“The Ameliorative Effect of Interleukin-17A Neutralization on Doxorubicin-Induced Cardiotoxicity by Modulating the NF-κB/NLRP3/Caspase-1/IL-1β Signaling Pathway in Rats” DOI Creative Commons

Mostafa D. Hassen,

Nahla O. Mousa,

Sara M. Radwan

et al.

Inflammation, Journal Year: 2025, Volume and Issue: unknown

Published: March 10, 2025

Doxorubicin (DOX) is used as a chemotherapeutic drug for treating cancer. Nevertheless, it causes damage to the heart by activating inflammatory pathways, resulting in cardiotoxicity. Imbalance cytokine production crucial component that might trigger initiation of processes. Inflammatory cytokines could be targeted therapies against cardiovascular diseases (CVDs). Interleukin-17A (IL-17A) promotes inflammation and stimulates harmful immunological reactions. The objective study was determine efficacy secukinumab (SEC), completely human monoclonal IgG1/κ antibody targets IL-17A, ameliorating DOX-induced cardiotoxicity (DIC). We administered 2.5 mg/kg DOX intraperitoneally male Wistar rats three times week 2 weeks simultaneously 0.9 SEC along with injection duration two weeks. findings indicated induced tissue, significant rise indicators (P < 0.001), well oxidative stress inflammation. DIC may have arisen from DOX's activation Pyrin domain containing 3 (NLRP3) inflammasome nuclear factor kappa beta (NF-κB) pathway. co-administration successfully reversed all abnormalities restoring cardiac functions their baseline levels, decreasing levels mediators such IL-17A interleukin-1β (IL-1β), improving reducing malondialdehyde (MDA) increasing reduced glutathione (GSH). Furthermore, mitigated heightened NF-κB/NLRP3 pathway caused DOX. This shows neutralization can prevent regulating NF-κB/NLRP3/Caspase-1/IL-1β potential therapeutic target CVDs.

Language: Английский

A two-pronged detection of atherosclerosis with a dual-channel fluorescent probe for viscosity and hypochlorous acid DOI
Zhenkai Wang, Shan Wang,

Bingya Wang

et al.

Chemical Engineering Journal, Journal Year: 2023, Volume and Issue: 464, P. 142687 - 142687

Published: March 29, 2023

Language: Английский

Citations

53
Cardiovascular Diseases DOI
Jin Li

Published: Nov. 22, 2024

Citations

21
Berberine: A Review of its Pharmacokinetics Properties and Therapeutic Potentials in Diverse Vascular Diseases DOI Creative Commons

Xiaopeng Ai,

Peiling Yu,

Li‐Xia Peng

et al.

Frontiers in Pharmacology, Journal Year: 2021, Volume and Issue: 12

Published: Nov. 3, 2021

Traditional Chinese medicine plays a significant role in the treatment of various diseases and has attracted increasing attention for clinical applications. Vascular affecting vasculature heart, cerebrovascular disease, atherosclerosis, diabetic complications have compromised quality life affected individuals increase burden on health care services. Berberine, naturally occurring isoquinoline alkaloid form Rhizoma coptidis , is widely used China as folk its antibacterial anti-inflammatory properties. Promisingly, an number studies identified several cellular molecular targets berberine, indicating potential alternative therapeutic strategy vascular diseases, well providing novel evidence that supports berberine to combat diseases. The purpose this review comprehensively systematically describe agent including pharmacological effects, mechanisms, pharmacokinetics. According data published so far, shows remarkable anti-inflammatory, antioxidant, antiapoptotic, antiautophagic activity via regulation multiple signaling pathways, AMP-activated protein kinase (AMPK), nuclear factor κB (NF-κB), mitogen-activated silent information regulator 1 (SIRT-1), hypoxia-inducible 1α (HIF-1α), endothelial growth phosphoinositide 3-kinase (PI3K), B (Akt), janus 2 (JAK-2), Ca 2+ channels, endoplasmic reticulum stress. Moreover, we discuss existing limitations give corresponding measures. In addition, propose some research perspectives challenges, provide solid base from which further can excavate effective drugs monomers.

Language: Английский

Citations

97
Advances in drug delivery to atherosclerosis: Investigating the efficiency of different nanomaterials employed for different type of drugs DOI Creative Commons
B. V. P. Perera, Yuao Wu, Nam‐Trung Nguyen

et al.

Materials Today Bio, Journal Year: 2023, Volume and Issue: 22, P. 100767 - 100767

Published: Aug. 7, 2023

Atherosclerosis is the build-up of fatty deposits in arteries. main underlying cause cardiovascular diseases and leading global morbidity mortality. Current pharmaceutical treatment options are unable to effectively treat plaque later stages disease. Instead, they aimed at resolving risk factors. Nanomaterials nanoparticle-mediated therapies have become increasingly popular for atherosclerosis due their targeted controlled release therapeutics. In this review, we discuss different types therapeutics used disease focus on nanomaterial strategies employed delivery these drugs, enabling effective efficient resolution atherosclerotic plaque. The ideal strategy each drug type (e.g. statins, nucleic acids, small molecule peptides) will be comprehensively discussed.

Language: Английский

Citations

27
VXX-401, a novel anti-PCSK9 vaccine, reduces LDL-C in cynomolgus monkeys DOI Creative Commons
Madeline M. Vroom,

Hanxin Lu,

Maggie Lewis

et al.

Journal of Lipid Research, Journal Year: 2024, Volume and Issue: 65(2), P. 100497 - 100497

Published: Jan. 10, 2024

Atherosclerotic cardiovascular disease (ASCVD) remains the leading cause of burden in world and is highly correlated with chronic elevations low-density lipoprotein cholesterol (LDL-C). LDL-C lowering drugs such as statins or monoclonal antibodies (mAbs) against proprotein convertase subtilisin/kexin type 9 (PCSK9) are known to reduce risk diseases, however associated limited efficacy poor adherence treatment, whereas PCSK9 inhibitors only prescribed a “high risk” patient population those who have failed other therapies. Based on proven safety profile existing antibodies, we developed peptide-based vaccine PCSK9, VXX-401, an alternative option treat hypercholesterolemia prevent ASCVD. VXX-401 designed trigger safe humoral immune response resulting production endogenous subsequent 30 40% reduction blood LDL-C. In this paper, demonstrates robust immunogenicity sustained serum effects non-human primates (NHP). Additionally, induced by bind human high affinity block inhibitory effect uptake hepatic cell model. A repeat-dose toxicity study conducted NHP under good laboratory practices (GLP toxicity) indicated suitable tolerability profile, injection site reactions being main findings. As promising effective therapy, may represent broadly accessible convenient

Language: Английский

Citations

11
Fatal attractions that trigger inflammation and drive atherosclerotic disease DOI Creative Commons
Hitesh Sharma, Karen L. Mossman, Richard C. Austin

et al.

European Journal of Clinical Investigation, Journal Year: 2024, Volume and Issue: 54(5)

Published: Jan. 29, 2024

Abstract Background Atherosclerosis is the salient, underlying cause of cardiovascular diseases, such as arrhythmia, coronary artery disease, cardiomyopathy, pulmonary embolism and myocardial infarction. In recent years, atherosclerosis pathophysiology has evolved from a lipid‐based to an inflammation‐centric ideology. Methods This narrative review comprised original articles that were found through PubMed search engine. The following terms or amalgamation used: “cardiovascular disease,” “atherosclerosis,” “inflammation,” “GRP78,” “Hsp60,” “oxidative low‐density lipoproteins,” “aldehyde dehydrogenase,” “β2‐glycoprotein,” “lipoprotein lipase A,” “human cytomegalovirus.” “SARS‐CoV‐2,” “ chlamydia pneumonia ,” “autophagy,” “thrombosis” “therapeutics.” Results Emerging evidence supports concept associated with interaction between cell surface expression stress response chaperones, including GRP78 Hsp60, their respective autoantibodies. Moreover, various other autoantigens autoantibodies have displayed compelling connection development atherosclerosis, oxidative lipoproteins, aldehyde dehydrogenase, β2‐glycoprotein lipoprotein A. progression also concurrent viral bacterial activators diseases. will focus on contributions human cytomegalovirus well SARS‐CoV‐2 in development. Notably, autoantigen presence foreign antigen can enhance inflammation development, which leads atherosclerotic lesion progression. Conclusion We highlight discuss complex role autoantibodies, antigens lesions relationship pro‐inflammatory responses.

Language: Английский

Citations

9
Plant production systems for recombinant immunotherapeutic proteins DOI

Caiquan Jin,

Peter Hinterdorfer,

Jeong Hwan Lee

et al.

Plant Biotechnology Reports, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 21, 2025

Language: Английский

Citations

1
Inflammation, Oxidative Stress, Senescence in Atherosclerosis: Thioredoxine-1 as an Emerging Therapeutic Target DOI Open Access
Khadija El Hadri,

Rémy Smith,

Eric Duplus

et al.

International Journal of Molecular Sciences, Journal Year: 2021, Volume and Issue: 23(1), P. 77 - 77

Published: Dec. 22, 2021

Atherosclerosis is a leading cause of cardiovascular diseases (CVD) worldwide and intimately linked to aging. This pathology characterized by chronic inflammation, oxidative stress, gradual accumulation low-density lipoproteins (LDL) particles fibrous elements in focal areas large medium arteries. These fibrofatty lesions the artery wall become progressively unstable thrombogenic heart attack, stroke or other severe ischemic syndromes. Elevated blood levels LDL are major triggering events for atherosclerosis. A cascade molecular cellular results atherosclerotic plaque formation, evolution, rupture. Moreover, senescence multiple cell types present vasculature were reported contribute progression destabilization. Classical therapeutic interventions consist lipid-lowering drugs, anti-inflammatory life style dispositions. targeting stress developing innovative antioxidant agents boosting systems also well-established strategy. Accumulation senescent cells (SC) another important feature atherosclerosis was detected various models. Hence, SCs appears as an emerging option, since senolytic favorably disturb plaques. In this review, we propose survey impact atherosclerosis; options, including thioredoxin-based approaches such anti-oxidant, anti-inflammatory, anti-atherogenic strategy with promising potential senomodulation.

Language: Английский

Citations

53
Th17 Cells and IL-17A in Ischemic Stroke DOI Creative Commons
Jingjing Wang,

Yuxiao Gao,

Yujia Yuan

et al.

Molecular Neurobiology, Journal Year: 2023, Volume and Issue: 61(4), P. 2411 - 2429

Published: Oct. 26, 2023

Abstract The neurological injury and repair mechanisms after ischemic stroke are complex. inflammatory response is present throughout onset functional recovery, in which CD4 + T helper(Th) cells play a non-negligible role. Th17 cells, differentiated from Th regulated by various extracellular signals, transcription factors, RNA, post-translational modifications. specifically produce interleukin-17A(IL-17A), has been reported to have pro-inflammatory effects many studies. Recently, experimental researches showed that IL-17A an important role promoting pathogenesis (atherosclerosis), inducing secondary damage stroke, regulating post-stroke repair. This makes possible target for the treatment of stroke. In this paper, we review mechanism action progress research on targeted therapy.

Language: Английский

Citations

17
A bibliometric analysis of vaccination against atherosclerosis DOI Creative Commons
Bochao Jia,

Rui Wei,

Chenlu Yuan

et al.

Human Vaccines & Immunotherapeutics, Journal Year: 2024, Volume and Issue: 20(1)

Published: June 19, 2024

A growing body of research indicates the promising potential vaccines in both preventing and treating atherosclerosis (AS). To gain a comprehensive understanding current landscape emerging trends this field, study conducted bibliometric analysis publications on AS using Web Science Core Collection (WoSCC) database, based "bibliometric" R package VOSviewer software. From 1991 to 2024, total 462 were identified WoSCC. The United States appeared as leading contributor terms citations. Vaccine journal exhibited highest output. Nilsson J from Lund University Sweden was author with most published articles, citations Hirsch index (H-index). Keywords thematic maps revealed passive immunotherapy (AS protective antibodies vaccines) hot mature theme, active antigens an booming while efficacy safety niche well-developed theme. These findings offered valuable insights into vaccination provided guidance for future domain.

Language: Английский

Citations

8