Experimental Biology and Medicine,
Journal Year:
2023,
Volume and Issue:
unknown
Published: Nov. 24, 2023
The
gut
microbiota
sit
at
an
important
interface
between
the
host
and
environment,
are
exposed
to
a
multitude
of
nutritive
non-nutritive
substances.
These
critical
maintaining
health,
but
their
supportive
roles
may
be
compromised
in
response
endogenous
compounds.
Numerous
substances
introduced
through
contaminated
foods,
with
three
common
groups
contaminants
being
bisphenols,
phthalates,
mycotoxins.
former
commonly
food
and/or
beverages
packaged
plastic,
while
mycotoxins
contaminate
various
crops
used
feed
livestock
humans
alike.
Each
group
have
been
shown
shift
microbial
communities
following
exposure;
however,
specific
patterns
responses
yet
identified,
little
is
known
about
capacity
metabolize
these
contaminants.
This
review
characterizes
state
existing
research
related
biotransformation
Collectively,
we
highlight
need
identify
consistent,
contaminant-specific
shifts,
whether
community
alterations
result
contaminant
effects
on
or
directly,
extent
by
microbiota,
including
if
transformations
occur
physiologically
relevant
contexts.
International Journal of Environmental Research and Public Health,
Journal Year:
2022,
Volume and Issue:
19(3), P. 1368 - 1368
Published: Jan. 26, 2022
Over
the
last
years,
research
has
focused
on
microbiota
to
establish
a
missing
link
between
neuronal
health
and
intestine
imbalance.
Many
studies
have
considered
as
critical
regulators
of
gut-brain
axis.
The
crosstalk
central
nervous
system
is
mainly
explained
through
three
different
pathways:
neural,
endocrine,
immune
pathways,
intricately
interconnected
with
each
other.
In
day-to-day
life,
human
beings
are
exposed
wide
variety
contaminants
that
affect
our
intestinal
alter
bidirectional
communication
gut
brain,
causing
disorders.
interplay
xenobiotics,
neurotoxicity
still
not
fully
explored,
especially
for
susceptible
populations
such
pregnant
women,
neonates,
developing
children.
Precisely,
early
exposure
can
trigger
neurodevelopmental
toxicity
long-term
diseases.
There
growing
but
limited
specific
mechanisms
microbiota-gut-brain
axis
(MGBA),
making
it
challenging
understand
effect
environmental
pollutants.
this
review,
we
discuss
biological
analyse
role
endocrine-disrupting
chemicals:
Bisphenol
A
(BPA),
Chlorpyrifos
(CPF),
Diethylhexyl
phthalate
(DEHP),
Per-
polyfluoroalkyl
substances
(PFAS)
in
MGBA
perturbations
subsequent
neurotoxicity.
complexity
changing
nature
pose
significant
challenges
future
research.
However,
emerging
in-silico
models
able
interpret
meta-omics
data
promising
option
understanding
processes
help
prevent
Journal of Xenobiotics,
Journal Year:
2023,
Volume and Issue:
13(4), P. 775 - 810
Published: Dec. 5, 2023
Bisphenol
A
(BPA;
4,4′-isopropylidenediphenol)
is
a
well-known
endocrine
disruptor.
Most
human
exposure
to
BPA
occurs
through
the
consumption
of
BPA-contaminated
foods.
Cardiovascular
or
cardiometabolic
diseases
such
as
diabetes,
obesity,
hypertension,
acute
kidney
disease,
chronic
and
heart
failure
are
leading
causes
death
worldwide.
Positive
associations
have
been
reported
between
blood
urinary
levels
cardiovascular
diseases.
also
induces
disorders
dysfunctions
in
tissues
associated
with
these
various
cell
signaling
pathways.
This
review
highlights
literature
elucidating
relationship
potential
mechanisms
underlying
BPA-mediated
vessels,
skeletal
muscle,
adipose
tissue,
liver,
pancreas,
kidney,
that
The Science of The Total Environment,
Journal Year:
2023,
Volume and Issue:
886, P. 163991 - 163991
Published: May 9, 2023
Endocrine
disrupting
chemicals
(EDCs)
can
interfere
with
hormonal
actions
and
have
been
associated
a
higher
incidence
of
metabolic
disorders.
They
affect
numerous
physiological,
biochemical,
endocrinal
activities,
including
reproduction,
metabolism,
immunity,
behavior.
The
purpose
this
review
was
to
elucidate
the
association
EDCs
in
food
gut
microbiota
EDC
exposure
induces
changes
that
lead
microbial
dysbiosis.
Products
by-products
released
by
metabolism
be
taken
up
host.
Changes
composition
production
metabolites
may
major
impact
on
host
metabolism.
Microorganisms,
Journal Year:
2022,
Volume and Issue:
11(1), P. 67 - 67
Published: Dec. 26, 2022
Bisphenol
A
(BPA)
pollution
poses
an
increasingly
serious
problem.
BPA
has
been
detected
in
a
variety
of
environmental
media
and
human
tissues.
Microbial
degradation
is
effective
method
remediation.
However,
also
biotoxic
to
microorganisms.
In
this
study,
Rhodococcus
equi
DSSKP-R-001
(R-001)
was
used
degrade
BPA,
the
effects
on
growth
metabolism,
gene
expression
patterns,
toxicity-resistance
mechanisms
were
analyzed.
The
results
showed
that
R-001
degraded
51.2%
5
mg/L
40
maximum
concentration
tolerated
by
strain
R-001.
Cytochrome
P450
monooxygenase
multicopper
oxidases
played
key
roles
degradation.
toxic
R-001,
exhibiting
nonlinear
inhibitory
metabolism
bacterium.
bacterial
biomass,
total
protein
content,
ATP
content
exhibited
V-shaped
trends
as
increased.
included
downregulation
genes
related
glycolysis/gluconeogenesis,
pentose
phosphate
glyoxylate
dicarboxylate
metabolism.
Genes
involved
aspects
BPA-resistance
response,
such
base
excision
repair,
osmoprotectant
transport,
iron-complex
some
energy
metabolisms,
upregulated
mitigate
loss
associated
with
exposure.
This
study
helped
clarify
biodegradation
toxicity
resistance,
our
provide
theoretical
basis
for
application
treatments.
Microorganisms,
Journal Year:
2023,
Volume and Issue:
11(9), P. 2132 - 2132
Published: Aug. 22, 2023
Bisphenol
A
(BPA),
one
of
the
most
widely
used
plasticizers,
is
an
endocrine-disrupting
chemical
that
released
from
plastic
products.
The
aim
this
study
was
to
screen
and
characterize
bacteria
with
excellent
BPA-degrading
abilities
for
application
in
foods.
BPA
degradation
ability
confirmed
127
129
bacterial
strains
were
isolated
fermented
soybean
Among
strains,
B.
subtilis
P74,
which
showed
highest
performance,
degraded
97.2%
10
mg/L
within
9
h.
This
strain
not
only
a
fairly
stable
performance
(min
>
88.2%)
over
wide
range
temperatures
(30–45
°C)
pH
(5.0–9.0)
but
also
exhibited
63%
against
high
concentrations
(80
mg/L).
metabolites
generated
during
analyzed
using
high-performance
liquid
chromatography–mass
spectrometry,
predicted
pathways
are
tentatively
proposed.
Finally,
fermentation
conducted
confirm
its
applicability
food.
mSystems,
Journal Year:
2024,
Volume and Issue:
9(3)
Published: March 1, 2024
ABSTRACT
Cumulative
xenobiotic
exposure
has
an
environmental
and
human
health
impact
which
is
currently
assessed
under
the
One
Health
approach.
Bisphenol
A
(BPA)
its
potential
link
with
childhood
obesity
that
parallelly
increased
during
last
decades
deserve
special
attention.
It
stands
prenatal
or
early
life
could
trigger
comorbidities
non-communicable
diseases
along
life.
Accumulation
in
nature
of
synthetic
chemicals
supports
“environmental
obesogen”
hypothesis,
such
as
BPA.
This
estrogen-mimicking
shown
endocrine
disruptive
obesogenic
effects
accompanied
by
gut
microbiota
misbalance
not
yet
well
elucidated.
study
aimed
to
investigate
specific
taxa
isolated
selected
direct
BPA
reveal
role
on
overall
children
community
dynamics,
driving
toward
dysbiosis.
total
333
BPA-resistant
species
obtained
through
culturing
after
several
conditions
were
evaluated
for
their
interplay
global
microbial
community.
The
BPA-cultured
biomarkers
showed
a
significant
alpha
diversity.
Specifically,
Clostridium
Romboutsia
positively
associated
promoting
richness
communities,
while
Intestinibacter
,
Escherichia-Shigella
Bifidobacterium
Lactobacillus
negatively
associated.
Microbial
dynamics
networks
analyses
differences
according
groups.
normal-weight
group
exhibited
more
enriched,
structured,
connected
network
compared
overweight
obese
groups,
represent
resilient
substances.
In
this
sense,
subnetwork
analysis
generated
genera
correlation
between
connectivity
diverse
enzymatic
degradation
capacities.
IMPORTANCE
Our
findings
indicate
how
capacity
grow
differentially
represented
within
differential
body
mass
index
groups
these
affected
patterns
diversity
generally
recognized
Community
corroborated
better
connectedness
stability
profiles
BMC Microbiology,
Journal Year:
2025,
Volume and Issue:
25(1)
Published: March 3, 2025
Phage
therapy
is
an
effective
strategy
to
combat
multidrug
resistance
in
bacteria
and
has
been
increasingly
utilized
protect
animals
from
bacterial
infections.
This
study
involved
the
isolation
purification
of
a
novel
myoviruses
phage,
vB_AceP_PAc,
drug-resistant
strain
Aeromonas
caviae.
Genome
sequence
analysis
based
on
nucleotide
sequences
revealed
that
vB_AceP_PAc
shared
significant
similarity
with
genomes
10
other
phages,
highest
coverage
rate
52%
phiA047.
Intraperitoneal
injection
1
×
10⁷
CFU/mL
(100
µL/mouse)
A.
caviae
AC-CY
resulted
diarrhea
mice
three
days
later.
At
this
time,
oral
administration
109
PFU/mL
effectively
alleviated
induced
by
Pseudomonas
aeruginosa
infection
mice.
Furthermore,
PFU/ml
µl/mouse)
healthy
significantly
reduced
inflammatory
cytokine
levels,
increased
tight
junction
molecule
improved
intestinal
barrier
function.
Moreover,
consumption
health
led
increase
abundance
Lactobacillaceae
gut,
while
expression
CD3+CD4+/CD3+CD8+
was
minimally
affected.
Overall,
findings
confirmed
promising
potential
bacteriophage
treating
caused
