Deciphering psychobiotics’ mechanism of action: bacterial extracellular vesicles in the spotlight DOI Creative Commons

Layla Bleibel,

Szymon Dziomba, Krzysztof Waleron

et al.

Frontiers in Microbiology, Journal Year: 2023, Volume and Issue: 14

Published: June 15, 2023

The intake of psychobiotic bacteria appears to be a promising adjunct neuropsychiatric treatment, and their consumption may even beneficial for healthy people in terms mental functioning. psychobiotics’ mechanism action is largely outlined by the gut-brain axis; however, it not fully understood. Based on very recent studies, we provide compelling evidence suggest novel understanding this mechanism: bacterial extracellular vesicles appear mediate many known effects that exert brain. In mini-review paper, characterize derived from demonstrate they can absorbed gastrointestinal tract, penetrate brain, carry intracellular content multidirectional action. Specifically, regulating epigenetic factors, psychobiotics enhance expression neurotrophic molecules, improve serotonergic neurotransmission, likely supply astrocytes with glycolytic enzymes favor neuroprotective mechanisms. As result, some data an antidepressant originate taxonomically remote bacteria. such, these regarded as postbiotics potentially therapeutic application. enriched illustrations better introduce complex nature brain signaling mediated indicates knowledge gaps require scientific exploration before further progress made. conclusion, represent missing piece puzzle psychobiotics.

Language: Английский

Taurine Chloramine-Mediated Nrf2 Activation and HO-1 Induction Confer Protective Effects in Astrocytes DOI Creative Commons

Song-I Seol,

In Soon Kang,

Jiseok Lee

et al.

Antioxidants, Journal Year: 2024, Volume and Issue: 13(2), P. 169 - 169

Published: Jan. 29, 2024

Taurine is ubiquitously distributed in mammalian tissues, with the highest levels brain, heart, and leukocytes. reacts hypochlorous acid (HOCl) to produce taurine chloramine (Tau-Cl) via myeloperoxidase (MPO) system. In this study, we elucidated antioxidative protective effects of Tau-Cl astrocytes. increased expression nuclear translocation factor E2-related (Nrf2) Nrf2-regulated antioxidant genes, including heme oxygenase 1 (HO-1). Nrf2 activity negatively regulated by Kelch-like ECH-associated protein (Keap1). decreased level reduced thiol groups Keap1, resulting disruption Keap1-Nrf2 complex. Consequently, rescued H2O2-induced cell death enhancing HO-1 suppressing reactive oxygen species. conclusion, confers astrocytes disrupting complex, thereby promoting nucleus, wherein it binds response element (ARE) accelerates transcription genes. Therefore, astrocytes, activation Keap1-Nrf2-ARE pathway may increase antioxidants anti-inflammatory mediators as well other cytoprotective proteins, conferring protection against brain infection injury.

Language: Английский

Citations

5
Dysregulated inter-mitochondrial crosstalk in glioblastoma cells revealed by in situ cryo-electron tomography DOI
Rui Wang, Huan Lei, Hongxiang Wang

et al.

Proceedings of the National Academy of Sciences, Journal Year: 2024, Volume and Issue: 121(9)

Published: Feb. 20, 2024

Glioblastomas (GBMs) are the most lethal primary brain tumors with limited survival, even under aggressive treatments. The current therapeutics for GBMs flawed due to failure accurately discriminate between normal proliferating cells and distinctive tumor cells. Mitochondria essential serve as potential therapeutical targets. Here, we utilize cryo-electron tomography quantitatively investigate nanoscale details of randomly sampled mitochondria in their native cellular context GBM Our results show that compared cancer-free cells, own more inter-mitochondrial junctions several types communications. Furthermore, our tomograms unveil microtubule-dependent mitochondrial nanotunnel-like bridges another structure. These quantified features, together other mitochondria-organelle intra-mitochondrial ones, sufficient distinguish from scrutiny predictive modeling. findings decipher high-resolution structural signatures provide clues diagnosis therapeutic interventions mitochondria-related diseases.

Language: Английский

Citations

5
Contribution of senescent and reactive astrocytes on central nervous system inflammaging DOI

Michel López-Teros,

Adriana Alarcón‐Aguilar, Norma Edith López‐Díazguerrero

et al.

Biogerontology, Journal Year: 2022, Volume and Issue: 23(1), P. 21 - 33

Published: Jan. 27, 2022

Language: Английский

Citations

21
The potential role of glucose metabolism, lipid metabolism, and amino acid metabolism in the treatment of Parkinson's disease DOI Creative Commons

Hangzhen Li,

Fancai Zeng,

Cancan Huang

et al.

CNS Neuroscience & Therapeutics, Journal Year: 2023, Volume and Issue: 30(2)

Published: Aug. 14, 2023

Abstract Purpose of Review Parkinson's disease (PD) is a common neurodegenerative disease, which can cause progressive deterioration motor function causing muscle stiffness, tremor, and bradykinesia. In this review, we hope to describe approaches that improve the life PD patients through modifications energy metabolism. Recent Findings The main pathological features are loss nigrostriatal dopaminergic neurons production Lewy bodies. Abnormal aggregation α‐synuclein (α‐Syn) leading formation bodies closely associated with neuronal dysfunction degeneration. causes said be mitochondrial damage, oxidative stress, inflammation, abnormal protein aggregation. Presence metabolism another PD. Many studies have found significant differences between diseases metabolic decompensation, has become biological hallmark diseases. Summary highlight relationship (Glucose metabolism, lipid amino acid metabolism) Improvement key molecules in glucose fat (e.g., glucose‐6‐phosphate dehydrogenase, triglycerides, levodopa) might potentially beneficial Some these indicators may serve well during diagnosis addition, modulation pathways potential target for treatment prevention

Language: Английский

Citations

12
Deciphering psychobiotics’ mechanism of action: bacterial extracellular vesicles in the spotlight DOI Creative Commons

Layla Bleibel,

Szymon Dziomba, Krzysztof Waleron

et al.

Frontiers in Microbiology, Journal Year: 2023, Volume and Issue: 14

Published: June 15, 2023

The intake of psychobiotic bacteria appears to be a promising adjunct neuropsychiatric treatment, and their consumption may even beneficial for healthy people in terms mental functioning. psychobiotics’ mechanism action is largely outlined by the gut-brain axis; however, it not fully understood. Based on very recent studies, we provide compelling evidence suggest novel understanding this mechanism: bacterial extracellular vesicles appear mediate many known effects that exert brain. In mini-review paper, characterize derived from demonstrate they can absorbed gastrointestinal tract, penetrate brain, carry intracellular content multidirectional action. Specifically, regulating epigenetic factors, psychobiotics enhance expression neurotrophic molecules, improve serotonergic neurotransmission, likely supply astrocytes with glycolytic enzymes favor neuroprotective mechanisms. As result, some data an antidepressant originate taxonomically remote bacteria. such, these regarded as postbiotics potentially therapeutic application. enriched illustrations better introduce complex nature brain signaling mediated indicates knowledge gaps require scientific exploration before further progress made. conclusion, represent missing piece puzzle psychobiotics.

Language: Английский

Citations

11