Free radical as a double-edged sword in disease: Deriving strategic opportunities for nanotherapeutics

Coordination Chemistry Reviews, Journal Year: 2022, Volume and Issue: 475, P. 214875 - 214875

Published: Oct. 14, 2022

Language: Английский

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H₂S‐Releasing Versatile Montmorillonite Nanoformulation Trilogically Renovates the Gut Microenvironment for Inflammatory Bowel Disease Modulation

Advanced Science, Journal Year: 2024, Volume and Issue: 11(14)

Published: Feb. 2, 2024

Abstract Abnormal activation of the intestinal mucosal immune system, resulting from damage to barrier and extensive invasion by pathogens, contributes pathogenesis inflammatory bowel disease (IBD). Current first‐line treatments for IBD have limited efficacy significant side effects. An innovative H 2 S‐releasing montmorillonite nanoformulation (DPs@MMT) capable remodeling homeostasis, repairing barrier, modulating gut microbiota is developed electrostatically adsorbing diallyl trisulfide‐loaded peptide dendrimer nanogels (DATS@PDNs, abbreviated as DPs) onto (MMT) surface. Upon rectal administration, DPs@MMT specifically binds covers damaged mucosa, promoting accumulation subsequent internalization DPs activated cells in site. release S intracellularly response glutathione, initiating multiple therapeutic In vitro vivo studies shown that effectively alleviates colitis eliminating reactive oxygen species (ROS), inhibiting inflammation, eradicating pathogens. RNA sequencing revealed exerts immunoregulatory repair effects, activating pathways such Nrf2/HO‐1, PI3K‐AKT, RAS/MAPK/AP‐1, p38/ERK MAPK, p65 NF‐κB, JAK‐STAT3 pathways, well glycolysis. 16S rRNA demonstrated remodels pathogens increasing probiotics. This study develops a promising management.

Language: Английский

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Emerging nitric oxide gas‐assisted cancer photothermal treatment

Exploration, Journal Year: 2024, Volume and Issue: 4(6)

Published: March 24, 2024

Abstract Photothermal therapy (PTT) has garnered significant attention in recent years, but the standalone application of PTT still faces limitations that hinder its ability to achieve optimal therapeutic outcomes. Nitric oxide (NO), being one most extensively studied gaseous molecules, presents itself as a promising complementary candidate for PTT. In response, various nanosystems have been developed enable simultaneous utilization and NO‐mediated gas (GT), with integration photothermal agents (PTAs) thermally‐sensitive NO donors prevailing approach. This combination seeks leverage synergistic effects GT while mitigating potential risks associated toxicity through use single laser irradiation. Furthermore, additional internal or external stimuli employed trigger release when combined different types PTAs, thereby further enhancing efficacy. comprehensive review aims summarize advancements gas‐assisted cancer treatment. It commences by providing an overview precursors, including those sensitive photothermal, light, ultrasound, reactive oxygen species, glutathione. These precursors are discussed context dual‐modal PTT/GT. Subsequently, incorporation other treatment modalities such chemotherapy (CHT), photodynamic (PDT), alkyl radical therapy, radiation immunotherapy (IT) creation triple‐modal nanoplatforms is presented. The explores tetra‐modal therapies, PTT/GT/CHT/PDT, PTT/GT/CHT/chemodynamic (CDT), PTT/GT/PDT/IT, PTT/GT/starvation (ST)/IT, PTT/GT/Ca 2+ overload/IT, PTT/GT/ferroptosis (FT)/IT, PTT/GT/CDT/IT. Finally, challenges future perspectives concerning these novel paradigms discussed. anticipated serve valuable resource studies focused on development innovative photothermal/NO‐based nanotheranostics.

Language: Английский

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Ultrasound-driven radical chain reaction and immunoregulation of piezoelectric-based hybrid coating for treating implant infection

Biomaterials, Journal Year: 2024, Volume and Issue: 307, P. 122532 - 122532

Published: March 14, 2024

Language: Английский

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Therapeutic gas‐releasing nanomedicines with controlled release: Advances and perspectives

Exploration, Journal Year: 2022, Volume and Issue: 2(5)

Published: May 25, 2022

Nanoparticle-based drug delivery has become one of the most popular approaches for maximising therapeutic potentials. With notable improvements, a greater challenge hinges on formulation gasotransmitters with unique challenges that are not met in liquid and solid active ingredients. Gas molecules upon release from formulations purposes have really been discussed extensively. Herein, we take critical look at four key gasotransmitters, is, carbon monoxide (CO), nitric oxide (NO), hydrogen sulphide (H

Language: Английский

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Self‐Powered, Implantable, and Wirelessly Controlled NO Generation System for Intracranial Neuroglioma Therapy

Advanced Materials, Journal Year: 2022, Volume and Issue: 34(50)

Published: Oct. 3, 2022

Gas therapy is an emerging technology for improving cancer with high efficiency and low side effects. However, due to the existence of gatekeeper blood-brain barrier (BBB) limited availability current drug delivery systems, there still have been no reports on gas intracranial neuroglioma. Herein, integrated, self-powered, wirelessly controlled gas-therapy system reported, which composed a self-powered triboelectric nanogenerator (TENG) implantable nitric oxide (NO) releasing device neuroglioma therapy. In system, patient self-driven TENG converts mechanical energy body movements into electricity as sustainable self-controlled power source. When delivering light light-emitting diode in NO via wireless control, encapsulated donor s-nitrosoglutathione (GSNO) can generate locally kill glioma cells. The efficacy proof-of-concept subcutaneous 4T1 breast model mice glioblastoma multiforme rats verified. This has great potential be effective adjuvant treatment modality inhibit tumor growth, relapse, invasion teletherapy.

Language: Английский

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Self-supply of H2O2 and O2 by a composite nanogenerator for chemodynamic therapy/hypoxia improvement and rapid therapy of biofilm-infected wounds

Chemical Engineering Journal, Journal Year: 2023, Volume and Issue: 459, P. 141507 - 141507

Published: Jan. 18, 2023

Language: Английский

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Elimination of methicillin-resistant Staphylococcus aureus biofilms on titanium implants via photothermally-triggered nitric oxide and immunotherapy for enhanced osseointegration

Military Medical Research, Journal Year: 2023, Volume and Issue: 10(1)

Published: May 4, 2023

Treatment of methicillin-resistant Staphylococcus aureus (MRSA) biofilm infections in implant placement surgery is limited by the lack antimicrobial activity titanium (Ti) implants. There a need to explore more effective approaches for treatment MRSA infections.Herein, an interfacial functionalization strategy proposed integration mesoporous polydopamine nanoparticles (PDA), nitric oxide (NO) release donor sodium nitroprusside (SNP) and osteogenic growth peptide (OGP) onto Ti implants, denoted as Ti-PDA@SNP-OGP. The physical chemical properties Ti-PDA@SNP-OGP were assessed scanning electron microscopy, X-ray photoelectron spectroscope, water contact angle, photothermal property NO behavior. synergistic antibacterial effect elimination biofilms evaluated 2',7'-dichlorofluorescein diacetate probe, 1-N-phenylnaphthylamine assay, adenosine triphosphate intensity, o-nitrophenyl-β-D-galactopyranoside hydrolysis activity, bicinchoninic acid leakage. Fluorescence staining, assays alkaline phosphatase collagen secretion extracellular matrix mineralization, quantitative real‑time reverse transcription‑polymerase chain reaction, enzyme-linked immunosorbent assay (ELISA) used evaluate inflammatory response ability bone marrow stromal cells (MSCs), RAW264.7 their co-culture system. Giemsa ELISA, micro-CT, hematoxylin eosin, Masson's trichrome immunohistochemistry staining eradication biofilms, inhibition response, promotion osseointegration vivo.Ti-PDA@SNP-OGP displayed NO-dependent against following near-infrared light irradiation, effectively eliminated formed inducing reactive oxygen species (ROS)-mediated oxidative stress, destroying bacterial membrane integrity causing leakage intracellular components (P < 0.01). In vitro experiments revealed that not only facilitated differentiation MSCs, but also promoted polarization pro-inflammatory M1 macrophages anti-inflammatory M2-phenotype 0.05 or P favorable osteo-immune microenvironment further osteogenesis MSCs anti-inflammation via multiple paracrine signaling pathways vivo evaluation confirmed aforementioned results induced ameliorative MRSA-infected femoral defect implantation model 0.01).These findings suggest promising multi-functional material high-efficient replacement surgeries.

Language: Английский

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Environment-triggered nanoagent with programmed gas release performance for accelerating diabetic infected wound healing

Chemical Engineering Journal, Journal Year: 2023, Volume and Issue: 479, P. 147645 - 147645

Published: Nov. 24, 2023

Language: Английский

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Gas-assisted phototherapy for cancer treatment

Journal of Controlled Release, Journal Year: 2023, Volume and Issue: 360, P. 564 - 577

Published: July 14, 2023

Language: Английский

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