Journal of Psychiatric Research, Journal Year: 2023, Volume and Issue: 161, P. 426 - 434
Published: April 4, 2023
Language: Английский
Signal Transduction and Targeted Therapy, Journal Year: 2023, Volume and Issue: 8(1)
Published: Dec. 6, 2023
Gut-liver-brain axis is a three-way highway of information interaction system among the gastrointestinal tract, liver, and nervous systems. In past few decades, breakthrough progress has been made in gut liver brain axis, mainly through understanding its formation mechanism increasing treatment strategies. this review, we discuss various complex networks including barrier permeability, hormones, microbial metabolites, vagus nerve, neurotransmitters, immunity, toxic β-amyloid (Aβ) metabolism, epigenetic regulation gut-liver-brain axis. Some therapies containing antibiotics, probiotics, prebiotics, synbiotics, fecal microbiota transplantation (FMT), polyphenols, low FODMAP diet nanotechnology application regulate Besides, some special treatments targeting gut-liver include farnesoid X receptor (FXR) agonists, takeda G protein-coupled 5 (TGR5) glucagon-like peptide-1 (GLP-1) antagonists fibroblast growth factor 19 (FGF19) analogs. Targeting gut-brain embraces cognitive behavioral therapy (CBT), antidepressants tryptophan metabolism-related therapies. liver-brain contains Aβ future, better interactions will promote development novel preventative strategies discovery precise therapeutic targets multiple diseases.
Language: Английский
Citations
86
Acta Diabetologica, Journal Year: 2023, Volume and Issue: 60(8), P. 1007 - 1017
Published: April 14, 2023
Abstract Aims The purpose of this review is to explore the interconnected pathways microbiota-gut-brain axis (MGBA), focusing on roles vagus nerve and glucagon like peptide-1 in appetite control, development obesity diabetes. Methods Type 2 diabetes mellitus (T2DM) are metabolic disorders whose prevalence has significantly increased recent decades expected increase every year, pandemic proportions. These two pathologies often coexist have substantial public health implications. term “diabesity” defines pathophysiological connection between overweight T2DM. gut microbiota affects many aspects host. Beyond regulation intestinal functions activation immune responses, plays a role central nervous system (i.e., mood, psychiatric conditions associated with stress memory) regulator metabolism appetite. Results MGBA involves such as autonomic enteric systems, hypothalamic– pituitary–adrenal axis, system, enteroendocrine cells, microbial metabolites. Notably, an essential eating behavior by modulating learning nutritional preferences. Conclusions Because its cell-mediated interaction microbiota, may provide potential pathway through which microorganisms influence host feeding control physiological pathological conditions.
Language: Английский
Citations
70
Biomedicine & Pharmacotherapy, Journal Year: 2022, Volume and Issue: 150, P. 113030 - 113030
Published: April 26, 2022
Depression is a common neuropsychiatric disorder characterized by persistent depressed mood and causes serious socioeconomic burden worldwide. Hyperactivity of the hypothalamic-pituitary-adrenal (HPA) axis, deficiency monoamine transmitters, neuroinflammation abnormalities gut flora are strongly associated with onset depression. The cyclic AMP (cAMP)/protein kinase A (PKA) cascade, major cross-species cellular signaling pathway, supposed as important player regulator depression controlling synaptic plasticity, cytokinesis, transcriptional regulation HPA axis. In central nervous system, cAMP-PKA cascade can dynamically shape neural circuits enhancing affect K+ channels phosphorylating Kir4.1, thereby regulating neuronal excitation. reduction affects excitation well ultimately leading to pathological outcome depression, while activation would provide rapid antidepressant effect. this review, we proposed reconsider function especially in Local or indirect PKA through adjusting anchor proteins new idea for acute treatment
Language: Английский
Citations
53
Nutrients, Journal Year: 2023, Volume and Issue: 15(6), P. 1496 - 1496
Published: March 20, 2023
There is growing interest in the role that intestinal microbiota and related autoimmune processes may have genesis presentation of some psychiatric diseases. An alteration communication microbiota-gut-brain axis, which constitutes a communicative model between central nervous system (CNS) gastro-enteric tract, has been identified as one possible causes The purpose this narrative review to describe evidence supporting gut diseases impact diet on mental health. Change composition could determine an increase permeability barrier, leading cytokine storm. This trigger systemic inflammatory activation immune response: series events repercussions release neurotransmitters, altering activity hypothalamic-pituitary-adrenal reducing presence trophic brain factors. Although disorders seem be connected, more effort needed understand potential causative mechanisms underlying interactions these systems.
Language: Английский
Citations
41
Molecules, Journal Year: 2023, Volume and Issue: 28(7), P. 3213 - 3213
Published: April 4, 2023
Depression is a common and complex mental emotional disorder that causes disability, morbidity, quite often mortality around the world. closely related to several physical metabolic conditions causing depression. Studies have indicated there relationship between intestinal microbiota brain, known as gut–brain axis. While this microbiota–gut–brain connection disturbed, dysfunctions of immune system, endocrine gastrointestinal tract occur. Numerous studies show dysbiosis characterized by abnormal dysfunction axis could be direct cause disorders. Traditional treatment depression includes psychotherapy pharmacotherapy, it mainly targets brain. However, restoration functions via using probiotics, their metabolites, prebiotics, healthy diet may alleviate depressive symptoms. Administration probiotics labeled psychobiotics metabolites metabiotics, especially an adjuvant antidepressants, improves It new approach prevention, management, illnesses, particularly major For effectiveness antidepressant therapy, should administered at dose higher than 1 billion CFU/day for least 8 weeks.
Language: Английский
Citations
31
Journal of Affective Disorders, Journal Year: 2023, Volume and Issue: 325, P. 141 - 150
Published: Jan. 5, 2023
Language: Английский
Citations
30
Frontiers in Cellular and Infection Microbiology, Journal Year: 2024, Volume and Issue: 14
Published: Feb. 16, 2024
Abnormal behavior of α-synuclein and prion proteins is the hallmark Parkinson’s disease (PD) illnesses, respectively, being complex neurological disorders. A primary cause protein aggregation, brain injury, cognitive loss in illnesses misfolding normal cellular (PrP C ) into an infectious form Sc ). Aggregation causes disruptions processes (PD), leading to dopamine-producing neurons motor symptoms. Alteration composition or activity gut microbes may weaken intestinal barrier make it possible for prions go from brain. The gut-brain axis linked neuroinflammation; metabolites produced by microbiota affect aggregation α-synuclein, regulate inflammation immunological responses, influence course neurotoxicity proteins, even if their targets are distinct proteins. This thorough analysis explores interactions that exist between neurodegenerative particularly involvement microbiota, a collection bacteria, archaea, fungi, viruses etc., various becoming increasingly recognized. microbiome influences neuroinflammation, neurotransmitter synthesis, mitochondrial function, integrity through axis, which contributes development progression disease. review delves molecular mechanisms underlie these relationships, emphasizing effects microbial such as bacterial lipopolysaccharides (LPS), short-chain fatty acids (SCFAs) regulating functioning. Additionally, looks at how environmental dietary decisions whether they could be risk factors illnesses. study concludes highlighting critical role plays It also provides promising direction future research treatment approaches. People afflicted difficult ailments find hope new preventive therapeutic approaches diseases better understood.
Language: Английский
Citations
15
Frontiers in Immunology, Journal Year: 2024, Volume and Issue: 14
Published: Jan. 26, 2024
The association between gut microbiota and central nervous system (CNS) development has garnered significant research attention in recent years. Evidence suggests bidirectional communication the CNS through brain-gut axis. As a long complex process, is highly susceptible to both endogenous exogenous factors. impacts by regulating neurogenesis, myelination, glial cell function, synaptic pruning, blood-brain barrier permeability, with implication various disorders. This review outlines relationship stages of (prenatal postnatal), emphasizing integral role microbes. Furthermore, explores implications neurodevelopmental disorders, such as autism spectrum disorder, Rett syndrome, Angelman offering insights into early detection, prompt intervention, innovative treatments.
Language: Английский
Citations
13
Brain Research Bulletin, Journal Year: 2024, Volume and Issue: 207, P. 110883 - 110883
Published: Jan. 18, 2024
The link between drug-induced dysbiosis and its influence on brain diseases through gut-residing bacteria their metabolites, named the microbiota-gut-brain axis (MGBA), remains largely unexplored. This review investigates effects of commonly prescribed drugs (metformin, statins, proton-pump-inhibitors, NSAIDs, anti-depressants) gut microbiota, comparing findings with altered bacterial populations in major (depression, multiple sclerosis, Parkinson's Alzheimer's). report aims to explore whether can development progression via MGBA. Central indicate that all explored induce dysbiosis. These patterns were associated disorders. varied across different taxa, possibly mediated by direct or metabolites. Each drug induced both positive negative changes abundance bacteria, indicating a counterbalancing effect. Moreover, above-mentioned exhibited similar effects, suggesting they may counteract enhance each other's when taken together comorbid patients. In conclusion, interplay species abundances have greater impact than individual strains. Future research is needed better understand implications for disease pathogenesis, potential develop more effective therapeutic options patients brain-related diseases.
Language: Английский
Citations
11
Microbiology Research, Journal Year: 2024, Volume and Issue: 15(2), P. 489 - 507
Published: April 5, 2024
The human gut has a rich and dynamic microbial population that plays an important role in many physiological activities. This review explores the complex interaction between microbiota health, with emphasis on its effect neurodegenerative illnesses. makeup of microbiome impact brain function through gut–brain axis is highlighted. Dysbiosis, characterized by changes microbiota’s composition, been linked to development diseases such as Alzheimer’s, Parkinson’s, Huntington’s, amyotrophic lateral sclerosis. A Bidirectional communication stomach takes place via variety channels, including neurotransmitters metabolites generated bacteria. We investigate processes which dysbiosis causes neuroinflammation, oxidative stress, neuronal damage, drive disease development. Potential therapeutic approaches focus microbiota, antibiotics, probiotics, prebiotics, fecal transplantation, are reviewed, promising preclinical clinical findings. Overall, this study emphasizes relevance illnesses, well need understand target gut-brain for future treatment options.
Language: Английский
Citations
10