, long term, alters architecture, while CBD shows promise improving quality without effects. Clinical studies suggest that modulates endocannabinoid signaling through several receptor sites, offering multifaceted approach to regulation. Similarly, palmitoylethanolamide (PEA), addition interacting with system, acts an agonist on peroxisome proliferator-activated receptors (PPARs). favorable safety profile PEA long-term use make them attractive alternative conventional pharmacotherapy. integration latter two compounds into comprehensive treatment strategies, together cognitive–behavioral therapy insomnia (CBT-I), represents holistic address multifactorial nature Further research is needed establish optimal dosage, safety, efficacy different patient populations, but offers hope improved general well-being.

Language: Английский

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Binge-like Alcohol Exposure in Adolescence: Behavioural, Neuroendocrine and Molecular Evidence of Abnormal Neuroplasticity… and Return

Biomedicines, Journal Year: 2021, Volume and Issue: 9(9), P. 1161 - 1161

Published: Sept. 4, 2021

Binge alcohol consumption among adolescents affects the developing neural networks underpinning reward and stress processing in nucleus accumbens (NAc). This study explores rats long-lasting effects of early intermittent exposure to intoxicating levels at adolescence, on: (1) response natural positive stimuli inescapable stress; (2) stress-axis functionality; (3) dopaminergic glutamatergic neuroadaptation NAc. We also assess potential non-intoxicating phytocannabinoid cannabidiol, counteract (or reverse) development detrimental consequences binge-like exposure. Our results show that adolescent alters sensitivity stimuli, exerts social novelty-triggered anxiety-like behaviour, passive stress-coping during prolonged withdrawal. In addition, serum corticosterone hypothalamic NAc corticotropin-releasing hormone progressively increase Besides, tyrosine hydroxylase late withdrawal, while expression dopamine transporter, D1 D2 receptors is dynamically altered binge Furthermore, markers excitatory postsynaptic signaling—PSD95; Homer-1 -2 activity-regulated spine-morphing proteins Arc, LIM Kinase 1 FOXP1—increase Notably, subchronic attenuates social- novelty-induced aversion rectifies hyper-responsive axis glutamate-related neuroplasticity. Overall, makes NAc, a locus minoris resistentiae as result perturbations neuroplasticity homeostasis. Cannabidiol holds promising for increasing behavioural, neuroendocrine molecular resilience against harmful effects.

Language: Английский

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Down and High: Reflections Regarding Depression and Cannabis

Frontiers in Psychiatry, Journal Year: 2021, Volume and Issue: 12

Published: May 14, 2021

In light of the recent changes in legal status cannabis Canada, understanding potential impact use by individuals suffering from depression is increasingly considered as being important. It fundamental that we look into existing literature to examine influence on psychiatric conditions, including mood disorders. this article, will explore relationship exists between and cannabis. We onset course depression, its treatment. have undertaken a wide-ranging review order address these questions. The evidence longitudinal studies suggest there bidirectional such increases risk for vice-versa. This possibly higher heavy users having initiated their consumption early adolescence. Clinical also suggests associated with worse prognosis major depressive disorder. link suicide remains controversial. Moreover, insufficient data determine cognition Preliminary suggesting endogenous cannabinoid system involved pathophysiology depression. need be confirmed future positron emission tomography studies. Randomized controlled trials are needed investigate efficacy motivational interviewing and/or cognitive behavioral therapy treatment disorder Finally, although preclinical cannabidiol has antidepressant properties, randomized properly possibility humans.

Language: Английский

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Geotemporospatial and causal inferential epidemiological overview and survey of USA cannabis, cannabidiol and cannabinoid genotoxicity expressed in cancer incidence 2003–2017: part 3 – spatiotemporal, multivariable and causal inferential pathfinding and exploratory analyses of prostate and ovarian cancers

Archives of Public Health, Journal Year: 2022, Volume and Issue: 80(1)

Published: March 30, 2022

The epidemiology of cannabinoid-related cancerogenesis has not been studied with cutting edge epidemiological techniques. Building on earlier bivariate papers in this series we aimed to conduct pathfinding studies address gap two tumours the reproductive tract, prostate and ovarian cancer.

Language: Английский

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Toxicological effects of atenolol and venlafaxine on zebrafish tissues: Bioaccumulation, DNA hypomethylation, and molecular mechanism

Environmental Pollution, Journal Year: 2022, Volume and Issue: 299, P. 118898 - 118898

Published: Jan. 23, 2022

Language: Английский

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Medicinal cannabis for the treatment of anxiety disorders

Australian Journal of General Practice, Journal Year: 2022, Volume and Issue: 51(8), P. 586 - 592

Published: Aug. 1, 2022

Anxiety is second most common reason for medicinal cannabis prescription in Australia and being treated with both Δ9-tetrahydrocannabinol (THC)-containing cannabidiol (CBD)-dominant products.The aim of this article to summarise recent advances the understanding treating anxiety trends prescribing.Clinical trials laboratory studies provide evidence anxiolytic effects CBD healthy volunteers clinical populations, although current insufficient support as a first-line treatment. The regarding use THC-dominant products ambiguous, exacerbation some individuals relief others. Caution required THC can impair driving cognitive function. Despite lack robust supportive evidence, increasing rapidly, while illicit widely used community self-medicate anxiety. Approximately 17% prescriptions are CBD- dominant liquid (oils), wafers capsules, remainder THC-containing (33%) herbal vaporisation (50%). Medical practitioners should carefully consider potential risks benefits when prescribing disorders 'start low go slow'.

Language: Английский

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