The relationship between non-HDL-C/HDL-C ratio and bone mineral density: an NHANES study DOI Creative Commons
Shuo Qi, Biao Peng,

Zhanwang Xu

et al.

Frontiers in Nutrition, Journal Year: 2025, Volume and Issue: 11

Published: Jan. 7, 2025

The non-high-density lipoprotein cholesterol to high-density ratio (NHHR) is a newly developed lipid parameter. However, the current research has only explored relationship with lumbar spine bone mineral density, lacking studies on density at other sites, total body and an analysis of risk factors. This study aims determine potential association between NHHR BMD, increase awareness impact levels health. By utilizing data from National Health Nutrition Examination Survey (NHANES) 2011 2018, we conducted univariate generalized linear models (GLMs) analysis, stratified threshold effect smooth curve fitting investigate BMD. were categorized into tertiles (low, medium, high) based their distribution among population. included 8,671participants, have shown, exhibits correlation (BMD). In BMI subgroup, significantly negatively correlated BMD multiple sites in low-to-middle group (BMI <25 kg/m2), while no significant found high ≥30 kg/m2). gender more pronounced male mainly reflected reduction age negative strongest younger (18-30 years), gradually weakening middle-aged (31-44 years) older groups (45-59 years). Further suggests that dyslipidemia may influence metabolism through pathways such as inflammation oxidative stress. (BMD) varies by BMI, gender, age. controlling be intervention target for health management, particularly individuals males, populations. These findings offer new perspective provide scientific evidence development personalized osteoporosis prevention treatment strategies.

Language: Английский

Current Status of the Diagnosis and Management of Osteoporosis DOI Open Access
Agustín Aibar‐Almazán, Ana Voltes-Martínez, Yolanda Castellote‐Caballero

et al.

International Journal of Molecular Sciences, Journal Year: 2022, Volume and Issue: 23(16), P. 9465 - 9465

Published: Aug. 21, 2022

Osteoporosis has been defined as the silent disease of 21st century, becoming a public health risk due to its severity, chronicity and progression affecting mainly postmenopausal women older adults. is characterized by an imbalance between bone resorption production. It diagnosed through different methods such densitometry dual X-rays. The treatment this pathology focuses on aspects. On one hand, pharmacological treatments are use anti-resorptive drugs, well emerging regenerative medicine cell therapies bioactive hydrogels. other non-pharmacological associated with lifestyle habits that should be incorporated, physical activity, diet cessation harmful high consumption alcohol or smoking. This review seeks provide overview theoretical basis in relation biology, existing for diagnosis osteoporosis, including development new strategies.

Language: Английский

Citations

227
Exercise and Nutrition Impact on Osteoporosis and Sarcopenia—The Incidence of Osteosarcopenia: A Narrative Review DOI Open Access
Sousana Κ. Papadopoulou, Konstantinos Papadimitriou, Gavriela Voulgaridou

et al.

Nutrients, Journal Year: 2021, Volume and Issue: 13(12), P. 4499 - 4499

Published: Dec. 16, 2021

Osteoporosis and sarcopenia are diseases which affect the myoskeletal system often occur in older adults. They characterized by low bone density loss of muscle mass strength, factors reduce quality life mobility. Recently, apart from pharmaceutical interventions, many studies have focused on non-pharmaceutical approaches for prevention osteoporosis with exercise nutrition to being most important well studied those. The purpose current narrative review is describe role adults define incidence osteosarcopenia. Most publications were included this show that resistance endurance exercises prevent development sarcopenia. Furthermore, protein vitamin D intake, as a healthy diet, present protective against above diseases. However, scientific data not sufficient reaching solid conclusions. Although roles seem been largely evaluated literature over recent years, conducted high heterogeneity small sample sizes. Therefore, they cannot reach final In addition, osteosarcopenia seems be caused effects elderly. Larger meta-analyses randomized controlled trials needed designed based strict inclusion criteria, order exact

Language: Английский

Citations

138
Inflammation and Bone Metabolism in Rheumatoid Arthritis: Molecular Mechanisms of Joint Destruction and Pharmacological Treatments DOI Open Access

Kazuhiro Maeda,

Ken Yoshida,

Tetsuro Nishizawa

et al.

International Journal of Molecular Sciences, Journal Year: 2022, Volume and Issue: 23(5), P. 2871 - 2871

Published: March 6, 2022

Rheumatoid arthritis (RA) is an inflammatory disease characterized by a variety of symptoms and pathologies often presenting with polyarthritis. The primary symptom in the initial stage joint swelling due to synovitis. With progression, cartilage bone are affected cause deformities. Advanced osteoarticular destruction deformation can irreversible physical disabilities. Physical disabilities not only deteriorate patients’ quality life but also have substantial medical economic effects on society. Therefore, prevention progression important task. Recent studies progressively improved our understanding molecular mechanism which synovitis caused immune disorders results activation osteoclasts; activated osteoclasts turn para-articular osteoporosis. In this paper, we review mechanisms metabolism under physiological RA conditions, describe therapeutic intervention against bone.

Language: Английский

Citations

84
Structural and Metabolic Changes in Bone DOI Creative Commons
Agata Wawrzyniak, Krzysztof Balawender

Animals, Journal Year: 2022, Volume and Issue: 12(15), P. 1946 - 1946

Published: July 31, 2022

As an essential component of the skeleton, bone tissue provides solid support for body and protects vital organs. Bone is a reservoir calcium, phosphate, other ions that can be released or stored in controlled manner to provide constant concentration fluids. Normally, development osteogenesis occurs through two ossification processes (intra-articular intra-chondral), but first produces woven bone, which quickly replaced by stronger lamellar bone. Contrary commonly held misconceptions, relatively dynamic organ undergoes significant turnover compared organs body. metabolism process involves simultaneous formation resorption, numerous factors. comprises key actions. Skeletal mass, structure, quality are accrued maintained throughout life, anabolic catabolic actions mostly balanced due tight regulation activity osteoblasts osteoclasts. This also provided circulating hormones cytokines. remodeling regulated various biologically active substances secreted cells, namely RANK, RANKL, MMP-1, MMP-9, type 1 collagen. Bone-derived factors (BDF) influence function metabolism, pathophysiological conditions lead dysfunction. work aims analyze evaluate current literature on local systemic immune system interactions affect its impairments.

Language: Английский

Citations

74
Osteoporosis: Molecular Pathology, Diagnostics, and Therapeutics DOI Open Access
Babapelumi Adejuyigbe,

Julie Kallini,

Daniel Chiou

et al.

International Journal of Molecular Sciences, Journal Year: 2023, Volume and Issue: 24(19), P. 14583 - 14583

Published: Sept. 26, 2023

Osteoporosis is a major public health concern affecting millions of people worldwide and resulting in significant economic costs. The condition characterized by changes bone homeostasis, which lead to reduced mass, impaired quality, an increased risk fractures. pathophysiology osteoporosis complex multifactorial, involving imbalances hormones, cytokines, growth factors. Understanding the cellular molecular mechanisms underlying essential for appropriate diagnosis management condition. This paper provides comprehensive review normal followed in-depth discussion proposed through osteoimmunological, gut microbiome, senescence models. Furthermore, diagnostic tools used assess osteoporosis, including mineral density measurements, biochemical markers turnover, imaging modalities, are also discussed. Finally, both current pharmacological non-pharmacological treatment algorithms options exploration osteoporotic fragility fractures, highlighted. reveals need further research fully elucidate develop more effective therapeutic strategies.

Language: Английский

Citations

55
Age-related bone diseases: Role of inflammaging DOI

Jiaming Bi,

Caimei Zhang,

Caihong Lu

et al.

Journal of Autoimmunity, Journal Year: 2024, Volume and Issue: 143, P. 103169 - 103169

Published: Feb. 1, 2024

Language: Английский

Citations

27
Comparative analysis of vision transformers and convolutional neural networks in osteoporosis detection from X-ray images DOI Creative Commons

Ali Sarmadi,

Zahra Sadat Razavi,

André J. van Wijnen

et al.

Scientific Reports, Journal Year: 2024, Volume and Issue: 14(1)

Published: Aug. 3, 2024

Within the scope of this investigation, we carried out experiments to investigate potential Vision Transformer (ViT) in field medical image analysis. The diagnosis osteoporosis through inspection X-ray radio-images is a substantial classification problem that were able address with assistance models. In order provide basis for comparison, conducted parallel analysis which sought solve same by employing traditional convolutional neural networks (CNNs), are well-known and commonly used techniques solution categorization issues. findings our research led us conclude ViT capable achieving superior outcomes compared CNN. Furthermore, provided methods have access sufficient quantity training data, probability increases both arrive at more appropriate solutions critical

Language: Английский

Citations

20
Advanced applications of cellulose-based composites in fighting bone diseases DOI

Junping Deng,

Qun Song, Siyuan Liu

et al.

Composites Part B Engineering, Journal Year: 2022, Volume and Issue: 245, P. 110221 - 110221

Published: Aug. 16, 2022

Language: Английский

Citations

70
Cellular senescence in skeletal disease: mechanisms and treatment DOI Creative Commons
Xu He, Wei Hu, Yuanshu Zhang

et al.

Cellular & Molecular Biology Letters, Journal Year: 2023, Volume and Issue: 28(1)

Published: Oct. 27, 2023

Abstract The musculoskeletal system supports the movement of entire body and provides blood production while acting as an endocrine organ. With aging, balance bone homeostasis is disrupted, leading to loss degenerative diseases, such osteoporosis, osteoarthritis, intervertebral disc degeneration. Skeletal diseases have a profound impact on motor cognitive abilities elderly, thus creating major challenge for both global health economy. Cellular senescence caused by various genotoxic stressors results in permanent cell cycle arrest, which considered be underlying mechanism aging. During senescent cells (SnCs) tend aggregate trigger chronic inflammation releasing senescence-associated secretory phenotypic factors. Multiple signalling pathways are involved regulating cellular marrow microenvironments. Targeted SnCs alleviate age-related diseases. However, association between remains unclear. This review summarises fundamental role skeletal highlights that mediate senescence, discusses potential therapeutic strategies targeting SnCs. Graphical

Language: Английский

Citations

35
Brain-derived extracellular vesicles promote bone-fat imbalance in Alzheimer's disease DOI Creative Commons
Xixi Liu,

Chunyuan Chen,

Yaling Jiang

et al.

International Journal of Biological Sciences, Journal Year: 2023, Volume and Issue: 19(8), P. 2409 - 2427

Published: Jan. 1, 2023

Inadequate osteogenesis and excessive adipogenesis of bone marrow mesenchymal stem cells (BMSCs) are key factors in the pathogenesis osteoporosis.Patients with Alzheimer's disease (AD) have a higher incidence osteoporosis than healthy adults, but underlying mechanism is not clear.Here, we show that brain-derived extracellular vesicles (EVs) from adult AD or wild-type mice can cross blood-brain barrier to reach distal tissue, while only EVs (AD-B-EVs) significantly promote shift BMSC differentiation fate induce bone-fat imbalance.MiR-483-5p highly enriched AD-B-EVs, brain tissues mice, plasma-derived patients.This miRNA mediates anti-osteogenic, pro-adipogenic, pro-osteoporotic effects AD-B-EVs by inhibiting Igf2.This study identifies role B-EVs as promoter transferring miR-483-5p.

Language: Английский

Citations

23