Cell Death Discovery,
Journal Year:
2022,
Volume and Issue:
8(1)
Published: June 7, 2022
Abstract
As
a
molecular
marker
of
the
female
reproductive
system,
Paired
Box
8
is
widely
used
in
pathological
diagnosis
gynecological
tumors,
but
it
not
clear
whether
its
expression
level
related
to
development
uterine
corpus
endometrial
carcinoma
and
subtype
classifications.
Here,
we
show
that
PAX8
up-regulated
TP53
mutation
category
UCEC,
which
result
from
low
methylation
UCEC.
We
have
identified
genes
connected
ribosome,
lysosome,
ribosome
biogenesis
cell
cycle
as
targets
demonstrate
modulation
PAX8-DDX5
interaction
influences
c-MYC
growth.
Our
work
defines
DDX5
critical
co-factor,
places
biological
context,
highlights
key
point
for
novel
anti-MYC
therapies
-mutation
Toxics,
Journal Year:
2024,
Volume and Issue:
12(6), P. 388 - 388
Published: May 26, 2024
Cadmium
(Cd),
a
prevalent
environmental
contaminant,
exerts
widespread
toxic
effects
on
human
health
through
various
biochemical
and
molecular
mechanisms.
This
review
encapsulates
the
primary
pathways
which
Cd
inflicts
damage,
including
oxidative
stress
induction,
disruption
of
Ca2+
signaling,
interference
with
cellular
signaling
pathways,
epigenetic
modifications.
By
detailing
absorption,
distribution,
metabolism,
excretion
(ADME)
Cd,
alongside
its
interactions
components
such
as
mitochondria
DNA,
this
paper
highlights
extensive
damage
caused
by
Cd2+
at
tissue
levels.
The
role
in
inducing
stress—a
pivotal
mechanism
behind
toxicity—is
discussed
emphasis
how
it
disrupts
balance
between
oxidants
antioxidants,
leading
to
apoptosis.
Additionally,
covers
Cd’s
impact
like
Mitogen-Activated
Protein
Kinase
(MAPK),
Nuclear
Factor
kappa-light-chain-enhancer
activated
B
cells
(NF-κB),
Tumor
53
(p53)
illustrating
these
contributes
pathological
conditions
carcinogenesis.
DNA
methylation
histone
modifications,
are
also
explored
explain
long-term
gene
expression
disease
manifestation.
comprehensive
analysis
not
only
elucidates
mechanisms
toxicity
but
underscores
critical
need
for
enhanced
strategies
mitigate
public
implications.
International Journal of Molecular Sciences,
Journal Year:
2022,
Volume and Issue:
23(15), P. 8582 - 8582
Published: Aug. 2, 2022
Cardiovascular
disease
is
the
most
common
cause
of
death
among
diabetic
patients
worldwide.
Hence,
cardiovascular
wellbeing
in
requires
utmost
importance
management.
Recent
studies
have
demonstrated
that
protein
kinase
C
activation
plays
a
vital
role
development
complications
via
its
mitogen-activated
(MAPK)
cascades,
also
known
as
PKC-MAPK
pathways.
In
fact,
persistent
hyperglycaemia
conditions
contribute
to
preserved
PKC
mediated
by
excessive
production
diacylglycerol
(DAG)
and
oxidative
stress.
pathways
are
involved
several
cellular
responses,
including
enhancing
stress
activating
signalling
lead
uncontrolled
cardiac
vascular
remodelling
their
subsequent
dysfunction.
this
review,
we
discuss
recent
discovery
on
pathways,
mechanisms
progression
complications,
potential
therapeutic
targets
for
management
patients.
Frontiers in Cell and Developmental Biology,
Journal Year:
2023,
Volume and Issue:
11
Published: Feb. 17, 2023
The
cytoskeleton
comprises
three
polymerizing
structures
that
have
been
studied
for
a
long
time,
actin
microfilaments,
microtubules
and
intermediate
filaments,
plus
more
recently
investigated
dynamic
assemblies
like
septins
or
the
endocytic-sorting
complex
required
transport
(ESCRT)
complex.
These
filament-forming
proteins
control
several
cell
functions
through
crosstalks
with
each
other
membranes.
In
this
review,
we
report
recent
works
address
how
bind
to
membranes,
influence
their
shaping,
organization,
properties
functions,
either
by
binding
them
directly
indirectly
elements.
Journal of Clinical Investigation,
Journal Year:
2024,
Volume and Issue:
134(4)
Published: Jan. 9, 2024
Effective
immunity
requires
a
large,
diverse
naïve
T
cell
repertoire
circulating
among
lymphoid
organs
in
search
of
antigen.
Sphingosine
1-phosphate
(S1P)
and
its
receptor
S1PR1
contribute
by
both
directing
migration
supporting
survival.
Here,
we
addressed
how
S1P
enables
survival,
the
implications
for
patients
treated
with
antagonists.
We
found
that
limited
apoptosis
maintaining
appropriate
balance
BCL2
family
members
via
restraint
JNK
activity.
Interestingly,
same
residues
enable
internalization
were
required
to
prevent
this
pro-apoptotic
cascade.
Findings
mice
recapitulated
ulcerative
colitis
antagonist
ozanimod,
loss
cells
B
responses.
Our
findings
highlighted
an
effect
antagonists
on
ability
mount
immune
responses
within
lymph
nodes,
beyond
their
node
egress,
suggested
limitations
additional
uses
important
class
drugs.
Cancer Cell International,
Journal Year:
2025,
Volume and Issue:
25(1)
Published: Feb. 21, 2025
Glioma
is
the
most
common
primary
malignant
tumor
of
central
nervous
system
in
adults,
characterized
by
high
mortality,
low
cure
rate
and
recurrence
rate.
Among
gliomas,
glioblastoma
multiforme
(GBM)
subtype.
Currently,
standard
treatment
for
patients
with
GBM
maximum
surgical
excision
combined
radiotherapy
chemotherapy.
But
only
a
small
percentage
benefit
from
this
treatment.
The
microenvironment
plays
an
important
role
occurrence
development
tumors.
It
primarily
composed
cells,
peripheral
blood
vessels,
extracellular
matrix,
signaling
molecules,
stromal
immune
cells.
cells
has
emerged
as
focus
current
research.
interaction
among
tumor,
stromal,
within
can
influence
development.
Traditional
research
drug
therapy
glioma
mainly
on
themselves,
but
recent
studies
have
found
that
targeting
also
modulate
progression
GBM.
Here,
we
review
its
related
mechanism,
well
molecular
targets
pathways,
providing
new
ideas
prognosis
Cellular and Molecular Life Sciences,
Journal Year:
2022,
Volume and Issue:
79(2)
Published: Feb. 1, 2022
During
development
and
tissue
homeostasis,
cells
must
communicate
with
their
neighbors
to
ensure
coordinated
responses
instructional
cues.
Cues
such
as
morphogens
growth
factors
signal
at
both
short
long
ranges
in
temporal-
tissue-specific
manners
guide
cell
fate
determination,
provide
positional
information,
activate
survival
responses.
The
precise
mechanisms
by
which
signals
traverse
the
extracellular
environment
reliable
delivery
intended
cellular
targets
are
not
yet
clear.
One
model
for
how
this
occurs
suggests
that
specialized
filopodia
called
cytonemes
extend
between
signal-producing
-receiving
function
membrane-bound
highways
along
information
flows.
A
growing
body
of
evidence
supports
a
crucial
role
cell-to-cell
communication.
Despite
this,
molecular
initiated,
they
grow,
deliver
specific
only
starting
be
revealed.
Herein,
we
discuss
recent
advances
toward
improved
understanding
cytoneme
biology.
We
similarities
differences
other
types
extensions,
summarize
what
is
known
about
originate,
activity
may
controlled
homeostasis.
conclude
highlighting
important
open
questions
regarding
biology,
comment
on
clear
opportunities
treating
or
preventing
disease.
Life Sciences,
Journal Year:
2024,
Volume and Issue:
350, P. 122750 - 122750
Published: May 25, 2024
C-Jun-N-terminal-kinases
(JNKs),
members
of
the
mitogen-activated-protein-kinase
family,
are
significantly
linked
with
neurological
and
neurodegenerative
pathologies
cancer
progression.
However,
JNKs
serve
key
roles
under
physiological
conditions,
particularly
within
central-nervous-system
(CNS),
where
they
critical
in
governing
neural
proliferation
differentiation
during
both
embryogenesis
adult
stages.
These
processes
control
development
CNS,
avoiding
neurodevelopment
disorders.
JNK
to
maintain
proper
activity
neural-stem-cells
(NSC)
neural-progenitors
(NPC)
that
exist
adults,
which
keep
convenient
brain
plasticity
homeostasis.
This
review
underscores
how
interaction
upstream
downstream
molecules
acts
as
a
regulatory
mechanism
manage
self-renewal
capacity
NSC/NPC
CNS
neurogenic
niches.
Evidence
suggests
is
reliant
on
non-canonical
Wnt
components,
Fbw7-ubiquitin-ligase,
WDR62-scaffold-protein,
regulating
substrates
such
transcription
factors
cytoskeletal
proteins.
Therefore,
understanding
pathways
interact
will
bring
knowledge
activation
orchestrates
neuronal
occur
