International Journal of Molecular Medicine,
Journal Year:
2025,
Volume and Issue:
55(3)
Published: Jan. 16, 2025
Sepsis
is
often
a
cause
of
mortality
in
patients
admitted
to
the
intensive
care
unit.
Notably,
heart
organ
most
susceptible
impact
sepsis
and
this
condition
referred
as
sepsis‑induced
cardiomyopathy
(SIC).
Low
triiodothyronine
(T3)
syndrome
frequently
occurs
with
sepsis,
one
important
target
organs
for
action
T3.
Phospholamban
(PLN)
key
protein
associated
Ca2+‑pump‑mediated
cardiac
diastolic
function
myocardium
mice
SIC,
PLN
negatively
regulated
by
The
present
study
aimed
explore
whether
T3
can
protect
during
investigate
specific
molecular
mechanism
underlying
regulation
C57BL/6J
H9C2
cells
were
used
establish
vivo
vitro
models,
respectively.
Myocardial
damage
was
detected
via
pathological
tissue
sections,
Cell
Counting
Kit-8
assay,
an
apoptosis
assay
crystal
violet
staining.
Intracellular
calcium
levels
reactive
oxygen
species
Fluo‑4AM
DHE
fluorescence.
mRNA
expression
JNK
c‑Jun
measured
western
blotting
reverse
transcription‑quantitative
PCR
mechanisms
involved.
Subsequently,
100
clinical
recruited
verify
application
value
SIC.
results
revealed
significant
negative
correlation
between
animal
disease
model.
Furthermore,
genes
proteins
JNK/c‑Jun
signaling
pathway
decreased,
whereas
sarcoplasmic
reticulum
ATPase
increased
after
treatment.
These
indicated
that
alleviated
myocardial
injury
SIC
inhibiting
its
phosphorylation,
which
may
be
related
pathway.
Accordingly,
have
diagnostic
Cells,
Journal Year:
2023,
Volume and Issue:
12(6), P. 918 - 918
Published: March 16, 2023
The
most
common
cause
of
acquired
thyroid
dysfunction
is
autoimmune
disease,
which
an
organ-specific
disease
with
two
presentation
phenotypes:
hyperthyroidism
(Graves-Basedow
disease)
and
hypothyroidism
(Hashimoto’s
thyroiditis).
Hashimoto’s
thyroiditis
distinguished
by
the
presence
autoantibodies
against
peroxidase
thyroglobulin.
Meanwhile,
TSH
receptor
have
been
found
in
Graves-Basedow
disease.
Numerous
susceptibility
genes,
as
well
epigenetic
environmental
factors,
contribute
to
pathogenesis
both
diseases.
This
review
summarizes
genetic,
epigenetic,
mechanisms
involved
Journal of Toxicology and Environmental Health Part B,
Journal Year:
2024,
Volume and Issue:
27(4), P. 153 - 187
Published: March 22, 2024
The
widespread
production
and
use
of
plastics
have
resulted
in
accumulation
plastic
debris
the
environment,
gradually
breaking
down
into
smaller
particles
over
time.
Nano-plastics
(NPs)
microplastics
(MPs),
defined
as
than
100
nanometers
5
millimeters,
respectively,
raise
concerns
due
to
their
ability
enter
human
body
through
various
pathways
including
ingestion,
inhalation,
skin
contact.
Various
investigators
demonstrated
that
these
may
produce
physical
chemical
damage
cells,
tissues,
organs,
disrupting
cellular
processes,
triggering
inflammation
oxidative
stress,
impacting
hormone
neurotransmitter
balance.
In
addition,
micro-
nano-plastics
(MNPLs)
carry
toxic
chemicals
pathogens,
exacerbating
adverse
effects
on
health.
magnitude
nature
are
not
yet
fully
understood,
requiring
further
research
for
a
comprehensive
risk
assessment.
Nevertheless,
evidence
available
suggests
environment
potential
uptake
causes
concern.
Urgent
measures
reduce
pollution
limit
exposure
MNPLs
necessary
safeguard
health
environment.
this
review,
current
knowledge
regarding
influence
is
summarized,
toxicity
mechanisms,
pathways,
outcomes
across
multiple
organs.
critical
need
additional
also
emphasized
comprehensively
assess
risks
posed
by
degradation
inform
strategies
addressing
emerging
environmental
challenge.
Finally,
new
directions
proposed
evaluation
gene
regulation
associated
with
exposure.
Bone Reports,
Journal Year:
2024,
Volume and Issue:
20, P. 101750 - 101750
Published: March 1, 2024
Age-associated
osteoporosis
(AAOP)
poses
a
significant
health
burden,
characterized
by
increased
fracture
risk
due
to
declining
bone
mass
and
strength.
Effective
prevention
early
treatment
strategies
are
crucial
mitigate
the
disease
burden
associated
healthcare
costs.
Current
therapeutic
approaches
effectively
target
individual
contributing
factors
AAOP.
Nonetheless,
management
of
AAOP
is
complicated
multitude
variables
that
affect
its
development.
Main
intrinsic
extrinsic
reviewed
here,
including
mechanical
unloading,
nutrient
deficiency,
hormonal
disbalance,
disrupted
metabolism,
cognitive
decline,
inflammation
circadian
disruption.
Furthermore,
it
discussed
how
these
can
be
targeted
for
treatment.
Although
valuable
as
targets
intervention,
interconnectedness
result
in
unique
etiology
every
patient.
Acknowledgement
multifaceted
nature
will
enable
development
more
effective
sustainable
strategies,
based
on
holistic,
patient-centered
approach.
Systematic Reviews,
Journal Year:
2024,
Volume and Issue:
13(1)
Published: April 30, 2024
Abstract
Background
Thyroid
dysfunction
(TD)
and
type
2
diabetes
mellitus
(T2DM)
frequently
co-occur
have
overlapping
pathologies,
their
risk
increases
with
age.
along
T2DM
will
worsen
macro-
microvascular
complications,
morbidity,
mortality.
Methods
The
Preferred
Reporting
Items
for
Systematic
Reviews
Meta-Analyses
statement
guideline
was
followed.
databases
used
were
Embase,
ScienceDirect,
PubMed,
Google
Scholar.
Joana
Briggs
Institute
(JBI)
scale
to
assess
the
quality
of
included
studies.
data
extracted
by
Microsoft
Excel
analyzed
through
STATA
version
14
software.
overall
pooled
prevalence
TD
its
main
components
estimated
using
random-effects
model.
consistency
studies
assessed
I
test
statistics.
Pooled
meta-logistic
regression
present
a
95%
confidence
interval
(CI).
Besides,
subgroup
sensitivity
analyses
employed.
Result
Thirty-eight
included.
20.24%
(95%
CI
:
17.85,
22.64).
subclinical
hypothyroidism,
hyperthyroidism,
hyperthyroidism
found
be
11.87%
6.90,
16.84),
7.75%
5.71,
9.79),
2.49%
0.73,
4.25),
2.51%
1.89,
3.13),
respectively.
Subgroup
analysis
based
on
continent
revealed
higher
in
Asia
Africa.
Factors
like
being
female,
HbA1c
≥
7%,
DM
duration
>
5
years,
family
history
TD,
central
obesity,
smoking,
presence
retinopathy,
neuropathy
associated
TD.
Conclusion
current
systematic
review
meta-analysis
showed
that
TD’s
relatively
than
general
population.
Therefore,
regular
screening
should
done
patients.
Current Nutrition Reports,
Journal Year:
2024,
Volume and Issue:
13(2), P. 194 - 213
Published: March 25, 2024
Abstract
Purpose
of
Review
This
review
aims
to
explore
in-depth
the
different
aspects
association
between
very
low-calorie
ketogenic
diet
(VLCKD),
obesity
and
obesity-related
thyroid
dysfunction.
Recent
Findings
The
VLCKD,
proposed
as
a
non-pharmacological
strategy
for
management
certain
chronic
diseases,
is
becoming
increasingly
popular
worldwide.
Initially
used
treat
epilepsy,
it
has
been
shown
be
effective
in
controlling
body
weight
gain
addressing
various
pathophysiological
conditions.
Research
that
low-calorie,
high-fat
can
affect
hormone
levels.
Weight
loss
also
influence
Studies
have
suggested
long-term
use
VLCKD
refractory
epilepsy
may
related
development
hypothyroidism,
with
an
effect
seen
populations.
In
particular,
women
following
tend
reduced
T3
Summary
We
propose
further
research
unravel
underlying
mechanisms
linking
International Journal of Molecular Sciences,
Journal Year:
2021,
Volume and Issue:
23(1), P. 44 - 44
Published: Dec. 21, 2021
Calciotropic
hormones,
parathyroid
hormone
(PTH)
and
calcitonin
are
involved
in
the
regulation
of
bone
mineral
metabolism
maintenance
calcium
phosphate
homeostasis
body.
Therefore,
an
understanding
environmental
genetic
factors
influencing
PTH
levels
is
crucial.
Genetic
estimated
to
account
for
60%
variations
levels,
while
background
interindividual
has
not
yet
been
studied.
In
this
review,
we
analyzed
literature
discussing
influence
(lifestyle
pollutants)
on
levels.
Among
lifestyle
factors,
smoking,
body
mass
index
(BMI),
diet,
alcohol,
exercise
were
analyzed;
among
pollutants,
heavy
metals
chemicals
analyzed.
Lifestyle
that
showed
clearest
association
with
BMI,
exercise,
micronutrients
taken
from
diet
(vitamin
D
calcium).
Smoking,
vitamin
D,
intake
led
a
decrease
higher
BMI
increase
terms
exposure
cadmium
lead
increased
Several
studies
have
investigated
effect
humans.
Compared
studies,
smaller
number
which
gives
great
variability
results.
Only
few
pollutants
The
factor
relationship
was
smoking
(smokers
had
levels).
Given
importance
maintaining
metabolism,
additional
could
affect
Ecotoxicology and Environmental Safety,
Journal Year:
2022,
Volume and Issue:
233, P. 113345 - 113345
Published: Feb. 23, 2022
Cadmium
(Cd)
is
a
highly
toxic
metal
pollutant
that
can
endanger
the
life
and
health
of
animals.
Toll-like
receptor
4
(TLR4)
result
in
testicular
cell
damage
by
positively
regulating
mitogen-activated
protein
kinase
(MAPK)/nuclear
factor-kappaB
(NF-κB)
signaling
pathway.
Meanwhile,
Testosterone
(T)
synthesis
disorder
affect
sexual
behavior.
However,
harmful
influence
Cd
on
animal
behavior
during
its
growth
development
role
TLR4/MAPK/NF-κB
pathway
testosterone
production
remained
poorly
understood.
Forty-two-day-old
male
piglets
were
fed
with
diets
contained
CdCl2
(20
mg
Cd/kg)
for
40
days
to
explore
effects
The
results
showed
activated
TLR4,
promoted
MAPK
(p-ERK,
p-JNK,
p-p38)/NF-κB
expression,
induced
apoptosis
(Caspase-3,
Cleaved
Caspase3,
Bax,
Cyt-c,
Caspase-9
expression
increased,
but
Bcl-2
decreased)
necroptosis
(MLKL,
RIPK1,
RIPK3
increased)
piglet
testis.
In
addition,
exposure
decreased
mRNA
STAR,
CYP11A1,
3β-HSD,
CYP17A1,
17β-HSD
testis
concentrations
T
thyroid-stimulating
hormone
(TSH).
Both
levels
major
genes
pathway,
increased
significantly
gradually
pig
Leydig
cells
cultured
vitro
after
being
treated
different
Cd.
Moreover,
reduced
(the
parameters
sniffing,
chin
resting,
mounting
piglets.
conclusion,
via
leading
reduction
Frontiers in Endocrinology,
Journal Year:
2023,
Volume and Issue:
14
Published: Aug. 11, 2023
Background
Published
data
on
the
relationship
between
polycystic
ovary
syndrome
(PCOS)
and
thyroid
dysfunction
are
sparse
confusing.
Objective
To
comprehensively
review
available
in
literature
regarding
PCOS
function,
its
abnormalities.
Methods
Nine
main
areas
of
interest
were
identified
analyzed
according
to
evidence:
1)
Evaluation
function
for
diagnosis;
2)
Epidemiology
function/disorders
patients
with
PCOS,
vice
versa;
3)
Experimental
supporting
PCOS;
4)
Effects
features,
5)
Effect
alterations
cardiometabolic
risk
women
6)
abnormalities
reproductive
outcomes
7)
Relationship
function/abnormalities
who
undergoing
fertility
treatment;
8)
treatments
diseases
9)
function.
An
extensive
search
specific
keywords
was
performed
articles
published
from
1970
March
2023
using
PubMed
Web
Science.
Data
reported
a
narrative
fashion.
Results
is
diagnosis
exclusion
which
possible
only
after
excluding
disorders
that
mimic
phenotype,
including
dysfunctions.
However,
tests
cutoff
values
used
this
not
specified.
Many
experimental
clinical
suggest
perturbations
PCOS.
Direct
unequivocal
evidence
effects
features
lacking.
High
thyroid-stimulating
hormone
levels
subclinical
hypothyroidism
may
be
associated
significant
worsening
several
intermediate
endpoints
Thyroid
worsen
outcomes,
especially
treatment.
date,
there
no
demonstrating
efficacy
medications
Lifestyle
modification
changes,
metformin,
vitamin
D
seem
improve
general
population.
Conclusion
closely
related,
their
coexistence
identify
higher
metabolic
risk.
Regular
screening
thyroid-specific
autoantibodies
particularly
before
during
pregnancy,
highly
recommended.
