Liposomes: structure, composition, types, and clinical applications

Heliyon, Journal Year: 2022, Volume and Issue: 8(5), P. e09394 - e09394

Published: May 1, 2022

Liposomes are now considered the most commonly used nanocarriers for various potentially active hydrophobic and hydrophilic molecules due to their high biocompatibility, biodegradability, low immunogenicity. also proved enhance drug solubility controlled distribution, as well capacity surface modifications targeted, prolonged, sustained release. Based on composition, liposomes can be have evolved from conventional, long-circulating, immune-liposomes stimuli-responsive actively targeted liposomes. Many liposomal-based delivery systems currently clinically approved treat several diseases, such cancer, fungal viral infections; more reached advanced phases in clinical trials. This review describes structure, preparation methods, applications.

Language: Английский

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Methods of Liposomes Preparation: Formation and Control Factors of Versatile Nanocarriers for Biomedical and Nanomedicine Application

Pharmaceutics, Journal Year: 2022, Volume and Issue: 14(3), P. 543 - 543

Published: Feb. 28, 2022

Liposomes are nano-sized spherical vesicles composed of an aqueous core surrounded by one (or more) phospholipid bilayer shells. Owing to their high biocompatibility, chemical composition variability, and ease preparation, as well large variety structural properties, liposomes have been employed in a nanomedicine biomedical applications, including nanocarriers for drug delivery, nutraceutical fields, immunoassays, clinical diagnostics, tissue engineering, theranostics formulations. Particularly important is the role drug-delivery they improve performance encapsulated drugs, reducing side effects toxicity enhancing its vitro- vivo-controlled delivery activity. These applications stimulated great effort scale-up formation processes view suitable industrial development. Despite improvements conventional approaches development novel routes liposome intrinsic sensitivity mechanical actions responsible some critical issues connected with limited colloidal stability reduced entrapment efficiency cargo molecules. This article analyzes main features fabrication techniques nanocarriers, special focus on structure, parameters, factors that influence stable formulation. Recent developments new methods preparation also discussed, objective updating reader providing future directions research

Language: Английский

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Liposomes for Tumor Targeted Therapy: A Review

International Journal of Molecular Sciences, Journal Year: 2023, Volume and Issue: 24(3), P. 2643 - 2643

Published: Jan. 31, 2023

Liposomes, the most widely studied nano-drug carriers in drug delivery, are sphere-shaped vesicles consisting of one or more phospholipid bilayers. Compared with traditional delivery systems, liposomes exhibit prominent properties that include targeted high biocompatibility, biodegradability, easy functionalization, low toxicity, improvements sustained release it carries and improved therapeutic indices. In wake rapid development nanotechnology, studies liposome composition have become increasingly extensive. The molecular diversity composition, which includes long-circulating PEGylated liposomes, ligand-functionalized stimuli-responsive advanced cell membrane-coated biomimetic nanocarriers, endows their unique physiological functions. This review describes types preparation methods discusses targeting strategies cancer therapy.

Language: Английский

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Quality by Design-Driven Zeta Potential Optimisation Study of Liposomes with Charge Imparting Membrane Additives

Pharmaceutics, Journal Year: 2022, Volume and Issue: 14(9), P. 1798 - 1798

Published: Aug. 26, 2022

Liposomal formulations, as versatile nanocarrier systems suitable for targeted delivery, have a highly focused role in the therapy development of unmet clinical needs and diagnostic imaging techniques. Formulating nanomedicine with zeta potential is an essential but challenging task. Formulations minimum ±30 mV are considered stable. The charge phospholipid bilayer can be adjusted membrane additives. present Quality by Design-derived study aimed to optimise liposomal formulations prepared via thin-film hydration technique applying stearylamine (SA) or dicetyl phosphate (DCP) imparting agents. This 3

Language: Английский

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Where Is Nano Today and Where Is It Headed? A Review of Nanomedicine and the Dilemma of Nanotoxicology

ACS Nano, Journal Year: 2022, Volume and Issue: 16(7), P. 9994 - 10041

Published: June 22, 2022

Worldwide nanotechnology development and application have fueled many scientific advances, but technophilic expectations technophobic demands must be counterbalanced in parallel. Some of the burning issues today are following: (1) Where is nano today? (2) How good communication investment networks between academia/research governments? (3) Is there any spotlight for nanotechnology? Nanomedicine a particular arm within healthcare landscape, focused on diagnosis, treatment, monitoring emerging (such as coronavirus disease 2019, COVID-19) contemporary (including diabetes, cardiovascular diseases, neurodegenerative disorders, cancer) diseases. However, it may only represent bright side coin. In fact, recent past, concept nanotoxicology has emerged to address dark shadows nanomedicine. The nanomedicine field requires more nanotoxicological studies identify undesirable effects guarantee safety. Here, we provide an overall perspective central pieces giant puzzle nanotechnology. First, impact education research highlighted, followed by market trends output tendencies. next section, dilemma addressed through interplay silico, vitro, vivo models with support omics microfluidic approaches. Lastly, reflection regulatory clinical trials provided. Finally, some conclusions future perspectives proposed clearer safer translation nanomedicines from bench bedside.

Language: Английский

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Nanomedicine-based commercial formulations: current developments and future prospects

Journal of Pharmaceutical Investigation, Journal Year: 2022, Volume and Issue: 53(1), P. 19 - 33

Published: Dec. 19, 2022

Language: Английский

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Functional ligands for improving anticancer drug therapy: current status and applications to drug delivery systems

Drug Delivery, Journal Year: 2022, Volume and Issue: 29(1), P. 1959 - 1970

Published: June 28, 2022

Conventional chemotherapy lacking target selectivity often leads to severe side effects, limiting the effectiveness of chemotherapy. Therefore, drug delivery systems ensuring both selective release and efficient intracellular uptake at sites are highly demanded in improve quality life patients with low toxicity. One effective approaches for tumor-selective is adoption functional ligands that can interact specific receptors overexpressed malignant cancer cells. Various including folic acid, hyaluronic transferrin, peptides, antibodies, have been extensively explored develop systems. Furthermore, cell-penetrating peptides or tight junction opening also actively pursued trafficking anticancer drugs. Sometimes, multiple different roles used combination enhance cellular as well In this review, current status various applicable overviewed a focus on their roles, characteristics, preclinical/clinical applications.

Language: Английский

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Cancer nanomedicine: a review of nano-therapeutics and challenges ahead

RSC Advances, Journal Year: 2023, Volume and Issue: 13(13), P. 8606 - 8629

Published: Jan. 1, 2023

Cancer is known as the most dangerous disease in world terms of mortality and lack effective treatment. Research on cancer treatment still active great social importance. Since 1930, chemotherapeutics have been used to treat cancer. However, such conventional treatments are associated with pain, side effects, a targeting. Nanomedicines an emerging alternative due their targeting, bioavailability, low toxicity. Nanoparticles target cells via passive mechanisms. FDA approval for Doxil®, several nano-therapeutics developed, few received use Along liposomes, solid lipid nanoparticles, polymeric nanoemulsions, even newer techniques involving extracellular vesicles (EVs) thermal nanomaterials now being researched implemented practice. This review highlights evolution current status therapy, focus clinical/pre-clinical nanomedicine studies. Insight also provided into prospects this regard.

Language: Английский

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Beneath the Skin: A Review of Current Trends and Future Prospects of Transdermal Drug Delivery Systems

Pharmaceutics, Journal Year: 2022, Volume and Issue: 14(6), P. 1152 - 1152

Published: May 28, 2022

The ideal drug delivery system has a bioavailability comparable to parenteral dosage forms but is as convenient and easy use for the patient oral solid forms. In recent years, there been increased interest in transdermal (TDD) non-invasive approach that generally regarded being administer more vulnerable age groups, such paediatric geriatric patients, while avoiding certain concerns arise from due poor absorbability metabolism concerns. However, despite its many merits, TDD remains restricted select few drugs. physiology of skin poses barrier against feasible drugs, limiting applicability only those drugs possess physicochemical properties allowing them be successfully delivered transdermally. Several techniques have developed enhance permeability Both chemical (e.g., thermal mechanical) passive (vesicle, nanoparticle, nanoemulsion, dispersion, nanocrystal) investigated substances across skin. Furthermore, hybrid approaches combining penetration enhancement technologies with physical are intensively researched improve permeation substances. This review aims summarize trends discuss merits drawbacks various chemical, physical, currently improving

Language: Английский

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Anti-rheumatoid drugs advancements: New insights into the molecular treatment of rheumatoid arthritis

Biomedicine & Pharmacotherapy, Journal Year: 2022, Volume and Issue: 151, P. 113126 - 113126

Published: May 26, 2022

Rheumatoid arthritis (RA) is one of more than 100 types arthritis. This chronic autoimmune disorder affects the lining synovial joints in about 0.5% people and may induce severe deformity disability. RA impacts health life from all sexes ages with prevalence elderly women people. Significant improvement has been noted last two decades revealing mechanisms development RA, early diagnosis new treatment options. Non-steroidal anti-inflammatory drugs (NSAIDs), corticosteroids, disease-modifying antirheumatic (DMARDs) remain most known treatments used against RA. However, not patients respond well to these therefore, solutions are immense need improve disease outcomes. In present review, we discuss highlight recent findings concerning different classes therapies including conventional modern drug therapies, as emerging options phyto-cannabinoid cell- RNA-based therapies. A better understanding their pathways might help find a specific target inflammation, cartilage damage, reduce side effects

Language: Английский

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