Impact of Environmental Pollutants on Gut Microbiome and Mental Health via the Gut–Brain Axis

Microorganisms, Journal Year: 2022, Volume and Issue: 10(7), P. 1457 - 1457

Published: July 19, 2022

Over the last few years, microbiome has emerged as a high-priority research area to discover missing links between brain health and gut dysbiosis. Emerging evidence suggests that commensal is an important regulator of gut–brain axis plays critical role in physiology. Engaging microbiome-generated metabolites such short-chain fatty acids, immune system, enteric nervous endocrine system (including HPA axis), tryptophan metabolism or vagus nerve crucial communication microbes brain. Humans are exposed wide range pollutants everyday life impact our intestinal microbiota manipulate bidirectional brain, resulting predisposition psychiatric neurological disorders. However, interaction xenobiotics, neurotoxicity yet be completely investigated. Although into precise processes microbiota–gut–brain growing rapidly, comprehending implications environmental contaminants remains challenging. In these milieus, we herein discuss how various phthalates, heavy metals, Bisphenol A particulate matter may alter intricate thereby impacting overall mental health.

Language: Английский

---

Neurotoxicities induced by micro/nanoplastics: A review focusing on the risks of neurological diseases

Journal of Hazardous Materials, Journal Year: 2024, Volume and Issue: 469, P. 134054 - 134054

Published: March 15, 2024

Language: Английский

---

Assessing the hepatotoxicity of PFOA, PFOS, and 6:2 Cl-PFESA in black-spotted frogs (Rana nigromaculata) and elucidating potential association with gut microbiota

Environmental Pollution, Journal Year: 2022, Volume and Issue: 312, P. 120029 - 120029

Published: Aug. 28, 2022

Language: Английский

---

Impact of per- and polyfluorinated alkyl substances (PFAS) on the marine environment: Raising awareness, challenges, legislation, and mitigation approaches under the One Health concept

Marine Pollution Bulletin, Journal Year: 2023, Volume and Issue: 194, P. 115309 - 115309

Published: Aug. 15, 2023

Per- and polyfluorinated alkyl substances (PFAS) have long been known for their detrimental effects on the ecosystems living organisms; however long-term impact marine environment is still insufficiently recognized. Based PFAS persistence bioaccumulation in complex food network, adverse will be exacerbated by global processes such as climate change synergies with other pollutants, like microplastics. The range of fluorochemicals currently included umbrella has significantly expanded due to updated OECD definition, raising new concerns about poorly understood dynamics negative ocean wildlife human health. Mitigation challenges approaches, including biodegradation studied materials environmental removal are proposed here, highlighting importance ongoing monitoring bridging research gaps. EU regulations, good practices legal frameworks discussed, emphasis recommendations improving ecosystem management.

Language: Английский

---

Prenatal Exposure to Legacy and Alternative Per- and Polyfluoroalkyl Substances and Neuropsychological Development Trajectories over the First 3 Years of Life

Environmental Science & Technology, Journal Year: 2023, Volume and Issue: 57(9), P. 3746 - 3757

Published: Feb. 17, 2023

The neurotoxic effects of prenatal exposure to per- and polyfluoroalkyl substances (PFAS) on offspring animals are well-documented. However, epidemiological evidence for legacy PFAS is inconclusive, alternative PFAS, it little known. In this investigation, we selected 718 mother–child pairs from the Chinese Maoming Birth Cohort Study measured 17 in third-trimester serum. Neuropsychological developments (communication, gross motor function, fine problem solving ability, personal–social skills) were assessed at 3, 6, 12, 18, 24, 36 months using Ages Stages Questionnaires 3rd edition. Trajectories each subscale classified into persistently low high groups via group-based trajectory modeling. Logistic regression grouped weighted quantile sum fitted assess potential individual their mixtures, respectively. Higher linear PFHxS levels associated with elevated odds trajectories communication (OR = 1.73; 95% CI: 1.12, 2.66) ability 2.11; 1.14, 3.90). Similar findings observed PFOS, 1m-PFOS, PFDA, PFDoDA, PFUnDA, mixture. no association was We provided insights longitudinal links between legacy/alternative neuropsychological development over first 3 years life.

Language: Английский

---

Emerging organic contaminants in drinking water systems: Human intake, emerging health risks, and future research directions

Chemosphere, Journal Year: 2024, Volume and Issue: 356, P. 141699 - 141699

Published: March 28, 2024

Language: Английский

---

Mood and microbes: a comprehensive review of intestinal microbiota’s impact on depression

Frontiers in Psychiatry, Journal Year: 2024, Volume and Issue: 15

Published: Feb. 9, 2024

Depression is considered a multifaceted and intricate mental disorder of growing concern due to its significant impact on global health issues. The human gut microbiota, also known as the “second brain,” has an important role in CNS by regulating it through chemical, immunological, hormonal, neurological processes. Various studies have found bidirectional link between brain gut, emphasizing onset depression therapies. biological molecular processes underlying microbiota are required, association may represent novel study. However, profound insights into stratification diversity still uncommon. This article investigates emerging evidence bacterial relationship brain’s system potential pathogenicity relevance. interplay immune system, nervous neurotransmitter synthesis, neuroplasticity transitions widely studied. consequences stress, dietary fibers, probiotics, prebiotics, antibiotics GB axis being Multiple revealed this led development effective microbiota-based drugs for both prevention treatment. Therefore, results support hypothesis that influences provide promising area research improved knowledge etiology disease future

Language: Английский

---

Transformation fate of bisphenol A in aerobic denitrifying cultures and its coercive mechanism on the nitrogen transformation pathway

Environmental Research, Journal Year: 2025, Volume and Issue: unknown, P. 120816 - 120816

Published: Jan. 1, 2025

Language: Английский

---

Impact of Pesticide Residues on the Gut-Microbiota–Blood–Brain Barrier Axis: A Narrative Review

International Journal of Molecular Sciences, Journal Year: 2023, Volume and Issue: 24(7), P. 6147 - 6147

Published: March 24, 2023

Accumulating evidence indicates that chronic exposure to a low level of pesticides found in diet affects the human gut-microbiota-blood-brain barrier (BBB) axis. This axis describes physiological and bidirectional connection between microbiota, intestinal (IB), BBB. Preclinical observations reported gut microbial alteration induced by pesticides, also known as dysbiosis, condition associated not only with gastrointestinal disorders but diseases affecting other distal organs, such However, interplay IB, BBB is still fully explored. In this review, we first consider similarities/differences these two barriers different pathways link microbiota better understand dialogue bacteria brain. We then discuss effects oral pesticide on gut-microbiota-BBB raise awareness danger exposure, especially during perinatal period (pregnant women offspring).

Language: Английский

---

Prenatal PFAS exposure, gut microbiota dysbiosis, and neurobehavioral development in childhood

Journal of Hazardous Materials, Journal Year: 2024, Volume and Issue: 469, P. 133920 - 133920

Published: March 3, 2024

Language: Английский

---