OBM Neurobiology, Journal Year: 2021, Volume and Issue: 6(1)
Published: Dec. 8, 2021
The editors of OBM Neurobiology would like to express their sincere gratitude the following reviewers for assessing manuscripts in 2021.We greatly appreciate contribution expert reviewers, which is crucial journal's editorial process.We aim recognize reviewer contributions through several mechanisms, annual publication names one.
Language: Английский
Molecular Aspects of Medicine, Journal Year: 2023, Volume and Issue: 92, P. 101193 - 101193
Published: June 16, 2023
Glaucoma is a common, complex, multifactorial neurodegenerative disease characterized by progressive dysfunction and then loss of retinal ganglion cells, the output neurons retina. most common cause irreversible blindness affects ∼80 million people worldwide with many more undiagnosed. The major risk factors for glaucoma are genetics, age, elevated intraocular pressure. Current strategies only target pressure management do not directly processes occurring at level cell. Despite to manage pressure, as 40% patients progress in least one eye during their lifetime. As such, neuroprotective that cell these great therapeutic need. This review will cover recent advances from basic biology on-going clinical trials neuroprotection covering degenerative mechanisms, metabolism, insulin signaling, mTOR, axon transport, apoptosis, autophagy, neuroinflammation. With an increased understanding both mechanisms disease, we closer than ever strategy glaucoma.
Language: Английский
Citations
57
Progress in Retinal and Eye Research, Journal Year: 2024, Volume and Issue: 100, P. 101261 - 101261
Published: March 26, 2024
Glaucoma is the leading cause of irreversible blindness globally. The disease causes vision loss due to neurodegeneration retinal ganglion cell (RGC) projection brain through optic nerve. associated with sensitivity intraocular pressure (IOP). Thus, mainstay treatments seek manage IOP, though many patients continue lose vision. To address directly, numerous preclinical studies develop protective or reparative therapies that act independently IOP. These include growth factors, compounds targeting metabolism, anti-inflammatory and antioxidant agents, neuromodulators. Despite success in experimental models, these approaches fail translate into clinical benefits. Several factors contribute this challenge. Firstly, anatomic structure nerve head differs between rodents, nonhuman primates, humans. Additionally, animal models do not replicate complex glaucoma pathophysiology Therefore, enhance translating findings, we propose two approaches. First, thorough evaluation targets multiple including should precede trials. Second, advocate for combination therapy, which involves using agents simultaneously, especially early potentially reversible stages disease. strategies aim increase chances successful neuroprotective treatment glaucoma.
Language: Английский
Citations
16
Frontiers in Cellular Neuroscience, Journal Year: 2023, Volume and Issue: 17
Published: June 9, 2023
Glaucomatous neurodegeneration, a blinding disease affecting millions worldwide, has need for the exploration of new and effective therapies. Previously, glucagon-like peptide-1 receptor (GLP-1R) agonist NLY01 was shown to reduce microglia/macrophage activation, rescuing retinal ganglion cells after IOP elevation in an animal model glaucoma. GLP-1R use is also associated with reduced risk glaucoma patients diabetes. In this study, we demonstrate that several commercially available agonists, administered either systemically or topically, hold protective potential mouse hypertensive Further, resulting neuroprotection likely occurs through same pathways previously NLY01. This work contributes growing body evidence suggesting agonists represent viable therapeutic option
Language: Английский
Citations
14
Frontiers in Endocrinology, Journal Year: 2024, Volume and Issue: 15
Published: June 17, 2024
Insulin resistance (IR) is becoming a worldwide medical and public health challenge as an increasing prevalence of obesity metabolic disorders. Accumulated evidence has demonstrated strong relationship between IR higher incidence several dramatically vision-threatening retinal diseases, including diabetic retinopathy, age-related macular degeneration, glaucoma. In this review, we provide schematic overview the associations certain ocular diseases further explore possible mechanisms. Although exact causes explaining these have not been fully elucidated, underlying mechanisms oxidative stress, chronic low-grade inflammation, endothelial dysfunction vasoconstriction, neurodegenerative impairments may be involved. Given that modifiable risk factor, it important to identify patients at high level with prompt treatment, which decrease developing diseases. Additionally, improving through activation insulin signaling pathways could become potential therapeutic target.
Language: Английский
Citations
5
Neural Regeneration Research, Journal Year: 2022, Volume and Issue: 18(5), P. 1139 - 1139
Published: Oct. 27, 2022
Central insulin resistance, the diminished cellular sensitivity to in brain, has been implicated diabetes mellitus, Alzheimer's disease and other neurological disorders. However, whether how central resistance plays a role eye remains unclear. Here, we performed intracerebroventricular injection of S961, potent specific blocker receptor adult Wistar rats test if leads pathological changes ocular structures. 80 mg S961 was stereotaxically injected into lateral ventricle experimental group twice at 7 days apart, whereas buffer solution sham control group. Blood samples, intraocular pressure, trabecular meshwork morphology, ciliary body markers, retinal optic nerve integrity, whole genome expression patterns were then evaluated. While neither blood glucose nor serum level significantly altered or group, found that but not increased pressure 14 24 after first injection, along with reduced porosity aquaporin 4 meshwork, tumor necrosis factor α body. In retina, cell density decreased ganglion layer upon injection. Fundus photography revealed peripapillary atrophy vascular dysregulation These accompanied by upregulation pro-inflammatory pro-apoptotic genes, downregulation anti-inflammatory, anti-apoptotic, neurotrophic as well genes involved signaling. Optic histology indicated microglial activation glial fibrillary acidic protein, α, 4. Molecular pathway architecture retina three most significant pathways being inflammation/cell stress, signaling, extracellular matrix regulation relevant neurodegeneration. There also multimodal crosstalk between signaling derangement inflammation-related genes. Taken together, our results indicate blocking nervous system can lead dysfunction, elevation, inflammation, activation, apoptosis nerve. Given may neurodegenerative phenotype visual system, targeting hold promise for vision disorders involving
Language: Английский
Citations
16
Translational research, Journal Year: 2024, Volume and Issue: 272, P. 81 - 94
Published: May 29, 2024
Language: Английский
Citations
3
Cellular and Molecular Neurobiology, Journal Year: 2022, Volume and Issue: 43(2), P. 561 - 574
Published: Feb. 28, 2022
Language: Английский
Citations
14
Frontiers in Ophthalmology, Journal Year: 2023, Volume and Issue: 3
Published: Nov. 8, 2023
The Warburg effect, which was first described a century ago, asserts that mitotic tumor cells generate higher quantities of lactate. Intriguingly, even in typical physiological circumstances, postmitotic retinal photoreceptor also produce elevated levels Initially classified as metabolic waste, lactate has since gained recognition significant intracellular signaling mediator and extracellular ligand. This current review endeavors to provide concise overview discourse on the following topics: localization lactate-producing enzymes, functional significance these functions lactate, its impact gene expression photoreceptors cells.
Language: Английский
Citations
7
Clinical and Experimental Ophthalmology, Journal Year: 2024, Volume and Issue: unknown
Published: Oct. 25, 2024
Abstract Background This study aims to assess the risk of drug‐associated glaucoma and track its epidemiological characteristics using real‐world data. Methods Adverse event reports from Food Drug Administration Event Reporting System (FAERS) January 2004 December 2023 were analysed. Disproportionality analysis Bayesian Confidence Propagation Neural Network algorithm used. The classified drugs associated with glaucoma, assessed levels, compared drug‐induced times across different categories. Results Eight hundred five linked in FAERS database. identified 46 significant risk, mainly adrenergic medications (clobetasol propionate, fluocinolone acetonide), antihypertensives (hydrochlorothiazide), insulin (insulin human), anticholinergics (umeclidinium, darifenacin), VEGF inhibitors (brolucizumab, faricimab), psychotropics (topiramate, ziprasidone). top three high‐risk clobetasol umeclidinium, acetonide. shortest observed indacaterol, salmeterol, umeclidinium. Anticholinergic had time among all Females (62.5%) elderly (average age 63.5 ± 16.8 years) predominantly affected. Reports increased over years. Conclusion Preventing is more effective than treatment. Identifying systemic ophthalmic can reduce occurrence risk. Clinical practitioners should be vigilant inform patients these risks.
Language: Английский
Citations
2
Frontiers in Immunology, Journal Year: 2023, Volume and Issue: 14
Published: March 31, 2023
Background Scleritis is a serious inflammatory eye disease that can lead to blindness. The etiology and pathogenesis of scleritis remain unclear, increasing evidence indicates some specific genes proteins are involved. This study aimed identify pivotal drug targets for scleritis, thus providing new directions the treatment this disease. Methods We screened candidate associated with by text-mining PubMed database using Python, assessed their functions DAVID database. Gene Ontology (GO) Kyoto Encyclopedia Genes Genomes (KEGG) analyses were used functional enrichment these proteins. Then, hub identified CytoHubba protein-protein interaction (PPI) network analysis. And serum from patients active healthy subjects validation genes. Finally, DGIdb was predict targeted drugs treating scleritis. Results A total 56 found be linked 65 significantly altered pathways in KEGG analysis (FDR < 0.05). Most top five involved categories “Rheumatoid arthritis,” “Inflammatory bowel disease”, “Type I diabetes mellitus,” “Graft-versus-host disease”. TNF IL6 considered 2 through CytoHubba. Based on our samples, expressed at high levels Five scleritis-targeting among 88 drugs. Conclusions provides key related bioinformatics mediators possible candidates may play an important role diagnosis future, which worthy further experimental clinical study.
Language: Английский
Citations
5