Current status of immunotherapy for non-small cell lung cancer DOI Creative Commons
Tao Yang, Yilin Xiong, Yufei Zeng

et al.

Frontiers in Pharmacology, Journal Year: 2022, Volume and Issue: 13

Published: Oct. 13, 2022

Nowadays, lung cancer is still the deadliest oncological disease in world. Among them, non-small cell (NSCLC) accounts for 80%∼85% of all cancers, and its 5-year survival rate less than 15%, making situation critical. In past decades, despite some clinical advances conventional treatments, overall NSCLC not optimistic due to unique physiological conditions frequent occurrence tumor escape. recent years, immunotherapy has become a new hot spot research, including antibody therapy therapy, which have been developed utilized one after another, especially immune checkpoint inhibitor (ICI). These approaches effectively improved objective response patients by enhancing capacity body targeting cells more effectively, specific toxic compared with chemotherapy, providing strategies treatment. this paper, we reviewed relevant targets, progress adverse reaction monoclonal antibodies, antibody-drug conjugates, ICI, bispecific T-cell receptor engineered T (TCR-T), Chimeric antigen (CAR-T), also report on their combination from immune-related background provide better treatment prospective.

Language: Английский

Cancer cell plasticity during tumor progression, metastasis and response to therapy DOI
Andrea Pérez-González, Kevin Bévant, Cédric Blanpain

et al.

Nature Cancer, Journal Year: 2023, Volume and Issue: 4(8), P. 1063 - 1082

Published: Aug. 3, 2023

Language: Английский

Citations

143
Molecular, cellular and systemic aspects of epithelial ovarian cancer and its tumor microenvironment DOI Creative Commons
Esther Schoutrop, Lidia Moyano‐Galceran, Stéphanie Lheureux

et al.

Seminars in Cancer Biology, Journal Year: 2022, Volume and Issue: 86, P. 207 - 223

Published: April 5, 2022

Ovarian cancer encompasses a heterogeneous group of malignancies that involve the ovaries, fallopian tubes and peritoneal cavity. Despite major advances made within field cancer, majority patients with ovarian are still being diagnosed at an advanced stage disease due to lack effective screening tools. The overall survival these has, therefore, not substantially improved over past decades. Most undergo debulking surgery treatment chemotherapy, but often micrometastases remain acquire resistance therapy, eventually leading recurrence. Here, we summarize current knowledge in epithelial development metastatic progression. For most common subtypes, focus further on properties functions immunosuppressive tumor microenvironment, including extracellular matrix. Current future modalities discussed finally provide overview different experimental models used develop novel therapies.

Language: Английский

Citations

90
The promising role of tumor-associated macrophages in the treatment of cancer DOI
Hongbin Wang,

Xueying Wang,

Xin Zhang

et al.

Drug Resistance Updates, Journal Year: 2024, Volume and Issue: 73, P. 101041 - 101041

Published: Jan. 3, 2024

Language: Английский

Citations

55
Tumor microenvironment in ovarian cancer peritoneal metastasis DOI Creative Commons
Shuangshuang Mei, Xing Chen, Kai Wang

et al.

Cancer Cell International, Journal Year: 2023, Volume and Issue: 23(1)

Published: Jan. 25, 2023

Abstract Ovarian cancer (OC) is one of the most common gynecological malignancies with high morbidity and mortality. The peritoneum metastatic sites in ovarian cancer, involving large amounts ascites. However, its mechanism unclear. peritoneal microenvironment composed effusion creates favorable conditions for progression metastasis. Here, we reviewed metastasis patterns molecular mechanisms as well major components microenvironment, effusion, immune investigated relationship between

Language: Английский

Citations

46
The CAR macrophage cells, a novel generation of chimeric antigen-based approach against solid tumors DOI Creative Commons
Kaveh Hadiloo,

Siavash Taremi,

Mahmood Heidari

et al.

Biomarker Research, Journal Year: 2023, Volume and Issue: 11(1)

Published: Nov. 28, 2023

Abstract Today, adoptive cell therapy has many successes in cancer therapy, and this subject is brilliant using chimeric antigen receptor T cells. The CAR with its FDA-approved drugs, could treat several types of hematological malignancies thus be very attractive for treating solid cancer. Unfortunately, the cannot functional cancers due to unique features. This treatment method harmful adverse effects that limit their applications, so novel treatments must use new cells like NK cells, NKT macrophage Among these innate features, are more tumor seem a better candidate prior methods. have vital roles microenvironment and, direct effect, can eliminate efficiently. In addition, being part immune system, attended sites. With high infiltration, modulations effective. review investigates last achievements CAR-macrophage future immunotherapy method.

Language: Английский

Citations

45
The role of tumor-associated macrophages in tumor immune evasion DOI Creative Commons

Ruizhe Huang,

Ting Kang, Siyu Chen

et al.

Journal of Cancer Research and Clinical Oncology, Journal Year: 2024, Volume and Issue: 150(5)

Published: May 7, 2024

Abstract Background Tumor growth is closely linked to the activities of various cells in tumor microenvironment (TME), particularly immune cells. During progression, circulating monocytes and macrophages are recruited, altering TME accelerating growth. These adjust their functions response signals from stromal Tumor-associated (TAMs), similar M2 macrophages, key regulators TME. Methods We review origins, characteristics, TAMs within This analysis includes mechanisms through which facilitate evasion promote metastasis. Additionally, we explore potential therapeutic strategies that target TAMs. Results instrumental mediating malignant behaviors. They release cytokines inhibit effector attract additional immunosuppressive primarily T cells, inducing exhaustion directly, influencing activity indirectly cellular interactions, or suppressing checkpoints. directly involved proliferation, angiogenesis, invasion, Summary Developing innovative tumor-targeted therapies immunotherapeutic currently a promising focus oncology. Given pivotal role evasion, several approaches have been devised them. include leveraging epigenetics, metabolic reprogramming, engineering repolarize TAMs, inhibiting recruitment activity, using as drug delivery vehicles. Although some these remain distant clinical application, believe future targeting will offer significant benefits cancer patients.

Language: Английский

Citations

44
Advances in Engineered Macrophages: A New Frontier in Cancer Immunotherapy DOI Creative Commons
Shuaixi Yang, Yuhang Wang,

Jiachi Jia

et al.

Cell Death and Disease, Journal Year: 2024, Volume and Issue: 15(4)

Published: April 1, 2024

Abstract Macrophages, as pivotal cells within the tumour microenvironment, significantly influence impact of and reactions to treatments for solid tumours. The rapid evolution bioengineering technology has revealed vast potential engineered macrophages in immunotherapy, disease diagnosis, tissue engineering. Given this landscape, goal harnessing innovating a novel strategy immunotherapy cannot be overstated. diverse strategies realm cancer encompassing macrophage drug delivery systems, chimeric antigen receptor therapy, synergistic treatment approaches involving bacterial outer membrane vesicles macrophages, are meticulously examined review. These methodologies designed enhance therapeutic efficacy against tumours, particularly those that drug-resistant metastatic. Collectively, these immunotherapies poised supplement refine current paradigms, thus heralding new frontier fight malignant

Language: Английский

Citations

21
Tumor-Associated Macrophages and Ovarian Cancer: Implications for Therapy DOI Open Access
David Schweer, Annabel M. McAtee,

Khaga R. Neupane

et al.

Cancers, Journal Year: 2022, Volume and Issue: 14(9), P. 2220 - 2220

Published: April 29, 2022

The tumor microenvironment (TME) has been implicated to play an important role in the progression of ovarian cancer. One most components TME is associated macrophages (TAMs). Phenotypically, are broadly categorized as M1 pro-inflammatory or M2 anti-inflammatory, based on cytokines and chemokines that they secrete. with phenotype which suppress surrounding immune environment, assist cells evading targeting, support growth metastasis. Contrarily, help mount response against tumors, a more favorable prognosis solid tumors. characteristic indicators poor cancer overrepresentation M2-type TAMs. As such, therapeutic modalities targeting TAMs increasing interest. Pharmacological approaches eliminate TAMs, include decreasing macrophage survival recruitment phagocytosis, have underwhelming. Clinical strategies these subtypes via repolarization antitumoral state deserve attention, may serve new modality for immunotherapy.

Language: Английский

Citations

67
Macrophages and Foam Cells: Brief Overview of Their Role, Linkage, and Targeting Potential in Atherosclerosis DOI Creative Commons
Anastasia V. Poznyak, Nikita G. Nikiforov, А. В. Стародубова

et al.

Biomedicines, Journal Year: 2021, Volume and Issue: 9(9), P. 1221 - 1221

Published: Sept. 14, 2021

Atherosclerosis is still one of the main causes death around globe. This condition leads to various life-threatening cardiovascular complications. However, no effective preventive measures are known apart from lifestyle corrections, and cure has been developed. Despite numerous studies in field atherogenesis, there huge gaps already poor understanding mechanisms that underlie disease. Inflammation lipid metabolism violations undoubtedly key players, but many other factors, such as oxidative stress, endothelial dysfunction, contribute pathogenesis atherosclerosis. overview focusing on role macrophages which at same time a part inflammatory response, also tightly linked foam cell formation, thus taking both crucial for atherogenesis processes. Being essentially involved atherosclerosis development, cells have attracted attention promising target therapeutic approaches.

Language: Английский

Citations

61
Role of macrophages in tumor progression and therapy (Review) DOI Creative Commons
Yi‐Wei Xu, Xiaomin Wang, Lijuan Liu

et al.

International Journal of Oncology, Journal Year: 2022, Volume and Issue: 60(5)

Published: April 1, 2022

The number and phenotype of macrophages are closely related to tumor growth prognosis. Macrophages recruited (and polarized at) the site thereby promoting growth, stimulating angiogenesis, facilitating cell migration, creating a favorable environment for subsequent colonization by survival of) cells. These phenomena contribute formation an immunosuppressive microenvironment (TME) therefore speed up proliferation metastasis reduce efficacy antitumor factors therapies. ability remodel TME through interactions with other cells corresponding changes in their number, activity, during conventional therapies, as well association between these drug resistance, make tumor‑associated new target In this review, advantages limitations existing strategies targeting Traditional Chinese Western medicine were analyzed, starting effect on tumors then role treatments was explored. Possible directions future developments field from all‑around multitarget standpoint also examined.

Language: Английский

Citations

58