Wnt and PI3K/Akt/mTOR Survival Pathways as Therapeutic Targets in Glioblastoma

International Journal of Molecular Sciences, Journal Year: 2022, Volume and Issue: 23(3), P. 1353 - 1353

Published: Jan. 25, 2022

Glioblastoma (GBM) is a devastating type of brain tumor, and current therapeutic treatments, including surgery, chemotherapy, radiation, are palliative at best. The design effective targeted chemotherapeutic strategies for the treatment GBM require thorough analysis specific signaling pathways to identify those serving as drivers progression invasion. Wnt/β-catenin PI3K/Akt/mTOR (PAM) key regulators important biological functions that include cell proliferation, epithelial–mesenchymal transition (EMT), metabolism, angiogenesis. Targeting regulatory components PAM has potential disrupt critical tumor achieve advancements in alternative enhance survival rate patients. In this review, we emphasize importance invasion into tissue explore their targets.

Language: Английский

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Targeting autophagy, oxidative stress, and ER stress for neurodegenerative disease treatment

Journal of Controlled Release, Journal Year: 2022, Volume and Issue: 345, P. 147 - 175

Published: March 4, 2022

Language: Английский

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The Dialogue Between Neuroinflammation and Adult Neurogenesis: Mechanisms Involved and Alterations in Neurological Diseases

Molecular Neurobiology, Journal Year: 2022, Volume and Issue: 60(2), P. 923 - 959

Published: Nov. 16, 2022

Language: Английский

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Epigallocatechin-3-Gallate (EGCG): New Therapeutic Perspectives for Neuroprotection, Aging, and Neuroinflammation for the Modern Age

Biomolecules, Journal Year: 2022, Volume and Issue: 12(3), P. 371 - 371

Published: Feb. 25, 2022

Alzheimer’s and Parkinson’s diseases are the two most common forms of neurodegenerative diseases. The exact etiology these disorders is not well known; however, environmental, molecular, genetic influences play a major role in pathogenesis Using disease (AD) as archetype, pathological findings include aggregation Amyloid Beta (Aβ) peptides, mitochondrial dysfunction, synaptic degradation caused by inflammation, elevated reactive oxygen species (ROS), cerebrovascular dysregulation. This review highlights neuroinflammatory neuroprotective epigallocatechin-3-gallate (EGCG): medicinal component green tea, known nutraceutical that has shown promise modulating AD progression due to its antioxidant, anti-inflammatory, anti-aging abilities. report also re-examines current literature provides innovative approaches for EGCG be used preventive measure alleviate other disorders.

Language: Английский

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Mitochondrial dysfunctions, oxidative stress and neuroinflammation as therapeutic targets for neurodegenerative diseases: An update on current advances and impediments

Neuroscience & Biobehavioral Reviews, Journal Year: 2022, Volume and Issue: 144, P. 104961 - 104961

Published: Nov. 14, 2022

Language: Английский

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Inflammation: A New Look at an Old Problem

International Journal of Molecular Sciences, Journal Year: 2022, Volume and Issue: 23(9), P. 4596 - 4596

Published: April 21, 2022

Pro-inflammatory stress is inherent in any cells that are subject to damage or threat of damage. It defined by a number universal components, including oxidative stress, cellular response DNA damage, unfolded protein mitochondrial and endoplasmic reticulum changes autophagy, inflammasome formation, non-coding RNA response, formation an inducible network signaling pathways, epigenetic changes. The presence receptor secretory phenotype many the cause tissue pro-inflammatory stress. key phenomenon determining occurrence classical inflammatory focus microvascular (exudation, leukocyte migration alteration zone). This same reaction at systemic level leads development life-critical inflammation. From this standpoint, we can characterize common mechanisms pathologies differ their clinical appearance. division inflammation into alternative variants has deep evolutionary roots. Evolutionary aspects also described review. aim review provide theoretical arguments for need up-to-date theory relationship between human pathological processes based on integrative role molecular

Language: Английский

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Mitochondrial quality control: a pathophysiological mechanism and potential therapeutic target for chronic obstructive pulmonary disease

Frontiers in Pharmacology, Journal Year: 2025, Volume and Issue: 15

Published: Jan. 3, 2025

Chronic obstructive pulmonary disease (COPD) is a prevalent chronic respiratory worldwide. Mitochondrial quality control mechanisms encompass processes such as mitochondrial biogenesis, fusion, fission, and autophagy, which collectively maintain the quantity, morphology, function of mitochondria, ensuring cellular energy supply progression normal physiological activities. However, in COPD, due to persistent stimulation harmful factors smoking air pollution, often become deregulated, leading dysfunction. dysfunction plays pivotal role pathogenesis contributing toinflammatory response, oxidative stress, senescence. therapeutic strategies targeting mitochondria remain underexplored. This review highlights recent advances focusing on their dysregulation progression. We emphasize significance pathophysiological COPD explore potential regulate improve through interventions, aiming treat effectively. Additionally, we analyze limitations challenges existing strategies, provide new insights methods for treatment.

Language: Английский

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Insights into the Pathogenesis of Neurodegenerative Diseases: Focus on Mitochondrial Dysfunction and Oxidative Stress

International Journal of Molecular Sciences, Journal Year: 2021, Volume and Issue: 22(21), P. 11847 - 11847

Published: Oct. 31, 2021

As the population ages, incidence of neurodegenerative diseases is increasing. Due to intensive research, important steps in elucidation pathogenetic cascades have been made and significantly implicated mitochondrial dysfunction oxidative stress. However, available treatment Alzheimer’s disease, Parkinson’s amyotrophic lateral sclerosis mainly symptomatic, providing minor benefits and, at most, slowing down progression disease. Although preclinical setting, drugs targeting stress yielded encouraging results, clinical trials failed or had inconclusive results. It likely that by time diagnosis, are full-blown significant numbers neurons already degenerated, making it impossible for mitochondria-targeted antioxidant molecules stop reverse process. Until further research will provide more efficient molecules, a healthy lifestyle, with plenty dietary antioxidants avoidance exogenous oxidants may postpone onset neurodegeneration, while familial cases benefit from genetic testing aggressive therapy started stage.

Language: Английский

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Enhancing autophagy in Alzheimer's disease through drug repositioning

Pharmacology & Therapeutics, Journal Year: 2022, Volume and Issue: 237, P. 108171 - 108171

Published: March 16, 2022

Language: Английский

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Role of Nrf2 in Synaptic Plasticity and Memory in Alzheimer’s Disease

Cells, Journal Year: 2021, Volume and Issue: 10(8), P. 1884 - 1884

Published: July 25, 2021

Nuclear factor erythroid 2-related 2 (Nrf2) is an important transcription that reduces oxidative stress. When reactive oxygen species (ROS) or nitrogen (RNS) are detected, Nrf2 translocates from the cytoplasm into nucleus and binds to antioxidant response element (ARE), which regulates expression of anti-inflammatory genes. impairments observed in majority neurodegenerative disorders, including Alzheimer’s disease (AD). The classic hallmarks AD include β-amyloid (Aβ) plaques, neurofibrillary tangles (NFTs). Oxidative stress early a novel therapeutic target for treatment AD. nuclear translocation impaired compared controls. Increased associated with memory synaptic plasticity. administration activators reverses plasticity rodent models Therefore, potential disorders

Language: Английский

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