RETRACTED: Liposomes: Structure, Biomedical Applications, and Stability Parameters With Emphasis on Cholesterol

Frontiers in Bioengineering and Biotechnology, Journal Year: 2021, Volume and Issue: 9

Published: Sept. 9, 2021

Liposomes are essentially a subtype of nanoparticles comprising hydrophobic tail and hydrophilic head constituting phospholipid membrane. The spherical or multilayered structures liposomes highly rich in lipid contents with numerous criteria for their classification, including structural features, parameters, size, synthesis methods, preparation, drug loading. Despite various liposomal applications, such as drug, vaccine/gene delivery, biosensors fabrication, diagnosis, food products use encounters many limitations due to physico-chemical instability stability is vigorously affected by the ingredients wherein cholesterol performs vital role It has well established that exerts its impact controlling fluidity, permeability, membrane strength, elasticity stiffness, transition temperature (Tm), retention, packing, plasma stability. Although undetermined optimum amount preparing stable controlled release vehicle been downside, but researchers still focused on promising material necessitating explanation promotion liposomes. Herein, prior art pertaining appliances, especially delivery cancer therapy, emphasizing roles cholesterol.

Language: Английский

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A Recent Review on Cancer Nanomedicine

Cancers, Journal Year: 2023, Volume and Issue: 15(8), P. 2256 - 2256

Published: April 12, 2023

Cancer is one of the most prevalent diseases globally and second major cause death in United States. Despite continuous efforts to understand tumor mechanisms various approaches taken for treatment over decades, no significant improvements have been observed cancer therapy. Lack specificity, dose-related toxicity, low bioavailability, lack stability chemotherapeutics are hindrances treatment. Nanomedicine has drawn attention many researchers due its potential tumor-specific delivery while minimizing unwanted side effects. The application these nanoparticles not limited just therapeutic uses; some them shown extremely promising diagnostic potential. In this review, we describe compare types their role advancing We further highlight nanoformulations currently approved therapy as well under different phases clinical trials. Finally, discuss prospect nanomedicine management.

Language: Английский

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Nanomaterials-Based Wound Dressing for Advanced Management of Infected Wound

Antibiotics, Journal Year: 2023, Volume and Issue: 12(2), P. 351 - 351

Published: Feb. 8, 2023

The effective prevention and treatment of bacterial infections is imperative to wound repair the improvement patient outcomes. In recent years, nanomaterials have been extensively applied in infection control healing due their special physiochemical biological properties. Incorporating antibacterial into dressing has associated with improved biosafety enhanced outcomes compared naked nanomaterials. this review, we discuss progress application nanomaterial-based dressings for advanced management infected wounds. Focus given therapy as well all-in-one detection infections. Notably, highlight use nanoparticles intrinsic performances, such metals metal oxide that are capable killing bacteria reducing drug-resistance through multiple antimicrobial mechanisms. addition, proven be ideal drug carriers delivery release antimicrobials either passive or stimuli-responsive manners. ability kill based on photo-triggered heat (photothermal therapy) ROS (photodynamic therapy), unparalleled advantages control. Moreover, examples intelligent can detect in-situ while providing timely Finally, challenges current provide further perspectives future healing.

Language: Английский

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Unravelling the in vivo dynamics of liposomes: Insights into biodistribution and cellular membrane interactions

Life Sciences, Journal Year: 2024, Volume and Issue: 346, P. 122616 - 122616

Published: April 8, 2024

Language: Английский

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Advancements in the Pharmaceutical Applications of Probiotics: Dosage Forms and Formulation Technology

International Journal of Nanomedicine, Journal Year: 2021, Volume and Issue: Volume 16, P. 7535 - 7556

Published: Nov. 1, 2021

Abstract: Probiotics have demonstrated their high potential to treat and/or prevent various diseases including neurodegenerative disorders, cancers, cardiovascular diseases, and inflammatory diseases. are also effective against multidrug-resistant pathogens help maintain a balanced gut microbiota ecosystem. Accordingly, the global market of probiotics is growing rapidly, research efforts develop into therapeutic adjuvants gaining momentum. However, because living microorganisms, many biological biopharmaceutical barriers limit clinical application. may lose activity in harsh gastric conditions stomach or presence bile salts. Moreover, they easily viability under thermal oxidative stress during preparation storage. Therefore, stable formulations required overcome physicochemical, biopharmaceutical, maximize effectiveness applicability. This review provides an overview pharmaceutical applications covers recent formulation approaches optimize delivery with particular emphasis on dosage forms technologies. Keywords: probiotic, adjuvant, formulation, drug system,

Language: Английский

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Therapeutic gas‐releasing nanomedicines with controlled release: Advances and perspectives

Exploration, Journal Year: 2022, Volume and Issue: 2(5)

Published: May 25, 2022

Nanoparticle-based drug delivery has become one of the most popular approaches for maximising therapeutic potentials. With notable improvements, a greater challenge hinges on formulation gasotransmitters with unique challenges that are not met in liquid and solid active ingredients. Gas molecules upon release from formulations purposes have really been discussed extensively. Herein, we take critical look at four key gasotransmitters, is, carbon monoxide (CO), nitric oxide (NO), hydrogen sulphide (H

Language: Английский

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The Advancement and Obstacles in Improving the Stability of Nanocarriers for Precision Drug Delivery in the Field of Nanomedicine

Current Topics in Medicinal Chemistry, Journal Year: 2024, Volume and Issue: 24(8), P. 686 - 721

Published: Feb. 27, 2024

Nanocarriers have emerged as a promising class of nanoscale materials in the fields drug delivery and biomedical applications. Their unique properties, such high surface area- tovolume ratios enhanced permeability retention effects, enable targeted therapeutic agents to specific tissues or cells. However, inherent instability nanocarriers poses significant challenges their successful application. This review highlights importance nanocarrier stability applications its impact on biocompatibility, delivery, long shelf life, performance, efficacy, reduced side prolonged circulation time, delivery. Enhancing requires careful design, engineering, optimization physical chemical parameters. Various strategies cutting-edge techniques employed improve are explored, with focus By understanding advances stability, this aims contribute development implementation nanocarrier- based therapies clinical settings, advancing field nanomedicine.

Language: Английский

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Liposomes to Cubosomes: The Evolution of Lipidic Nanocarriers and Their Cutting-Edge Biomedical Applications

ACS Applied Bio Materials, Journal Year: 2024, Volume and Issue: 7(5), P. 2677 - 2694

Published: April 13, 2024

Lipidic nanoparticles have undergone extensive research toward the exploration of their diverse therapeutic applications. Although several liposomal formulations are in clinic (e.g., DOXIL) for cancer therapy, there many challenges associated with traditional liposomes. To address these issues, modifications structure and further functionalization desirable, leading to emergence solid lipid more recent liquid nanoparticles. In this context, "cubosomes", third-generation lipidic nanocarriers, attracted significant attention due numerous advantages, including porous structure, structural adaptability, high encapsulation efficiency resulting from internal surface area, enhanced stability, biocompatibility. Cubosomes offer potential both cellular uptake controlled release encapsulated payloads. Beyond cubosomes demonstrated effectiveness wound healing, antibacterial treatments, various dermatological review, authors provide an overview evolution spanning conventional liposomes nanoparticles, a special emphasis on development application cubosomes. Additionally, it delves into applications preclinical trials cubosome formulations, which could be interest readers backgrounds nanomedicine clinicians.

Language: Английский

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Advancements in Nanomedicine for the Diagnosis and Treatment of Kidney Stones

International Journal of Nanomedicine, Journal Year: 2025, Volume and Issue: Volume 20, P. 1401 - 1423

Published: Feb. 1, 2025

Abstract: Kidney stones constitute a common condition impacting the urinary system. In clinical diagnosis and management, traditional surgical interventions pharmacological treatments are primarily utilized; however, these methods possess inherent limitations. Presently, field of nanomedicine is undergoing significant advancements. The application nanomaterials in biosensors enables accurate assessment ion composition. Furthermore, contrast agents developed from materials can improve signal-to-noise ratio enhance image clarity. By mitigating oxidative stress-induced cellular damage, inhibit formation kidney efficacy drug delivery as effective carriers. Additionally, by modifying physical chemical properties bacteria, effectively eliminate bacterial presence, thereby preventing severe complications. This review explores advancements technology related to early detection risk factors, diagnosis, treatment their associated Keywords: nanomaterials, stones, stress, biomaterial

Language: Английский

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Self-Assembling Drug Formulations with Tunable Permeability and Biodegradability

Molecules, Journal Year: 2021, Volume and Issue: 26(22), P. 6786 - 6786

Published: Nov. 10, 2021

This review focuses on key topics in the field of drug delivery related to design nanocarriers answering biomedicine criteria, including biocompatibility, biodegradability, low toxicity, and ability overcome biological barriers. For these reasons, much attention is paid amphiphile-based carriers composed natural building blocks, lipids, their structural analogues synthetic surfactants that are capable self-assembly with formation a variety supramolecular aggregates. The latter dynamic structures can be used as nanocontainers for hydrophobic drugs increase solubility bioavailability. In this section, biodegradable cationic bearing cleavable fragments discussed, ester- carbamate-containing analogs, well amino acid derivatives received special attention. Drug through barriers challenging task, which highlighted by example transdermal method administration. paper, nonionic primarily application fabrication nanocarriers, surfactant-skin interactions, mechanisms modulating permeability, factors controlling encapsulation, release, targeted delivery. Different types covered, niosomes, transfersomes, invasomes chitosomes, morphological specificity, beneficial characteristics limitations discussed.

Language: Английский

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