Therapeutic trials for long COVID-19: A call to action from the interventions taskforce of the RECOVER initiative

Frontiers in Immunology, Journal Year: 2023, Volume and Issue: 14

Published: March 9, 2023

Although most individuals recover from acute SARS-CoV-2 infection, a significant number continue to suffer Post-Acute Sequelae of (PASC), including the unexplained symptoms that are frequently referred as long COVID, which could last for weeks, months, or even years after phase illness. The National Institutes Health is currently funding large multi-center research programs part its Researching COVID Enhance Recover (RECOVER) initiative understand why some do not fully COVID-19. Several ongoing pathobiology studies have provided clues potential mechanisms contributing this condition. These include persistence antigen and/or genetic material, immune dysregulation, reactivation other latent viral infections, microvascular dysfunction, and gut dysbiosis, among others. our understanding causes remains incomplete, these early pathophysiologic suggest biological pathways be targeted in therapeutic trials aim ameliorate symptoms. Repurposed medicines novel therapeutics deserve formal testing clinical trial settings prior adoption. While we endorse trials, especially those prioritize inclusion diverse populations affected by COVID-19 discourage off-label experimentation uncontrolled unsupervised settings. Here, review ongoing, planned, future interventions based on current pathobiological processes underlying We focus clinical, pharmacological, feasibility data, with goal informing interventional studies.

Language: Английский

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Higher vulnerability to poor circadian light hygiene in individuals with a history of COVID-19

Chronobiology International, Journal Year: 2025, Volume and Issue: unknown, P. 1 - 14

Published: Jan. 6, 2025

Seven-day actigraphy was performed within 1 month in 122 community-dwelling adults (mean age 24.40 y, 31 (25.4%) men) the same city of Tyumen, Russia. Groups with different COVID-19 status (present, COVID-19(+),

Language: Английский

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The potential role of ischaemia–reperfusion injury in chronic, relapsing diseases such as rheumatoid arthritis, Long COVID, and ME/CFS: evidence, mechanisms, and therapeutic implications

Biochemical Journal, Journal Year: 2022, Volume and Issue: 479(16), P. 1653 - 1708

Published: Aug. 31, 2022

Ischaemia-reperfusion (I-R) injury, initiated via bursts of reactive oxygen species produced during the reoxygenation phase following hypoxia, is well known in a variety acute circumstances. We argue here that I-R injury also underpins elements pathology chronic, inflammatory diseases, including rheumatoid arthritis, ME/CFS and, our chief focus and most proximally, Long COVID. Ischaemia may be fibrin amyloid microclot blockage capillaries, for instance as exercise started; reperfusion necessary corollary when it finishes. rehearse mechanistic evidence these occurrences here, terms their manifestation oxidative stress, hyperinflammation, mast cell activation, production marker metabolites related activities. Such microclot-based phenomena can explain both breathlessness/fatigue post-exertional malaise observed conditions, many other observables. The recognition processes implies, mechanistically, therapeutic benefit potentially to had from antioxidants, anti-inflammatories, iron chelators, suitable, safe fibrinolytics, and/or anti-clotting agents. review considerable existing consistent with this, biochemical mechanisms involved.

Language: Английский

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Melatonin and Related Compounds: Antioxidant and Anti-Inflammatory Actions

Antioxidants, Journal Year: 2022, Volume and Issue: 11(3), P. 532 - 532

Published: March 10, 2022

Melatonin, an indoleamine derived from tryptophan and produced in the pineal gland other tissues [...].

Language: Английский

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Melatonin: highlighting its use as a potential treatment for SARS-CoV-2 infection

Cellular and Molecular Life Sciences, Journal Year: 2022, Volume and Issue: 79(3)

Published: Feb. 20, 2022

Abstract Numerous pharmaceutical drugs have been repurposed for use as treatments COVID-19 disease. These not consistently demonstrated high efficacy in preventing or treating this serious condition and all side effects to differing degrees. We encourage the continued consideration of antioxidant anti-inflammatory agent, melatonin, a countermeasure SARS-CoV-2 infection. More than 140 scientific publications identified melatonin likely useful agent treat Moreover, cited provide rationale prophylactic against condition. Melatonin has pan-antiviral it diminishes severity viral infections reduces death animals infected with numerous different viruses, including three coronaviruses. Network analyses, which compared used humans, also predicted that would be most effective preventing/treating COVID-19. Finally, when seriously patients were treated either alone combination other medications, these reduced infection, lowered rate, shortened duration hospitalization. Melatonin’s ability arrest may reduce health care exhaustion by limiting need Importantly, safety profile over wide range doses lacks significant toxicity. Some molecular processes resists infection are summarized. The authors believe available, potentially beneficial drugs, lack toxicity should pandemics such caused SARS-CoV-2.

Language: Английский

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Precision nutrition to reset virus-induced human metabolic reprogramming and dysregulation (HMRD) in long-COVID

npj Science of Food, Journal Year: 2024, Volume and Issue: 8(1)

Published: March 30, 2024

Language: Английский

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Current landscape of long COVID clinical trials

International Immunopharmacology, Journal Year: 2024, Volume and Issue: 132, P. 111930 - 111930

Published: March 27, 2024

Language: Английский

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A mid‑pandemic night's dream: Melatonin, from harbinger of anti‑inflammation to mitochondrial savior in acute and long COVID‑19 (Review)

International Journal of Molecular Medicine, Journal Year: 2024, Volume and Issue: 53(3)

Published: Jan. 26, 2024

Coronavirus disease 2019 (COVID‑19), a systemic illness caused by severe acute respiratory distress syndrome 2 (SARS‑CoV‑2), has triggered worldwide pandemic with symptoms ranging from asymptomatic to chronic, affecting practically every organ. Melatonin, an ancient antioxidant found in all living organisms, been suggested as safe and effective therapeutic option for the treatment of SARS‑CoV‑2 infection due its good safety characteristics broad‑spectrum antiviral medication properties. Melatonin is essential various metabolic pathways governs physiological processes, such sleep‑wake cycle circadian rhythms. It exhibits oncostatic, anti‑inflammatory, anti‑aging properties, exhibiting promise use numerous disorders, including COVID‑19. The preventive effects melatonin have widely explored number conditions well‑established experimental ischemia/reperfusion investigations, particularly coronary heart stroke. Clinical research evaluating COVID‑19 shown improved outcomes, reduced hospitalization durations; however, trials are small. can alleviate mitochondrial dysfunction COVID‑19, improve immune cell function provide However, potential remains underexplored funding limitations thus further investigations required.

Language: Английский

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Melatonin as a master regulatory hormone for genetic responses to biotic and abiotic stresses in model plant Arabidopsis thaliana: a comprehensive review

Functional Plant Biology, Journal Year: 2024, Volume and Issue: 51(2)

Published: Feb. 4, 2024

Melatonin is a naturally occurring biologically active amine produced by plants, animals and microbes. This review explores the biosynthesis of melatonin in with particular focus on its diverse roles Arabidopsis thaliana , model species. affects abiotic biotic stress resistance A. . Exogenous endogenous addressed association various conditions, including cold stress, high light intense heat infection Botrytis cinerea or Pseudomonas as well seed germination lateral root formation. Furthermore, confers initiating antioxidant system, remedying photosynthesis suppression, regulating transcription factors involved (CBF, DREB, ZAT, CAMTA, WRKY33, MYC2, TGA) other stress-related hormones (abscisic acid, auxin, ethylene, jasmonic acid salicylic acid). article additionally addresses precursors, metabolic components, expression genes (COR CBF SNAT ASMT PIN PR1 PDF1.2 HSFA ) proteins (JAZ, NPR1) associated reducing both biological environmental stressors. future perspective rich agri-crops explored to enhance plant tolerance stresses, maximise crop productivity nutritional worth, which may help improve food security.

Language: Английский

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Association between parental control and depressive symptoms among college freshmen in China: The chain mediating role of chronotype and sleep quality

Journal of Affective Disorders, Journal Year: 2022, Volume and Issue: 317, P. 256 - 264

Published: Aug. 31, 2022

Language: Английский

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