Mitochondrial Oxidative Stress—A Causative Factor and Therapeutic Target in Many Diseases

International Journal of Molecular Sciences, Journal Year: 2021, Volume and Issue: 22(24), P. 13384 - 13384

Published: Dec. 13, 2021

The excessive formation of reactive oxygen species (ROS) and impairment defensive antioxidant systems leads to a condition known as oxidative stress. main source free radicals responsible for stress is mitochondrial respiration. deleterious effects ROS on cellular biomolecules, including DNA, well-known phenomenon that can disrupt function contribute damage death, the subsequent development various disease processes. In this review, we summarize most important findings implicated in wide variety pathologies from Alzheimer (AD) autoimmune type 1 diabetes. This review also discusses attempts affect therapeutic avenue.

Language: Английский

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Amyloid Beta in Aging and Alzheimer’s Disease

International Journal of Molecular Sciences, Journal Year: 2022, Volume and Issue: 23(21), P. 12924 - 12924

Published: Oct. 26, 2022

Alzheimer’s disease (AD), is a progressive neurodegenerative that affects behavior, thinking, learning, and memory in elderly individuals. AD occurs two forms, early onset familial late-onset sporadic; genetic mutations PS1, PS2, APP genes cause AD, combination of lifestyle, environment factors causes the sporadic form disease. However, accelerated progression noticed patients with AD. Disease-causing pathological changes are synaptic damage, mitochondrial structural functional changes, addition to increased production accumulation phosphorylated tau (p-tau), amyloid beta (Aβ) affected brain regions patients. Aβ peptide derived from precursor protein (APP) by proteolytic cleavage gamma secretases. glycoprotein plays significant role maintaining neuronal homeostasis like signaling, development, intracellular transport. reported have both protective toxic effects neurons. The purpose our article summarize recent developments its association synapses, mitochondria, microglia, astrocytes, interaction p-tau. Our also covers therapeutic strategies reduce toxicities discusses reasons for failures therapeutics.

Language: Английский

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Pathogenesis of Alzheimer’s Disease

International Journal of Molecular Sciences, Journal Year: 2022, Volume and Issue: 24(1), P. 107 - 107

Published: Dec. 21, 2022

Alzheimer's disease (AD) is the most common type of dementia, accounting for 60% to 80% all cases [...].

Language: Английский

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PINK1/Parkin-mediated mitophagy in neurodegenerative diseases

Ageing Research Reviews, Journal Year: 2022, Volume and Issue: 84, P. 101817 - 101817

Published: Dec. 9, 2022

Language: Английский

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Mitochondrial dysfunction in aging

Ageing Research Reviews, Journal Year: 2023, Volume and Issue: 88, P. 101955 - 101955

Published: May 15, 2023

Language: Английский

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Deregulated mitochondrial microRNAs in Alzheimer's disease: Focus on synapse and mitochondria

Ageing Research Reviews, Journal Year: 2021, Volume and Issue: 73, P. 101529 - 101529

Published: Nov. 20, 2021

Language: Английский

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Molecular Mechanisms of Neuroinflammation in Aging and Alzheimer’s Disease Progression

International Journal of Molecular Sciences, Journal Year: 2023, Volume and Issue: 24(3), P. 1869 - 1869

Published: Jan. 18, 2023

Aging is the most prominent risk factor for late-onset Alzheimer’s disease. associates with a chronic inflammatory state both in periphery and central nervous system, evidence thereof mechanisms leading to neuroinflammation being discussed. Nonetheless, significantly enhanced by accumulation of amyloid beta accelerates progression disease through various pathways discussed present review. Decades clinical trials targeting 2 abnormal proteins disease, tau, led many failures. As such, via different strategies could prove valuable therapeutic strategy, although much research still needed identify appropriate time window. Active focusing on identifying early biomarkers help translating these novel from bench bedside.

Language: Английский

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Environmental Chemical Exposures and Mitochondrial Dysfunction: a Review of Recent Literature

Current Environmental Health Reports, Journal Year: 2022, Volume and Issue: 9(4), P. 631 - 649

Published: July 28, 2022

Abstract Purpose of Review Mitochondria play various roles that are important for cell function and survival; therefore, significant mitochondrial dysfunction may have chronic consequences extend beyond the cell. already susceptible to damage, which be exacerbated by environmental exposures. Therefore, aim this review is summarize recent literature (2012–2022) looking at effects six ubiquitous classes compounds on in human populations. Recent Findings The suggests there a number biomarkers commonly used identify dysfunction, each with certain advantages limitations. Classes toxicants such as polycyclic aromatic hydrocarbons, air pollutants, heavy metals, endocrine-disrupting compounds, pesticides, nanomaterials can damage mitochondria varied ways, changes mtDNA copy measures oxidative most measured Other include membrane potential, calcium levels, ATP levels. Summary This identifies characterize but emerging biomarkers, cell-free blood cardiolipin provide greater insight into impacts exposures function. using novel approaches addition well-characterized ones create standardized protocols. We identified dearth studies populations exposed chemicals, nanoparticles gap knowledge needs attention.

Language: Английский

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Aging Hallmarks and Progression and Age-Related Diseases: A Landscape View of Research Advancement

ACS Chemical Neuroscience, Journal Year: 2023, Volume and Issue: 15(1), P. 1 - 30

Published: Dec. 14, 2023

Aging is a dynamic, time-dependent process that characterized by gradual accumulation of cell damage. Continual functional decline in the intrinsic ability living organisms to accurately regulate homeostasis leads increased susceptibility and vulnerability diseases. Many efforts have been put forth understand prevent effects aging. Thus, major cellular molecular hallmarks aging identified, their relationships age-related diseases malfunctions explored. Here, we use data from CAS Content Collection analyze publication landscape recent aging-related research. We review advances knowledge delineate trends research advancements on factors attributes across time geography. also current concepts related molecular, cellular, organismic level, age-associated diseases, with attention brain health, as well biochemical processes associated Major outlined, correlations features are hope this will be helpful for apprehending field mechanisms progression, an effort further solve remaining challenges fulfill its potential.

Language: Английский

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Mitochondrial disorders leading to Alzheimer’s disease—perspectives of diagnosis and treatment

GeroScience, Journal Year: 2024, Volume and Issue: 46(3), P. 2977 - 2988

Published: March 8, 2024

Abstract Alzheimer’s disease (AD) is a neurodegenerative disorder and the most common cause of dementia globally. The pathogenesis AD remains still unclear. three main features are extracellular deposits amyloid beta (Aβ) plaque, accumulation abnormal formation hyper-phosphorylated tau protein, neuronal loss. Mitochondrial impairment plays an important role in AD. There problems with decreased activity multiple complexes, disturbed mitochondrial fusion, fission or reactive oxygen species (ROS). Moreover, transport impaired Mouse models many research show disruptions anterograde retrograde transport. Both transportation network have huge impact on synapse loss and, as result, cognitive impairment. One very serious also disruption insulin signaling which impairs Aβ removal. Discovering precise mechanisms leading to enables us find new treatment possibilities. Recent studies indicate positive influence metformin antioxidants such MitoQ, SS-31, SkQ, MitoApo, MitoTEMPO, MitoVitE functioning hence prevent decline. Impairments may be treated division inhibitor-1 ceramide. Graphical (Graphic content via Canva Pro)

Language: Английский

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