Focus on the Contribution of Oxidative Stress in Skin Aging

Antioxidants, Journal Year: 2022, Volume and Issue: 11(6), P. 1121 - 1121

Published: June 6, 2022

Skin aging is one of the most evident signs human aging. Modification skin during life span characterized by fine lines and wrinkling, loss elasticity volume, laxity, rough-textured appearance, pallor. In contrast, photoaged associated with uneven pigmentation (age spot) markedly wrinkled. At cellular molecular level, it consists multiple interconnected processes based on biochemical reactions, genetic programs, occurrence external stimulation. The principal perturbation in driving senescence alteration oxidative balance. chronological aging, reactive oxygen species (ROS) are produced mainly through metabolism adenosine triphosphate (ATP) generation from glucose mitochondrial dysfunction, whereas extrinsic redox equilibrium caused environmental factors, such as ultraviolet radiation, pollution, cigarette smoking, inadequate nutrition. During process, stress attributed to both augmented ROS production reduced levels enzymatic non-enzymatic protectors. Apart appearance structural change, throughout gradually loses its natural functional characteristics regenerative potential. With immune system also undergoes manifested a ability counteract infections frequency autoimmune neoplastic diseases. This review proposes an update role clinical manifestation well mechanisms that underline this phenomenon sometimes accelerated factors.

Language: Английский

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The Potential Role of Gut Microbiota in Alzheimer’s Disease: From Diagnosis to Treatment

Nutrients, Journal Year: 2022, Volume and Issue: 14(3), P. 668 - 668

Published: Feb. 5, 2022

Gut microbiota is emerging as a key regulator of many disease conditions and its dysregulation implicated in the pathogenesis several gastrointestinal extraintestinal disorders. More recently, gut microbiome alterations have been linked to neurodegeneration through increasingly defined brain axis, opening possibility for new microbiota-based therapeutic options. Although studies conducted unravel possible relationship between Alzheimer’s Disease (AD) progression, diagnostic potential approaches aiming at restoring eubiosis remain be fully addressed. In this narrative review, we briefly summarize role homeostasis health disease, present evidence AD patients. Based on these observations, then discuss how dysbiosis might exploited tool early advanced stages, examine prebiotics, probiotics, fecal transplantation, diets complementary interventions thus offering insights into diagnosis treatment devastating progressive disease.

Language: Английский

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Current insights and future perspectives of ultraviolet radiation (UV) exposure: Friends and foes to the skin and beyond the skin

Environment International, Journal Year: 2024, Volume and Issue: 185, P. 108535 - 108535

Published: Feb. 27, 2024

Ultraviolet (UV) radiation is ubiquitous in the environment, which has been classified as an established human carcinogen. As largest and outermost organ of body, direct exposure skin to sunlight or UV can result sunburn, inflammation, photo-immunosuppression, photoaging even cancers. To date, there are tactics protect by preventing reducing amount skin. Nevertheless, deciphering essential regulatory mechanisms may pave way for therapeutic interventions against UV-induced disorders. Additionally, light considered beneficial specific skin-related conditions medical therapy. Recent evidence indicates that biological effects extend beyond include treatment inflammatory diseases, solid tumors certain abnormal behaviors. This review mainly focuses on Moreover, novel findings other organs systems also summarized. through affects organism remain be fully elucidated achieve a more comprehensive understanding its effects.

Language: Английский

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Current and emerging applications of saccharide-modified chitosan: a critical review

Biotechnology Advances, Journal Year: 2023, Volume and Issue: 66, P. 108172 - 108172

Published: May 9, 2023

Language: Английский

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Beyond the Hayflick limit: How microbes influence cellular aging

Ageing Research Reviews, Journal Year: 2025, Volume and Issue: 104, P. 102657 - 102657

Published: Jan. 7, 2025

Language: Английский

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Interventions on Gut Microbiota for Healthy Aging

Cells, Journal Year: 2022, Volume and Issue: 12(1), P. 34 - 34

Published: Dec. 22, 2022

In recent years, the improvement in health and social conditions has led to an increase average lifespan. Since aging is most important risk factor for majority of chronic human diseases, development therapies intervention stop, lessen or even reverse various age-related morbidities target ameliorate quality life elderly. The gut microbiota, that is, complex ecosystem microorganisms living gastrointestinal tract, plays role, not yet fully understood, maintaining host’s homeostasis, influencing metabolic, oxidative cognitive status; this reason, it also named “the forgotten endocrine organ” second brain”. On other hand, microbiota diversity richness are affected by unmodifiable factors, such as sex, modifiable ones, diet, pharmacological lifestyle. review, we discuss changes, mostly disadvantageous, health, induced aging, composition effects dietary intervention, supplementation with probiotics, prebiotics, synbiotics, psychobiotics antioxidants physical exercise. integrated strategy implement will help goal healthy aging.

Language: Английский

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Kombucha: Perceptions and Future Prospects

Foods, Journal Year: 2022, Volume and Issue: 11(13), P. 1977 - 1977

Published: July 4, 2022

Kombucha is an increasingly consumed product classified as a nutraceutical. Legislative efforts about these products remain confusing and without global harmonization. This natural has been developed to improve or promote physical mental health. However, it needs regulatory guidelines control the production guarantee product's efficacy safety.The study intends draw attention need for potential of this in market peoples' health.The lack regulation low level literacy can limit its development, marketing, impact on Thus, essential highlight value invest development marketing. Likewise, important spread awareness among population their impacts people's focuses pertinent theme alerts legislation products, inexistent legislative consequent better safer consumption.

Language: Английский

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Gut-microbiome-brain axis: the crosstalk between the vagus nerve, alpha-synuclein and the brain in Parkinson’s disease

Neural Regeneration Research, Journal Year: 2023, Volume and Issue: 18(12), P. 2611 - 2614

Published: May 12, 2023

This critical review of the literature shows that there is a close link between microbiome, gut, and brain in Parkinson's disease. The vagus nerve, main component parasympathetic nervous system, involved regulation immune response, digestion, heart rate, control mood. It can detect microbiota metabolites through its afferents, transferring this gut information to central system. Preclinical clinical studies have shown important role played by microbiome gut-related factors disease development progression, as well treatment responses. These findings suggest may be valuable target for new therapeutic strategies More are needed better understand underlying biology how axis modulated patient's benefit.

Language: Английский

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Anti-Aging Activity and Modes of Action of Compounds from Natural Food Sources

Biomolecules, Journal Year: 2023, Volume and Issue: 13(11), P. 1600 - 1600

Published: Oct. 31, 2023

Aging is a natural and inescapable phenomenon characterized by progressive deterioration of physiological functions, leading to increased vulnerability chronic diseases death. With economic medical development, the elderly population gradually increasing, which poses great burden society, economy field. Thus, healthy aging has now become common aspiration among people over world. Accumulating evidence indicates that substances can mediate deteriorated processes are highly likely have potential prolong lifespan improve aging-associated diseases. Foods from sources full bioactive compounds, such as polysaccharides, polyphenols, carotenoids, sterols, terpenoids vitamins. These compounds their derivatives been shown be able delay and/or diseases, thereby prolonging lifespan, via regulation various processes. Here, we summarize current understanding anti-aging activities vitamins food sources, modes action in delaying improving This will certainly provide reference for further research on effects sources.

Language: Английский

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How Microbiomes Affect Skin Aging: The Updated Evidence and Current Perspectives

Life, Journal Year: 2022, Volume and Issue: 12(7), P. 936 - 936

Published: June 22, 2022

The skin has a multifactorial aging process, caused by both intrinsic and extrinsic factors. A major theory of involves cellular senescence or apoptosis resulting from oxidative damage as the skin's antioxidant system tends to weaken with age. human microbiota is complex ecosystem that made up microorganisms (bacteria, fungi, viruses). Both gut have essential roles in protection against invading pathogens, mediating inflammatory conditions, modulation immune which involved innate adaptive responses. However, microbiome could be changed during life stage affected various perturbations. An alteration intestinal bacteria results "microbial dysbiosis" associated influence diseases, including aging. interactome novel integration "genome-microbiome-exposome" plays significant role health. Mitigating negative impacts factors influencing should future strategy protect, prevent, delay along preserving healthy conditions. This review summarizes current evidence on how microbiomes affect demonstrates possible interventions, relating microbiomes, modulate health Probiotics-based products are currently available mainly for add-on treatment many dermatologic at this point, there limited clinical studies anti-aging purposes more required evolving concept rise might provide an insight into therapeutic options.

Language: Английский

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